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Peripheral differentiation patterns of human T cells

Heikkilä N, et al.
European Journal of Immunology
May 2022
Authors and Affiliates
Nelli Heikkilä 1, Iivo Hetemäki 1, Silja Sormunen 2, Helena Isoniemi 3, Eliisa Kekäläinen 4, Jari Saramäki 2, T Petteri Arstila 1; 1 Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU), Department of Bacteriology and Immunology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland. 2 Department of Computer Science, Aalto University, Espoo, Finland. 3 Division of Transplantation and Liver Surgery, Helsinki University Central Hospital, Helsinki, Finland. 4 Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU), Department of Bacteriology and Immunology, Medicum, Faculty of Medicine, HUSLAB Clinical Microbiology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland.

Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation

Snyder ME, et al.
Journal of Experimental Medicine
May 2022
Authors and Affiliates
Mark E Snyder 1,2,3, Kaveh Moghbeli 1, Anna Bondonese 1, Andrew Craig 1, Iulia Popescu 1, Li Fan 1, Tracy Tabib 1, Robert Lafyatis 1, Kong Chen 1, Humberto E Trejo Bittar 4, Elizabeth Lendermon 1, Joseph Pilewski 1, Bruce Johnson 1, Silpa Kilaru 1, Yingze Zhang 1, Pablo G Sanchez 5, Jonathan K Alder 1, Peter A Sims 6, John F McDyer 1,3; 1 Department of Medicine, University of Pittsburgh, Pittsburgh, PA. 2 Department of Immunology, University of Pittsburgh, Pittsburgh, PA. 3 Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA. 4 Department of Pathology, University of Pittsburgh, Pittsburgh, PA. 5 Department of Surgery, University of Pittsburgh, Pittsburgh, PA. 6 Department of Systems Biology, Columbia University Irving Medical Center, New York, NY.

SARS-CoV-2 (COVID-19)-specific T cell and B cell responses in convalescent rheumatoid arthritis: Monozygotic twins pair case observation

Arruda LCM, et al.
Scandinavian Journal of Immunology
May 2022
Authors and Affiliates
Lucas C M Arruda 1, Ahmed Gaballa 1, Rui Da Silva Rodrigues 2, Bartek Makower 3, Michael Uhlin 1,2,4; 1 Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden. 2 Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden. 3 Mabtech AB, Nacka Strand, Sweden. 4 Department of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden.

Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma.

Lakhotia R, et al.
Blood Advances
April 2022
Authors and Affiliates
Rahul Lakhotia,1 Christopher Melani,1 Kieron Dunleavy,2 Stefania Pittaluga,3 Nakhle Saba,4 Liza Lindenberg,5 Esther Mena,5 Ethan Bergvall,6 Andrea Nicole Lucas,7 Allison Jacob,8 Erik Yusko,8 Seth M. Steinberg,9 Elaine S. Jaffe,3 Adrian Wiestner,10 Wyndham H. Wilson,1, and Mark Roschewski1, 1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD; 2Department of Hematology-Oncology, Georgetown University, Washington, DC; 3Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD; 4Section of Hematology and Medical Oncology, Deming Department of Medicine, Tulane University, New Orleans, LA; 5Molecular Imaging Branch, National Cancer Institute, Bethesda, MD; 6Nuclear Medicine Department, Uniformed Services University of the Health Sciences, Bethesda, MD; 7Department of Nursing, Center for Cancer Research, National Cancer Institute, Bethesda, MD; 8Adaptive Biotechnologies, Seattle, WA; 9Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD; and 10Laboratory of Lymphoid Malignancies, National Heart, Lung and Blood Institute, Bethesda, MD

Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL.

Siddiqi T, et al.
Blood
March 2022
Authors and Affiliates
Tanya Siddiqi,1 Jacob D. Soumerai,2 Kathleen A. Dorritie,3 Deborah M. Stephens,4 Peter A. Riedell,5 Jon Arnason,6 Thomas J. Kipps,7 Heidi H. Gillenwater,8 Lucy Gong,8 Lin Yang,8 Ken Ogasawara,9 Jerill Thorpe,8 and William G. Wierda10 1Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; 2Department of Medicine, Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA, USA; 3 Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; 4Internal Medicine/Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; 5Hematopoietic Cellular Therapy Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA; 6Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Moores Cancer Center, Evelyn and Edwin Tasch Chair in Cancer Research, University of California San Diego, San Diego, CA, USA; 8Bristol Myers Squibb, Seattle, WA, USA; 9Bristol Myers Squibb, Princeton, NJ, USA; and 10Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

Geron I, et al.
Nature Communications
March 2022
Authors and Affiliates
Ifat Geron #,1,2,3, Angela Maria Savino #,1,2,3, Hila Fishman 1,2,3, Noa Tal 1,2, John Brown 4, Virginia A Turati 4, Chela James 4, Jolanda Sarno 5, Michal Hameiri-Grossman 3, Yu Nee Lee 1,6, Avigail Rein 1,2,3, Hillary Maniriho 1,3, Yehudit Birger 1,2,3, Anna Zemlyansky 3, Inna Muler 2, Kara L Davis 5, Victoria Marcu-Malina 7, Nicole Mattson 8, Oren Parnas 9, Rabea Wagener 10, Ute Fischer 10, João T Barata 11, Catriona H M Jamieson 12, Markus Müschen 8, Chun-Wei Chen 8, Arndt Borkhardt 10, Ilan Richard Kirsch 13, Arnon Nagler 1,14, Tariq Enver 4, Shai Izraeli 15,16,17,18; 1 Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel. 2 Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel. 3 The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel. 4 Department of Cancer Biology, UCL Cancer Institute, UCL, London, UK. 5 Department of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA. 6 Pediatric Department and the Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital Sheba Medical Center, Tel-Hashomer, Israel. 7 Cytogenetic Unit laboratory of Hematology, Chaim Sheba Medical Center Tel Hashomer, Tel Hashomer, Israel. 8 Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA. 9 The Concern Foundation Laboratories at the Lautenberg Center for immunology and Cancer Research, IMRIC, Hebrew University Faculty of Medicine, Jerusalem, Israel. 10 Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. 11 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. 12 UC San Diego, Moores Cancer Center, Division of Regenerative Medicine, Department of Medicine and Sanford Stem Cell Clinical Center, Ja Jolla, CA, USA. 13 Adaptive Biotechnologies, Inc., Seattle, WA, USA. 14 Hematology Division BMT and Cord Blood Bank Chaim Sheba Medical Center Tel-Hashomer, Tel-Hashomer, Israel. 15 Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel. sizraeli@gmail.com. 16 Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel. sizraeli@gmail.com. 17 The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel. sizraeli@gmail.com. 18 Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA. sizraeli@gmail.com. # Contributed equally

Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia

Bhattacharya D, et al.
Blood Cancer Journal
March 2022
Authors and Affiliates
Dipabarna Bhattacharya #,1,2, Antonella Teramo #,3, Vanessa Rebecca Gasparini #,3, Jani Huuhtanen #,1,2,4, Daehong Kim 1,2, Jason Theodoropoulos 1,2,4, Gianluca Schiavoni 5, Gregorio Barilà 3, Cristina Vicenzetto 3, Giulia Calabretto 3, Monica Facco 3, Toru Kawakami 6, Hideyuki Nakazawa 6, Brunangelo Falini 5, Enrico Tiacci 5, Fumihiro Ishida 7, Gianpietro Semenzato 3, Tiina Kelkka 1,2, Renato Zambello 3, Satu Mustjoki 8,9,10; 1 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. 2 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. 3 Department of Medicine, Hematology and Clinical Immunology Branch, University of Padova and Veneto Institute of Molecular Medicine (VIMM), Padova, Italy. 4 Department of Computer Science, Aalto University, Espoo, Finland. 5 Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy. 6 Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, Matsumoto, Japan. 7 Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto, Japan. 8 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi. 9 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi. 10 iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. satu.mustjoki@helsinki.fi. # Contributed equally.

Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate

Lagattuta KA, et al.
Nature Immunology
March 2022
Authors and Affiliates
Kaitlyn A Lagattuta 1,2,3,4,5, Joyce B Kang 1,2,3,4,5, Aparna Nathan 1,2,3,4,5, Kristen E Pauken 6,7, Anna Helena Jonsson 3, Deepak A Rao 3, Arlene H Sharpe 5,6,7, Kazuyoshi Ishigaki #,8,9,10,11, Soumya Raychaudhuri #,12,13,14,15,16,17; 1 Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. 2 Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 3 Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 4 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. 5 Broad Institute of MIT and Harvard, Cambridge, MA, USA. 6 Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. 7 Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. 8 Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. kazuyoshi.ishigaki@riken.jp. 9 Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. kazuyoshi.ishigaki@riken.jp. 10 Broad Institute of MIT and Harvard, Cambridge, MA, USA. kazuyoshi.ishigaki@riken.jp. 11 Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. kazuyoshi.ishigaki@riken.jp. 12 Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. soumya@broadinstitute.org. 13 Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org. 14 Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org. 15 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org. 16 Broad Institute of MIT and Harvard, Cambridge, MA, USA. soumya@broadinstitute.org. 17 Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. soumya@broadinstitute.org. # Contributed equally.
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