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Immunological Ignorance Is an Enabling Feature of the Oligo-Clonal T Cell Response to Melanoma Neoantigens

Linette et al.
Proceedings of the National Academy of Sciences
November 2019
Authors and Affiliates
Gerald P Linette 1 2 3 4, Michelle Becker-Hapak 5 6 7, Zachary L Skidmore 5 6 7, Miren Lorea Baroja 1 2 3 4, Chong Xu 1 2 3 4, Jasreet Hundal 5 6 7, David H Spencer 5 6 7, Weixuan Fu 1 2 3 4 8, Casey Cummins 1 2 3 4, Maya Robnett 1 2 3 4, Saghar Kaabinejadian 9, William H Hildebrand 9, Vincent Magrini 10 11, Ryan Demeter 5 6 7, Alexander S Krupnick 12, Obi L Griffith 5 6 7, Malachi Griffith 5 6 7, Elaine R Mardis 10 11, Beatriz M Carreno 13 2 3 4; 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 2The Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 4Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 5McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110. 6Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110. 7Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110. 8Bioinformatics Core, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 9Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104. 10Institute for Genomic Medicine, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH 43205. 11Department of Pediatrics, Ohio State University College of Medicine, Columbus, OH 43205. 12Department of Surgery, University of Virginia, Charlottesville, VA 22908. 13Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; bcarreno@upenn.edu.

Lack of specific T- and B-cell clonal expansions in multiple sclerosis patients with progressive multifocal leukoencephalopathy

Bertoli et al.
Scientific Reports
November 2019
Authors and Affiliates
Diego Bertoli,1,2 Alessandra Sottini,1 Ruggero Capra,3 Cristina Scarpazza,3,4 Roberto Bresciani,2 Luigi D. Notarangelo,5 and Luisa Imberti1; 1Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili, Brescia, Italy 2Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy 3Multiple Sclerosis Center, ASST Spedali Civili, Brescia, Italy 4Department of General Psychology, University of Padova, Padova, Italy 5Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States

Pembrolizumab in Combination with the Oncolytic Virus Pelareorep and Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma: A Phase Ib Study

Mahalingam et al.
Clinical Cancer Research
November 2019
Authors and Affiliates
Mahalingam D1,2, Wilkinson GA3, Eng KH4, Fields P5, Raber P5, Moseley JL2, Cheetham K3, Coffey M3, Nuovo G6, Kalinski P4, Zhang B7, Arora SP2, Fountzilas C4; 1 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois. Mahalingam@northwestern.edu. 2 Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas. 3 Oncolytics Biotech Inc, Calgary, Alberta, Canada. 4 Roswell Park Comprehensive Cancer Center, Buffalo, New York. 5 Adaptive Biotechnologies, Seattle, Washington. 6 Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio. 7 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.

Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development

Stras et al.
Developmental Cell
November 2019
Authors and Affiliates
Stras SF1, Werner L2, Toothaker JM3, Olaloye OO1, Oldham AL1, McCourt CC1, Lee YN4, Rechavi E4, Shouval DS5, Konnikova L6; 1 Division of Newborn Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. 2 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. 3 Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA. 4 Pediatric Department A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. 5 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: dror.shouval@gmail.com. 6 Division of Newborn Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: liza.konnikova@chp.edu.

Synovial IL-17A+ CD8+ T cells display a polyfunctional, pro-inflammatory and tissue-resident memory phenotype and function in psoriatic arthritis

Steel et al.
Arthritis and Rheumatology
November 2019
Authors and Affiliates
Steel KJA1, Srenathan U1, Ridley M1, Durham LE1, Wu SY1, Ryan SE1, Hughes CD1,2, Chan E2, Kirkham BW2, Taams LS1; 1 Centre for Inflammation Biology and Cancer Immunology (CIBCI), Department of Inflammation Biology, School of Immunology & Microbial Sciences, King's College London. 2 Department Rheumatology, Guy's & St Thomas' Hospital, London, UK.

Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis

Steel KJA, et al.
Arthritis and Rheumatology
November 2019
Authors and Affiliates
Kathryn J A Steel 1, Ushani Srenathan 1, Michael Ridley 1, Lucy E Durham 1, Shih-Ying Wu 1, Sarah E Ryan 1, Catherine D Hughes 2, Estee Chan 3, Bruce W Kirkham 3, Leonie S Taams 1; 1 King's College London, London, UK. 2 King's College London, Guy's Hospital, and St. Thomas' Hospital, London, UK. 3 Guy's Hospital and St. Thomas' Hospital, London, UK.

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

Gros et al.
Journal of Clinical Investigation
November 2019
Authors and Affiliates
Alena Gros,1 Eric Tran,2,3 Maria R. Parkhurst,2 Sadia Ilyas,2 Anna Pasetto,4 Eric M. Groh,2 Paul F. Robbins,2 Rami Yossef,2 Andrea Garcia-Garijo,1 Carlos A. Fajardo,1 Todd D. Prickett,2 Li Jia,2 Jared J. Gartner,2 Satyajit Ray,2 Lien Ngo,2 John R. Wunderllich,2 James C. Yang,2 and Steven A. Rosenberg2 1Vall d’Hebron Institute of Oncology, Cellex Center, Barcelona, Spain. 2Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA. 3Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, Oregon, USA. 4Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.

Immune and circulating tumor DNA profiling following radiation treatment for oligometastatic NSCLC; translational correlatives from a mature randomized phase II trial

Tang et al.
International Journal of Radiation Oncology &Biology & Physics
October 2019
Authors and Affiliates
Tang C1, Lee WC2, Reuben A3, Chang L4, Tran H3, Little L5, Gumbs C5, Wargo J6, Futreal A5, Liao Z7, Xia X4, Yi X4, Swisher SG8, Heymach JV9, Gomez D10, Zhang J11; 1 Departments of Radiation Oncology; Investigational Cancer Therapeutics, MD Anderson Cancer Center, Houston TX USA. 2 Genomic Medicine; Thoracic/Head and Neck Medical Oncology. 3 Thoracic/Head and Neck Medical Oncology. 4 Geneplus institute-Beijing, Beijing China. 5 Genomic Medicine. 6 Genomic Medicine; Surgical Oncology. 7 Departments of Radiation Oncology. 8 Thoracic Surgery. 9 Thoracic/Head and Neck Medical Oncology. Electronic address: jheymach@mdanderson.org. 10 Departments of Radiation Oncology. Electronic address: dgomez@mdanderson.org. 11 Genomic Medicine; Thoracic/Head and Neck Medical Oncology. Electronic address: jzhang20@mdanderson.org

Single-cell immune landscape of human atherosclerotic plaques

Fernandez et al.
Nature Medicine
October 2019
Authors and Affiliates
Fernandez DM1, Rahman AH2,3,4, Fernandez NF3, Chudnovskiy A2, Amir ED3, Amadori L4, Khan NS1, Wong CK1, Shamailova R1, Hill CA1, Wang Z5, Remark R2,6, Li JR7, Pina C7, Faries C7, Awad AJ8,9, Moss N1, Bjorkegren JLM4,10, Kim-Schulze S2,3,11, Gnjatic S2,3,12, Ma'ayan A5, Mocco J8, Faries P7, Merad M2,3,12, Giannarelli C13,14,15; 1 Cardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2 The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3 Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 4 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5 Mount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 6 Innate Pharma, Marseille, France. 7 Department of Surgery, Vascular Division, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 8 Cerebrovascular Center, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9 Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA. 10 Integrated Cardio MetabolicCentre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden. 11 Hematology and Medical Oncology Division, The Tish Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 12 Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 13 Cardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. chiara.giannarelli@mssm.edu. 14 The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. chiara.giannarelli@mssm.edu. 15 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. chiara.giannarelli@mssm.edu.

Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies

Xu-Monette et al.
Journal for ImmunoTherapy of Cancer
October 2019
Authors and Affiliates
Xu-Monette ZY1,2, Li J2, Xia Y2, Crossley B3, Bremel RD4, Miao Y2, Xiao M2, Snyder T3, Manyam GC5, Tan X2, Zhang H2, Visco C6, Tzankov A7, Dybkaer K8, Bhagat G9, Tam W10, You H11, Hsi ED12, van Krieken JH13, Huh J14, Ponzoni M15, Ferreri AJM15, Møller MB16, Piris MA17, Winter JN18, Medeiros JT2, Xu B19, Li Y20, Kirsch I3, Young KH21,22,23; 1 Hematopathology Division, Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA. 2 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3 Adaptive Biotechnologies, Seattle, WA, USA. 4 ioGenetics LLC, Madison, WI, USA. 5 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 6 San Bortolo Hospital, Vicenza, Italy. 7 Institute of Pathology and Medical Genetics, University Hospital of Basel, Basel, Switzerland. 8 Aalborg University Hospital, Aalborg, Denmark. 9 Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA. 10 Weill Medical College of Cornell University, New York, NY, USA. 11 Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China. 12 Cleveland Clinic, Cleveland, OH, USA. 13 Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. 14 Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. 15 San Raffaele H. Scientific Institute, Milan, Italy. 16 Odense University Hospital, Odense, Denmark. 17 Hospital Universitario Marqués de Valdecilla, Santander, Spain. 18 Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 19 Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, China. 20 Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 21 Hematopathology Division, Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA. ken.young@duke.edu. 22 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ken.young@duke.edu. 23 Duke University Medical Center, Duke Cancer Institute, Durham, NC, 27710, USA. ken.young@duke.edu.
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