Browse our 650+ Publications
Latest Publications
Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy
Luoma AM, et al.
Cell
August 2022
Authors and Affiliates
Adrienne M Luoma 1, Shengbao Suo 2, Yifan Wang 3, Lauren Gunasti 4, Caroline B M Porter 5, Nancy Nabilsi 3, Jenny Tadros 3, Andrew P Ferretti 3, Sida Liao 3, Cagan Gurer 3, Yu-Hui Chen 6, Shana Criscitiello 4, Cora A Ricker 7, Danielle Dionne 5, Orit Rozenblatt-Rosen 5, Ravindra Uppaluri 8, Robert I Haddad 7, Orr Ashenberg 5, Aviv Regev 9, Eliezer M Van Allen 7, Gavin MacBeath 3, Jonathan D Schoenfeld 10, Kai W Wucherpfennig 11;
1 Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
2 Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Guangzhou Laboratory, Guangzhou, Guangdong 510005, China. Electronic address: suo_shengbao@gzlab.ac.cn.
3 TScan Therapeutics, Waltham, MA 02451, USA.
4 Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
5 Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
6 Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
7 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
8 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
9 Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
10 Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: jonathan_schoenfeld@dfci.harvard.edu.
11 Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: kai_wucherpfennig@dfci.harvard.edu.
Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4
Campisi L, et al.
Nature
August 2022
Authors and Affiliates
Laura Campisi 1, Shahab Chizari 2,3, Jessica S Y Ho 4, Anastasia Gromova 5,6,7,8, Frederick J Arnold 5,6,7,8, Lorena Mosca 9, Xueyan Mei 10, Yesai Fstkchyan 4, Denis Torre 11,12,13, Cindy Beharry 4, Marta Garcia-Forn 14,15,16,17, Miguel Jiménez-Alcázar 18, Vladislav A Korobeynikov 19, Jack Prazich 2,3, Zahi A Fayad 10, Marcus M Seldin 20, Silvia De Rubeis 14,15,16,17, Craig L Bennett 5,6,7,8, Lyle W Ostrow 21, Christian Lunetta 22,23, Massimo Squatrito 18, Minji Byun 24, Neil A Shneider 25, Ning Jiang 2,3, Albert R La Spada 26,27,28,29, Ivan Marazzi 30,31,32;
1 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. laura.campisi@mssm.edu.
2 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
3 Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
4 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
5 Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
6 Department of Neurology, University of California, Irvine, Irvine, CA, USA.
7 Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
8 UCI Institute for Neurotherapeutics, University of California, Irvine, Irvine, CA, USA.
9 Medical Genetics Unit, Department of Laboratory Medicine, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
10 BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
11 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
12 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
13 Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
14 Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
15 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
16 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
17 Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
18 Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain.
19 Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
20 Department of Biological Chemistry, Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA.
21 Neuromuscular Division of the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
22 NEMO Clinical Center, Fondazione Serena Onlus, Milan, Italy.
23 Neurorehabilitation Department, Istituti Clinici Scientifici Maugeri, IRCCS, Milan, Italy.
24 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
25 Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA.
26 Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu.
27 Department of Neurology, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu.
28 Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu.
29 UCI Institute for Neurotherapeutics, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu.
30 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu.
31 Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu.
32 Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu.
A multi-omic single cell sequencing approach to develop a CD8 T cell specific gene signature for anti-PD1 response in solid tumors
Kumar N, et al.
August 2022
Authors and Affiliates
Namit Kumar 1, Simon Papillon-Cavanagh 1, Hao Tang 1, Shiliang Wang 1, Caitlyn Stromko 1, Ching-Ping Ho 1, Sonal Soni-Sheth 1, Steven Vasquez-Grinnell 1, Miranda L Broz 1, Daniel J Tenney 1, Michael J Wichroski 1, Alice M Walsh 1, Yanhua Hu 1, Joseph L Benci 1;
1 Bristol Myers Squibb: Research & Early Development, Princeton, New Jersey, USA.
T-cell receptor diversity in minimal change disease in the NEPTUNE study
Liu S, et al.
August 2022
Authors and Affiliates
Shiying Liu 1,2, William S Bush 1,2,3, Kristy Miskimen 1,2,3, Agustin Gonzalez-Vicente 4, Jessica N Cooke Bailey 1,2, Ioanna Konidari 5, Jacob L McCauley 5, John R Sedor 4, John F O'Toole 4, Dana C Crawford 6,7,8;
1 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
2 Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
3 Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
4 Glickman Urological and Kidney Disease and Lerner Research Institutes, Cleveland Clinic, Cleveland, OH, USA.
5 John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
6 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. dana.crawford@case.edu.
7 Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA. dana.crawford@case.edu.
8 Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. dana.crawford@case.edu.
Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers
Apavaloaei A, et al.
Cell Reports
August 2022
Authors and Affiliates
Anca Apavaloaei 1, Leslie Hesnard 2, Marie-Pierre Hardy 2, Basma Benabdallah 3, Gregory Ehx 2, Catherine Thériault 2, Jean-Philippe Laverdure 2, Chantal Durette 2, Joël Lanoix 2, Mathieu Courcelles 2, Nandita Noronha 1, Kapil Dev Chauhan 4, Sébastien Lemieux 5, Christian Beauséjour 6, Mick Bhatia 7, Pierre Thibault 8, Claude Perreault 9;
1 Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC H3T 1J4, Canada; Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada.
2 Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC H3T 1J4, Canada.
3 CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
4 Faculty of Health Sciences, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
5 Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC H3T 1J4, Canada; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada.
6 CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada; Department of Pharmacology and Physiology, University of Montreal, Montreal, QC H3T 1J4, Canada.
7 Faculty of Health Sciences, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
8 Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC H3T 1J4, Canada; Department of Chemistry, University of Montreal, Montreal, QC H3T 1J4, Canada. Electronic address: pierre.thibault@umontreal.ca.
9 Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC H3T 1J4, Canada; Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada. Electronic address: claude.perreault@umontreal.ca.
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results
Palmer CD, et al.
Nature Medicine
August 2022
Authors and Affiliates
Christine D Palmer 1, Amy R Rappaport 1, Matthew J Davis 1, Meghan G Hart 1, Ciaran D Scallan 1, Sue-Jean Hong 1, Leonid Gitlin 1, Lauren D Kraemer 1, Sonia Kounlavouth 1, Aaron Yang 1, Lindsey Smith 1, Desiree Schenk 1, Mojca Skoberne 1, Kiara Taquechel 1, Martina Marrali 1, Jason R Jaroslavsky 1, Charmaine N Nganje 1, Elizabeth Maloney 1, Rita Zhou 1, Daniel Navarro-Gomez 1, Adrienne C Greene 1, Gijsbert Grotenbreg 1, Renee Greer 1, Wade Blair 1, Minh Duc Cao 1, Shawn Chan 1, Kyounghwa Bae 1, Alexander I Spira 2, Sameek Roychowdhury 3, David P Carbone 3, Brian S Henick 4, Charles G Drake 4, Benjamin J Solomon 5, Daniel H Ahn 6, Amit Mahipal 7, Steve B Maron 8, Benny Johnson 9, Raphael Rousseau 1, Roman Yelensky 1, Chih-Yi Liao 10, Daniel V T Catenacci 10, Andrew Allen 1, Andrew R Ferguson 1, Karin Jooss 11;
1 Gritstone bio, Inc., Emeryville, CA, USA.
2 Virginia Cancer Specialists, Virginia Cancer Specialists, VA, Fairfax, USA.
3 The Ohio State University Medical Center, Columbus, OH, USA.
4 Columbia University Medical Center, New York, NY, USA.
5 Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
6 Mayo Clinic, Phoenix, AZ, USA.
7 Mayo Clinic Cancer Center, Rochester, MN, USA.
8 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
9 The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
10 University of Chicago Comprehensive Cancer Center, Chicago, IL, USA.
11 Gritstone bio, Inc., Emeryville, CA, USA. kjooss@gritstone.com.
The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages
Burn TN, et al.
Journal of Immunology
August 2022
Authors and Affiliates
Thomas N Burn 1,2, Charline Miot 3, Scott M Gordon 1,4, Erica J Culberson 3, Tamir Diamond 1,5, Portia A Kreiger 3, Katharina E Hayer 6, Anamika Bhattacharyya 7, Jessica M Jones 7, Craig H Bassing 8,3,9, Edward M Behrens 8,2;
1 Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
2 Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA.
3 Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
4 Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA.
5 Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA.
6 Department of Biomedical and Health Bioinformatics, The Children's Hospital of Philadelphia, Philadelphia, PA.
7 Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC; and.
8 Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; bassing@chop.edu behrens@chop.edu.
9 Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer
Hoyos V, et al.
August 2022
Authors and Affiliates
Valentina Hoyos 1, Spyridoula Vasileiou 2, Manik Kuvalekar 2, Ayumi Watanabe 2, Ifigeneia Tzannou 2, Yovana Velazquez 2, Matthew French-Kim 2, Wingchi Leung 2, Suhasini Lulla 2, Catherine Robertson 2, Claudette Foreman 3, Tao Wang 3, Shaun Bulsara 3, Natalia Lapteva 2, Bambi Grilley 2, Matthew Ellis 3, Charles Kent Osborne 3, Angela Coscio 3, Julie Nangia 3, Helen E Heslop 2, Cliona M Rooney 2, Juan F Vera 2, Premal Lulla 2, Mothaffar Rimawi 3, Ann M Leen 2;
1 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX, USA Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1102 Bates Ave, Feigin Center 17th Floor. Houston, TX 77030, USA.
2 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX, USA.
3 Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity
Ruck T, et al.
August 2022
Authors and Affiliates
Tobias Ruck 1,2, Sumanta Barman 2, Andreas Schulte-Mecklenbeck 1, Steffen Pfeuffer 1, Falk Steffen 3, Christopher Nelke 1, Christina B Schroeter 2, Alice Willison 2, Michael Heming 1, Thomas Müntefering 2, Nico Melzer 1, Julia Krämer 1, Maren Lindner 1, Marianne Riepenhausen 1, Catharina C Gross 1, Luisa Klotz 1, Stefan Bittner 3, Paolo A Muraro 4, Tilman Schneider-Hohendorf 1, Nicholas Schwab 1, Gerd Meyer Zu Hörste 1, Norbert Goebels 2, Sven G Meuth 1 2, Heinz Wiendl 1;
1 Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, Germany.
2 Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
3 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
4 Department of Brain Sciences, Imperial College London, London, UK.