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Generation of self-reactive, shared T-cell receptor α chains in the human thymus

Heikkilä N., et al.
Journal of Autoimmunity
March 2021
Authors and Affiliates
Nelli Heikkilä 1, Silja Sormunen 2, Joonatan Mattila 3, Taina Härkönen 4, Mikael Knip 5, Emmi-Leena Ihantola 6, Tuure Kinnunen 7, Ilkka P Mattila 8, Jari Saramäki 2, T Petteri Arstila 3; 1 Research Programs Unit, Translational Immunology, and Medicum, University of Helsinki, Haartmaninkatu 3, 00290, Helsinki, Finland. Electronic address: nelli.heikkila@helsinki.fi. 2 Department of Computer Science, Aalto University, Konemiehenkatu 2, 02150, Espoo, Finland. 3 Research Programs Unit, Translational Immunology, and Medicum, University of Helsinki, Haartmaninkatu 3, 00290, Helsinki, Finland. 4 Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland. 5 Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland; Folkhälsan Research Center, Topeliuksenkatu 25, 00250, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Elämänaukio 2, 33520, Tampere, Finland. 6 Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Puijonlaaksontie 2, 70210, Kuopio, Finland. 7 Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Puijonlaaksontie 2, 70210, Kuopio, Finland; Eastern Finland Laboratory Centre (ISLAB), Puijonlaaksontie 2, 70210, Kuopio, Finland. 8 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland.

CD52/GPI-negative T-cells are enriched for alloreactive specificity and predict acute GvHD after stem cell transplantation.

Kinsella FA., et al.
March 2021
Authors and Affiliates
Francesca A. Kinsella 1,2, Charlotte. F. Inman 1, Wayne Croft 1, Jianmin Zuo 1, Hayden Pearce 1, Sara Barbieri 2, Charles Craddock 2, Ram Malladi 2, Paul Moss 1,2; 1 Institute of Immunology and Immunotherapy, College of Medical and Dental Studies, University of Birmingham and Birmingham Health Partners, Birmingham, UK 2 Centre for Clinical Haematology, Queen Elizabeth NHS Foundation Trust and Birmingham Health Partners, Birmingham, UK

Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation

Fu J., et al.
Journal of Clinical Investigation
March 2021
Authors and Affiliates
Jianing Fu 1, Julien Zuber 1, Brittany Shonts 1, Aleksandar Obradovic 1, Zicheng Wang 2, Kristjana Frangaj 1, Wenzhao Meng 3, Aaron M Rosenfeld 3, Elizabeth E Waffarn 1, Peter Liou 4, Sai-Ping Lau 1, Thomas M Savage 1, Suxiao Yang 1, Kortney Rogers 1, Nichole M Danzl 1, Shilpa Ravella 5, Prakash Satwani 6, Alina Iuga 7, Siu-Hong Ho 1, Adam Griesemer 4, Yufeng Shen 2, Eline T Luning Prak 3, Mercedes Martinez 6, Tomoaki Kato 4, Megan Sykes 1; 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, United States of America. 2 Center for Computational Biology and Bioinformatics, Department of Systems , Columbia University, New York, United States of America. 3 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, United States of America. 4 Department of Surgery, Columbia University, New York, United States of America. 5 Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, United States of America. 6 Department of Pediatrics, Columbia University, New York, United States of America. 7 Department of Pathology and Cell Biology, Columbia University, New York, United States of America.

VJ Segment Usage of TCR-Beta Repertoire in Monozygotic Cystic Fibrosis Twins

Fischer S., et al.
Frontiers in Immunology
March 2021
Authors and Affiliates
Sebastian Fischer 1, Frauke Stanke 1,2 and Burkhard Tümmler 1,2; 1 Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany 2 Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany

Systemic Inflammation and Tumour-Infiltrating T-Cell Receptor Repertoire Diversity Are Predictive of Clinical Outcome in High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements

Olschewski V., et al.
Cancers
March 2021
Authors and Affiliates
Vito Olschewski 1,†, Hanno M. Witte 1,2,3,† , Veronica Bernard 4,†, Konrad Steinestel 3 , Wolfgang Peter 5,6, Hartmut Merz 4, Johannes Rieken 1, Harald Biersack 1, Nikolas von Bubnoff 1 , Alfred C. Feller 4 and Niklas Gebauer 1,*; 1 Department of Haematology and Oncology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany 2 Department of Hematology and Oncology, Federal Armed Forces Hospital Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany 3 Institute of Pathology and Molecular Pathology, Federal Armed Forces Hospital of Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany 4 Hämatopathologie Lübeck, Reference Center for Lymph Node Pathology and Hematopathology, 23562 Lübeck, Germany 5 HLA Typing Laboratory of the Stefan-Morsch-Foundation, 55765 Birkenfeld, Germany 6 Institute for Transfusion Medicine, University Hospital of Cologne, Kerpenerstr 62, 50937 Köln, Germany * Author to whom correspondence should be addressed. † These authors contributed equally to this manuscript.

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

Cascone T., et al.
February 2021
Authors and Affiliates
Tina Cascone 1, William N William Jr 2,3, Annikka Weissferdt 4,5, Cheuk H Leung 6, Heather Y Lin 6, Apar Pataer 5, Myrna C B Godoy 7, Brett W Carter 7, Lorenzo Federico 8, Alexandre Reuben 2, Md Abdul Wadud Khan 9, Hitoshi Dejima 10,11, Alejandro Francisco-Cruz 10, Edwin R Parra 10, Luisa M Solis 10, Junya Fujimoto 10, Hai T Tran 2, Neda Kalhor 4, Frank V Fossella 2, Frank E Mott 2, Anne S Tsao 2, George Blumenschein Jr 2, Xiuning Le 2, Jianjun Zhang 2, Ferdinandos Skoulidis 2, Jonathan M Kurie 2, Mehmet Altan 2, Charles Lu 2, Bonnie S Glisson 2, Lauren Averett Byers 2, Yasir Y Elamin 2, Reza J Mehran 5, David C Rice 5, Garrett L Walsh 5, Wayne L Hofstetter 5, Jack A Roth 5, Mara B Antonoff 5, Humam Kadara 10, Cara Haymaker 10, Chantale Bernatchez 8,10, Nadim J Ajami 12, Robert R Jenq 12,13,14, Padmanee Sharma 15,16, James P Allison 16, Andrew Futreal 12, Jennifer A Wargo 9, Ignacio I Wistuba 2,10, Stephen G Swisher 5, J Jack Lee 6, Don L Gibbons 2, Ara A Vaporciyan 5, John V Heymach #,2,17, Boris Sepesi #,5; 1 Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. tcascone@mdanderson.org. 2 Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3 Oncology Center, Hospital BP, a Beneficencia Portuguesa de São Paulo, São Paulo, Brazil. 4 Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 5 Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 6 Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 7 Thoracic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 8 Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 9 Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 10 Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 11 Teikyo University School of Medicine, Itabashi, Tokyo, Japan. 12 Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 13 Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 14 CPRIT Scholar in Cancer Research, Houston, TX, USA. 15 Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 16 Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 17 Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. # Contributed equally.

Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice

Khosravi-Maharlooei M, et al.
Journal of Autoimmunity
February 2021
Authors and Affiliates
Mohsen Khosravi-Maharlooei 1, HaoWei Li 1, Markus Hoelzl 1, Guiling Zhao 1, Amanda Ruiz 1, Aditya Misra 1, Yang Li 1, Nato Teteloshvili 1, Grace Nauman 1, Nichole Danzl 1, Xiaolan Ding 1, Elisha Y Pinker 1, Aleksandar Obradovic 1, Yong-Guang Yang 1, Alina Iuga 2, Remi J Creusot 1, Robert Winchester 3, Megan Sykes 4; 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA. 2 Department of Pathology, Columbia University Medical Center, Columbia University, New York, NY, 10032, USA. 3 Department of Pathology, Columbia University Medical Center, Columbia University, New York, NY, 10032, USA; Division of Rheumatology, Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA. 4 Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA; Department of Microbiology & Immunology, Columbia University Medical Center, Columbia University, New York, NY, 10032, USA; Department of Surgery, Columbia University Medical Center, Columbia University, New York, NY, 10032, USA. Electronic address: megan.sykes@columbia.edu.

Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells

Wanjalla CN., et al.
February 2021
Authors and Affiliates
Celestine N. Wanjalla 1,2,5,14, Wyatt J. McDonnell 1,2,3,4,11, Ramesh Ram 10, Abha Chopra 10, Rama Gangula 15, Shay Leary 10, Mona Mashayekhi 6, Joshua D. Simmons 15, Christian M. Warren 15, Samuel Bailin 1, Curtis L. Gabriel 8, Liang Guo 12, Briana D. Furch 15, Morgan C. Lima 15, Beverly O. Woodward 15, LaToya Hannah 6, Mark A. Pilkinton 12, Daniela T. Fuller 12, Kenji Kawai 12, Renu Virmani 12, Aloke V. Finn 12, Alyssa H. Hasty 9,13, Simon A. Mallal 1,2,4,5,7,10, Spyros A. Kalams 1,2,4,5, John R. Koethe 1,2,5,13,15; 1 Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA 2 Center for Translational Immunology and Infectious Disease, Vanderbilt University Medical Center, Nashville, TN, USA 3 Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA 4 Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA 5 Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, USA 6 Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA 7 VANTAGE, Vanderbilt University Medical Center, Nashville, TN, USA 8 Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University, Nashville, TN, USA 9 Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA 10 Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia 11 10x Genomics, Pleasanton, CA, USA 12 CVPath Institute, Gaithersburg, MD, USA 13 Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA
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