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B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy

Moore et al.
American Journal of Transplantation
December 2019
Authors and Affiliates
Moore C1,2,3, Gao B1,4, Roskin KM2,3,5, Vasilescu EM6, Addonizio L7, Givertz MM8, Madsen JC1,9, Zorn E1,10. 1 Center for Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2 Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 3 Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 4 Transplant Center, The First Hospital of Jilin University, Changchun, China. 5 Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA. 6 Department of Pathology & Cell Biology, Columbia University Medical Center, New York, New York, USA. 7 Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA. 8 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 9 Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 10 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York, USA.

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

Gaballa et al.
Stem Cells International
December 2019
Authors and Affiliates
Ahmed Gaballa ,1 Lucas C. M. Arruda ,1 Emelie Rådestad ,1 and Michael Uhlin 1,2,3 1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden 2Department of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden 3Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden

The Utility of T-Cell Clonality in Differential Diagnostics of Acute Graft-versus-Host Disease from Drug Hypersensitivity Reaction

Chang et al.
Journal of Investigative Dermatology
December 2019
Authors and Affiliates
Li-Wei Chang1, Linda T. Doan2, Paul Fields3, Marissa Vignali3 and Oleg E. Akilov1,* 1Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; 2Department of Dermatology, University of California Irvine, Irvine, California, USA; and 3Adaptive Biotechnologies, Seattle, Washington, USA *Corresponding author e-mail: akilovoe@ upmc.edu

Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy

Flores et al.
Science Advances
November 2019
Authors and Affiliates
Flores C1, Wildes T1, Dean BD1, Moore G1, Drake J1, Abraham R1, Gil J1, Yegorov O1, Yang C1, Dean J1, Moneypenny C1, Shin D1,2, Pham C1, Krauser J1, King J1, Grant G3, Driscoll T4, Kurtzberg J4, McLendon R5, Gururangan S1,6, Mitchell D1; 1 University of Florida Brain Tumor Immunotherapy Program, Preston A. Wells, Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. 2 U.S. Army, 1600 Spearhead Division Ave., Fort Knox, KY, USA. 3 Department of Neurosurgery, Stanford University Medical Center, Palo Alto, CA, USA. 4 Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. 5 Department of Pathology, Duke University Medical Center, Durham, NC, USA. 6 Department of Pediatrics, University of Florida, Gainesville, FL, USA.

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Søndergaard et al.
Cell Reports
November 2019
Authors and Affiliates
Søndergaard E1, Rauch A2, Michaut M3, Rapin N3, Rehn M1, Wilhelmson AS1, Camponeschi A4, Hasemann MS1, Bagger FO3, Jendholm J1, Knudsen KJ1, Mandrup S2, Mårtensson IL4, Porse BT5; 1 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. 2 Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark. 3 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; The Bioinformatics Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. 4 Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. 5 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: bo.porse@finsenlab.dk.

Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation

Buhler et al.
Leukemia
November 2019
Authors and Affiliates
Buhler S1, Bettens F2, Dantin C3, Ferrari-Lacraz S2, Ansari M4, Mamez AC3, Masouridi-Levrat S3, Chalandon Y3, Villard J5; 1 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. stephane.buhler@hcuge.ch. 2 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. 3 Service of Haematology, Department of Oncology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 4 Pediatric Department, Onco-Hematology Unit, Geneva University Hospitals and Cansearch research laboratory, Geneva Medical School, Geneva, Switzerland. 5 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. jean.villard@hcuge.ch.

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

Ogongo et al.
Journal of Clinical Investigation
November 2019
Authors and Affiliates
Ogongo P1,2,3, Steyn AJ1, Karim F1, Dullabh KJ4, Awala I4, Madansein R4, Leslie A1,5, Behar SM6; 1 Africa Health Research Institute, and. 2 School of Laboratory Medicine, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 3 Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya. 4 Department of Cardiothoracic Surgery, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 5 Department of Infection and Immunity, University College London, London, United Kingdom. 6 Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Loss of Setd4 delays radiation-induced thymic lymphoma in mice

Feng et al.
DNA Reapir
November 2019
Authors and Affiliates
Feng X1, Lu H1, Yue J1, Schneider N1, Liu J1, Denzin LK2, Chan CS3, De S3, Shen Z4; 1 Rutgers Cancer Institute of New Jersey, Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. 2 Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA. 3 Center for Systems and Computational Biology, Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ 08901, USA. 4 Rutgers Cancer Institute of New Jersey, Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. Electronic address: shenzh@cinj.rutgers.edu.

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy

Chowell et al.
Nature Medicine
November 2019
Authors and Affiliates
Chowell D1,2, Krishna C3, Pierini F4, Makarov V1,2, Rizvi NA5, Kuo F2, Morris LGT2,6, Riaz N2,7, Lenz TL8, Chan TA9,10,11,12; 1 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany. 5 Department of Medicine, Columbia University Medical Center, New York, NY, USA. 6 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany. lenz@post.harvard.edu. 9 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 10 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 11 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 12 Weill Cornell School of Medicine, New York, NY, USA. chant@mskcc.org.

Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer

Zhang et al.
Clinical Cancer Research
November 2019
Authors and Affiliates
Jiajia Zhang1,2, Zhicheng Ji3 , Justina X. Caushi1,2, Margueritta El Asmar1,2, Valsamo Anagnostou1,2, Tricia R. Cottrell1,2,4, Hok Yee Chan1,2, Prerna Suri1,2, Haidan Guo1,2, Taha Merghoub5 , Jamie E. Chaft5 , Joshua E. Reuss1,2, Ada J. Tam1,2, Richard L. Blosser1,2, Mohsen Abu-Akeel5 , John-William Sidhom1,2, Ni Zhao3 , Jinny S. Ha2,6, David R. Jones7 , Kristen A. Marrone1,2, Jarushka Naidoo1,2, Edward Gabrielson1,2, Janis M. Taube1,2,4, Victor E. Velculescu1,2, Julie R. Brahmer1,2, Franck Housseau1,2, Matthew D. Hellmann5 , Patrick M. Forde1,2, Drew M. Pardoll1,2, Hongkai Ji3 , and Kellie N. Smith1,2; 1 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland. 2 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. 3 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland. 4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 5 Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York. 6 Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. 7 Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York
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