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Jun Li 1, Yuehong Li 1, Suhong Sun 2, Liwen Yang 1, Long Ma 1, Bin Shi 1, Rui Ma 1, Xinsheng Yao 3; 1 Department of Immunology, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi City, China. 2 Department of Breast Surgery, The First Affiliated Hospital of ZunYi Medical University, Zunyi City, China. 3 Department of Immunology, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi City, China. Electronic address: immunology01@126.com.

Xuedan He 1, Shiqi Zhou 1, Breandan Quinn 1, Wei-Chiao Huang 1, Dushyant Jahagirdar 2, Michael Vega 3, Joaquin Ortega 2, Mark D Long 4, Fumito Ito 5,6,7, Scott I Abrams 5, Jonathan F Lovell 1; 1 University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. 2 Department of Anatomy and Cell Biology, McGill University Montreal, Quebec, H3A1Y2, Canada. 3 Division of Research and Innovation Partnerships, Northern Illinois University, DeKalb, IL, 60115, USA. 4 Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center (RPCCC), Buffalo, NY, 14263, USA. 5 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. 6 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. 7 Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.

John W Mellors 1, Shuang Guo 2, Asma Naqvi 1, Leah D Brandt 1, Ling Su 2, Zhonghe Sun 2, Kevin W Joseph 1, Dimiter Demirov 2, Elias K Halvas 1, Donna Butcher 2, Beth Scott 3, Aaron Hamilton 3, Marintha Heil 3, Baktiar Karim 2, Xiaolin Wu 2, Stephen H Hughes 4; 1 Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. 2 Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 3 Roche Molecular Diagnostics, Pleasanton, CA, USA. 4 HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, MD, USA.

Xiuyuan Lu 1, Yuki Hosono 1,2,3, Masamichi Nagae 1,2, Shigenari Ishizuka 1,2, Eri Ishikawa 1,2, Daisuke Motooka 4, Yuki Ozaki 4, Nicolas Sax 5, Yuichi Maeda 3,6, Yasuhiro Kato 3,7, Takayoshi Morita 3,7, Ryo Shinnakasu 8, Takeshi Inoue 8, Taishi Onodera 9, Takayuki Matsumura 9, Masaharu Shinkai 10, Takashi Sato 10, Shota Nakamura 4, Shunsuke Mori 11,12, Teru Kanda 13, Emi E Nakayama 14, Tatsuo Shioda 14,15, Tomohiro Kurosaki 8,15,16, Kiyoshi Takeda 6,15,17, Atsushi Kumanogoh 3,7,15, Hisashi Arase 11,12,15, Hironori Nakagami 18, Kazuo Yamashita 5, Yoshimasa Takahashi 9, Sho Yamasaki 1,2,15,19,20; 1 Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 2 Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 3 Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Japan. 4 Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 5 KOTAI Biotechnologies, Inc., Suita, Japan. 6 Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Japan. 7 Department of Immunopathology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 8 Laboratory of Lymphocyte Differentiation, Immunology Frontier Research Center, Osaka University, Suita, Japan. 9 Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan. 10 Tokyo Shinagawa Hospital, Tokyo, Japan. 11 Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 12 Laboratory of Immunochemistry, Immunology Frontier Research Center, Osaka University, Suita, Japan. 13 Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan. 14 Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 15 Center for Infectious Disease Education and Research, Osaka University, Suita, Japan. 16 Laboratory of Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. 17 Department of Mucosal Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 18 Department of Health Development and Medicine, Graduate School of Medicine, Osaka University, Suita, Japan. 19 Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan. 20 Division of Molecular Design, Research Center for Systems Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

L Federico 1, D J McGrail 2, S-E Bentebibel 3, C Haymaker 4, A Ravelli 3, M-A Forget 3, T Karpinets 5, P Jiang 6, A Reuben 6, M V Negrao 6, J Li 5, R Khairullah 6, J Zhang 5, A Weissferdt 7, A A Vaporciyan 8, M B Antonoff 8, G Walsh 8, S-Y Lin 2, A Futreal 5, I Wistuba 4, J Roth 8, L A Byers 6, P-O Gaudreau 9, N Uraoka 4, A F Cruz 4, H Dejima 4, R N Lazcano 4, L M Solis 4, E R Parra 4, J J Lee 10, S Swisher 8, T Cascone 6, J V Heymach 6, J Zhang 11, B Sepesi 12, D L Gibbons 13, C Bernatchez 14; 1 Therapeutics Discovery Division. 2 Department of Systems Biology. 3 Department of Melanoma Medical Oncology. 4 Department of Translational Molecular Pathology. 5 Department of Genomic Medicine. 6 Department of Thoracic and Head & Neck Medical Oncology. 7 Department of Pathology. 8 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. 9 Department of Oncology, Queens’ University and the Canadian Cancer Trials Group; Kingston, Ontario, Canada. 10 Department of Biostatistics. 11 Department of Genomic Medicine; Department of Thoracic and Head & Neck Medical Oncology. Electronic address: jzhang20@mdanderson.org. 12 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: bsepesi@mdanderson.org. 13 Department of Thoracic and Head & Neck Medical Oncology; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: dlgibbon@mdanderson.org. 14 Department of Melanoma Medical Oncology. Electronic address: cbernatchez@mdanderson.org.

Adi Diab 1, Omid Hamid 2, John A Thompson 3, Willeke Ros 4, Ferry A L M Eskens 5, Toshihiko Doi 6, Siwen Hu-Lieskovan 7, Samuel J Klempner 8, Bishu Ganguly 9, Catherine Fleener 10, Xiao Wang 11, Tenshang Jo 11, Ken Liao 12, Shahram Salek-Ardakani 13, Carrie Turich Taylor 9, Jeffrey Chou 14, Anthony B El-Khoueiry 15; 1 Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center adiab@mdanderson.org. 2 Research, The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate. 3 Medicine/Medical Oncology, University of Washington. 4 Netherlands Cancer Institute. 5 Department of Medical Oncology, Erasmus MC Cancer Institute. 6 Department of Experimental Therapeutics, National Cancer Center Hospital East. 7 David Geffen School of Medicine at UCLA. 8 Oncology, Massachusetts General Hospital. 9 Pfizer Inc. 10 Translational Medicine, Xencor Inc. 11 Pfizer (United States). 12 Clinical Pharmacology, Pfizer (United States). 13 Cancer Immunology Discovery, Pfizer (United States). 14 WRDM, Pfizer (United States). 15 Division of Medical Oncology, USC Norris Comprehensive Cancer Center.

Luca Biavati 1, Carol Ann Huff 2, Anna Ferguson 3, Amy Sidorski 4, M Amanda Stevens 5, Lakshmi Rudraraju 6, Cristina Zucchinetti 1, Syed Abbas Ali 2, Philip Imus 1, Christian B Gocke 2, Rachel M Gittelman 7, Sarah Johnson 8, Catherine Sanders 9, Marissa Vignali 10, Anita Gandhi 11, Xiaobu Ye 3, Kimberly A Noonan 6, Ivan Borrello 12; 1 Oncology, Johns Hopkins Medicine. 2 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine. 3 Oncology, Johns Hopkins University. 4 Johns Hopkins University School of Medicine. 5 Hematologic Malignancies, Johns Hopkins Medicine. 6 Johns Hopkins Medicine. 7 Adaptive Biotechnologies (United States). 8 Computational Biology, Adaptive Biotechnologies (United States). 9 Business Development, Adaptive Biotechnologies (United States). 10 Adaptive Biotechnology. 11 Bristol-Myers Squibb (United States). 12 Oncology, Johns Hopkins University School of Medicine iborrell@jhmi.edu.

Xianliang Hou 1, Wentao Fan 2, Guangyu Wang 3, Xiaoyan Chen 4, Chune Mo 1, Yongsi Wang 2, Weiwei Gong 1, Xuyan Wen 5, Hui Chen 2, Dan He 2, Lijun Mo 6, Shaofeng Jiang 7, Minglin Ou 8, Haonan Guo 9, Hongbo Liu 10; 1 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. 2 Guangzhou Huayin Health Medical Group Co., Ltd (Guangzhou, China). 3 College of Laboratory Medicine, Guilin Medical University, Guilin, 541199, China. 4 Department of State owned Assets Management, Affiliated Hospital of Guilin Medical University, Guilin, 541001, China. 5 Department of pathology, Affiliated Hospital of Guilin Medical University, Guilin, 541001. 6 Clinical Laboratory, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199. 7 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, 541199, China. 8 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: minglinou@glmc.edu.cn. 9 Department of Clinical Laboratory, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, China. Electronic address: guohaonan@glmc.edu.cn. 10 Department of Laboratory Medicine, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: hbliu@glmc.edu.cn.

Tobias Ruck #,1,2, Stefanie Bock #,3, Steffen Pfeuffer 4, Christina B Schroeter 4, Derya Cengiz 4,3, Paul Marciniak 4,3, Maren Lindner 3, Alexander Herrmann 4, Marie Liebmann 3, Stjepana Kovac 3, Lukas Gola 3, Leoni Rolfes 4, Marc Pawlitzki 4 3, Nils Opel 5, Tim Hahn 5, Udo Dannlowski 5, Thomas Pap 6, Felix Luessi 7, Julian A Schreiber 8,9, Bernhard Wünsch 8, Tanja Kuhlmann 10, Guiscard Seebohm 9, Björn Tackenberg 11, Patricia Seja 12, Frank Döring 13, Erhard Wischmeyer 13, Achmet Imam Chasan 14, Johannes Roth 14, Luisa Klotz 3, Gerd Meyer Zu Hörste 3, Heinz Wiendl 3, Tobias Marschall 15, Stefan Floess 16, Jochen Huehn 16, Thomas Budde 17, Tobias Bopp 18, Stefan Bittner 7, Sven G Meuth 4,3; 1 Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. tobias.ruck@med.uni-duesseldorf.de. 2 Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. tobias.ruck@med.uni-duesseldorf.de. 3 Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. 4 Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. 5 Institute for Translational Psychiatry, University of Münster, Münster, Germany. 6 Institute of Experimental Musculoskeletal Medicine (IMM), University of Münster, Münster, Germany. 7 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. 8 Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany. 9 Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases (IfGH), University of Münster, Münster, Germany. 10 Institute of Neuropathology, University of Münster, Münster, Germany. 11 Department of Neurology, Philipps-University, Marburg, Germany. 12 Laboratory of Neurobiology, University of Helsinki, Helsinki, Finland. 13 Molecular Electrophysiology, Institute of Physiology and Center of Mental Health, University of Würzburg, Würzburg, Germany. 14 Institute of Immunology, University of Münster, Münster, Germany. 15 Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. 16 Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany. 17 Institute for Physiology I, University of Münster, Münster, Germany. 18 Institute of Immunology, Focus Program Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. # Contributed equally.

Xinjian Liu #,1,2, Xuhui Bao #,1, Mengjie Hu 1, Hanman Chang 1, Meng Jiao 1, Jin Cheng 3, Liyi Xie 4, Qian Huang 3, Fang Li 1, Chuan-Yuan Li 5,6,7; 1 Department of Dermatology, Duke University Medical Center, Durham, NC, USA. 2 Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China. 3 Molecular Diagnostic Laboratory of Cancer Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 4 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. 5 Department of Dermatology, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. 6 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. 7 Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. # Contributed equally.