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SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children

Lam KP, et al.
Clinical Immunology
September 2022
Authors and Affiliates
Ki Pui Lam 1, Marcos Chiñas 2, Amélie M Julé 3, Maria Taylor 1, Marina Ohashi 4, Mehdi Benamar 1, Elena Crestani 1, Mary Beth F Son 1, Janet Chou 1, Catherine Gebhart 4, Talal Chatila 1, Jane Newburger 5, Adrienne Randolph 6, Maria Gutierrez-Arcelus 2, Lauren A Henderson 7; 1 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 2 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. 3 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. 4 HLA-Lab, American Red Cross, Dedham, MA, USA. 5 Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 6 Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 7 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lauren.henderson@childrens.harvard.edu.

T Cell Receptor Sequencing Reveals Reduced Clonal Breadth of T Cell Responses against SARS-CoV-2 after Natural Infection and Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Pradier A, et al.
Annals of Oncology
September 2022
Authors and Affiliates
A Pradier 1, A C Mamez 2, C Stephan 3, F Giannotti 3, S Masouridi-Levrat 3, S Wang 4, S Morin 3, D Neofytos 5, D L Vu 5, A Melotti 4, I Arm 6, C S Eberhardt 7, J Tamburini 4, L Kaiser 8, Y Chalandon 1, F Simonetta 9; 1 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 2 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland. Electronic address: anne-claire.mamez@hcuge.ch. 3 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland. 4 Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 5 Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland. 6 Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva, Switzerland. 7 Center for Vaccinology, University Hospitals of Geneva Division of General Pediatrics, Department of Woman, Child and Adolescent Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 8 Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland; Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva, Switzerland; Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland. 9 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address: federico.simonetta@unige.ch.

Novel peptide-based vaccine targeting heat shock protein 90 induces effective antitumor immunity in a HER2+ breast cancer murine model

Kang J, et al.
Journal for ImmunoTherapy of Cancer
September 2022
Authors and Affiliates
Jinho Kang ,1 Hye-Jin Lee,1 Jimin Lee,1 Jinhwa Hong,1 Yeul Hong Kim,1 Mary L Disis,2 Jeong-An Gim,3 Kyong Hwa Park1; 1 Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. 2 Department of Medicine, University of Washington, Seattle, Washington, USA. 3 Center for Research Support, Korea University College of Medicine, Seoul, South Korea. 4 Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea khpark@korea.ac.kr.

Ixazomib, lenalidomide and dexamethasone consolidation with randomized ixazomib or lenalidomide maintenance after autologous transplant in newly diagnosed multiple myeloma.

Slade M, et al.
September 2022
Authors and Affiliates
Michael Slade 1, Thomas G. Martin2, Nitya Nathwani3, Mark A. Fiala 1, Michael P. Rettig1, Feng Gao1, Abhinav Deol4,Francis K. Buadi 5, Jonathan L. Kaufman 6, Craig C. Hofmeister 6, Tara K. Gregory7, Jesus Berdeja 8, Ajai Chari9,Ashley Rosko10 and Ravi Vij1 1Washington University School of Medicine, St. Louis, MO, USA. 2University of California- San Francisco, San Francisco, CA, USA. 3Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. 4Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA. 5Mayo Clinic, Rochester,MN, USA. 6Emory University, Atlanta, GA, USA. 7Sarah Cannon Research Institute, Denver, CO, USA. 8Sarah Cannon Research Institute, Nashville, TN, USA. 9Icahn School of Medicine at Mount Sinai, New York City, NY, USA. 10Ohio State University, Columbus, OH, USA.

TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL

Kirsch IR, et al.
Science Translational Medicine
August 2022
Authors and Affiliates
Ilan R Kirsch #,1, Rei Watanabe #,2, John T O'Malley 2, David W Williamson 1, Laura-Louise Scott 2, Christopher P Elco 3, Jessica E Teague 2, Ahmed Gehad 2, Elizabeth L Lowry 2, Nicole R LeBoeuf 2,4, James G Krueger 5, Harlan S Robins 1, Thomas S Kupper 2,4, Rachael A Clark 2,4; 1 Adaptive Biotechnologies, Seattle, WA, USA. 2 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 3 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 4 Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA. 5 Department of Dermatology, Rockefeller University, New York, NY, USA. # Contributed equally.

Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice

Jaini R, et al.
August 2022
Authors and Affiliates
Ritika Jaini 1,2,3, Matthew G Loya 1, Alexander T King 1, Stetson Thacker 1,2, Nicholas B Sarn 1,4, Qi Yu 1, George R Stark 5,2,4, Charis Eng 1,2,4,3; 1 Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. 2 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. 3 Germline High Risk Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. 4 Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. 5 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Genesis of the αβ T-cell receptor

Dupic T, et al.
August 2022
Authors and Affiliates
Thomas Dupic 1,2, Quentin Marcou 2, Aleksandra M Walczak 2, Thierry Mora 2; 1 Laboratoire de physique théorique et hautes énergies, CNRS and Sorbonne Université, 4 Place Jussieu, 75005 Paris, France. 2 Laboratoire de physique de l'ENS, CNRS, Sorbonne Université, and École normale supérieure (PSL), 24 rue Lhomond, 75005 Paris, France.

CTL Clonotypes with Higher TCR Affinity Have Better Ability to Reduce the HIV Latent Reservoir

Lima NS, et al.
Journal of Immunology
August 2022
Authors and Affiliates
Noemia S Lima 1,2,3, Hiroshi Takata 1,2,4, Szu-Han Huang 5,6, Alexander Haregot 1,2, Julie Mitchell 1,2,4, Stephen Blackmore 1,2, Ayanna Garland 1,2, Aaron Sy 1,2, Pearline Cartwright 7, Jean-Pierre Routy 8, Nelson L Michael 1, Victor Appay 9,10, R Brad Jones 5,6, Lydie Trautmann 11,2,4; 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910. 2 Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817. 3 Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814. 4 Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006. 5 Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY 10021. 6 Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037. 7 Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, FL 34987. 8 Division of Hematology and Chronic Viral Illness Service, McGill University, Montreal, Quebec H3A 0G4, Canada. 9 Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, INSERM, Paris 75005, France; and. 10 International Research Center of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan. 11 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910; trautmly@ohsu.edu.

Comprehensive mapping of immune perturbations associated with severe COVID-19

Kuri-Cervantes L, et al.
Science Immunology
August 2022
Authors and Affiliates
Leticia Kuri-Cervantes #,1,2, M Betina Pampena #,1,2, Wenzhao Meng 3, Aaron M Rosenfeld 3, Caroline A G Ittner 4, Ariel R Weisman 4, Roseline S Agyekum 4, Divij Mathew 1,5, Amy E Baxter 1,5, Laura A Vella 2,6, Oliva Kuthuru 2,5, Sokratis A Apostolidis 2,5,7, Luanne Bershaw 2,5, Jeanette Dougherty 2,5, Allison R Greenplate 2,5, Ajinkya Pattekar 2,8, Justin Kim 2,5, Nicholas Han 2,5, Sigrid Gouma 1,2, Madison E Weirick 1,2, Claudia P Arevalo 1,2, Marcus J Bolton 1,2, Eileen C Goodwin 1,2, Elizabeth M Anderson 1,2, Scott E Hensley 1,2, Tiffanie K Jones 4, Nilam S Mangalmurti 2,4, Eline T Luning Prak 3, E John Wherry 9,5,10, Nuala J Meyer 11, Michael R Betts 12,2; 1 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 2 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 3 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA. 4 Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 5 Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 6 Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA. 7 Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 8 Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 9 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. 10 Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 11 Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. 12 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. # Contributed equally.

Tyrosine kinase inhibition alters intratumoral CD8+ T-cell subtype composition and activity

Tieniber AD, et al.
Cancer Immunology Research
August 2022
Authors and Affiliates
Andrew D Tieniber 1, Andrew N Hanna 1, Benjamin D Medina 2, Gerardo A Vitiello 3, Mark S Etherington 4, Mengyuan Liu 5, Kevin J Do 6, Ferdinand Rossi 7, Ronald P DeMatteo 4; 1 University of Pennsylvania, Philadelphia, PA, United States. 2 Memorial Sloan Kettering Cancer Center, New York, United States. 3 Memorial Sloan Kettering Cancer Center, New York, NY, United States. 4 Hospital of the University of Pennsylvania, Philadelphia, PA, United States. 5 Weill Cornell Medicine, New York, NY, United States. 6 University of Pennsylvania, Philadelphia, Pennsylvania, United States. 7 Hospital of the University of Pennsylvania, Philadelphia, United States.
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