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Omar Nadeem 1,2,3,10, David M. Cordas dos Santos 1,2,10, Sarah Nikiforow2, Anna Bosch-Vilaseca2, Elizabeth O’Donnell1,2, Robert Redd4, Kevin C. DeBraganca5, Adam S. Sperling 2,6, Yuxin Liu1,2, Caleb McEntire6, Frances Arters1,2, Colin O’Donnell3, Brendan Kineavy3, Marjorie Marto1,2, Amy Bergeron1,2, Emilie Swenson3, Kristin McHugh3, Abigail Caron3, Quentin Berry3, Hope Wei 3, Emily Durlacher 3, Elizabeth Grimm3, Francesco Corrado1,2, Nayda Bidikian1,2, Rocio Montes de Oca7, Tamar Lengil8, Denise De Wiest8, Casey Gervais2, Kevin Panaro 2, Eric L. Smith 2, Kenneth Anderson 2, Caron Jacobson2, Nikhil C. Munshi 2, Paul Richardson2, Deepu Madduri8, Jordan M. Schecter8, Craig Tendler8, Mark A. Wildgust8, Lorenzo Trippa4, Maria Victoria Mateos 9, Jerome Ritz 2 & Irene M. Ghobrial 1,2 1Center for Early Detection and Interception of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA, USA. 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 3Immune Effector Cell Therapy Program, Dana-Farber Cancer Institute, Boston, MA, USA. 4Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. 5Janssen Research & Development, Raritan, NJ, USA. 6Brigham and Women’s Hospital, Boston, MA, USA. 7Johnson & Johnson, Spring House, PA, USA. 8Johnson & Johnson, Raritan, NJ, USA. 9Instituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, Spain. 10These authors contributed equally: Omar Nadeem, David M. Cordas dos Santos.

Francesca Gay  1 , Wilfried Roeloffzen  2 , Meletios A. Dimopoulos  3,4, Laura Rosiñol  5 , Marjolein van der Klift6 , Roberto Mina  1 , Albert Oriol  7 , Eirini Katodritou8 , Ka Lung Wu9 , Paula Rodríguez Otero10, Roman Hájek11,12, Elisabetta Antonioli13, Mark van Duin14, Mattia D’Agostino1 , Joaquín Martínez-López  15, Elena M. van Leeuwen-Segarceanu16, Elena Zamagni17,18, Niels W. C. J. van de Donk  19, Katja C. Weisel  20, Luděk Pour21, Jakub Radocha22, Angelo Belotti23, Fredrik Schjesvold  24,25, Joan Bladé  4 , Hermann Einsele  26, Pieter Sonneveld  14,27, Mario Boccadoro28 & Annemiek Broijl14 1 Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy. 2 Department of Hematology, University Medical Center Groningen, Groningen, the Netherlands. 3 Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece. 4 Department of Medicine, Korea University, Seoul, South Korea. 5 Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS, and PETHEMA/GEM, Barcelona, Spain. 6 Department of Internal Medicine, Amphia Hospital, Breda, the Netherlands. 7 Institut Català d’Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona, Spain. 8 Department of Hematology, Theagenion Cancer Hospital, Thessaloniki, Greece. 9 ZAS Cadix, Antwerp, Belgium. 10Cancer Center Clínica Universidad de Navarra, Pamplona, Spain. 11Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic. 12Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic. 13Hematology Unit, AOU Careggi, Florence, Italy. 14Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. 15Hematology Department, Hospital Universitario de Octubre, Medicine Department Complutense University, imas12, CNIO, Madrid, Spain. 16Department of Hematology, St. Antonius Hospital, Nieuwegein, the Netherlands. 17IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia ‘Seràgnoli’, Bologna, Italy. 18Department of Medical and Surgical Sciences, Bologna University School of Medicine, Bologna, Italy. 19Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, the Netherlands. 20Department of Oncology, Hematology and BMT, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany. 21Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic. 224th Department of Internal Medicine-Hematology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic. 23Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy. 24Oslo Myeloma Center, Department of Hematology, Oslo University Hospital, Oslo, Norway. 25KG Jebsen Center for B cell malignancies, University of Oslo, Oslo, Norway. 26Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany. 27European Myeloma Network (EMN), Rotterdam, the Netherlands. 28European Myeloma Network (EMN), Turin, Italy