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Combination anti-HIV antibodies provide sustained virological suppression

Sneller MS, et al.
Nature
August 2022
Authors and Affiliates
Michael C Sneller #,1, Jana Blazkova #,1, J Shawn Justement 1, Victoria Shi 1, Brooke D Kennedy 1, Kathleen Gittens 2, Jekaterina Tolstenko 1, Genevieve McCormack 1, Emily J Whitehead 1, Rachel F Schneck 1, Michael A Proschan 3, Erika Benko 4, Colin Kovacs 4, Cihan Oguz 5,6, Michael S Seaman 7, Marina Caskey 8, Michel C Nussenzweig 8,9, Anthony S Fauci 1, Susan Moir #,1, Tae-Wook Chun #,10; 1 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. 2 Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, USA. 3 Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA. 4 Maple Leaf Medical Clinic, Toronto, Ontario, Canada. 5 NIAID Collaborative Bioinformatics Resource, NIAID, NIH, Bethesda, MD, USA. 6 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 7 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 8 Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA. 9 Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. 10 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. twchun@nih.gov. # Contributed equally.

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet + B cells

Csomos K, et al.
Nature Immunology
August 2022
Authors and Affiliates
Krisztian Csomos 1, Boglarka Ujhazi 2, Peter Blazso 2,3, Jose L Herrera 4,5, Christopher M Tipton 6, Tomoki Kawai 7, Sumai Gordon 2, Maryssa Ellison 2, Kevin Wu 2, Matthew Stowell 2, Lauren Haynes 2, Rachel Cruz 2, Bence Zakota 2, Johnny Nguyen 8, Michelle Altrich 9, Christoph B Geier 10, Svetlana Sharapova 11, Joseph F Dasso 2, Jennifer W Leiding 2, Grace Smith 12, Waleed Al-Herz 13, Mayra de Barros Dorna 14, Olajumoke Fadugba 15, Eva Fronkova 16, Veronika Kanderova 16, Michael Svaton 16, Sarah E Henrickson 17,18, Joseph D Hernandez 19, Taco Kuijpers 20, Snezhina Mihailova Kandilarova 21, Elizaveta Naumova 21, Tomas Milota 22, Anna Sediva 22, Despina Moshous 23,24,25, Benedicte Neven 23,24,26, Tara Saco 27, Ravishankar Sargur 28, Sinisa Savic 29,30, John Sleasman 31, Gauri Sunkersett 32, Brant R Ward 33, Masanobu Komatsu 4,5, Stefania Pittaluga 12, Attila Kumanovics 34, Manish J Butte 35, Michael P Cancro 36, Shiv Pillai 37, Eric Meffre 38,39, Luigi D Notarangelo 7, Jolan E Walter 40,41; 1 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. kcsomos@usf.edu. 2 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 3 Department of Pediatrics, University of Szeged, Szeged, Hungary. 4 Cancer and Blood Disorders Institute and Department of Surgery, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 5 Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Department of Medicine, Division of Rheumatology, Emory University, Atlanta, GA, USA. 7 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. 8 Department of Pathology & Laboratory Medicine, Johns Hopkins All Children's Hospital, St Petersburg, FL, USA. 9 Eurofins Viracor Laboratories, Lee Summit's, MO, USA. 10 Immunology Outpatient Clinic, Vienna, Austria. 11 Belarusian Research Center for Pediatric Oncology, Minsk, Belarus. 12 Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 13 Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait. 14 Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. 15 Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 16 Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. 17 Allergy Immunology Division, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. 18 Institute for Immunology, the University of Pennsylvania, Philadelphia, PA, USA. 19 Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA. 20 Deptartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands. 21 Department of Clinical Immunology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria. 22 Department of Immunology, Second Faculty of Medicine Charles University and University Hospital Motol, Prague, Czech Republic. 23 Université de Paris, Paris, France. 24 Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades Université Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. 25 Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Institut Imagine, Paris, France. 26 Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR1163, Institut Imagine, Paris, France. 27 Windom Allergy, Asthma and Sinus, Sarasota, FL, USA. 28 Department of Immunology and Allergy, Sheffield Teaching Hospitals, Sheffield, UK. 29 Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, UK. 30 National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK. 31 Division of Allergy, Immunology and Pulmonary Medicine, Duke University School of Medicine, Durham, NC, USA. 32 Cancer and Blood Disorder Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 33 Division of Allergy and Immunology, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA. 34 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 35 Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics and Jeffrey Modell Diagnostic and Research Center, University of California, Los Angeles, Los Angeles, CA, USA. 36 Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 37 Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of technology and Harvard University, Cambridge, MA, USA. 38 Department of Immunobiology, Yale University, New Haven, CT, USA. 39 Section of Rheumatology, Allergy and Clinical Immunology, Yale School of Medicine, New Haven, CT, USA. 40 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. jolanwalter@usf.edu. 41 Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. jolanwalter@usf.edu.

A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Wu Y, et al.
Nature Cancer
August 2022
Authors and Affiliates
Yin Wu #1,2,3,4, Dhruva Biswas #1,2,5, Ieva Usaite 1, Mihaela Angelova 2, Stefan Boeing 6, Takahiro Karasaki 1,2, Selvaraju Veeriah 1, Justyna Czyzewska-Khan 1, Cienne Morton 3, Magdalene Joseph 3,4, Sonya Hessey 1,7, James Reading 1,8, Andrew Georgiou 1,8, Maise Al-Bakir 2, TRACERx Consortium, Nicholas McGranahan 1,9, Mariam Jamal-Hanjani 1,7, Allan Hackshaw 10, Sergio A. Quezada 1,8, Adrian C. Hayday 3,4, and Charles Swanton 1,2; 1 Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. 2 Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. 3 Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King’s College London, London, UK. 4 Immunosurveillance Laboratory, The Francis Crick Institute, London, UK. 5 Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK. 6 Bioinformatics & Biostatistics and Software Development & Machine Learning Team, The Francis Crick Institute, London, UK. 7 Cancer Metastasis Lab, University College London Cancer Institute, London, UK. 8 Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK. 9 Cancer Genome Evolution Research Group, University College London Cancer Institute, London, UK. 10 Cancer Research UK & University College London Cancer Trials Centre, University College London, London, UK. # These authors contributed equally

T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma

Wang X, et al.
Journal for ImmunoTherapy of Cancer
August 2022
Authors and Affiliates
Xuefeng Wang 1, Jameel Muzaffar 2, Kedar Kirtane 2, Feifei Song 2, Matthew Johnson 2, Michael J Schell 1, Jiannong Li 1, Sean J Yoder 3, Jose R Conejo-Garcia 4, Jose A Guevara-Patino 4, Marcelo Bonomi 5, Priyanka Bhateja 5, James W Rocco 6, Conor E Steuer 7, Nabil F Saba 7, Christine H Chung 8; 1 Department of Biostatistics and Bioinformatics, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 2 Department of Head and Neck-Endocrine Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 3 Department of Molecular Genomics Core, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 4 Department of Immunology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 5 Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 6 Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 7 Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA. 8 Department of Head and Neck-Endocrine Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA Christine.chung@moffitt.org.

EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity

Jing R, et al.
Cell Stem Cell
August 2022
Authors and Affiliates
Ran Jing 1, Irene Scarfo 2, Mohamad Ali Najia 3, Edroaldo Lummertz da Rocha 4, Areum Han 1, Michael Sanborn 5, Trevor Bingham 5, Caroline Kubaczka 1, Deepak K Jha 1, Marcelo Falchetti 6, Thorsten M Schlaeger 7, Trista E North 8, Marcela V Maus 2, George Q Daley 9; 1 Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. 2 Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. 3 Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. 4 Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. 5 Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA. 6 Graduate Program of Pharmacology, Center for Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. 7 Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA. 8 Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Developmental and Regenerative Biology Program, Harvard Medical School, Boston, MA 02115, USA. 9 Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Developmental and Regenerative Biology Program, Harvard Medical School, Boston, MA 02115, USA. Electronic address: george.daley@childrens.harvard.edu.

Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses

Lyudovyk O, et al.
Cancer Cell
August 2022
Authors and Affiliates
Olga Lyudovyk 1, Justin Y Kim 2, David Qualls 3, Madeline A Hwee 4, Ya-Hui Lin 4, Sawsan R Boutemine 5, Yuval Elhanati 1, Alexander Solovyov 1, Melanie Douglas 3, Eunise Chen 6, N Esther Babady 7, Lakshmi Ramanathan 8, Pallavi Vedantam 9, Chaitanya Bandlamudi 9, Sigrid Gouma 10, Philip Wong 9, Scott E Hensley 11, Benjamin Greenbaum 12, Alexander C Huang 13, Santosha A Vardhana 14; 1 Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 3 Lymphoma Service, Division of Hematologic Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 5 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA. 7 Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 9 Memorial Sloan Kettering Cancer Center, New York, NY, USA. 10 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 11 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 12 Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA. Electronic address: greenbab@mskcc.org. 13 Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Electronic address: alexander.huang@pennmedicine.upenn.edu. 14 Lymphoma Service, Division of Hematologic Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Electronic address: vardhans@mskcc.org.

Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5 hi PD-1 hi T follicular helper cells

Yeh C, et al.
Immunity
August 2022
Authors and Affiliates
Chen-Hao Yeh 1, Joel Finney 1, Takaharu Okada 2, Tomohiro Kurosaki 3, Garnett Kelsoe 4; 1 Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA. 2 Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa 230-0045, Japan; Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa 230-0045, Japan. 3 Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa 230-0045, Japan. 4 Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Surgery and Duke University Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: ghkelsoe@duke.edu.

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Schad SE, et al.
Journal of Experimental Medicine
August 2022
Authors and Affiliates
Sara E Schad 1,2, Andrew Chow 1,3, Levi Mangarin 1, Heng Pan 2,4, Jiajia Zhang 5,6, Nicholas Ceglia 7, Justina X Caushi 5,6, Nicole Malandro 1,2, Roberta Zappasodi 1,2, Mathieu Gigoux 1, Daniel Hirschhorn 1, Sadna Budhu 1, Masataka Amisaki 8, Monica Arniella 9, David Redmond 2, Jamie Chaft 3, Patrick M Forde 5,6, Justin F Gainor 10, Matthew D Hellmann 3, Vinod Balachandran 1,3,8,11, Sohrab Shah 7, Kellie N Smith 5,6, Drew Pardoll 5,6, Olivier Elemento 2,4, Jedd D Wolchok 1,2,3,12, Taha Merghoub 1,2,3,12; 1 Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, NY. 2 Weill Cornell Medical College, New York, NY. 3 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. 4 Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY. 5 John Hopkins University School of Medicine, Baltimore, MD. 6 Bloomberg-Kimmel Institute for Cancer Immunotherapy at John Hopkins, Baltimore, MD. 7 Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY. 8 Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY. 9 Broad Institute of MIT and Harvard, Cambridge, MA. 10 Department of Medicine, Massachusetts General Hospital, Boston, MA. 11 Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. 12 Human Oncology Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY.

Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition

Alvarez-Breckenridge C, et al.
Cancer Immunology Research
August 2022
Authors and Affiliates
Christopher Alvarez-Breckenridge #,1,2, Samuel C Markson #,3,4,5,6, Jackson H Stocking 7, Naema Nayyar 7, Matt Lastrapes 5,6,8, Matthew R Strickland 7,9, Albert E Kim 7,9, Magali de Sauvage 7, Ashish Dahal 7, Juliana M Larson 7, Joana L Mora 5,6,9, Andrew W Navia 10,11,12,13, Robert H Klein 7, Benjamin M Kuter 7, Corey M Gill 7, Mia Bertalan 7, Brian Shaw 7, Alexander Kaplan 7, Megha Subramanian 7, Aarushi Jain 7, Swaminathan Kumar 14, Husain Danish 15,16, Michael White 7, Osmaan Shahid 6, Kristen E Pauken 3,4, Brian C Miller 3,4,5,17, Dennie T Frederick 18, Christine Hebert 19, McKenzie Shaw 19, Maria Martinez-Lage 19, Matthew Frosch 20, Nancy Wang 7, Elizabeth Gerstner 9, Brian V Nahed 2, William T Curry 2, Bob Carter 2, Daniel P Cahill 2, Genevieve Marie Boland 18, Benjamin Izar 21,22, Michael A Davies 14, Arlene H Sharpe 3,4,5, Mario L Suvà 5,19, Ryan J Sullivan 7,9, Priscilla K Brastianos #,5,7,9, Scott L Carter #,5,6; 1 Departments of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2 Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts. 3 Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts. 4 Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts. 5 Broad Institute, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts. 6 Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts. 7 Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts. 8 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 9 Massachusetts General Hospital Cancer Center, Boston, Massachusetts. 10 Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts. 11 Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. 12 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. 13 Ragon Institute, Harvard University, Massachusetts Institute of Technology, and Massachusetts General Hospital, Cambridge, Massachusetts. 14 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 15 Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York. 16 Weill Cornell Medical Center, New York, New York. 17 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. 18 Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. 19 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 20 C. S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 21 Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, New York. 22 Columbia Center for Translational Immunology, New York, New York. # Contributed equally.

Sensory nerves impede the formation of tertiary lymphoid structures and development of protective anti-melanoma immune responses

Vats K, et al.
Cancer Immunology Research
August 2022
Authors and Affiliates
Kavita Vats 1, Oleg Kruglov 2, Bikram Sahoo 3, Vishal Soman 1, Jiying Zhang 4, Galina V Shurin 5, Uma R Chandran 6, Pavel Skums 7, Michael R Shurin 5, Alex Zelikovsky 8, Walter J Storkus 6, Yuri L Bunimovich 6; 1 University of Pittsburgh, United States. 2 University of Pittsburgh, Pittsburgh, United States. 3 Georgia State University, Atlanta, Georgia, United States. 4 University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. 5 University of Pittsburgh Medical Center, Pittsburgh, PA, United States. 6 University of Pittsburgh, Pittsburgh, PA, United States. 7 Georgia State University, Atlanta, GA, United States. 8Georgia State University, Atlanta, Ga, United States.