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High-sensitivity next-generation sequencing MRD assessment in ALL identifies patients at very low risk of relapse.

Short NJ, et al.
Blood Advances
July 2022
Authors and Affiliates
Nicholas J. Short,1 Hagop Kantarjian,1 Farhad Ravandi,1 Marina Konopleva,1 Nitin Jain,1 Rashmi Kanagal-Shamanna,2 Keyur P. Patel,2 Walid Macaron,1 Tapan M. Kadia,1 Sa Wang,2 Jeffrey L. Jorgensen,2 Joseph D. Khoury,2 Musa Yilmaz,1 Partow Kebriaei,3 Koichi Takahashi,1 Guillermo Garcia-Manero,1 Naval Daver,1 Sean M. Post,1 Xuelin Huang,4 Steven M. Kornblau,1 Sara Pelletier,1 Wilmer Flores,1 Jairo Matthews,1 Rebecca Garris,1 and Elias Jabbour1 1Department of Leukemia, 2Department of Hematopathology, 3Department of Stem Cell Transplantation & Cellular Therapy, and 4Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX

Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma.

Richardson PG, et al.
New England Journal of Medicine
June 2022
Authors and Affiliates
P.G. Richardson, S.J. Jacobus, E.A. Weller, H. Hassoun, S. Lonial, N.S. Raje, E. Medvedova, P.L. McCarthy, E.N. Libby, P.M. Voorhees, R.Z. Orlowski, L.D. Anderson, Jr., J.A. Zonder, C.P. Milner, C. Gasparetto, M.E. Agha, A.M. Khan, D.D. Hurd, K. Gowin, R.T. Kamble, S. Jagannath, N. Nathwani, M. Alsina, R.F. Cornell, H. Hashmi, E.L. Campagnaro, A.C. Andreescu, T. Gentile, M. Liedtke, K.N. Godby, A.D. Cohen, T.H. Openshaw, M.C. Pasquini, S.A. Giralt, J.L. Kaufman, A.J. Yee, E. Scott, P. Torka, A. Foley, M. Fulciniti, K. Hebert, M.K. Samur, K. Masone, M.E. Maglio, A.A. Zeytoonjian, O. Nadeem, R.L. Schlossman, J.P. Laubach, C. Paba-Prada, I.M. Ghobrial, A. Perrot, P. Moreau, H. Avet-Loiseau, M. Attal, K.C. Anderson, and N.C. Munshi, for the DETERMINATION Investigators The Department of Medical Oncology, Dana–Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center (P.G.R., M.F., M.K.S., K.M., M.E.M., A.A.Z., O.N., R.L.S., J.P.L., C.P.-P., I.M.G., K.C.A., N.C.M.), the Department of Data Science, Dana–Farber Cancer Institute (S.J.J., K.H.), the Division of Hematology and Oncology, Boston Children’s Hospital (E.A.W.), the Center for Multiple Myeloma, Massachusetts General Hospital (N.S.R., A.J.Y.), Harvard Medical School (P.G.R., S.J.J., E.A.W., N.S.R., A.J.Y.. M.F., K.H., M.K.S., K.M., M.E.M., A.A.Z., O.N., R.L.S., J.P.L., C.P.-P., I.M.G., K.C.A., N.C.M.), and the Veterans Affairs Boston Healthcare System (N.C.M.), Boston, and the Department of Medical Oncology, Davenport–Mugar Cancer Center, Cape Cod Hospital, Hyannis (T.H.O.) — all in Massachusetts; Myeloma Service, the Department of Medicine, Memorial Sloan Kettering Cancer Center (H. Hassoun, S.A.G.), and the Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai (S.J.), New York, the Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo (P.L.M., P.T.), and State University of New York Upstate Medical University, Syracuse (T.G.) — all in New York; the Winship Cancer Institute of Emory University, Atlanta (S.L., J.L.K.); Knight Cancer Institute, Oregon Health and Science University, Portland (E.M., E.S.); the Division of Medical Oncology and Fred Hutchinson Cancer Research Center, University of Washington, Seattle (E.N.L.); the Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte (P.M.V.), Duke University Medical Center, Durham (C.G.), and the Hematology and Oncology–Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem (D.D.H.) — all in North Carolina; the Department of Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer Center (R.Z.O.), and Center for Cell and Gene Therapy, Baylor College of Medicine and Houston Methodist Hospital (R.T.K.), Houston, and Myeloma, Waldenstrom’s, and Amyloidosis Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas (L.D.A.) — all in Texas; the Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit (J.A.Z.), and the Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor (E.L.C.) — both in Michigan; the Division of Hematology and Oncology, University of Mississippi Medical Center, Jackson (C.P.M.); University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh (M.E.A.), and the Abramson Cancer Center, University of Pennsylvania, Philadelphia (A.D.C.) — both in Pennsylvania; the Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus (A.M.K.); the Department of Bone Marrow Transplant and Cellular Therapy, University of Arizona, Tucson (K.G.); Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope Comprehensive Cancer Center, Duarte (N.N.), and the Department of Medicine, Division of Hematology, Stanford University, Stanford (M.L.) — both in California; the Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida (M. Alsina); Vanderbilt University Medical Center, Nashville (R.F.C.); the Division of Hematology Oncology, Medical University of South Carolina, Charleston (H. Hashmi); Northern Light Eastern Maine Medical Center Cancer Care, Brewer (A.C.A.), and the Cancer Care Center of Maine, Bangor (T.H.O.); O’Neal Comprehensive Cancer Center, the University of Alabama at Birmingham, Birmingham (K.N.G.); the Center for International Blood and Marrow Transplant Research (CIBMTR), Division of Hematology andOncology, Department of Medicine, Medical College of Wisconsin, Milwaukee (M.C.P.); the National Marrow Donor Program, CIBMTR, Minneapolis (A.F.); and the Department of Hematology (A.P., M. Attal) and Unit for Genomics in Myeloma (H.A.-L.), Institut Universitaire du Cancer de Toulouse–Oncopole, University Hospital, Toulouse, and the Department of Hematology, University Hospital Hôtel-Dieu, Nantes (P.M.) — both in France.

Ciltacabtagene Autoleucel, an Anti-B-cell Maturation Antigen Chimeric Antigen Receptor T-Cell Therapy, for Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 2-Year Follow-Up.

Martin T, et al.
Journal of Clinical Oncology
June 2022
Authors and Affiliates
Thomas Martin, MD1; Saad Z. Usmani, MD2; Jesus G. Berdeja, MD3; Mounzer Agha, MD4; Adam D. Cohen, MD5; Parameswaran Hari, MD6;David Avigan, MD7; Abhinav Deol, MD8; Myo Htut, MD9; Alexander Lesokhin, MD2; Nikhil C. Munshi, MD10,11; Elizabeth O’Donnell, MD12; A. Keith Stewart, MBChB13; Jordan M. Schecter, MD14; Jenna D. Goldberg, MD14; Carolyn C. Jackson, MD, MPH14; Tzu-Min Yeh, MS14; Arnob Banerjee, MD15; Alicia Allred, PhD15; Enrique Zudaire, PhD15; William Deraedt, MSc16; Yunsi Olyslager, MSc16; Changwei Zhou, PhD17; Lida Pacaud, MD17; Deepu Madduri, MD14; Andrzej Jakubowiak, MD18; Yi Lin, MD, PhD19; and Sundar Jagannath, MD20 1UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 2Memorial Sloan Kettering Cancer Center, New York, NY 3Sarah Cannon Research Institute, Nashville, TN 4UPMC Hillman Cancer Center, Pittsburgh, PA 5Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 6Medical College of Wisconsin, Milwaukee, WI 7Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 8Karmanos Cancer Institute, Wayne State University, Detroit, MI 9 City of Hope Comprehensive Cancer Center, Duarte, CA 10Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 11VA Boston Healthcare System, West Roxbury, MA 12Massachusetts General Hospital, Harvard Medical School, Boston, MA 13University Health Network and the Princess Margaret Cancer Centre, Toronto, ON, Canada 14Janssen R&D, Raritan, NJ 15Janssen R&D, Spring House, PA 16Janssen R&D, Beerse, Belgium 17Legend Biotech, Inc, Piscataway, NJ 18University of Chicago, Chicago, IL 19Mayo Clinic, Rochester, MN 20Mount Sinai Medical Center, New York, NY

Three-Year Follow-Up of KTE-X19 in Patients With Relapsed/Refractory Mantle Cell Lymphoma, Including High-Risk Subgroups, in the ZUMA-2 Study.

Wang M, et al.
Journal of Clinical Oncology
June 2022
Authors and Affiliates
Michael Wang, MD1; Javier Munoz, MD, MS, MBA2; Andre Goy, MD, MS3; Frederick L. Locke, MD4; Caron A. Jacobson, MD, MMSc5;Brian T. Hill, MD, PhD6; John M. Timmerman, MD7; Houston Holmes, MD, MBA8; Samantha Jaglowski, MD9; Ian W. Flinn, MD, PhD10;Peter A. McSweeney, MB, ChB11; David B. Miklos, MD, PhD12; John M. Pagel, MD, PhD, DSc13; Marie Jose Kersten, MD, PhD ´ 14;Krimo Bouabdallah, MD15; Rashmi Khanal, MD16; Max S. Topp, MD17; Roch Houot, MD, PhD18; Amer Beitinjaneh, MD19;Weimin Peng, PhD20; Xiang Fang, PhD20; Rhine R. Shen, PhD20; Rubina Siddiqi, PhD20; Ioana Kloos, MD20; and Patrick M. Reagan, MD21 1The University of Texas MD Anderson Cancer Center, Houston, TX 2Banner MD Anderson Cancer Center, Gilbert, AZ 3John Theurer Cancer Center, Hackensack University, Hackensack, NJ 4Moffitt Cancer Center, Tampa, FL 5Dana-Farber Cancer Institute, Boston, MA 6Cleveland Clinic Foundation, Cleveland, OH 7David Geffen School of Medicine at UCLA, Los Angeles, CA 8Texas Oncology, Dallas, TX 9The Ohio State University Comprehensive Cancer Center, Columbus, OH 10Sarah Cannon Research Institute and Tennessee Oncology, Nashville, TN 11Colorado Blood Cancer Institute, Denver, CO 12Stanford University School of Medicine, Stanford, CA 13Swedish Cancer Institute, Seattle, WA 14Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, the Netherlands, on behalf of HOVON/LLPC 15CHU Bordeaux, Service d’Hematologie et th ´ erapie Cellulaire, ´Bordeaux, France 16Fox Chase Cancer Center, Philadelphia, PA 17Medizinische Klinik und Poliklinik II, Universitatsklinikum W ¨ urzburg, ¨Wurzburg, Germany ¨ 18CHU Rennes, Universite Rennes, INSERM & EFS, Rennes, France ´ 19University of Miami, Miami, FL 20Kite, a Gilead Company, Santa Monica, CA 21University of Rochester Medical Center, Rochester, NY

Combining CD34+ stem cell selection with prophylactic pathogen and leukemia directed T-cell immunotherapy to simultaneously reduce graft versus host disease, infection, and leukemia recurrence after allogeneic stem cell transplant

Gottlieb DJ, et al.
American Journal of Hematology
May 2022
Authors and Affiliates
David J Gottlieb 1,2,3,4, Gaurav Sutrave 1,2,4, Wei Jiang 1,2, Selmir Avdic 2,4, Janine A Street 2,4, Renee Simms 1,2, Leighton E Clancy 1,4,5, Vicki Antonenas 5, Brian S Gloss 6, Caroline Bateman 2,4,7, David C Bishop 1,2,4, Kenneth P Micklethwaite 1,2,3,5, Emily Blyth 1,2,3,4; 1 Blood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, New South Wales. 2 Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales. 3 Department of Haematology, Westmead Hospital, Sydney, New South Wales. 4 T-Cell Therapies Group, Westmead Institute for Medical Research, Sydney, New South Wales. 5 Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead, New South Wales, Australia. 6 Westmead Research Hub, Westmead Institute for Medical Research, Sydney, New South Wales, Australia. 7 Departments of Haematology and Oncology, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage

Wang G, et al.
Genes & Genomics
May 2022
Authors and Affiliates
Guangyu Wang #,1, Yongsi Wang #,2, Shaofeng Jiang #,3, Wentao Fan 2, Chune Mo 1, Weiwei Gong 1, Hui Chen 2, Dan He 2, Jinqing Huang 3, Minglin Ou 4,5, Xianliang Hou 6; 1 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. 2 Guangzhou Huayin Health Medical Group Co., Ltd, Guangzhou, China. 3 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, 541199, Guangxi, China. 4 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. minglinou@glmc.edu.cn. 5 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, 541199, Guangxi, China. minglinou@glmc.edu.cn. 6 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. houxianliang@zju.edu.cn. # Contributed equally.

Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy

Towlerton AMH, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Andrea M H Towlerton 1, Shashidhar Ravishankar 1, David G Coffey 1,2,3, Camille E Puronen 1,2, Edus H Warren 1,2; 1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. 2 Division of Medical Oncology, University of Washington, Seattle, WA, United States. 3 Division of Hematology, University of Miami, Miami, FL, United States.

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

Narayan V, et al.
Nature Medicine
May 2022
Authors and Affiliates
Vivek Narayan 1,2, Julie S Barber-Rotenberg 3, In-Young Jung #,2,3,4, Simon F Lacey #,3,5, Andrew J Rech #,2,3,5,6, Megan M Davis #,3, Wei-Ting Hwang 7, Priti Lal 2,5, Erica L Carpenter 2,6, Shannon L Maude 8,9, Gabriela Plesa 3, Neha Vapiwala 1,2, Anne Chew 3, Michael Moniak 3, Ronnie A Sebro 2,10, Michael D Farwell 2,10, Amy Marshall 3, Joan Gilmore 3, Lester Lledo 3, Karen Dengel 3, Sarah E Church 11, Tyler D Hether 11, Jun Xu 3, Mercy Gohil 3, Thomas H Buckingham 2,6, Stephanie S Yee 2,6, Vanessa E Gonzalez 3, Irina Kulikovskaya 3, Fang Chen 3, Lifeng Tian 3, Kyle Tien 2,6, Whitney Gladney 3, Christopher L Nobles 4, Hayley E Raymond 4, Prostate Cancer Cellular Therapy Program Investigators; Elizabeth O Hexner 1,2,3, Donald L Siegel 3,5, Frederic D Bushman 4, Carl H June #,12,13,14,15, Joseph A Fraietta #,16,17,18,19,20, Naomi B Haas #,21,22; 1 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 2 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 4 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 5 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 6 Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. 7 Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 8 Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. 9 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 10 Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 11 NanoString Technologies, Inc., Seattle, WA, USA. 12 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu. 13 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu. 14 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu. 15 Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu. 16 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu. 17 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu. 18 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu. 19 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu. 20 Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu. 21 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. naomi.haas@pennmedicine.upenn.edu. 22 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. naomi.haas@pennmedicine.upenn.edu. # Contributed equally.

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Capelle CM, et al.
Cell Reports Medicine
May 2022
Authors and Affiliates
Christophe M Capelle 1,2, Séverine Ciré 1, Olivia Domingues 1, Isabelle Ernens 3, Fanny Hedin 4, Aurélie Fischer 3, Chantal J Snoeck 1, Wim Ammerlaan 5, Maria Konstantinou 4, Kamil Grzyb 6, Alexander Skupin 6,7, Cara L Carty 8, Christiane Hilger 1, Georges Gilson 9, Aljosa Celebic 10, Paul Wilmes 2,6, Antonio Del Sol 6,11,12, Ian M Kaplan 8, Fay Betsou 5,13, Tamir Abdelrahman 13, Antonio Cosma 4, Michel Vaillant 10, Guy Fagherazzi 3, Markus Ollert 1,14, Feng Q Hefeng 1; 1 Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg. 2 Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. 3 Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. 4 National Cytometry Platform, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. 5 Integrated BioBank of Luxembourg (IBBL), Dudelange, Luxembourg. 6 Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg. 7 Department of Neuroscience, University California San Diego, La Jolla, CA, USA. 8 Adaptive Biotechnologies, Seattle, WA, USA. 9 Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg. 10 Translational Medicine Operations Hub, Competence Centre for Methodology and Statistics, Luxembourg Institute of Health, Strassen, Luxembourg. 11 CIC bioGUNE, Bizkaia Technology Park, Derio, Spain. 12 IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. 13 Laboratoire National de Santé (LNS), Dudelange, Luxembourg. 14 Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), University of Southern Denmark, Odense, Denmark.

A Phase 1/2 Trial Combining Avelumab and Trabectedin for Advanced Liposarcoma and Leiomyosarcoma

Wagner MJ, et al.
Clinical Cancer Research
May 2022
Authors and Affiliates
Michael J Wagner 1, Yuzheng Zhang 2, Lee D Cranmer 1, Elizabeth T Loggers, Graeme Black 3, Sabrina McDonnell 4, Shannon Maxwell 5, Rylee Johnson 5, Roxanne Moore 1, Pedro Hermida de Viveiros 6, Lauri Aicher 4, Kimberly S Smythe 4, Qianchuan He 3, Robin L Jones 7, Seth M Pollack 6; 1 University of Washington, Seattle, WA, United States. 2 Fred Hutchinson Cancer Research Center, Seattle, United States. 3 Fred Hutchinson Cancer Research Center, Seattle, WA, United States. 4 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States. 5 Seattle Cancer Care Alliance, Seattle, United States. 6 Northwestern University, Chicago, IL, United States. 7Royal Marsden Hospital / Institute of Cancer Research, London, Chelsea, United Kingdom.