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Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Caushi JX, et al.
Nature
July 2021
Justina X Caushi #,1,2,3, Jiajia Zhang #,1,2,3, Zhicheng Ji 4,5, Ajay Vaghasia 3, Boyang Zhang 4, Emily Han-Chung Hsiue 3,6,7, Brian J Mog 3,6,7, Wenpin Hou 4, Sune Justesen 8, Richard Blosser 1,3, Ada Tam 1,3, Valsamo Anagnostou 1,3, Tricia R Cottrell 1,2,3,9, Haidan Guo 1,2,3, Hok Yee Chan 1,2,3, Dipika Singh 1,2,3, Sampriti Thapa 1,2,3, Arbor G Dykema 1,2,3, Poromendro Burman 1,2,3, Begum Choudhury 1,2,3, Luis Aparicio 1,2,3, Laurene S Cheung 1,2,3, Mara Lanis 1,3, Zineb Belcaid 1,3, Margueritta El Asmar 1,3, Peter B Illei 3, Rulin Wang 3, Jennifer Meyers 3, Kornel Schuebel 3, Anuj Gupta 3, Alyza Skaist 3, Sarah Wheelan 3, Jarushka Naidoo 1,3,10, Kristen A Marrone 1,3, Malcolm Brock 3, Jinny Ha 3, Errol L Bush 3, Bernard J Park 11, Matthew Bott 11, David R Jones 11, Joshua E Reuss 3,12, Victor E Velculescu 1,3, Jamie E Chaft 11, Kenneth W Kinzler 3,6,7, Shibin Zhou 3,6,7, Bert Vogelstein 3,6,7, Janis M Taube 1,2,3, Matthew D Hellmann 11, Julie R Brahmer 1,3, Taha Merghoub 11,13,14, Patrick M Forde 1,3, Srinivasan Yegnasubramanian 15,16,17, Hongkai Ji 18, Drew M Pardoll 19,20,21, Kellie N Smith 22,23,24; 1 Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD, USA. 2 The Mark Center for Advanced Genomics and Imaging at Johns Hopkins, Baltimore, MD, USA. 3 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA. 4 Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. 5 Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA. 6 Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD, USA. 7 Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA. 8 Immunitrack, Copenhagen, Denmark. 9 Ontario Institute for Cancer Research, Queens University, Kingston, Ontario, Canada. 10 Beaumont Hospital Dublin, RCSI University of Medicine and Health Science, Dublin, Ireland. 11 Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA. 12 Georgetown Lombardi Comprehensive Cancer Center at Georgetown University, Washington, DC, USA. 13 The Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, NY, USA. 14 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 15 Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD, USA. syegnasu@jhmi.edu. 16 The Mark Center for Advanced Genomics and Imaging at Johns Hopkins, Baltimore, MD, USA. syegnasu@jhmi.edu. 17 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA. syegnasu@jhmi.edu. 18 Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. hji@jhu.edu. 19 Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD, USA. dpardol1@jhmi.edu. 20 The Mark Center for Advanced Genomics and Imaging at Johns Hopkins, Baltimore, MD, USA. dpardol1@jhmi.edu. 21 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA. dpardol1@jhmi.edu. 22 Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD, USA. kellie@jhmi.edu. 23 The Mark Center for Advanced Genomics and Imaging at Johns Hopkins, Baltimore, MD, USA. kellie@jhmi.edu. 24 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA. kellie@jhmi.edu. # Contributed equally.

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Andrews MC, et al.
Nature Medicine
July 2021
Miles C Andrews # 1 2 3, Connie P M Duong # 4 5 6, Vancheswaran Gopalakrishnan # 1, Valerio Iebba # 4 5, Wei-Shen Chen # 7 8, Lisa Derosa # 4 5 6, Md Abdul Wadud Khan 1, Alexandria P Cogdill 4 5 6 7, Michael G White 1, Matthew C Wong 7, Gladys Ferrere 4 5 6, Aurélie Fluckiger 4 5 6, Maria P Roberti 4 5 6, Paule Opolon 4, Maryam Tidjani Alou 4 5 6, Satoru Yonekura 4 5 6, Whijae Roh 7, Christine N Spencer 9, Irina Fernandez Curbelo 10, Luis Vence 10, Alexandre Reuben 11, Sarah Johnson 1, Reetakshi Arora 1, Golnaz Morad 1, Matthew Lastrapes 12, Erez N Baruch 7, Latasha Little 7, Curtis Gumbs 7, Zachary A Cooper 13, Peter A Prieto 14, Khalida Wani 15, Alexander J Lazar 7 15, Michael T Tetzlaff 15, Courtney W Hudgens 15, Margaret K Callahan 9 16, Matthew Adamow 16 17, Michael A Postow 16 17, Charlotte E Ariyan 18, Pierre-Olivier Gaudreau 1, Luigi Nezi 19, Didier Raoult 20, Catalin Mihalcioiu 21, Arielle Elkrief 22, Rossanna C Pezo 23, Lauren E Haydu 1, Julie M Simon 1, Hussein A Tawbi 24, Jennifer McQuade 24, Patrick Hwu 24, Wen-Jen Hwu 24, Rodabe N Amaria 24, Elizabeth M Burton 1, Scott E Woodman 7 24, Stephanie Watowich 10, Adi Diab 24, Sapna P Patel 24, Isabella C Glitza 24, Michael K Wong 24, Li Zhao 7, Jianhua Zhang 7, Nadim J Ajami 7, Joseph Petrosino 25, Robert R Jenq 7, Michael A Davies 24, Jeffrey E Gershenwald 1, P Andrew Futreal 7, Padmanee Sharma 10, James P Allison 10, Bertrand Routy 4 5 6, Laurence Zitvogel 26 27 28, Jennifer A Wargo 29 30; 1 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 2 Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia. 3 Deparment of Medicine, Monash University, Melbourne, Victoria, Australia. 4 Gustave Roussy Cancer Campus (GRCC), Villejuif, France. 5 Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France. 6 Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France. 7 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 8 Department of Dermatology, University of South Florida Morsani College of Medicine, Tampa, FL, USA. 9 Department of Informatics, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. 10 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 11 Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 12 MD Anderson Cancer Center University of Texas Health Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA. 13 AstraZeneca, Gaithersburg, MD, USA. 14 Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA. 15 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 16 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 17 Division of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 18 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 19 Istituto Europeo di Oncologia, Milan, Italy. 20 Aix-Marseille Université, MEPHI, IRD, IHU Méditerranée Infection, Marseille, France. 21 Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Quebec, Canada. 22 Cedars Cancer Center, McGill University Health Centre, Montreal, Quebec, Canada. 23 Division of Medical Oncology, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada. 24 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 25 Department of Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. 26 Gustave Roussy Cancer Campus (GRCC), Villejuif, France. laurence.zitvogel@gustaveroussy.fr. 27 Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France. laurence.zitvogel@gustaveroussy.fr. 28 Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France. laurence.zitvogel@gustaveroussy.fr. 29 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org. 30 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org. # Contributed equally.

Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma

Leko V, et al.
Journal for ImmunoTherapy of Cancer
July 2021
Vid Leko 1, Gal Cafri 2, Rami Yossef 3, Biman Paria 4, Victoria Hill 3, Devikala Gurusamy 3, Zhili Zheng 3, Jared J Gartner 3, Todd D Prickett 3, Stephanie L Goff 3, Paul Robbins 3, Yong-Chen Lu 3, Steven A Rosenberg 3; 1 Surgery Branch, National Cancer Institute, Bethesda, Maryland, USA vid.leko@nih.gov. 2 Sheba Medical Center, Ramat Gan, Israel. 3 Surgery Branch, National Cancer Institute, Bethesda, Maryland, USA. 4 Program Coordination and Referral Branch, National Cancer Institute, Bethesda, Maryland, USA.

Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation

Pagliuca S, et al.
JCI Insight
July 2021
Simona Pagliuca 1,2, Carmelo Gurnari 1,3, Sanghee Hong 4, Ran Zhao 5, Sunisa Kongkiatkamon 1, Laila Terkawi 1, Misam Zawit 1, Yihong Guan 1, Hassan Awada 1, Ashwin Kishtagari 1, Cassandra M Kerr 1, Thomas LaFramboise 6, Bhumika J Patel 7, Babal K Jha 1, Hetty E Carraway 4, Valeria Visconte 1, Navneet S Majhail 4, Betty K Hamilton 4, Jaroslaw P Maciejewski 1; 1 Translational Hematology and Oncology Research Program, Department of Hematology and Oncology, Cleveland Clinic, Cleveland, Ohio, USA. 2 University of Paris, Paris, France. 3 Department of Biomedicine and Prevention, School of Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy. 4 Blood and Marrow Transplant Program, Department of Hematology and Oncology and. 5 Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA. 6 Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. 7 Leukemia and Myeloid Disorders Program, Department of Hematology and Oncology, Cleveland Clinic, Cleveland, Ohio, USA.

Deep learning identifies antigenic determinants of severe SARS-CoV-2 infection within T-cell repertoires

Sidhom JW and Baras AS
Scientific Reports
July 2021
John-William Sidhom 1,2,3, Alexander S Baras 4,5,6; 1 Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jsidhom1@jhmi.edu. 2 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jsidhom1@jhmi.edu. 3 Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jsidhom1@jhmi.edu. 4 Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. 5 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. 6 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Evaluating T-cell cross-reactivity between tumors and immune-related adverse events with TCR sequencing: pitfalls in interpretations of functional relevance

Cottrell T, et al.
July 2021
Tricia Cottrell #,1,2,3, Jiajia Zhang #,2,4,5, Boyang Zhang 6, Genevieve J Kaunitz 7, Poromendro Burman 2,4,5, Hok-Yee Chan 2,4,5, Franco Verde 8, Jody E Hooper 1, Hans Hammers 4,9, Mohamad E Allaf 2,4, Hongkai Ji 6, Janis Taube 1,2,4,10, Kellie N Smith 11,4,5,10; 1 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 2 Bloomberg~Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA. 3 Queen’s Cancer Research Institute at Queens University, Kingston, Ontario, Canada. 4 Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA. 5 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA. 7 Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 8 Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA. 9 Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, USA. 10 The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA. 11 Bloomberg~Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA ksmit228@jhmi.edu. # Contributed equally.

Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy

Béziat V, et al.
Cell
July 2021
Vivien Béziat 1, Franck Rapaport 2, Jiafen Hu 3, Matthias Titeux 4, Mathilde Bonnet des Claustres 4, Mathieu Bourgey 5, Heather Griffin 6, Élise Bandet 4, Cindy S Ma 7, Roya Sherkat 8, Hassan Rokni-Zadeh 9, David M Louis 10, Majid Changi-Ashtiani 11, Ottavia M Delmonte 12, Toshiaki Fukushima 13, Tanwir Habib 14, Andrea Guennoun 14, Taushif Khan 14, Noemi Bender 15, Mahbuba Rahman 14, Frédégonde About 4, Rui Yang 2, Geetha Rao 7, Claire Rouzaud 16, Jingwei Li 3, Debra Shearer 3, Karla Balogh 3, Fatima Al Ali 14, Manar Ata 14, Soroosh Dabiri 17, Mana Momenilandi 18, Justine Nammour 4, Marie-Alexandra Alyanakian 19, Marianne Leruez-Ville 19, David Guenat 20, Marie Materna 4, Léa Marcot 4, Natasha Vladikine 4, Christine Soret 20, Hassan Vahidnezhad 21, Leila Youssefian 21, Amir Hossein Saeidian 21, Jouni Uitto 21, Émilie Catherinot 22, Shadi Sadat Navabi 23, Mohammed Zarhrate 4, David T Woodley 24, Mohamed Jeljeli 25, Thomas Abraham 3, Serkan Belkaya 2, Lazaro Lorenzo 4, Jérémie Rosain 16, Mousa Bayat 17, Fanny Lanternier 16, Olivier Lortholary 16, Faramarz Zakavi 26, Philippe Gros 27, Gérard Orth 28, Laurent Abel 29, Jean-Luc Prétet 20, Sylvie Fraitag 19, Emmanuelle Jouanguy 29, Mark M Davis 30, Stuart G Tangye 7, Luigi D Notarangelo 12, Nico Marr 14, Tim Waterboer 15, David Langlais 27, John Doorbar 6, Alain Hovnanian 16, Neil Christensen 3, Xavier Bossuyt 18, Mohammad Shahrooei 31, Jean-Laurent Casanova 32; 1 University of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; The Rockefeller University, New York, NY 10065, USA. Electronic address: vivien.beziat@inserm.fr. 2 The Rockefeller University, New York, NY 10065, USA. 3 Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. 4 University of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France. 5 McGill University, Montreal, QC H3A 0G1, Canada. 6 University of Cambridge, Cambridge CB2 1QP, UK. 7 Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent’s Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia. 8 Isfahan University of Medical Sciences, AIRC, Isfahan 81746-73461, Iran. 9 Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran. 10 Stanford University Medical School, Stanford, CA 94305, USA. 11 Institute for Research in Fundamental Sciences (IPM), Tehran 19395-5746, Iran. 12 National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. 13 Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8501, Japan. 14 Sidra Medicine, Doha, Qatar. 15 German Cancer Research Center, 69120 Heidelberg, Germany. 16 University of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; Necker Hospital for Sick Children, AP-HP, 75015 Paris, France. 17 Zahedan University of Medical Sciences, 054 Zahedan, Iran. 18 University of Leuven, 3000 Leuven, Belgium. 19 Necker Hospital for Sick Children, AP-HP, 75015 Paris, France. 20 Papillomavirus National Reference Center, Besançon Hospital, 25030 Besançon, France. 21 Thomas Jefferson University, Philadelphia, PA 19107, USA. 22 Foch Hospital, 92150 Suresnes, France. 23 Dr. Shahrooei Lab, Ahvaz, Iran. 24 University of Southern California, Los Angeles, CA 90033, USA. 25 Cochin University Hospital, AP-HP, 75014 Paris, France. 26 Ahvaz Jundishapur University of Medical Sciences, 061 Ahvaz, Iran. 27 McGill University, Montreal, QC H3A 0G1, Canada; McGill Research Centre on Complex Traits, Montreal, QC H3G 0B1, Canada. 28 Pasteur Institute, 75015 Paris, France. 29 University of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; The Rockefeller University, New York, NY 10065, USA. 30 HHMI, Stanford University Medical School, Stanford, CA 94305, USA. 31 University of Leuven, 3000 Leuven, Belgium; Dr. Shahrooei Lab, Ahvaz, Iran. 32 University of Paris, Imagine Institute, INSERM U1163, 75015 Paris, France; The Rockefeller University, New York, NY 10065, USA; HHMI, New York, NY 10065, USA. Electronic address: casanova@rockefeller.edu.

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

Ogishi M, et al.
July 2021
Masato Ogishi 1,2, Rui Yang 3, Caner Aytekin 4, David Langlais 5, Mathieu Bourgey 6, Taushif Khan 7, Fatima Al Ali 7, Mahbuba Rahman 7, Ottavia M Delmonte 8, Maya Chrabieh 9,10, Peng Zhang 3, Conor Gruber 11,12,13,14, Simon J Pelham 3, András N Spaan 3, Jérémie Rosain 9,10, Wei-Te Lei 3, Scott Drutman 3, Matthew D Hellmann 15,16, Margaret K Callahan 15,16, Matthew Adamow 17,18, Phillip Wong 17, Jedd D Wolchok 15,16,18,19, Geetha Rao 20, Cindy S Ma 20,21, Yuka Nakajima 22, Tomonori Yaguchi 22, Kenji Chamoto 22, Samuel C Williams 23,24, Jean-Francois Emile 25, Flore Rozenberg 26, Michael S Glickman 27, Franck Rapaport 3, Gaspard Kerner 9,10, Garrett Allington 28,29,30, Ilhan Tezcan 31, Deniz Cagdas 31, Ferda O Hosnut 32, Figen Dogu 33, Aydan Ikinciogullari 33, V Koneti Rao 34, Leena Kainulainen 35, Vivien Béziat 3,9,10, Jacinta Bustamante 3,9,10,36, Silvia Vilarinho #,28,29,30, Richard P Lifton #,28,37, Bertrand Boisson #,3,9,10, Laurent Abel #,3,9,10, Dusan Bogunovic #,11,12,13,14, Nico Marr #,7,38, Luigi D Notarangelo #,8, Stuart G Tangye #,20,21, Tasuku Honjo #,22, Philippe Gros #,39,40, Stéphanie Boisson-Dupuis #,41,42,43, Jean-Laurent Casanova #,44,45,46,47; 1 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. mogishi@rockefeller.edu. 2 The David Rockefeller Graduate Program, Rockefeller University, New York, NY, USA. 3 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. 4 Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey. 5 Department of Human Genetics, McGill University, Montreal, Quebec, Canada. 6 McGill University Genome Center, Montreal, Quebec, Canada. 7 Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. 8 Immune Deficiency Genetics Section, Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 9 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France. 10 University of Paris, Imagine Institute, Paris, France. 11 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 12 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 13 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 14 Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 15 Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 16 Weill Cornell Medicine, New York, NY, USA. 17 Immune Monitoring Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 18 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. 19 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 20 Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. 21 St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia. 22 Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. 23 Laboratory of Investigative Dermatology, Rockefeller University, New York, NY, USA. 24 Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA. 25 Department of Pathology, Assistance Publique-Hôpitaux de Paris, Ambroise Paré Hospital, Boulogne-Billancourt, France. 26 Department of Virology, Cochin Hospital, University of Paris, Paris, France. 27 Immunology Program, Sloan Kettering Institute, New York, NY, USA. 28 Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. 29 Section of Digestive Diseases, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. 30 Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. 31 Department of Pediatric Immunology, Hacettepe University Medical Faculty, Ankara, Turkey. 32 Department of Pediatric Gastroenterology, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey. 33 Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey. 34 Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 35 Department of Pediatrics and Department of Medicine, Turku University Hospital, Turku, Finland. 36 Study Center of Immunodeficiencies, Necker Hospital for Sick Children, Paris, France. 37 Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA. 38 College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. 39 McGill Research Centre on Complex Traits, Montreal, Quebec, Canada. 40 Department of Biochemistry, McGill University, Montreal, Quebec, Canada. 41 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. stbo603@rockefeller.edu. 42 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France. stbo603@rockefeller.edu. 43 University of Paris, Imagine Institute, Paris, France. stbo603@rockefeller.edu. 44 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. casanova@rockefeller.edu. 45 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France. casanova@rockefeller.edu. 46 University of Paris, Imagine Institute, Paris, France. casanova@rockefeller.edu. 47 Howard Hughes Medical Institute, New York, NY, USA. casanova@rockefeller.edu. # Contributed equally.

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

Roper N, et al.
Nature Communications
July 2021
Nitin Roper 1, Moises J Velez 2, Alberto Chiappori 3, Yoo Sun Kim 1, Jun S Wei 4, Sivasish Sindiri 4, Nobuyuki Takahashi 1, Deborah Mulford 2, Suresh Kumar 1, Kris Ylaya 5, Christopher Trindade 5, Irena Manukyan 5, Anna-Leigh Brown 6, Jane B Trepel 1, Jung-Min Lee 7, Stephen Hewitt 5, Javed Khan 4, Anish Thomas 8; 1 Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA. 2 Department of Pathology and Internal Medicine, University of Rochester, Rochester, NY, USA. 3 Moffitt Cancer Center, Tampa, FL, USA. 4 Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA. 5 Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA. 6 National Center for Biotechnology Information, NIH, NLM, Bethesda, MD, USA. 7 Women’s Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA. 8 Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA

Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells

Schiferle EB, et al.
Science Advances
July 2021
Erik B Schiferle 1, Se Yun Cheon 1, Seokjin Ham 2, Heehwa G Son 1, Jonathan L Messerschmidt 1, Donald P Lawrence 3, Justine V Cohen 3, Keith T Flaherty 3, James J Moon 4, Christine G Lian 5, Ryan J Sullivan 3, Shadmehr Demehri 6; 1 Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology, Center for Cancer Research, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. 2 Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon, South Korea. 3 Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. 4 Center for Immunology and Inflammatory Diseases and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. 5 Program in Dermatopathology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA. 6 Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology, Center for Cancer Research, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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