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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma
Algazi et al.
Clinical Cancer Research
June 2020
Authors and Affiliates
Alain P Algazi # 1, Christopher G Twitty # 2, Katy K Tsai 1, Mai Le 3, Robert Pierce 4, Erica Browning 2, Reneta Hermiz 2, David A Canton 2, Donna Bannavong 2, Arielle Oglesby 1, Murray Francisco 2, Lawrence Fong 1, Mikael J Pittet 5, Sean P Arlauckas 6, Christopher Garris 7, Lauren P Levine 1, Carlos Bifulco 8, Carmen Ballesteros-Merino 8, Shailender Bhatia 4, Sharron Gargosky 2, Robert H I Andtbacka 9, Bernard A Fox 8, Michael D Rosenblum 1, Adil I Daud 10;
1University of California, San Francisco, San Francisco, California.
2OncoSec Medical Incorporated, Pennington, New Jersey.
3DR HOPE LLC, Seattle, Washington.
4Fred Hutchinson Cancer Research Center, Seattle, Washington.
5Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
6Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
7Rockefeller University, New York, New York.
8Earle A. Chiles Research Institute, Portland, Oregon.
9Huntsman Cancer Institute, Salt Lake City, Utah.
10University of California, San Francisco, San Francisco, California. Adil.daud@ucsf.edu.
#Contributed equally.
A circulating T-cell differentiation marker to predict response to immune checkpoint inhibitors
Yamauchi et al.
bioRxiv
June 2020
Authors and Affiliates
Takayoshi Yamauchi1 , Toshifumi Hoki1 , Takaaki Oba1 , Vaibhav Jain1 , Hongbin Chen1, Kristopher Attwood4 , Sebastiano Battaglia1,5, Saby George2,3, Gurkamal Chatta2 , Igor Puzanov2, Carl Morrison6 , Kunle Odunsi1,7,8, Brahm H. Segal2,3,8, Grace K. Dy2, Marc S. Ernstoff2,3 , Fumito Ito1,8,9,10* Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 2 Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York 3 Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, the State University of New York, Buffalo, NY 4 Department of Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 5 Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 6 Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 7 Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 8 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 9 Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 10 Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, the State University of New York, Buffalo, NY
Immunotyping of clinically divergent p.Phe508del homozygous monozygous cystic fibrosis twins
Schamschula et al.
Journal of Cystic Fibrosis
June 2020
Authors and Affiliates
Esther Schamschula 1, Wolfgang Hagmann 2, Yassen Assenov 2, Silke Hedtfeld 3, Ahmed K Farag 4, Lennart M Roesner 4, Lutz Wiehlmann 5, Frauke Stanke 6, Sebastian Fischer 3, Angela Risch 7, Burkhard Tümmler 8;
1Department of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.
2Division of Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany.
3Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
4Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany.
5Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Research Core Unit Genomics, Hannover Medical School, Hannover, Germany.
6Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany.
7Department of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria; Division of Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.
8Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany. Electronic address: tuemmler.burkhard@mh-hannover.de.
Immunotherapy of CT26 Murine Tumors Is Characterized by an Oligoclonal Response of Tissue-Resident Memory T Cells Against the AH1 Rejection Antigen
Stringhini et al.
European Journal of Immunology
May 2020
Authors and Affiliates
Marco Stringhini 1, Philipp Probst 1, Dario Neri 1;
1Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab
Casneuf et al.
Leukemia
May 2020
Authors and Affiliates
Tineke Casneuf1 Homer C. Adams III2 Niels W.C.J. van de Donk3 Yann Abraham1 Jaime Bald2 Greet Vanhoof1 Koen Van der Borght1 Tina Smets1 Brad Foulk2 Karl C. Nielsen2 Joshua Rusbuldt2 Amy Axel2
Andrew Lysaght4 Hugo Ceulemans1 Frederik Stevenaert1 Saad Z. Usmani5 Torben Plesner6
Herve Avet-Loiseau7 Inger Nijhof3 Tuna Mutis3 Jordan M. Schecter8 Christopher Chiu2 Nizar J. Bahlis9
1 Janssen Research & Development, Beerse, Belgium
2 Janssen Research & Development, LLC, Spring House, PA, USA
Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
3 Vejle Hospital and University of Southern Denmark,
4 Immuneering Corp, Cambridge, MA, USA 5 Levine Cancer Institute/Carolinas Healthcare System, Charlotte, NC, USA
6
Vejle, Denmark
7
Toulouse, France
8 9
Janssen Research & Development, LLC, Raritan, NJ, USA
Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada
T Cell Clonal Dynamics Determined by High-Resolution TCR-β Sequencing in Recipients after Allogeneic Hematopoietic Cell Transplantation
Leick et al.
Biology of Blood and Marrow Transplantation
May 2020
Authors and Affiliates
Mark Leick 1, Rachel M Gittelman 2, Erik Yusko 2, Catherine Sanders 2, Harlan Robins 2, Zachariah DeFilipp 1, Sarah Nikiforow 3, Jerome Ritz 3, Yi-Bin Chen 4
1Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts.
2Adaptive Biotechnologies, Seattle, Washington.
3Division of Hematological Malignancies, Dana-Farber Cancer Institute, Boston, Massachusetts.
4Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: ychen6@partners.org.
Feasibility and efficacy of CD19-targeted CAR T cells with concurrent ibrutinib for CLL after ibrutinib failure
Gauthier J, et al.
Blood
May 2020
Authors and Affiliates
Jordan Gauthier,1-3 Alexandre V. Hirayama,1,3 Janaki Purushe,1 Kevin A. Hay,1,4 James Lymp,5 Daniel H. Li,5 Cecilia C. S. Yeung,1,6 Alyssa Sheih,1
Barbara S. Pender,1 Reed M. Hawkins,1 Aesha Vakil,1 Tinh-Doan Phi,1 Rachel N. Steinmetz,1 Mazyar Shadman,1,2 Stanley R. Riddell,1-3
David G. Maloney,1-3 and Cameron J. Turtle1-3
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 2Division of Medical Oncology, Department of Medicine, University of
Washington, Seattle, WA; 3Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA; 4Department of Medicine,
University of British Columbia, Vancouver, BC, Canada; 5Juno Therapeutics, a Bristol-Myers Squibb Company, Seattle, WA; and 6Department of Pathology,
University of Washington, Seattle, WA
Somatic mTOR Mutation in Clonally Expanded T Lymphocytes Associated With Chronic Graft Versus Host Disease
Kim et al.
Nature Communications
May 2020
Authors and Affiliates
Daehong Kim 1 2, Giljun Park 1 2, Jani Huuhtanen 1 2, Sofie Lundgren 1 2, Rajiv K Khajuria 1, Ana M Hurtado 3, Cecilia Muñoz-Calleja 4, Laura Cardeñoso 5, Valle Gómez-García de Soria 6, Tzu Hua Chen-Liang 3, Samuli Eldfors 7, Pekka Ellonen 7, Sari Hannula 7, Matti Kankainen 1 2 8 9, Oscar Bruck 1 2 9, Anna Kreutzman 1 2, Urpu Salmenniemi 10, Tapio Lönnberg 11, Andrés Jerez 3, Maija Itälä-Remes 10, Mikko Myllymäki 1 2, Mikko A I Keränen 1 2 12, Satu Mustjoki 13 14 15;
1Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, 00290, Helsinki, Finland.
2Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, 00014, Helsinki, Finland.
3Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación, Universidad de Murcia, IMIB, 30008, Murcia, Spain.
4Department of Immunology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain.
5Department of Microbiology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain.
6Department of Hematology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain.
7Institute of Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.
8Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland.
9iCAN Digital Precision Cancer Medicine, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland.
10Stem Cell transplantation unit, Turku University Hospital, 20521, Turku, Finland.
11Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland.
12Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, 00029, Helsinki, Finland.
13Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, 00290, Helsinki, Finland. satu.mustjoki@helsinki.fi.
14Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, 00014, Helsinki, Finland. satu.mustjoki@helsinki.fi.
15iCAN Digital Precision Cancer Medicine, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland. satu.mustjoki@helsinki.fi.
Genetic and Immune Changes Associated with Disease Progression under the Pressure of Oncolytic Therapy in A Neuroblastoma Outlier Patient
Franco-Luzon et al.
Cancers
April 2020
Authors and Affiliates
Lidia Franco-Luzón 1, Sandra García-Mulero 2 3, Rebeca Sanz-Pamplona 3, Gustavo Melen 4 5, David Ruano 5, Álvaro Lassaletta 5, Luís Madero 1 5 6, África González-Murillo 4 5, Manuel Ramírez 4 5; 1Children Oncohematology Foundation, 28079 Madrid, Spain.
2Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
3Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
4Biomedical Research Foundation, Niño Jesús Children Hospital, 28009 Madrid, Spain.
5La Princesa Institute of Health Research, 28006 Madrid, Spain.
6Oncohematology Unit, Hospital Infantil Universitario Niño Jesús, 28009 Madrid, Spain.