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Loss of Setd4 delays radiation-induced thymic lymphoma in mice

Feng et al.
DNA Reapir
November 2019
Authors and Affiliates
Feng X1, Lu H1, Yue J1, Schneider N1, Liu J1, Denzin LK2, Chan CS3, De S3, Shen Z4; 1 Rutgers Cancer Institute of New Jersey, Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. 2 Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA. 3 Center for Systems and Computational Biology, Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ 08901, USA. 4 Rutgers Cancer Institute of New Jersey, Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. Electronic address: shenzh@cinj.rutgers.edu.

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy

Chowell et al.
Nature Medicine
November 2019
Authors and Affiliates
Chowell D1,2, Krishna C3, Pierini F4, Makarov V1,2, Rizvi NA5, Kuo F2, Morris LGT2,6, Riaz N2,7, Lenz TL8, Chan TA9,10,11,12; 1 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany. 5 Department of Medicine, Columbia University Medical Center, New York, NY, USA. 6 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany. lenz@post.harvard.edu. 9 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 10 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 11 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 12 Weill Cornell School of Medicine, New York, NY, USA. chant@mskcc.org.

Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer

Zhang et al.
Clinical Cancer Research
November 2019
Authors and Affiliates
Jiajia Zhang1,2, Zhicheng Ji3 , Justina X. Caushi1,2, Margueritta El Asmar1,2, Valsamo Anagnostou1,2, Tricia R. Cottrell1,2,4, Hok Yee Chan1,2, Prerna Suri1,2, Haidan Guo1,2, Taha Merghoub5 , Jamie E. Chaft5 , Joshua E. Reuss1,2, Ada J. Tam1,2, Richard L. Blosser1,2, Mohsen Abu-Akeel5 , John-William Sidhom1,2, Ni Zhao3 , Jinny S. Ha2,6, David R. Jones7 , Kristen A. Marrone1,2, Jarushka Naidoo1,2, Edward Gabrielson1,2, Janis M. Taube1,2,4, Victor E. Velculescu1,2, Julie R. Brahmer1,2, Franck Housseau1,2, Matthew D. Hellmann5 , Patrick M. Forde1,2, Drew M. Pardoll1,2, Hongkai Ji3 , and Kellie N. Smith1,2; 1 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland. 2 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. 3 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland. 4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 5 Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York. 6 Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. 7 Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York

Immunological Ignorance Is an Enabling Feature of the Oligo-Clonal T Cell Response to Melanoma Neoantigens

Linette et al.
Proceedings of the National Academy of Sciences
November 2019
Authors and Affiliates
Gerald P Linette 1 2 3 4, Michelle Becker-Hapak 5 6 7, Zachary L Skidmore 5 6 7, Miren Lorea Baroja 1 2 3 4, Chong Xu 1 2 3 4, Jasreet Hundal 5 6 7, David H Spencer 5 6 7, Weixuan Fu 1 2 3 4 8, Casey Cummins 1 2 3 4, Maya Robnett 1 2 3 4, Saghar Kaabinejadian 9, William H Hildebrand 9, Vincent Magrini 10 11, Ryan Demeter 5 6 7, Alexander S Krupnick 12, Obi L Griffith 5 6 7, Malachi Griffith 5 6 7, Elaine R Mardis 10 11, Beatriz M Carreno 13 2 3 4; 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 2The Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 4Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 5McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110. 6Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110. 7Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110. 8Bioinformatics Core, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 9Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104. 10Institute for Genomic Medicine, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH 43205. 11Department of Pediatrics, Ohio State University College of Medicine, Columbus, OH 43205. 12Department of Surgery, University of Virginia, Charlottesville, VA 22908. 13Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; bcarreno@upenn.edu.

Lack of specific T- and B-cell clonal expansions in multiple sclerosis patients with progressive multifocal leukoencephalopathy

Bertoli et al.
Scientific Reports
November 2019
Authors and Affiliates
Diego Bertoli,1,2 Alessandra Sottini,1 Ruggero Capra,3 Cristina Scarpazza,3,4 Roberto Bresciani,2 Luigi D. Notarangelo,5 and Luisa Imberti1; 1Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili, Brescia, Italy 2Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy 3Multiple Sclerosis Center, ASST Spedali Civili, Brescia, Italy 4Department of General Psychology, University of Padova, Padova, Italy 5Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States

Pembrolizumab in Combination with the Oncolytic Virus Pelareorep and Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma: A Phase Ib Study

Mahalingam et al.
Clinical Cancer Research
November 2019
Authors and Affiliates
Mahalingam D1,2, Wilkinson GA3, Eng KH4, Fields P5, Raber P5, Moseley JL2, Cheetham K3, Coffey M3, Nuovo G6, Kalinski P4, Zhang B7, Arora SP2, Fountzilas C4; 1 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois. Mahalingam@northwestern.edu. 2 Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas. 3 Oncolytics Biotech Inc, Calgary, Alberta, Canada. 4 Roswell Park Comprehensive Cancer Center, Buffalo, New York. 5 Adaptive Biotechnologies, Seattle, Washington. 6 Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio. 7 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.

Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development

Stras et al.
Developmental Cell
November 2019
Authors and Affiliates
Stras SF1, Werner L2, Toothaker JM3, Olaloye OO1, Oldham AL1, McCourt CC1, Lee YN4, Rechavi E4, Shouval DS5, Konnikova L6; 1 Division of Newborn Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. 2 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. 3 Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA. 4 Pediatric Department A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. 5 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: dror.shouval@gmail.com. 6 Division of Newborn Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: liza.konnikova@chp.edu.

Synovial IL-17A+ CD8+ T cells display a polyfunctional, pro-inflammatory and tissue-resident memory phenotype and function in psoriatic arthritis

Steel et al.
Arthritis and Rheumatology
November 2019
Authors and Affiliates
Steel KJA1, Srenathan U1, Ridley M1, Durham LE1, Wu SY1, Ryan SE1, Hughes CD1,2, Chan E2, Kirkham BW2, Taams LS1; 1 Centre for Inflammation Biology and Cancer Immunology (CIBCI), Department of Inflammation Biology, School of Immunology & Microbial Sciences, King's College London. 2 Department Rheumatology, Guy's & St Thomas' Hospital, London, UK.

Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis

Steel KJA, et al.
Arthritis and Rheumatology
November 2019
Authors and Affiliates
Kathryn J A Steel 1, Ushani Srenathan 1, Michael Ridley 1, Lucy E Durham 1, Shih-Ying Wu 1, Sarah E Ryan 1, Catherine D Hughes 2, Estee Chan 3, Bruce W Kirkham 3, Leonie S Taams 1; 1 King's College London, London, UK. 2 King's College London, Guy's Hospital, and St. Thomas' Hospital, London, UK. 3 Guy's Hospital and St. Thomas' Hospital, London, UK.

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

Gros et al.
Journal of Clinical Investigation
November 2019
Authors and Affiliates
Alena Gros,1 Eric Tran,2,3 Maria R. Parkhurst,2 Sadia Ilyas,2 Anna Pasetto,4 Eric M. Groh,2 Paul F. Robbins,2 Rami Yossef,2 Andrea Garcia-Garijo,1 Carlos A. Fajardo,1 Todd D. Prickett,2 Li Jia,2 Jared J. Gartner,2 Satyajit Ray,2 Lien Ngo,2 John R. Wunderllich,2 James C. Yang,2 and Steven A. Rosenberg2 1Vall d’Hebron Institute of Oncology, Cellex Center, Barcelona, Spain. 2Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA. 3Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, Oregon, USA. 4Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
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