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Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression

Mueller et al.
Journal of Clinical Investigation
Papers
December 2013
Authors and Affiliates
Christian Mueller1, Jeffrey D. Chulay2, Bruce C. Trapnell3, Margaret Humphries1, Brenna Carey3, Robert A. Sandhaus4, Noel G. McElvaney5, Louis Messina1, Qiushi Tang1, Farshid N. Rouhani6, Martha Campbell-Thompson6, Ann Dongtao Fu6, Anthony Yachnis6, David R. Knop2, Guo-jie Ye2, Mark Brantly6, Roberto Calcedo7, Suryanarayan Somanathan7, Lee P. Richman8, Robert H. Vonderheide8, Maigan A. Hulme6, Todd M. Brusko6, James M. Wilson7, and Terence R. Flotte1, 8 1University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2Applied Genetic Technologies Corp., Alachua, Florida, USA. 3Cincinnati Children’s Hospital, Cincinnati, Ohio, USA. 4National Jewish Health, Denver, Colorado, USA. 5Beaumont Hospital, Dublin, Ireland. 6University of Florida College of Medicine, Gainesville, Florida, USA. 7Gene Therapy Program and 8Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Ultra-deep T-cell receptor sequencing reveals the complexity and intratumour heterogeneity of T-cell clones in renal cell carcinomas

Marco et al.
Journal of Pathology
Papers
December 2013
Authors and Affiliates
Marco Gerlinger,1,2 Sergio A Quezada,3 Karl S Peggs,3 Andrew JS Furness,3,4 Rosalie Fisher,4 Teresa Marafioti,5Vishvesh H Shende,5 Nicholas McGranahan,1,6 Andrew J Rowan,1 Steven Hazell,4 David Hamm,7 Harlan S Robins,8Lisa Pickering,4 Martin Gore,4 David L Nicol,4 James Larkin,4 and Charles Swanton1,3 1Cancer Research UK, London Research Institute, UK, 2Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, London, UK, 3UCL Cancer Institute, London, UK, 4Royal Marsden Hospital, London, UK, 5Departments of Pathology and Histopathology, University College Hospital, London, UK, 6Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, UK, 7Adaptive Biotechnologies, Seattle, WA, USA, 8Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Digital genomic quantification of tumor-infiltrating lymphocytes

Robins et al.
Papers
Science Translational Medicine
December 2013
Authors and Affiliates
Robins HS1, Ericson NG, Guenthoer J, O’Briant KC, Tewari M, Drescher CW, Bielas JH. 1Herbold Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

High-throughput sequencing of T cell receptors reveals a homogeneous repertoire of tumor-infiltrating lymphocytes in ovarian cancer

Emerson et al.
Journal of Pathology
Papers
December 2013
Authors and Affiliates
Ryan O. Emerson,#1 Anna M. Sherwood,#1 Mark J. Rieder,1 Jamie Guenthoer,2 David W. Williamson,1 Christopher S. Carlson,2 Charles W. Drescher,2,3 Muneesh Tewari,2,3 Jason H. Bielas,2 and Harlan S. Robins2 1Adaptive Biotechnologies, Seattle, WA. 2Fred Hutchinson Cancer Research Center, Seattle, WA. 3University of Washington School of Medicine, Seattle, WA. #Contributed equally.

Peripheral blood mononuclear cells of patients with breast cancer can be reprogrammed to enhance anti-HER-2/neu reactivity and overcome myeloid-derived suppressor cells

Payne et al.
Breast Cancer Research and Treatment
Papers
November 2013
Authors and Affiliates
Kyle K Payne,1 Christine K Zoon,1 Wen Wan,1 Khin Marlar,2 Rebecca C Keim,1 Mehrab Nasiri Kenari,2 Latif Kazim,2Harry D Bear,1 and Masoud H Manjili1 1Virginia Commonwealth University - Massey Cancer Center, Richmond, VA, USA, 2Roswell Park Cancer Institute, Buffalo, NY, USA.

Peripheral T-cell lymphoma emerging in a patient with aggressive polymyositis: molecular evidence for neoplastic transformation of an oligoclonal T-cell infiltrate

Tsankova et al.
Acta Neuropathologica
Papers
October 2013
Authors and Affiliates
Tsankova NM1, Bevan C, Jobanputra V, Ko YC, Mayer EW, Lefkowitch JH, Mansukhani M, Rowland LP, Bhagat G, Tanji K. 1 Division of Neuropathology, Department of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, 630 W. 168th Street, PH15-124, New York, 10032, USA, nmt2111@columbia.edu.

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

Cooper et al.
OncoImmunology
Papers
October 2013
Authors and Affiliates
Zachary A Cooper, 1 , 2 Dennie T Frederick, 3 Vikram R Juneja, 4 , 5 Ryan J Sullivan, 6 , 7 Donald P Lawrence, 6 ,7 Adriano Piris, 7 , 8 Arlene H Sharpe, 4 David E Fisher, 7 , 9 Keith T Flaherty, 6 , 7 and Jennifer A Wargo 1 , 2 1Department of Surgical Oncology; University of Texas MD Anderson Cancer Center; Houston, TX USA 2Department of Genomic Medicine; University of Texas MD Anderson Cancer Center; Houston, TX USA 3Division of Surgical Oncology; Massachusetts General Hospital; Boston, MA USA 4Department of Microbiology and Immunobiology; Harvard Medical School; Boston, MA USA 5Division of Health Sciences and Technology; Massachusetts Institute of Technology; Cambridge, MA USA 6Division of Medical Oncology; Massachusetts General Hospital; Boston, MA USA 7Harvard Medical School; Boston, MA USA 8Division of Dermatophathology; Massachusetts General Hospital; Boston, MA USA 9Division of Dermatology; Massachusetts General Hospital; Boston, MA USA
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