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Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System

Gardner CL, et al.,
Journal of Clinical Immunology
March 2021
Authors and Affiliates
Cameron L Gardner 1,2, Mara Pavel-Dinu 3, Kerry Dobbs 1, Marita Bosticardo 1, Paul K Reardon 2, Justin Lack 4,5, Suk See DeRavin 1, Kent Le 1, Ezekiel Bello 1, Francesca Pala 1, Ottavia M Delmonte 1, Harry Malech 1, Amelie Montel-Hagan 6, Gay Crooks 6, Oreste Acuto 7, Matthew H Porteus 8, Luigi D Notarangelo 9; 1 Immune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, DIR, NIAID, NIH, 10 Center Drive, Bldg. 10 CRC, Room 5-3950, Bethesda, MD, 20892-1456, USA. 2 Sir William Dunn School of Pathology, University of Oxford, Oxford, OX14RE, UK. 3 Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA. 4 NIAID Collaborative Bioinformatics Resource, NIAID, NIH, Bethesda, MD, USA. 5 Advanced Biomedical Computational Science (ABCS), Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 6 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 7 Sir William Dunn School of Pathology, University of Oxford, Oxford, OX14RE, UK. oreste.acuto@path.ox.ac.uk. 8 Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA. mporteus@stanford.edu. 9 Immune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, DIR, NIAID, NIH, 10 Center Drive, Bldg. 10 CRC, Room 5-3950, Bethesda, MD, 20892-1456, USA. luigi.notarangelo2@nih.gov.

T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

Yamauchi T., et al.,
Nature Communications
March 2021
Authors and Affiliates
Takayoshi Yamauchi 1, Toshifumi Hoki 1,2, Takaaki Oba 1, Vaibhav Jain 1, Hongbin Chen 3,4, Kristopher Attwood 5, Sebastiano Battaglia 1,6, Saby George 3,4, Gurkamal Chatta 3, Igor Puzanov 3, Carl Morrison 7, Kunle Odunsi 1,8,9,10, Brahm H Segal 3,4,9, Grace K Dy 3, Marc S Ernstoff 3,4,11, Fumito Ito 12,13,14,15; 1 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 2 Merck Sharp & Dohme, Tokyo, Japan. 3 Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 4 Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY, USA. 5 Department of Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 6 Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 7 Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 8 Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 9 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 10 University of Chicago Comprehensive Cancer Center, Chicago, IL, USA. 11 Division of Cancer Treatment and Diagnosis, Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD, USA. 12 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. fumito.ito@roswellpark.org. 13 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. fumito.ito@roswellpark.org. 14 Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. fumito.ito@roswellpark.org. 15 Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY, USA. fumito.ito@roswellpark.org.

Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse

Kamal Y, et al.,
OncoImmunology
March 2021
Authors and Affiliates
Yasmin Kamal 1, Dennis Dwan 1, Hannah J. Hoehn 2, Rebeca Sanz-Pamplona 3,4, M. Henar Alonso 3,4,5, Victor Moreno 3,4,5, Chao Cheng 6,7,8, Michael J. Schell 9, Youngchul Kim 9, Seth I. Felder 10, Hedy S. Rennert 11,12, Marilena Melas 13, 14, Charalampos Lazaris 13,15,16, Joseph D. Bonner 17, Erin M. Siegel 18, David Shibata 19, Gad Rennert 11,12, Stephen B. Gruber 7, H. Robert Frost 1, Christopher I. Amos 1,7,8, and Stephanie L. Schmit 2,10; 1 Department of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Hanover, NH, USA 2 Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA 3 Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain 4 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain 5 Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain 6 Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA 7 Department of Medicine, Baylor College of Medicine, Houston, TX, USA 8 Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA 9 Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Columbus, OH, USA 10 Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Columbus, OH, USA 11 Department of Community Medicine & Epidemiology, Lady Davis Carmel Medical Center, Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel 12 Steve and Cindy Rasmussen Institute for Genomic Medicine, Lady Davis Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel 13 Department of Medical Oncology and Therapeutics Research, Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA 14 Nationwide Children’s Hospital, Columbus, OH, USA 15 Whitehead Institute for Biomedical Research, Cambridge, MA, USA 16 Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA 17 Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA 18 Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Columbus, OH, USA 19 Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA

Generation of self-reactive, shared T-cell receptor α chains in the human thymus

Heikkilä N., et al.
Journal of Autoimmunity
March 2021
Authors and Affiliates
Nelli Heikkilä 1, Silja Sormunen 2, Joonatan Mattila 3, Taina Härkönen 4, Mikael Knip 5, Emmi-Leena Ihantola 6, Tuure Kinnunen 7, Ilkka P Mattila 8, Jari Saramäki 2, T Petteri Arstila 3; 1 Research Programs Unit, Translational Immunology, and Medicum, University of Helsinki, Haartmaninkatu 3, 00290, Helsinki, Finland. Electronic address: nelli.heikkila@helsinki.fi. 2 Department of Computer Science, Aalto University, Konemiehenkatu 2, 02150, Espoo, Finland. 3 Research Programs Unit, Translational Immunology, and Medicum, University of Helsinki, Haartmaninkatu 3, 00290, Helsinki, Finland. 4 Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland. 5 Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland; Folkhälsan Research Center, Topeliuksenkatu 25, 00250, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Elämänaukio 2, 33520, Tampere, Finland. 6 Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Puijonlaaksontie 2, 70210, Kuopio, Finland. 7 Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Puijonlaaksontie 2, 70210, Kuopio, Finland; Eastern Finland Laboratory Centre (ISLAB), Puijonlaaksontie 2, 70210, Kuopio, Finland. 8 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland.

CD52/GPI-negative T-cells are enriched for alloreactive specificity and predict acute GvHD after stem cell transplantation.

Kinsella FA., et al.
March 2021
Authors and Affiliates
Francesca A. Kinsella 1,2, Charlotte. F. Inman 1, Wayne Croft 1, Jianmin Zuo 1, Hayden Pearce 1, Sara Barbieri 2, Charles Craddock 2, Ram Malladi 2, Paul Moss 1,2; 1 Institute of Immunology and Immunotherapy, College of Medical and Dental Studies, University of Birmingham and Birmingham Health Partners, Birmingham, UK 2 Centre for Clinical Haematology, Queen Elizabeth NHS Foundation Trust and Birmingham Health Partners, Birmingham, UK

Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation

Fu J., et al.
Journal of Clinical Investigation
March 2021
Authors and Affiliates
Jianing Fu 1, Julien Zuber 1, Brittany Shonts 1, Aleksandar Obradovic 1, Zicheng Wang 2, Kristjana Frangaj 1, Wenzhao Meng 3, Aaron M Rosenfeld 3, Elizabeth E Waffarn 1, Peter Liou 4, Sai-Ping Lau 1, Thomas M Savage 1, Suxiao Yang 1, Kortney Rogers 1, Nichole M Danzl 1, Shilpa Ravella 5, Prakash Satwani 6, Alina Iuga 7, Siu-Hong Ho 1, Adam Griesemer 4, Yufeng Shen 2, Eline T Luning Prak 3, Mercedes Martinez 6, Tomoaki Kato 4, Megan Sykes 1; 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, United States of America. 2 Center for Computational Biology and Bioinformatics, Department of Systems , Columbia University, New York, United States of America. 3 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, United States of America. 4 Department of Surgery, Columbia University, New York, United States of America. 5 Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, United States of America. 6 Department of Pediatrics, Columbia University, New York, United States of America. 7 Department of Pathology and Cell Biology, Columbia University, New York, United States of America.

VJ Segment Usage of TCR-Beta Repertoire in Monozygotic Cystic Fibrosis Twins

Fischer S., et al.
Frontiers in Immunology
March 2021
Authors and Affiliates
Sebastian Fischer 1, Frauke Stanke 1,2 and Burkhard Tümmler 1,2; 1 Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany 2 Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany

Systemic Inflammation and Tumour-Infiltrating T-Cell Receptor Repertoire Diversity Are Predictive of Clinical Outcome in High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements

Olschewski V., et al.
Cancers
March 2021
Authors and Affiliates
Vito Olschewski 1,†, Hanno M. Witte 1,2,3,† , Veronica Bernard 4,†, Konrad Steinestel 3 , Wolfgang Peter 5,6, Hartmut Merz 4, Johannes Rieken 1, Harald Biersack 1, Nikolas von Bubnoff 1 , Alfred C. Feller 4 and Niklas Gebauer 1,*; 1 Department of Haematology and Oncology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany 2 Department of Hematology and Oncology, Federal Armed Forces Hospital Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany 3 Institute of Pathology and Molecular Pathology, Federal Armed Forces Hospital of Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany 4 Hämatopathologie Lübeck, Reference Center for Lymph Node Pathology and Hematopathology, 23562 Lübeck, Germany 5 HLA Typing Laboratory of the Stefan-Morsch-Foundation, 55765 Birkenfeld, Germany 6 Institute for Transfusion Medicine, University Hospital of Cologne, Kerpenerstr 62, 50937 Köln, Germany * Author to whom correspondence should be addressed. † These authors contributed equally to this manuscript.
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