Adaptive and Collaborators to Present More than 30 Abstracts at 2023 ASH Annual Meeting

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Complete loss of TP53 and RB1 is associated with complex genome and low immune infiltrate in pleomorphic rhabdomyosarcoma

Beird H et al.
HGG Advances
February 2024
Authors and Affiliates
Hannah C. Beird; Chia-Chin Wu; Michael Nakazawa; Davis Ingram; Joseph R. Daniele; Rossana Lazcano; Latasha Little; Christopher Davies; Najat C. Daw; Khalida Wani; Wei-Lien Wang; Xingzhi Song; Curtis Gumbs; Jianhua Zhang; Brian Rubin; Anthony Conley; Adrienne M. Flanagan; Alexander J. Lazar and P. Andrew Futreal.

Antigen-presenting B cells promote TCF-1+ PD1-stem-like CD8+ T-cell proliferation in glioblastoma

Hou D et al.
Frontiers in Immunology
February 2024
Authors and Affiliates
David Hou; Hanxiao Wan; Joshua L. Katz; Si Wang; Brandyn A. Castro; Gustavo I. Vazquez-Cervantes; Victor A. Arrieta; Silpol Dhiantravan; Hinda Najem; Aida Rashidi; Tzu-yi Chia; Tarlan Arjmandi; Jimena Collado; Leah Billingham; Aurora Lopez-Rosas; Yu Han; Adam M. Sonabend; Amy B. Heimberger; Peng Zhang; Jason Miska and Catalina Lee-Chang.

Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation

Huuhtanen, J et al.
Nature
February 2024
Authors and Affiliates
Jani Huuhtanen; Shady Adnan-Awad; Jason Theodoropoulos; Sofia Forstén; Rebecca Warfvinge; Olli Dufva; Jonas Bouhlal; Parashar Dhapola; Hanna Duàn; Essi Laajala; Tiina Kasanen; Jay Klievink; Mette Ilander; Taina Jaatinen; Ulla Olsson-Strömberg; Henrik Hjorth-Hansen; Andreas Burchert; Göran Karlsson; Anna Kreutzman; Harri Lähdesmäki and Satu Mustjoki.

Daratumumab in Myeloma Patients With Early or Late Relapse After Initial Therapy: Subgroup Analysis of CASTOR and POLLUX.

Spencer A, et al.
Blood Advances
January 2024
Authors and Affiliates
Andrew Spencer, Philippe Moreau, M V Mateos, Hartmut Goldschmidt, Kenshi Suzuki, Mark-David Levin, Pieter Sonneveld, Robert Z Orlowski, Sung-Soo Yoon, Saad Z Usmani, Katja C Weisel, Donna Reece, Tahamtan Ahmadi, Huiling Pei, Wendy Garvin Mayo, Xue Gai, Jodi Carey, J Blake Bartlett, Robin Carson, Meletios-Athanasios A Dimopoulos

Locus folding mechanisms determine modes of antigen receptor gene assembly

Allyn BM, et al.
Journal of Experimental Medicine
January 2024
Authors and Affiliates
Brittney M Allyn 1,2, Katharina E Hayer 2,3,4, Clement Oyeniran 5, Vincent Nganga 5, Kyutae Lee 2, Bikash Mishra 5, Ahmet Sacan 3, Eugene M Oltz 5, Craig H Bassing 1,2; 1 Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA. 2 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3 Biomedical Engineering Doctoral Degree Program, School of Biomedical Engineering, Science and Health Systems, Drexel University , Philadelphia, PA, USA. 4 Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA, USA. 5 Department of Microbial Infection and Immunity, Ohio State College of Medicine, Ohio State University, Columbus, OH, USA.

Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals

Delmonte OM, et al.
Journal of Allergy and Clinical Immunology
January 2024
Authors and Affiliates
Ottavia M Delmonte 1, Cihan Oguz 2, Kerry Dobbs 3, Katherine Myint-Hpu 3, Boaz Palterer 3, Michael S Abers 3, Deborah Draper 3, Meng Truong 3, Ian M Kaplan 4, Rachel M Gittelman 4, Yu Zhang 3, Lindsey B Rosen 3, Andrew L Snow 5, Clifton L Dalgard 6, Peter D Burbelo 7, Luisa Imberti 8, Alessandra Sottini 8, Eugenia Quiros-Roldan 9, Francesco Castelli 9, Camillo Rossi 10, Duilio Brugnoni 11, Andrea Biondi 12, Laura Rachele Bettini 12, Mariella D'Angio' 12, Paolo Bonfanti 13, Megan V Anderson 14, Annalisa Saracino 15, Maria Chironna 16, Mariantonietta Di Stefano 17, Jose Ramon Fiore 17, Teresa Santantonio 17, Riccardo Castagnoli 18, Gian Luigi Marseglia 18, Mary Magliocco 19, Marita Bosticardo 3, Francesca Pala 3, Elana Shaw 3, Helen Matthews 19, Sarah E Weber 19, Sandhya Xirasagar 20, Jason Barnett 20, Andrew J Oler 20, Dimana Dimitrova 21, Jenna R E Bergerson 3, David H McDermott 22, V Koneti Rao 3, Philip M Murphy 22, Steven M Holland 3, Andrea Lisco 14, Helen C Su 3, Michail S Lionakis 3, Jeffrey I Cohen 23, Alexandra F Freeman 3, Thomas M Snyder 4, Justin Lack 2, Luigi D Notarangelo 24; 1 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ottavia.delmonte@nih.gov. 2 Integrated Data Sciences Section, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 3 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 4 Adaptive Biotechnologies, Seattle, WA 98109, USA. 5 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20892, USA. 6 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20815, USA. 7 Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. 8 Section of Microbiology, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. 9 Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy. 10 Direzione Sanitaria, ASST Spedali Civili di Brescia, Italy. 11 Laboratorio Analisi Chimico-Cliniche, ASST Spedali Civili, Brescia, Italy. 12 Pediatric Department and Centro Tettamanti-European Reference Network on Paediatric Cancer, European Reference Network on Haematological Diseases, and European Reference Network on Hereditary Metabolic Disorders-University of Milano-Bicocca-Fondazione MBBM, Monza, Italy. 13 Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. 14 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 15 Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari, Bari, Italy. 16 Hygiene Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy. 17 Department of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, Foggia, Italy. 18 Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 19 Molecular Development of the Immune System Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA. 20 Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 21 Center for Immuno-Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. 22 Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 23 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious diseases, National Institutes of Health, Bethesda, MD 20892, USA. 24 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: luigi.notarangelo2@nih.gov.

Multistep tumor genetic evolution and changes in immunogenicity trigger immune-mediated disease eradication in stage IV melanoma: lessons from a single case

Vallacchi V, et al.
Journal for ImmunoTherapy of Cancer
January 2024
Authors and Affiliates
Viviana Vallacchi 1, Elisabetta Vergani 1, Mara Cossa 2, Chiara Gargiuli 3, Adele Busico 4, Andrea Devecchi 4, Matteo Dugo 5, Laura Bergamaschi 1, Loris De Cecco 6, Stefano Cavalieri 7,8, Barbara Valeri 2, Elena Tamborini 4, Gianfrancesco Gallino 9, Michele Del Vecchio 7, Mario Santinami 9, Marialuisa Sensi 3, Licia Rivoltini 1, Lorenza Di Guardo 7, Monica Rodolfo 10; 1 Department of Experimental Oncology, Unit of Translational Immunology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 2 Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 3 Applied Research and Technology Development Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 4 Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 5 Department of Medical Oncology, San Raffaele Hospital, Milan, Italy. 6 Integrated Biology of Rare Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 7 Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 8 Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. 9 Melanoma Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 10 Department of Experimental Oncology, Unit of Translational Immunology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy monica.rodolfo@istitutotumori.mi.it.

ANHL1522: Durable Immunity to EBV post Rituximab and Third Party LMP-specific T-cells: A Children’s Oncology Group Study

Wistinghausen B, et al.
Blood Advances
January 2024
Authors and Affiliates
Birte Wistinghausen 1, Keri Toner 2, Donald A Barkauskas 3, Lauren P Jerkins 4, Hannah Kinoshita 5, Pamela Chansky 6, Gloria Pezzella 7, Lauren Saguilig 4, Robert J Hayashi 8, Harshal A Abhyankar 9, Brooks Scull 10, Vivekanudeep Karri 10, Jay Tanna 5, Patrick J Hanley 1, Michelle L Hermiston 11, Carl E Allen 10, Catherine M Bollard 4; 1 Children's National Medical Center, Washington, District of Columbia, United States. 2 Children's National Health System, Washington, District of Columbia, United States. 3 University of Southern California, United States. 4 Children's National Hospital, United States. 5 Childrens National Medical Center, Washington, District of Columbia, United States. 6 The George Washington University School of Medicine and Health Sciences, United States. 7 Children's National Hospital, Washington, District of Columbia, United States. 8 Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States. 9 Baylor College Of Medicine, Houston, Texas, United States. 10 Baylor College of Medicine, Houston, Texas, United States. 11 University of California, San Francisco, San Francisco, California, United States.

Discovery of U2AF1 neoantigens in myeloid neoplasms

Biernacki MA, et al.
Journal for ImmunoTherapy of Cancer
January 2024
Authors and Affiliates
Melinda Ann Biernacki 1,2, Jessica Lok 3, Ralph Graeme Black 3, Kimberly A Foster 4, Carrie Cummings 3, Kyle B Woodward 3, Tim Monahan 3, Vivian G Oehler 3,2, Derek L Stirewalt 3,2, David Wu 5, Anthony Rongvaux 3, Hans Joachim Deeg 3,2, Marie Bleakley 3,6; 1 Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA mbiernac@fredhutch.org. 2 Department of Medicine, University of Washington, Seattle, Washington, USA. 3 Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA. 4 Department of Immunology, University of Washington, Seattle, Washington, USA. 5 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA. 6 Department of Pediatrics, University of Washington, Seattle, Washington, USA.
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