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Ottavia M Delmonte 1, Cihan Oguz 2, Kerry Dobbs 3, Katherine Myint-Hpu 3, Boaz Palterer 3, Michael S Abers 3, Deborah Draper 3, Meng Truong 3, Ian M Kaplan 4, Rachel M Gittelman 4, Yu Zhang 3, Lindsey B Rosen 3, Andrew L Snow 5, Clifton L Dalgard 6, Peter D Burbelo 7, Luisa Imberti 8, Alessandra Sottini 8, Eugenia Quiros-Roldan 9, Francesco Castelli 9, Camillo Rossi 10, Duilio Brugnoni 11, Andrea Biondi 12, Laura Rachele Bettini 12, Mariella D'Angio' 12, Paolo Bonfanti 13, Megan V Anderson 14, Annalisa Saracino 15, Maria Chironna 16, Mariantonietta Di Stefano 17, Jose Ramon Fiore 17, Teresa Santantonio 17, Riccardo Castagnoli 18, Gian Luigi Marseglia 18, Mary Magliocco 19, Marita Bosticardo 3, Francesca Pala 3, Elana Shaw 3, Helen Matthews 19, Sarah E Weber 19, Sandhya Xirasagar 20, Jason Barnett 20, Andrew J Oler 20, Dimana Dimitrova 21, Jenna R E Bergerson 3, David H McDermott 22, V Koneti Rao 3, Philip M Murphy 22, Steven M Holland 3, Andrea Lisco 14, Helen C Su 3, Michail S Lionakis 3, Jeffrey I Cohen 23, Alexandra F Freeman 3, Thomas M Snyder 4, Justin Lack 2, Luigi D Notarangelo 24; 1 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ottavia.delmonte@nih.gov. 2 Integrated Data Sciences Section, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 3 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 4 Adaptive Biotechnologies, Seattle, WA 98109, USA. 5 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20892, USA. 6 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20815, USA. 7 Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. 8 Section of Microbiology, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. 9 Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy. 10 Direzione Sanitaria, ASST Spedali Civili di Brescia, Italy. 11 Laboratorio Analisi Chimico-Cliniche, ASST Spedali Civili, Brescia, Italy. 12 Pediatric Department and Centro Tettamanti-European Reference Network on Paediatric Cancer, European Reference Network on Haematological Diseases, and European Reference Network on Hereditary Metabolic Disorders-University of Milano-Bicocca-Fondazione MBBM, Monza, Italy. 13 Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. 14 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 15 Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari, Bari, Italy. 16 Hygiene Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy. 17 Department of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, Foggia, Italy. 18 Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 19 Molecular Development of the Immune System Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA. 20 Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 21 Center for Immuno-Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. 22 Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 23 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious diseases, National Institutes of Health, Bethesda, MD 20892, USA. 24 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: luigi.notarangelo2@nih.gov.