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A critical insulin TCR contact residue selects high affinity and pathogenic insulin specific T cells

Bettini et al.
Diabetes
December 2019
Authors and Affiliates
Maria Bettini,1,2,7 Marissa A. Scavuzzo,4,6 Baoyu Liu,5 Elizabeth Kolawole,5 Lin Guo,1 Brian D. Evavold,5 Malgorzata Borowiak2,3,4 and Matthew L. Bettini1,2,7 1Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2 USA. 3 4 5Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112 6 Present address: Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106 USA 7Present address: Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112

Epigenetic and transcriptional analysis supports human regulatory T cell commitment at the CD4+CD8+ thymocyte stage

Vanhanen et al.
Cellular Immunology
December 2019
Authors and Affiliates
Vanhanen R1, Leskinen K2, Mattila IP3, Saavalainen P2, Arstila TP4; 1 Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland. Electronic address: reetta.vanhanen@helsinki.fi. 2 Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland. 3 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, 00290 Helsinki, Finland. 4 Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland; Medicum, University of Helsinki, 00014 Helsinki, Finland.

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Jansen et al.
Nature
December 2019
Authors and Affiliates
Caroline S. Jansen1, Nataliya Prokhnevska1, Viraj A. Master1,2, Martin G. Sanda1,2, Jennifer W. Carlisle2,3, Mehmet Asim Bilen2,3, Maria Cardenas1, Scott Wilkinson4, Ross Lake4, Adam G. Sowalsky4, Rajesh M. Valanparambil5,6, William H. Hudson5,6, Donald McGuire5,6, Kevin Melnick1, Amir I. Khan1, Kyu Kim1, Yun Min Chang5, Alice Kim1, Christopher P. Filson1,2, Mehrdad Alemozaffar1,2, Adeboye O. Osunkoya1,2,7, Patrick Mullane7, Carla Ellis7, Rama Akondy5,6, Se Jin Im5,6, Alice O. Kamphorst8, Adriana Reyes1, Yuan Liu2,9 & Haydn Kissick1,2,5,6* 1Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. 2Winship Cancer Institute of Emory University, Atlanta, GA, USA. 3Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA, USA. 4Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, MD, USA. 5Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. 6Emory Vaccine Centre, Emory University School of Medicine, Atlanta, GA, USA. 7Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA. 8Department of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. 9Rollins School of Public Health, Emory University, Atlanta, GA, USA. *e-mail: haydn.kissick@emory.edu

B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy

Moore et al.
American Journal of Transplantation
December 2019
Authors and Affiliates
Moore C1,2,3, Gao B1,4, Roskin KM2,3,5, Vasilescu EM6, Addonizio L7, Givertz MM8, Madsen JC1,9, Zorn E1,10. 1 Center for Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2 Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 3 Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 4 Transplant Center, The First Hospital of Jilin University, Changchun, China. 5 Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA. 6 Department of Pathology & Cell Biology, Columbia University Medical Center, New York, New York, USA. 7 Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA. 8 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 9 Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 10 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York, USA.

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

Gaballa et al.
Stem Cells International
December 2019
Authors and Affiliates
Ahmed Gaballa ,1 Lucas C. M. Arruda ,1 Emelie Rådestad ,1 and Michael Uhlin 1,2,3 1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden 2Department of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden 3Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden

The Utility of T-Cell Clonality in Differential Diagnostics of Acute Graft-versus-Host Disease from Drug Hypersensitivity Reaction

Chang et al.
Journal of Investigative Dermatology
December 2019
Authors and Affiliates
Li-Wei Chang1, Linda T. Doan2, Paul Fields3, Marissa Vignali3 and Oleg E. Akilov1,* 1Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; 2Department of Dermatology, University of California Irvine, Irvine, California, USA; and 3Adaptive Biotechnologies, Seattle, Washington, USA *Corresponding author e-mail: akilovoe@ upmc.edu

Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy

Flores et al.
Science Advances
November 2019
Authors and Affiliates
Flores C1, Wildes T1, Dean BD1, Moore G1, Drake J1, Abraham R1, Gil J1, Yegorov O1, Yang C1, Dean J1, Moneypenny C1, Shin D1,2, Pham C1, Krauser J1, King J1, Grant G3, Driscoll T4, Kurtzberg J4, McLendon R5, Gururangan S1,6, Mitchell D1; 1 University of Florida Brain Tumor Immunotherapy Program, Preston A. Wells, Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. 2 U.S. Army, 1600 Spearhead Division Ave., Fort Knox, KY, USA. 3 Department of Neurosurgery, Stanford University Medical Center, Palo Alto, CA, USA. 4 Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. 5 Department of Pathology, Duke University Medical Center, Durham, NC, USA. 6 Department of Pediatrics, University of Florida, Gainesville, FL, USA.

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Søndergaard et al.
Cell Reports
November 2019
Authors and Affiliates
Søndergaard E1, Rauch A2, Michaut M3, Rapin N3, Rehn M1, Wilhelmson AS1, Camponeschi A4, Hasemann MS1, Bagger FO3, Jendholm J1, Knudsen KJ1, Mandrup S2, Mårtensson IL4, Porse BT5; 1 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. 2 Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark. 3 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; The Bioinformatics Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. 4 Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. 5 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: bo.porse@finsenlab.dk.

Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation

Buhler et al.
Leukemia
November 2019
Authors and Affiliates
Buhler S1, Bettens F2, Dantin C3, Ferrari-Lacraz S2, Ansari M4, Mamez AC3, Masouridi-Levrat S3, Chalandon Y3, Villard J5; 1 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. stephane.buhler@hcuge.ch. 2 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. 3 Service of Haematology, Department of Oncology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 4 Pediatric Department, Onco-Hematology Unit, Geneva University Hospitals and Cansearch research laboratory, Geneva Medical School, Geneva, Switzerland. 5 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. jean.villard@hcuge.ch.

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

Ogongo et al.
Journal of Clinical Investigation
November 2019
Authors and Affiliates
Ogongo P1,2,3, Steyn AJ1, Karim F1, Dullabh KJ4, Awala I4, Madansein R4, Leslie A1,5, Behar SM6; 1 Africa Health Research Institute, and. 2 School of Laboratory Medicine, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 3 Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya. 4 Department of Cardiothoracic Surgery, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 5 Department of Infection and Immunity, University College London, London, United Kingdom. 6 Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
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