Hope restored: The critical role that Minimal Residual Disease can play in blood cancer patient care

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Cross-reactivity of SARS-CoV-2- and influenza A-specific T cells in individuals exposed to SARS-CoV-2

Chaisawangwong W, et al.
JCI Insight
November 2022
Worarat Chaisawangwong 1, Hanzhi Wang 2, Theodore Kouo 3, Sebastian F Salathe 1, Ariel Isser 4,5, Joan Glick Bieler 1, Maya L Zhang 2, Natalie K Livingston 4, Shuyi Li 1, Joseph J Horowitz 6, Ron E Samet 7, Israel Zyskind 8, Avi Z Rosenberg 1, Jonathan P Schneck 1,4,5,9,10; 1 Department of Pathology, School of Medicine. 2 Department of Biomedical Engineering, Whiting School of Engineering. 3 Department of Pediatrics, Division of Emergency Medicine. 4 Department of Biomedical Engineering, School of Medicine, and. 5 Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. 6 ExpressCare Urgent Care, Bel Air, Maryland, USA. 7 Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA. 8 Department of Pediatrics, NYU Langone Medical Center, New York, New York, USA; Maimonides Medical Center, New York, New York, USA. 9 Institute for Nanobiotechnology and. 10 Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir

Benner SE, et al.
JCI Insight
November 2022
Sarah E Benner 1, Yolanda Eby 1, Xianming Zhu 1, Reinaldo E Fernandez 2, Eshan U Patel 1,3, Jessica E Ruff 1, Feben Habtehyimer 2, Haley A Schmidt 1, Charles S Kirby 1, Sarah Hussain 2, Darin Ostrander 2, Niraj M Desai 4, Sander Florman 5, Meenakshi M Rana 6, Rachel Friedman-Moraco 7, Marcus R Pereira 8, Shikha Mehta 9, Peter Stock 10, Alexander Gilbert 11, Michele I Morris 12, Valentina Stosor 13, Sapna A Mehta 14, Catherine B Small 15, Karthik Ranganna 16, Carlos Aq Santos 17, Saima Aslam 18, Jennifer Husson 19, Maricar Malinis 20, Nahel Elias 21, Emily A Blumberg 22, Brianna L Doby 23,24, Allan B Massie 14, Melissa L Smith 25, Jonah Odim 26, Thomas C Quinn 2,26, Gregory M Laird 27, Robert F Siliciano 2, Dorry L Segev 4,14, Andrew D Redd 2,26, Christine M Durand 2, Aaron Ar Tobian 1; 1 Department of Pathology and. 2 Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. 4 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 5 Recanati/Miller Transplantation Institute and. 6 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 7 Department of Medicine, Emory University, Atlanta, Georgia, USA. 8 Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA. 9 Department of Medicine, University of Alabama Heersink School of Medicine, Birmingham, Alabama, USA. 10 Department of Surgery, University of California, San Francisco, San Francisco, California, USA. 11 Medstar Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA. 12 Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA. 13 Departments of Medicine and Surgery, Divisions of Infectious Diseases and Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. 14 Department of Surgery, New York University Grossman School of Medicine, NYU Langone Health, New York, New York, USA. 15 Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA. 16 Department of Medicine, Drexel University, Philadelphia, Pennsylvania, USA. 17 Divison of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA. 18 Department of Medicine, University of California, San Diego, San Diego, California, USA. 19 Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA. 20 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. 21 Department of Surgery and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. 22 Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. 23 Positive Rhetoric LLC, Bowling Green, Kentucky, USA. 24 Department of Public Health Sciences, College of Health, Education, and Social Transformation, New Mexico State University, Las Cruces, New Mexico, USA. 25 Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky, USA. 26 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. 27 AccelevirDx, Baltimore, Maryland, USA.

Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment

Akhave N, et al.
Lung Cancer
November 2022
Neal Akhave 1, Jiexin Zhang 2, Erin Bayley 3, Meredith Frank 1, Shin-Heng Chiou 4, Carmen Behrens 5, Runzhe Chen 1, Xin Hu 6, Edwin Roger Parra 7, Won-Chul Lee 6, Stephen Swisher 3, Luisa Solis 7, Annikka Weissferdt 8, Cesar Moran 8, Neda Kalhor 8, Jianhua Zhang 6, Paul Scheet 8, Ara A Vaporciyan 3, Boris Sepesi 3, Don L Gibbons 1, John V Heymach 1, Jack J Lee 9, Ignacio I Wistuba 5, P Andrew Futreal 6, Jianjun Zhang 10, Junya Fujimoto 11, Alexandre Reuben 12; 1 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 2 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 3 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 4 Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA. 5 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 6 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 7 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 8 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 9 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 10 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. Electronic address: jzhang20@mdanderson.org. 11 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. Electronic address: jfujimot@mdanderson.org. 12 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.

Combination Nivolumab, CD137 Agonism, and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma

Hall MS, et al.
Clinical Cancer Research
November 2022
MacLean S Hall 1, John E Mullinax 1, Cheryl A Cox 1, Amy M Hall 1, Matthew S Beatty 1, Jamie Blauvelt 1, Patrick Innamarato 1, Luz Nagle 1, Holly Branthoover 1, Doris Wiener 1, Benjamin Schachner 1, Alberto J Martinez 1, Allison D Richards 1, Carolyn J Rich 1, Marjorie Colón Colón 1, Michael J Schell 1, Jamie K Teer 2, Nikhil I Khushalani 1, Jeffrey S Weber 3, James J Mule 1, Vernon K Sondak 1, Shari Pilon-Thomas 4, Amod A Sarnaik 1; 1 Moffitt Cancer Center, Tampa, FL, United States. 2 H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States. 3 NYU Langone Medical Center, New York, NY, United States. 4 H Lee Moffitt Cancer Center, Tampa, FL, United States.

Distorted TCR repertoires define multisystem inflammatory syndrome in children

Malik A, et al.
PLOS ONE
November 2022
Amna Malik 1, Eszter N Tóth 2, Michelle S Teng 2, Jacob Hurst 2, Eleanor Watt 3, Lauren Wise 4, Natalie Kent 4, Jack Bartram 5, Louis Grandjean 6, Margarita Dominguez-Villar 7, Stuart Adams 4, Nichola Cooper 1; 1 Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom. 2 Etcembly Ltd, Magdalen Centre, Robert Robinson Way, Oxford, United Kingdom. 3 Molecular and Cellular Immunology Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. 4 SIHMDS-Haematology, Great Ormond Street Hospital for Children, London, United Kingdom. 5 Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom. 6 Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, United Kingdom. 7 Department of Infectious Diseases, Imperial College London, London, United Kingdom.

Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling

Tuovinen EA, et al.
JCI
November 2022
Elina A Tuovinen 1 2 3, Sakari Pöysti # 4, Firas Hamdan # 1 5 6, Kim My Le 1 3, Salla Keskitalo 7, Tanja Turunen 7, Léa Minier 1 8, Nanni Mamia 1 3, Kaarina Heiskanen 3 9, Markku Varjosalo 7, Vincenzo Cerullo 1 5 6, Juha Kere 2 10 11, Mikko R J Seppänen 1 3 12, Arno Hänninen 4, Juha Grönholm 13 14; 1Translational Immunology Research Program, University of Helsinki, Helsinki, Finland. 2Folkhälsan Research Center, Helsinki, Finland. 3Pediatric Research Center, New Children’s Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland. 4Department of Clinical Microbiology and Immunology, Turku University Hospital, Turku, Finland. 5Drug Research Program Helsinki (DRP), Faculty of Pharmacy, University of Helsinki, Helsinki, Finland. 6Digital Precision Cancer Medicine Flagship (iCAN), University of Helsinki, Helsinki, Finland. 7Systems Biology Research Group and Proteomics Unit, Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. 8Faculty of Science and Technology, University of Lille, Lille, France. 9Children’s Immunodeficiency Unit, New Children’s Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland. 10Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. 11Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland. 12Rare Diseases Center and Pediatric Research Center, New Children’s Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland. 13Translational Immunology Research Program, University of Helsinki, Helsinki, Finland. juha.gronholm@helsinki.fi. 14Pediatric Research Center, New Children’s Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland. juha.gronholm@helsinki.fi. #Contributed equally.

Evolution and modulation of antigen-specific T cell responses in melanoma patients

Huuhtanen J, et al.
Nature Communications
November 2022
Jani Huuhtanen 1 2 3 4, Liang Chen 5 6, Emmi Jokinen 4, Henna Kasanen 1 2 3, Tapio Lönnberg 7 8, Anna Kreutzman 1 2 3, Katriina Peltola 3 9, Micaela Hernberg 9, Chunlin Wang 5 6, Cassian Yee 10 11, Harri Lähdesmäki 4, Mark M Davis 12 13 14, Satu Mustjoki 15 16 17 18; 1Translational Immunology Research Program, University of Helsinki, Helsinki, Finland. 2Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. 3iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. 4Department of Computer Science, Aalto University, Espoo, Finland. 5Department of Immunology and Microbiology, Stanford University, Stanford, CA, USA. 6Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. 7Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. 8InFLAMES Research Flagship Center, University of Turku, Turku, Finland. 9Department of Oncology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. 10Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 11Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 12Department of Immunology and Microbiology, Stanford University, Stanford, CA, USA. mmdavis@stanford.edu. 13Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu. 14Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu. 15Translational Immunology Research Program, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi. 16Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi. 17iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. satu.mustjoki@helsinki.fi. 18Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi.

Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma

Ravindranathan S, et al.
November 2022
Sruthi Ravindranathan 1,2, Tenzin Passang 3,4, Jian-Ming Li 3,4, Shuhua Wang 3,4, Rohan Dhamsania 3,4, Michael Brandon Ware 3,4, Mohammad Y Zaidi 3,4, Jingru Zhu 3,4, Maria Cardenas 5, Yuan Liu 4,6, Sanjeev Gumber 7,8, Brian Robinson 7, Anish Sen-Majumdar 9, Hanwen Zhang 3, Shanmuganathan Chandrakasan 10, Haydn Kissick 4,5,11, Alan B Frey 9, Susan N Thomas 12,13, Bassel F El-Rayes 3,4, Gregory B Lesinski 3,4, Edmund K Waller 14,15; 1 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. 2 Winship Cancer Institute, Emory University, Atlanta, GA, USA. 3 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. 4 Winship Cancer Institute, Emory University, Atlanta, GA, USA. 5 Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. 6 Rollins School of Public Health, Emory University, Atlanta, GA, USA. 7 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. 8 Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. 9 Cambium Oncology LLC, Atlanta, GA, USA. 10 Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, USA. 11 Emory Vaccine Centre, Emory University, Atlanta, GA, USA. 12 Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. 13 Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. 14 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. 15 Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster

Laing KJ, et al.
Nature Communications
November 2022
Kerry J Laing 1, Werner J D Ouwendijk 2, Victoria L Campbell 3, Christopher L McClurkan 3, Shahin Mortazavi 3, Michael Elder Waters 3, Maxwell P Krist 3, Richard Tu 3, Nhi Nguyen 3, Krithi Basu 3, Congrong Miao 4, D Scott Schmid 4, Christine Johnston 3,5, Georges M G M Verjans 2, David M Koelle 3,5,6,7,8; 1 Department of Medicine, University of Washington, Seattle, WA, USA. laingk@uw.edu. 2 HerpeslabNL of the Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. 3 Department of Medicine, University of Washington, Seattle, WA, USA. 4 Centers for Disease Control and Prevention, Division of Viral Diseases, Atlanta, GA, USA. 5 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. 6 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. 7 Department of Global Health, University of Washington, Seattle, WA, USA. 8 Department of Translational Research, Benaroya Research Institute, Seattle, WA, USA.

A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Darragh LB, et al.
Nature Cancer
November 2022
Laurel B Darragh 1,2, Michael M Knitz 1, Junxiao Hu 3, Eric T Clambey 4, Jennifer Backus 1, Andrew Dumit 1, Von Samedi 5, Andrew Bubak 6, Casey Greene 3,7, Timothy Waxweiler 1, Sanjana Mehrotra 5, Shilpa Bhatia 1, Jacob Gadwa 1, Thomas Bickett 1, Miles Piper 1, Kareem Fakhoury 1, Arthur Liu 8, Joshua Petit 8, Daniel Bowles 9, Ashesh Thaker 10, Kimberly Atiyeh 11, Julie Goddard 12, Robert Hoyer 9, Adrie Van Bokhoven 5, Kimberly Jordan 2, Antonio Jimeno 9, Angelo D’Alessandro 7, David Raben 1, Jessica D McDermott 9, Sana D Karam 13,14; 1 Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 2 Department of Immunology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 3 Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA. 4 Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 5 Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 6 Department of Neurology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 7 Department of Biochemistry and Molecular Genetics, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 8 Department of Radiation Oncology, University of Colorado, Poudre Valley Hospital, Fort Collins, CO, USA. 9 Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO, USA. 10 Department of Radiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 11 Department of Otolaryngology Head and Neck Surgery, University of Colorado, Memorial South Hospital, Colorado Springs, CO, USA. 12 Department of Otolaryngology Head and Neck Surgery, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 13 Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. sana.karam@cuanschutz.edu. 14 Department of Immunology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. sana.karam@cuanschutz.edu.
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