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The T-Cell Response to SARS-CoV-2 Vaccination in Inflammatory Bowel Disease is Augmented with Anti-TNF Therapy

Li D, et al.
Inflamm Bowel Dis
May 2022
Authors and Affiliates
Dalin Li 1, Alexander Xu 2, Emebet Mengesha 1, Rebecca Elyanow 3, Rachel M Gittelman 3, Heidi Chapman 3, John C Prostko 4, Edwin C Frias 4, James L Stewart 4, Valeriya Pozdnyakova 1, Philip Debbas 1, Angela Mujukian 1, Arash A Horizon 5, Noah Merin 2, Sandy Joung 6, Gregory J Botwin 1, Kimia Sobhani 7, Jane C Figueiredo 2, Susan Cheng 6, Ian M Kaplan 2, Dermot P B McGovern 1, Akil Merchant 2, Gil Y Melmed 1, Jonathan Braun 1,7; 1 *F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 2 Cedars Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 3 Adaptive Biotechnologies, Seattle, WA, USA. 4 Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL. 5 Center for Rheumatology Medical Group, Los Angeles, CA, USA. 6 Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 7 Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis

Bonami RH, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Rachel H Bonami 1,2,3, Christina E Thurman 4, Sonam Verma 5, Camille S Westlake 4, Lindsay E Nyhoff 4, Bridgette B Barron 4, Andrea Reboldi 6, Peggy L Kendall 2,3,4,5; 1 Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. 2 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. 3 Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Nashville, TN, United States. 4 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States. 5 Department of Medicine, Division of Allergy and Immunology, Washington University School of Medicine, St. Louis, MO, United States. 6 Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, United States.

Neoantigen-specific CD4 + T cells in human melanoma have diverse differentiation states and correlate with CD8 + T cell, macrophage, and B cell function

Veatch JR, et al.
Cancer Cell
May 2022
Authors and Affiliates
Joshua R Veatch 1, Sylvia M Lee 2, Carolyn Shasha 3, Naina Singhi 3, Julia L Szeto 3, Ata S Moshiri 4, Teresa S Kim 5, Kimberly Smythe 3, Paul Kong 3, Matthew Fitzgibbon 3, Brenda Jesernig 3, Shailender Bhatia 2, Scott S Tykodi 2, Evan T Hall 2, David R Byrd 5, John A Thompson 2, Venu G Pillarisetty 5, Thomas Duhen 6, A McGarry Houghton 3, Evan Newell 3, Raphael Gottardo 3, Stanley R Riddell 3; 1 Department of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: jveatch@fredhutch.org. 2 Department of Medical Oncology, University of Washington, Seattle, WA, USA. 3 Department of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 4 Department of Dermatology, University of Washington, Seattle, WA, USA. 5 Department of Surgery, University of Washington, Seattle, WA, USA. 6 Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.

Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8 + T-cell large granular lymphocytic leukemia

Huuhtanen J, et al.
Nature Communications
May 2022
Authors and Affiliates
Jani Huuhtanen #,1,2,3, Dipabarna Bhattacharya #,1,2, Tapio Lönnberg 4,5, Matti Kankainen 1,2, Cassandra Kerr 6, Jason Theodoropoulos 1,2,3, Hanna Rajala 1,2, Carmelo Gurnari 6, Tiina Kasanen 1,2, Till Braun 7, Antonella Teramo 8,9, Renato Zambello 8,9, Marco Herling 7,10, Fumihiro Ishida 11,12, Toru Kawakami 11,12, Marko Salmi 5,13, Thomas Loughran 14, Jaroslaw P Maciejewski 6, Harri Lähdesmäki 3, Tiina Kelkka 1,2, Satu Mustjoki 15,16,17; 1 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. 2 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. 3 Department of Computer Science, Aalto University, Espoo, Finland. 4Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. 5 InFlames Flagship Center, University of Turku, Turku, Finland. 6 Translational Hematology and Oncology Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA. 7 Department I of Internal Medicine, Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, University of Cologne (UoC), Cologne, Germany. 8 Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine, Padova, Italy. 9 Veneto Institute of Molecular Medicine (VIMM), Padova, Italy. 10 Clinic of Hematology and Cellular Therapy, University of Leipzig, Leipzig, Germany. 11 Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto, Japan. 12 Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan. 13 MediCity Research Laboratory and Institute of Biomedicine, University of Turku, Turku, Finland. 14 Division of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia, Charlottesville, VA, USA. 15 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi. 16 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi. 17 iCAN Digital Precision Medicine Flagship, Helsinki, Finland. satu.mustjoki@helsinki.fi. # Contributed equally.

Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes

Kim JK, et al.
OncoImmunology
May 2022
Authors and Affiliates
Jin K Kim 1, Chin-Tung Chen 1, Ajaratu Keshinro 1, Asama Khan 1, Canan Firat 2, Chad Vanderbilt 2, Neil Segal 3, Zsofia Stadler 3, Jinru Shia 2, Vinod P Balachandran 1,4, Martin R Weiser 1; 1 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 2 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 3 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 4 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Immune correlates of clinical parameters in patients with HPV-associated malignancies treated with bintrafusp alfa

Tasi Y, et al.
May 2022
Authors and Affiliates
Yo-Ting Tsai 1, Julius Strauss 1, Nicole J Toney 1, Caroline Jochems 1, David J Venzon 2, James L Gulley 3, Jeffrey Schlom #,4, Renee N Donahue #,1; 1 Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. 2 Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. 3 Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. 4 Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA schlomj@mail.nih.gov. # Contributed equally.

T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity

Elyanow R, et al.
JCI Insight
May 2022
Authors and Affiliates
Rebecca Elyanow 1, Thomas M Snyder 1, Sudeb C Dalai 1 2, Rachel M Gittelman 1, Jim Boonyaratanakornkit 3,4, Anna Wald 3,4,5,6, Stacy Selke 6, Mark H Wener 3,6, Chihiro Morishima 6, Alexander L Greninger 6, Michael Gale Jr 7,8,9, Tien-Ying Hsiang 7, Lichen Jing 3, Michael R Holbrook 10, Ian M Kaplan 1, H Jabran Zahid 11, Damon H May 1, Jonathan M Carlson 11, Lance Baldo 1, Thomas Manley 1, Harlan S Robins 1, David M Koelle 3,4,6,9,12; 1 Adaptive Biotechnologies, Seattle, Washington, USA. 2 Stanford University School of Medicine, Stanford, California, USA. 3 Department of Medicine, University of Washington, Seattle, Washington, USA. 4 Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 5 Department of Epidemiology. 6 Department of Laboratory Medicine and Pathology. 7 Department of Immunology. 8 Department of Microbiology, and. 9 Department of Global Health, University of Washington, Seattle, Washington, USA. 10 National Institute of Allergy and Infectious Diseases (NIAID) Integrated Research Facility, Frederick, Maryland, USA. 11 Microsoft Research, Redmond, Washington, USA. 12 Benaroya Research Institute, Seattle, Washington, USA.

PD-1 and ICOS co-expression identifies tumor-reactive CD4 T cells in human solid tumors

Duhen R, et al.
Journal of Clinical Investigation
May 2022
Authors and Affiliates
Rebekka Duhen 1, Olivier Fesneau 1, Kimberly A Samson 1, Alexandra K Frye 1, Michael Beymer 1, Venkatesh Rajamanickam 1, David Ross 1, Eric Tran 1, Brady Bernard 1, Andrew D Weinberg 1, Thomas Duhen 1; 1 Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, United States of America.

Longitudinal analysis of T-cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection

Gittelman RM, et al.
JCI Insight
May 2022
Authors and Affiliates
Rachel M Gittelman 1, Enrico Lavezzo 2, Thomas M Snyder 1, H Jabran Zahid 3, Cara L Carty 1, Rebecca Elyanow 1, Sudeb C Dalai 1, Ilan Kirsch 1, Lance Baldo 1, Laura Manuto 2, Elisa Franchin 2, Claudia Del Vecchio 2, Monia Pacenti 4, Caterina Boldrin 4, Margherita Cattai 4, Francesca Saluzzo 5, Andrea Padoan 6, Mario Plebani 6, Fabio Simeoni 7, Jessica Bordini 8, Nicola I Lorè 5, Dejan Lazarević 7, Daniela Maria Cirillo 5, Paolo Ghia 9, Stefano Toppo 2, Jonathan M Carlson 3, Harlan S Robins 1, Andrea Crisanti 10, Giovanni Tonon 7; 1 Computational Biology, Adaptive Biotechnologies, Seattle, United States of America. 2 Department of Molecular Medicine, University of Padova, Padua, Italy. 3 eScieince Group, Microsoft Research, Redmond, United States of America. 4 Azienda Ospedale Padova, Microbiology and Virology Unit, Azienda Ospedale Padova, Microbiology and Virology Unit, Padua, Italy. 5 Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milan, Italy. 6 Department of Medicine, University of Padova, Padua, Italy. 7 Center for Omics Sciences, COSR, IRCCS San Raffaele Scientific Institute, Milan, Italy. 8 Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy. 9 Division of Molecular Oncology, Università Vita-Salute San Raffaele, Milan, Italy. 10 Department of Life Sciences, Imperial College London, London, United Kingdom.

Durable Expansion of TCR-δ Meta-Clonotypes After BCG Revaccination in Humans

James CA, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Charlotte A James 1, Krystle K Q Yu 1, Koshlan Mayer-Blackwell 2, Andrew Fiore-Gartland 2, Malisa T Smith 1, Erik D Layton 1, John L Johnson 3, Willem A Hanekom 4, Thomas J Scriba 4, Chetan Seshadri 1,5; 1 Department of Medicine, University of Washington, Seattle, WA, United States. 2 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. 3 Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, United States. 4 South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. 5 Tuberculosis Research and Training Center, University of Washington, Seattle, WA, United States.
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