Adaptive and Collaborators to Present More than 30 Abstracts at 2023 ASH Annual Meeting

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Latest Publications

NKG2D receptor signaling shapes T cell thymic education

Perez C, et al.
journal of leukocyte biology
December 2023
Authors and Affiliates
Cynthia Perez 1, Lourdes Plaza-Rojas 2, Justin C Boucher 2, Mate Z Nagy 2, Elena Kostenko 2, Kushal Prajapati 1, Brianna Burke 1, Michael Delos Reyes 1, Anna L Austin 2, Shubin Zhang 1,3, Phong T Le 1,3, José A Guevara-Patino 1,2; 1 Department of Cancer Biology, Loyola University Chicago, 2160 S. First Ave, Maywood, IL 60153, United States. 2 Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States. 3 Department of Microbiology and Immunology, Loyola University Chicago, 2160 S. First Ave, Maywood, IL 60153, United States.

Exploratory analysis of the cervix tumoral HPV antigen-specific T-cell repertoire during chemoradiation and after brachytherapy

Manzar GS, et al.
Brachytherapy
December 2023
Authors and Affiliates
Gohar S Manzar 1, Molly B El Alam 1, Erica J Lynn 1, Tatiana V Karpinets 2, Timothy Harris 1, David Lo 1, Kyoko Yoshida-Court 1, Tatiana Cisneros Napravnik 1, Julie Sammouri 1, Daniel Lin 1, Lauren M Andring 1, Julianna Bronk 1, Xiaogang Wu 2, Travis T Sims 3, Geena Mathew 1, Kathleen M Schmeler 3, Patricia J Eifel 1, Anuja Jhingran 1, Lilie L Lin 1, Melissa M Joyner 1, Jianhua Zhang 2, Andrew Futreal 2, Ann H Klopp 1, Lauren E Colbert 4; 1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. 2 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX. 3 Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX. 4 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: lcolbert@mdanderson.org.

The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination

Culberson EJ, at al.
Journal of Immunology
December 2023
Authors and Affiliates
Erica J Culberson 1, Kymberle C Shields 1, Rebecca A Glynn 1,2, Brittney M Allyn 1,3, Katharina E Hayer 1,4,5, Craig H Bassing 1,2,3; 1 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 2 Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 3 Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 4 Biomedical Engineering Doctoral Degree Program, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA. 5 Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA.

TCRseq Reveals Selected Donor-reactive CD8+ T cell Clones Resist Anti-Thymocyte Globulin Depletion after Kidney Transplantation

Ningoo M, et al.
American Journal of Transplantation
December 2023
Authors and Affiliates
Mehek Ningoo 1, Pamela Cruz-Encarnación 1, Calla Khilnani 1, Peter S Heeger 2, Miguel Fribourg 3; 1 Translational Transplant Research Center, Division of Nephrology, Department of Medicine; Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. 3 Translational Transplant Research Center, Division of Nephrology, Department of Medicine; Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: miguel.fribourg@mssm.edu.

The ERK inhibitor LY3214996 augments anti-PD-1 immunotherapy in preclinical mouse models of BRAFV600E melanoma brain metastasis

de Sauvage MA, at al.
neuro-oncology
December 2023
Authors and Affiliates
Magali A de Sauvage 1,2, Consuelo Torrini 1, Edwin Nieblas-Bedolla 1, Elizabeth Summers 1, Emily Sullivan 1, Britney S Zhang 1, Emily Batchelor 1, Braxton Marion 1, Erika Yamazawa 1, Samuel C Markson 3,4, Hiroaki Wakimoto 1, Naema Nayyar 1, Priscilla Brastianos 1,5; 1 Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. 2 University of Utah School of Medicine, Salt Lake City, UT, USA. 3 Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. 4 Broad Institute of MIT and Harvard, Cambridge, MA, USA. 5 Division of Hematology/Oncology and Neuro-Oncology, Department of Medicine & Neurology, Massachusetts General Hospital. Boston, MA.

Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations

Borna S, et al.
Science Translational Medicine
December 2023
Authors and Affiliates
Šimon Borna 1, Esmond Lee 1,2, Jason Nideffer 1, Akshaya Ramachandran 1, Bing Wang 1, Jeanette Baker 3, Melissa Mavers 1, Uma Lakshmanan 1, Mansi Narula 1, Amy Kang-Hee Garrett 1, Janika Schulze 4, Sven Olek 5, Louis Marois 6, Yael Gernez 7, Monica Bhatia 8, Hey Jin Chong 9, Jolan Walter 10, Maleewan Kitcharoensakkul 11, Abigail Lang 12,13, Megan A Cooper 14, Alice Bertaina 1,15, Maria Grazia Roncarolo 1,2,15, Eric Meffre 16, Rosa Bacchetta 1,15; 1 Department of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. 2 Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. 3 Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA. 4 Epimune GmbH, Berlin 12489, Germany. 5 Ivana Turbachova Laboratory for Epigenetics, Precision for Medicine GmbH, Berlin 12489, Germany. 6 Department of Medicine, Immunology and Allergy Service, CHU de Québec-Laval University, Quebec G1V 4G2, Canada. 7 Department of Pediatrics, Division of Allergy, Rheumatology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. 8 Columbia University Irving Medical Center, New York, NY 10032, USA. 9 Division of Allergy and Immunology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. 10 Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins All Children's Hospital, University of South Florida, St. Petersburg, FL 33701, USA. 11 Divisions of Rheumatology/Immunology and Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110, USA. 12 Department of Pediatrics, Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. 13 Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 14 Department of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA. 15 Center for Definitive and Curative Medicine (CDCM), Stanford University School of Medicine, Stanford, CA 94305, USA. 16 Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA 94305, USA.

Tracking DNA-based antigen-specific T cell receptors during progression to type 1 diabetes

Mitchell AM, et al.
Science Advances
December 2023
Authors and Affiliates
Angela M Mitchell 1, Erin E Baschal 1, Kristen A McDaniel 1, Theodore Fleury 1, Hyelin Choi 1, Laura Pyle 1,2, Liping Yu 1,3, Marian J Rewers 1,3,4, Maki Nakayama 1,3,5, Aaron W Michels 1,3,4,5; 1 Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA. 2 Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO, USA. 3 Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. 4 Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. 5 Department of Immunology, University of Colorado School of Medicine, Aurora, CO, USA.

LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma

Nielsen M, et al.
OncoImmunology
December 2023
Authors and Affiliates
Morten Nielsen 1, Tine Monberg 1, Vibeke Sundvold 2, Benedetta Albieri 1, Dorrit Hovgaard 3, Michael Mørk Petersen 3, Anders Krarup-Hansen 4, Özcan Met 1 5, Ketil Camilio 2, Trevor Clancy 6, Richard Stratford 6, Baldur Sveinbjornsson 2, Øystein Rekdal 2, Niels Junker 4, Inge Marie Svane 1; 1 National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark. 2 Lytix Biopharma, Oslo, Norway. 3 Department of Orthopedic Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 4 Department of Oncology, Herlev and Gentofte Hospital, Herlev, Denmark. 5 Department of Health Technology, Technical University of Denmark, Lyngby, Denmark. 6 NEC Oncoimmunity AS, Oslo, Norway.

Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown

Reuschle Q, et al.
Journal of Autoimmunity
December 2023
Authors and Affiliates
Quentin Reuschlé 1, Laurien Van Heddegem 2, Victor Bosteels 2, Matthieu Moncan 3, Sabine Depauw 4, Nadège Wadier 4, Sandra Maréchal 2, Clint De Nolf 5, Virginia Delgado 4, Yosra Messai 6, Marie-Claude Stolzenberg 3, Aude Magérus 3, Angélique Werck 7, Jérôme Olagne 8, Quan Li 9, Guillaume Lefevre 10, Anne-Sophie Korganow 11, Frédéric Rieux-Laucat 3, Sophie Janssens 2, Pauline Soulas-Sprauel 12; 1 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France; Arthritis R&D, Neuilly sur Seine, France. 2 Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. 3 Université Paris Cité, Laboratoire d'immunogénétique des maladies auto-immunes pédiatriques, Institut Imagine, INSERM UMR_S1163, Paris, France. 4 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France. 5 Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Barriers in Inflammation, VIB Center for Inflammation Research, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. 6 Arthritis R&D, Neuilly sur Seine, France. 7 Department of Pathology, University Hospital, Strasbourg, France. 8 Department of Pathology, University Hospital, Strasbourg, France; Department of Adult Nephrology, University Hospital, Strasbourg, France. 9 Department of Immunology, UT Southwestern Medical Center, Dallas, TX, USA. 10 Inserm, U1286 - INFINITE - Institute for Translational Research in Inflammation, University of Lille, CHU Lille, Lille, France. 11 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France; Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, F-67000, Strasbourg, France. 12 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France; Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, F-67000, Strasbourg, France. Electronic address: soulaspa@unistra.fr.