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IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells

Newman et al.
Molecular Genetics and Genomic Medicine
April 2019
Authors and Affiliates
Newman JH1, Shaver A2, Sheehan JH3, Mallal S4, Stone JH5, Pillai S6, Bastarache L7, Riebau D8, Allard-Chamard H6, Stone WM6, Perugino C6, Pilkinton M4, Smith SA4, McDonnell WJ4, Capra JA3, Meiler J3, Cogan J1,9, Xing K6, Mahajan VS6, Mattoo H6, Hamid R1,9, Phillips JA 3rd1,9; Undiagnosed Disease Network. 1 Vanderbilt Center for Undiagnosed Disease, Vanderbilt University, Nashville, Tennessee. 2 Department of Pathology, Microbiology and of Immunology, Vanderbilt University, Nashville, Tennessee. 3 Department of Biochemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee. 4 Department of Medicine, Center for Translational Immunology and Infectious Diseases, Vanderbilt University, Nashville, Tennessee. 5 Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. 6 Ragon Institute of MGH, MIT and Harvard Medical School, Boston, Massachusetts. 7 BioVU, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee. 8 Department of Neurology, Vanderbilt University, Nashville, Tennessee. 9 Department of Pediatrics, Division of Medical Genetics, Vanderbilt University, Nashville, Tennessee.

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire

Khosravi-Maharlooei et al.
Journal of Clinical Investigation
March 2019
Authors and Affiliates
Khosravi-Maharlooei M1, Obradovic A1, Misra A1, Motwani K2, Holzl M1, Seay HR2, DeWolf S1, Nauman G1,3, Danzl N1, Li H1, Ho SH1, Winchester R4, Shen Y5, Brusko TM2, Sykes M1,3,6; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA. 2 Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA. 3 Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, New York, USA. 4 Division of Rheumatology, Department of Medicine. 5 Center for Computational Biology and Bioinformatics, and. 6 Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York, USA.

Subclonal STAT3 mutations solidify clonal dominance

Kerr et al.
Blood Advances
March 2019
Authors and Affiliates
Cassandra M. Kerr,1 Michael J. Clemente,1 Peter W. Chomczynski,1 Bartlomiej Przychodzen,1 Yasunobu Nagata,1 Vera Adema,1 Valeria Visconte,1 Alan E. Lichtin,2 Satu Mustjoki,3,4 Tomas Radivoyevitch,5 Mikkael A. Sekeres,2 and Jaroslaw P. Maciejewski1,2 1Department of Translational Hematology and Oncology Research and 2Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; 3Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland; 4Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Helsinki, Finland; and 5Quantitative Health Sciences Department, Cleveland Clinic, Cleveland, OH

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Cloughesy et al.
Nature Medicine
March 2019
Authors and Affiliates
Cloughesy TF1,2,3, Mochizuki AY4, Orpilla JR5, Hugo W6, Lee AH7,5, Davidson TB8,4, Wang AC5, Ellingson BM8,9, Rytlewski JA10, Sanders CM10, Kawaguchi ES11, Du L11, Li G8,11, Yong WH12, Gaffey SC13, Cohen AL14, Mellinghoff IK15, Lee EQ13, Reardon DA13, O'Brien BJ16, Butowski NA17, Nghiemphu PL18, Clarke JL17, Arrillaga-Romany IC19, Colman H14, Kaley TJ15, de Groot JF16, Liau LM8,5, Wen PY13, Prins RM20,21,22,23. 1 Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. tcloughesy@mednet.ucla.edu. 2 Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. tcloughesy@mednet.ucla.edu. 3 Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. tcloughesy@mednet.ucla.edu. 4 Division of Hematology/Oncology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 5 Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 6 Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 7 Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 8 Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. 9 Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 10 Adaptive Biotechnologies, Seattle, WA, USA. 11 Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. 12 Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 13 Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 14 Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. 15 Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 16 Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 17 Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. 18 Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 19 Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA, USA. 20 Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. rprins@mednet.ucla.edu. 21 Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. rprins@mednet.ucla.edu. 22 Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. rprins@mednet.ucla.edu. 23 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. rprins@mednet.ucla.edu.

Graft γδ TCR Sequencing Identifies Public Clonotypes Associated with Hematopoietic Stem Cell Transplantation Efficacy in Acute Myeloid Leukemia Patients and Unravels Cytomegalovirus Impact on Repertoire Distribution

Arruda et al.
Journal of Immunology
March 2019
Authors and Affiliates
Arruda LCM1, Gaballa A2, Uhlin M2,3,4. 1 Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm 141 86, Sweden; lucas.arruda@ki.se. 2 Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm 141 86, Sweden. 3 Department of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Stockholm 141 86, Sweden; and. 4 Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm 141 86, Sweden.

A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation

Cippà et al.
Nature Communications
March 2019
Authors and Affiliates
Cippà PE1,2, Liu J3, Sun B4, Kumar S3, Naesens M5,6, McMahon AP7. 1 Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, 90033-9080, CA, USA. pietro.cippa@eoc.ch. 2 Division of Nephrology, Regional Hospital Lugano, Lugano, 6900, Switzerland. pietro.cippa@eoc.ch. 3 Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, 90033-9080, CA, USA. 4 Molecular and Computational Biology, University of Southern California, Los Angeles, 90089-2910, CA, USA. 5 Department of Microbiology and Immunology, KU Leuven, Leuven, 3000, Belgium. 6 Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, 3000, Belgium. 7 Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, 90033-9080, CA, USA. amcmahon@med.usc.edu.

Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells

Montel-Hagen wt al.
Cell Stem Cell
March 2019
Authors and Affiliates
Montel-Hagen A1, Seet CS2, Li S3, Chick B1, Zhu Y1, Chang P4, Tsai S5, Sun V4, Lopez S1, Chen HC1, He C1, Chin CJ1, Casero D1, Crooks GM6 1 Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA. 2 Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA. 3 Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA. 4 Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Molecular Biology Interdepartmental Program, UCLA, Los Angeles, CA, USA. 5 Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. 6 Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA; Division of Pediatric Hematology-Oncology, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. Electronic address: gcrooks@mednet.ucla.edu

Association of Tumor Microenvironment T-Cell Repertoire and Mutational Load With Clinical Outcome After Sequential Checkpoint Blockade in Melanoma

Yusko et al.
Cancer Immunology Research
March 2019
Authors and Affiliates
Yusko E1, Vignali M1, Wilson RK2, Mardis ER2, Hodi FS3, Horak C4, Chang H4, Woods DM5, Robins H1,6, Weber J7 1 Adaptive Biotechnologies, Seattle, Washington. 2 McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri. 3 Dana-Farber Cancer Center, Boston, Massachusetts. 4 Bristol-Myers Squibb, Princeton, New Jersey. 5 Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, New York, New York. 6 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. 7 Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, New York, New York.

Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire.

Lu et al.
Nature Communications
March 2019
Authors and Affiliates
Lu J1, Van Laethem F2, Bhattacharya A2, Craveiro M2, Saba I2, Chu J1, Love NC2, Tikhonova A2, Radaev S1, Sun X3, Ko A3, Arnon T4,5, Shifrut E4, Friedman N4, Weng NP3, Singer A6, Sun PD7 1 Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA. 2 Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. 3 Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health, Baltimore, MD, 21224, USA. 4 Department of Immunology, Weizmann Institute of Science, 76100, Rehovot, Israel. 5 Department of Physics and Astronomy, Alfred University, 1 Saxon Drive, Alfred, NY, 14802, USA. 6 Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. singera@nih.gov. 7 Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA. psun@nih.gov.
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