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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller et al.
Nature Immunology
March 2019
Authors and Affiliates
Miller BC1,2,3,4,5, Sen DR1,3,6, Al Abosy R1,3, Bi K1,3, Virkud YV7, LaFleur MW1,3,4,5,6, Yates KB1,3, Lako A8, Felt K8, Naik GS8, Manos M2,8, Gjini E2,8, Kuchroo JR4,5,6, Ishizuka JJ1,2,3, Collier JL1,3,4,5,6, Griffin GK1,3,9, Maleri S4,5, Comstock DE1,3,6, Weiss SA1,3,6, Brown FD1,3,4,5,6, Panda A1,3, Zimmer MD3, Manguso RT3, Hodi FS2,8, Rodig SJ8,9, Sharpe AH3,4,5,6, Haining WN10,11,12 1 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 2 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 3 Broad Institute of MIT and Harvard, Cambridge, MA, USA. 4 Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. 5 Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. 6 Division of Medical Sciences, Harvard Medical School, Boston, MA, USA. 7 Division of Pediatric Allergy and Immunology, Massachusetts General Hospital, Boston, MA, USA. 8 Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 9 Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. 10 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. wnhaining@gmail.com. 11 Broad Institute of MIT and Harvard, Cambridge, MA, USA. wnhaining@gmail.com. 12 Division of Medical Sciences, Harvard Medical School, Boston, MA, USA. wnhaining@gmail.com

Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires

Thornton et al.
European Journal of Immunology
March 2019
Authors and Affiliates
Thornton AM1, Lu J2, Korty PE1, Kim YC1, Martens C3, Sun PD2, Shevach EM1 1 Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 2 Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 3 Rocky Mountain Laboratories Genomics Unit, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

Fischer et al.
Cancer Discovery
February 2019
Authors and Affiliates
Fischer GM1,2,3, Jalali A4, Kircher DA5, Lee WC6, McQuade JL2, Haydu LE7, Joon AY8, Reuben A9, de Macedo MP10, Carapeto FCL3, Yang C11, Srivastava A12, Ambati CR13,14, Sreekumar A13,14, Hudgens CW3, Knighton B2, Deng W2, Ferguson SD15, Tawbi HA2, Glitza IC2, Gershenwald JE1,7, Vashisht Gopal YN2,3, Hwu P2, Huse JT3,16, Wargo JA6,7, Futreal PA6, Putluri N13,14, Lazar AJ3,6,16, DeBerardinis RJ11,17, Marszalek JR18, Zhang J6, Holmen SL5,19, Tetzlaff MT3,16, Davies MA20,3,21 1 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 3 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 4 Department of Neurosurgery, Baylor College of Medicine, Houston, Texas. 5 Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah. 6 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. 7 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 8 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 9 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 10 Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil. 11 Children's Medical Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas. 12 Department of Computational Sciences, The Jackson Lab for Genomic Medicine, Farmington, Connecticut. 13 Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas. 14 Advanced Technology Core, Alkek Center for Molecular Discovery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas. 15 Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. 16 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 17 Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas. 18 Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas. 19 Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah. 20 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. mdavies@mdanderson.org. 21 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells

Çuburu et al.
Journal of Immunology
February 2019
Authors and Affiliates
Çuburu N1, Kim R2, Guittard GC3, Thompson CD2, Day PM2, Hamm DE4, Pang YS2, Graham BS5, Lowy DR2, Schiller JT1. 1 Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; cuburun@mail.nih.gov schillej@mail.nih.gov. 2 Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. 3 Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. 4 Adaptive Biotechnologies, Seattle, WA 98102; and. 5 Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Preliminary analysis of spatial-temporal homogeneity and heterogeneity of TCR β chain CDR3 repertoires in BALB/c mice

Li et al.
International Journal of Molecular Epidemiology and Genetics
February 2019
Authors and Affiliates
Yuehong Li,1,* Long Ma,1,* Xiaoheng Dong,1,* Yurong Pan,1 Bin Shi,2 Xiaoyan He,1 Teng Zhang,1 Suhong Sun,3 and Xinsheng Yao1 1 Department of Immunology, Research Center for Medicine and Biology, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563003, China, 2 Department of Laboratory Medicine, Zunyi Medical University, Zunyi 563003, China, 3 Department of Breast Surgery, The First Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China,

T cell clonal expansions in ileal Crohn’s disease are associated with smoking behaviour and postoperative recurrence

Allez et al.
Gut
February 2019
Authors and Affiliates
Allez M1,2, Auzolle C1, Ngollo M2, Bottois H2, Chardiny V2, Corraliza AM3, Salas A3, Perez K2, Stefanescu C4, Nancey S5, Buisson A6, Pariente B7, Fumery M8, Sokol H9, Tréton X10, Barnich N11, Seksik P9, Le Bourhis L2; REMIND Study Group; Author information 1 Department of Gastroenterology, Hopital Saint Louis, Paris, France. 2 INSERM U1160, Hôpital Saint-Louis, Paris, France. 3 Hospital Clinic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain. 4 Service de Gastroentérologie, MICI et Assistance Nutritive, Hôpital Beaujon, Clichy, France. 5 Department of Gastroenterology, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre Benite, Lyon, France. 6 Gastroenterology Department, University Hospital Estaing, Clermont-Ferrand, France. 7 Department of Gastroenterology, Hopital Claude huriez, Lille, France. 8 Hepato-Gastroenterology Department, CHU Amiens, Amiens, France. 9 Department of Gastroenterology, Hopital Saint-Antoine, Paris, Île-de-France, France. 10 Service de Gastroentérologie, MICI et Assistance Nutritive, Hopital Beaujon, Clichy, France. 11 M2iSH, UMR Inserm U1071, USC INRA 2018, Université d'Auvergne, Clermont Ferrand, France.

Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool

Fu et al.
Cell Stem Cell
February 2019
Authors and Affiliates
Fu J1, Zuber J1, Martinez M2, Shonts B1, Obradovic A1, Wang H1, Lau SP1, Xia A1, Waffarn EE1, Frangaj K1, Savage TM1, Simpson MT1, Yang S1, Guo XV3, Miron M4, Senda T5, Rogers K1, Rahman A3, Ho SH1, Shen Y6, Griesemer A5, Farber DL7, Kato T8, Sykes M9. 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA. 2 Department of Pediatrics, Columbia University, New York, NY 10032, USA. 3 Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 4 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA. 5 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 6 Center for Computational Biology and Bioinformatics, Department of Systems Biology, Columbia University, New York, NY 10032, USA. 7 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 8 Department of Surgery, Columbia University, New York, NY 10032, USA. 9 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. Electronic address: megan.sykes@columbia.edu.

High frequency of shared clonotypes in human B cell receptor repertoires

Soto et al.
Nature
February 2019
Authors and Affiliates
Soto C1,2, Bombardi RG1, Branchizio A1, Kose N1, Matta P1, Sevy AM3, Sinkovits RS4, Gilchuk P1, Finn JA3, Crowe JE Jr5,6,7. 1 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. 2 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. 3 Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA. 4 San Diego Supercomputer Center, University of California, San Diego, San Diego, CA, USA. 5 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 6 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 7 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu.

Altered T Cell Receptor Beta Repertoire Patterns in Pediatric Ulcerative Colitis

Werner et al.
Clinical and Experimental Immunology
January 2019
Authors and Affiliates
Werner L1,2, Nunberg MY1,2, Rechavi E2,3,4,5, Lev A2,3,4,5, Braun T1,2, Haberman Y1,2, Lahad A1,2, Shteyer E6, Schvimer M7, Somech R2,3,4,5, Weiss B1,2, Lee YN2,3,4,5, Shouval DS1,2. 1 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3 Pediatric Department A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 4 Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 5 Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 6 Juliet Keidan Institute of Pediatric Gastroenterology, Hepatology and Nutrition, Shaare Zedek Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israel. 7 Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel.
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