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A Circulating Reservoir of Pathogenic-Like CD4+ T Cells Shares a Genetic and Phenotypic Signature with the Inflamed Synovial Micro-Environment

Spreafico et al.
Ann Rheum Dis
Papers
December 2014
Authors and Affiliates
Spreafico R1,2, Rossetti M1,2, van Loosdregt J1, Wallace CA3, Massa M4, Magni-Manzoni S5, Gattorno M6, Martini A6, Lovell DJ7,8, Albani S1,2 Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, CA1; Singhealth Translational Immuology and Inflammation Centre, Singhealth and Duke-NUS Graduate Medical School, Singapore, Singapore2; Seattle Children's Hospital and Research Institute, Seattle, WA3; Lab Biotecnologie, Fondazione IRCCS Piloclinico San Matteo, Pavia, Italy4; Pediatric Rheumatology Unit, IRCCS Ospedale Pediatrico Bambino Gesu, Rome, Italy5; Second Pediatrics Division, University of Genoa and G Gaslini Institute, Genova, Italy6; Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH7; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH8

Emergence of a STAT3 Mutated NK Clone in LGL Leukemia

Yan et al.
Leukemia Research Reports
Papers
December 2014
Authors and Affiliates
Yan Y1, Olson TL2, Nyland SB2, Feith DJ2, Loughran Jr TP2 Department of Medicine, York Hospital, York, PA1; University of Virginia Cancer Center, Charlottesville, VA2

Functional Heterogeneity of Human Memory CD4+ T Cell Clones Primed By Pathogens or Vaccines

Becattini et al.
Papers
ScienceXpress
December 2014
Authors and Affiliates
Becattini S1,2, Latorre D1, Mele F1, Foglierini M1, De Gregorio C1, Cassotta A1, Fernandez B1, Kelderman S3, Schumacher TN3, Corti D1, Lanzavecchia A1,2, Sallusto F1 Institute for Research in Biomedicine, Universita della Svizzera Italiana, Bellinzona, Switzerland1; Institute of Microbiology, ETH Zurich, Zurich, Switzerland2; Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands3

Immune activation and a 9-year ongoing complete remission following CD40 antibody therapy and metastasectomy in a patient with metastatic melanoma

Bajor et al.
Cancer Immunology Research
Papers
November 2014
Authors and Affiliates
Bajor DL1, Xu X2, Torigian DA3, Mick R4, Garcia LR5, Richman LP5, Desmarais C6, Nathanson KL7, Schuchter LM1, Kalos M2, Vonderheide RH8 1Abramson Cancer Center, University of Pennsylvania, Philadelphia. Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 2Abramson Cancer Center, University of Pennsylvania, Philadelphia. Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 3Abramson Cancer Center, University of Pennsylvania, Philadelphia. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 4Abramson Cancer Center, University of Pennsylvania, Philadelphia. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 5Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, 6Adaptive Biotechnologies, Seattle, Washington, 7Abramson Cancer Center, University of Pennsylvania, Philadelphia. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 8Abramson Cancer Center, University of Pennsylvania, Philadelphia. Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia. rhv@exchange.upenn.edu.

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Tumeh et al.
Nature
Papers
November 2014
Authors and Affiliates
Tumeh PC1, Harview CL2, Yearley JH3, Shintaku IP2, Taylor EJ2, Robert L2, Chmielowski B1, Spasic M2, Henry G2, Ciobanu V2, West AN2, Carmona M2, Kivork C2, Seja E2, Cherry G2, Gutierrez AJ2, Grogan TR2, Mateus C4, Tomasic G4, Glaspy JA1, Emerson RO5, Robins H6, Pierce RH3, Elashoff DA1, Robert C4, Ribas A1. 1University of California Los Angeles (UCLA), Los Angeles, California 90095, USA [2] Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA. 2University of California Los Angeles (UCLA), Los Angeles, California 90095, USA. 3Merck &Co, Palo Alto, California 94304, USA. 4Gustave Roussy and INSERM U981, Villejuif, Paris Sud, France. 5Adaptive Biotechnologies, Seattle, Washington 98102, USA. 6Adaptive Biotechnologies, Seattle, Washington 98102, USA [2] Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

Spatial map of human T cell compartmentalization and maintenance over decades of life

Thome et al.
Cell
Papers
November 2014
Authors and Affiliates
Thome JJ1, Yudanin N1, Ohmura Y2, Kubota M2, Grinshpun B3, Sathaliyawala T4, Kato T2, Lerner H5, Shen Y3, Farber DL6 1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. 2Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA. 3Department of Systems Biology and Biomedical Informatics, and the JP Sulzberger Columbia Genome Center, Columbia University, New York, NY 10032, USA. 4Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA. 5The New York Organ Donor Network (NYODN), New York, NY 10001, USA. 6Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: df2396@cumc.columbia.edu.
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