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Rational design of anti-GITR-based combination immunotherapy

Zappasodi et al.
Nature Medicine
April 2019
Authors and Affiliates
Zappasodi R1,2, Sirard C3, Li Y1,2, Budhu S1, Abu-Akeel M1, Liu C1, Yang X1, Zhong H1, Newman W3, Qi J2,4, Wong P2,4, Schaer D1, Koon H5, Velcheti V6, Hellmann MD2,7,8, Postow MA7,8, Callahan MK2,7,8, Wolchok JD9,10,11,12, Merghoub T13,14,15; Author information 1 Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Leap Therapeutics, Cambridge, MA, USA. 4 Immune Monitoring Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 5 Case Western Reserve University, Cleveland, OH, USA. 6 Department of Hematology and Oncology, New York University School of Medicine, New York, NY, USA. 7 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 Weill Cornell Medical College, New York, NY, USA. 9 Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA. wolchokj@mskcc.org. 10 Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. wolchokj@mskcc.org. 11 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. wolchokj@mskcc.org. 12 Weill Cornell Medical College, New York, NY, USA. wolchokj@mskcc.org. 13 Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA. merghout@mskcc.org. 14 Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. merghout@mskcc.org. 15 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. merghout@mskcc.org.

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Yang et al.
Nature Medicine
April 2019
Authors and Affiliates
Yang W1,2, Lee KW1, Srivastava RM2, Kuo F2, Krishna C3, Chowell D2, Makarov V2, Hoen D2, Dalin MG4, Wexler L5, Ghossein R6, Katabi N6, Nadeem Z7, Cohen MA7, Tian SK8, Robine N8, Arora K8, Geiger H8, Agius P8, Bouvier N9, Huberman K9, Vanness K9, Havel JJ1,2, Sims JS2, Samstein RM10, Mandal R2,7, Tepe J7, Ganly I7, Ho AL11, Riaz N2,10, Wong RJ7, Shukla N6, Chan TA12,13,14, Morris LGT15,16,17; 1 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden. 5 Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7 Department of Surgery (Head and Neck Service), Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 New York Genome Center, New York, NY, USA. 9 Integrated Genomics Operation, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 10 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 11 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 12 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 13 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 14 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 15 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. morrisl@mskcc.org. 16 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. morrisl@mskcc.org. 17 Department of Surgery (Head and Neck Service), Memorial Sloan Kettering Cancer Center, New York, NY, USA. morrisl@mskcc.org.

Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States

Wei et al.
Immunity
April 2019
Authors and Affiliates
Wei SC1, Sharma R2, Anang NAS1, Levine JH3, Zhao Y4, Mancuso JJ1, Setty M3, Sharma P5, Wang J4, Pe'er D6, Allison JP7; 1Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 2 Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA; Department of Applied Physics and Applied Mathematics, Columbia University, New York, NY 10027, USA. 3 Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA. 4 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 5 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 6 Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. 7 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jallison@mdanderson.org.

A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL-2-Receptor Beta/Gamma (βγ)-Biased Cytokine, in Patients With Advanced or Metastatic Solid Tumors

Bentebibel et al.
Cancer Discovery
April 2019
Authors and Affiliates
Salah-Eddine Bentebibel1*, Michael E. Hurwitz2*, Chantale Bernatchez1*, Cara Haymaker1, Courtney W. Hudgens1, Harriet M. Kluger2, Michael T. Tetzlaff1, Mary A. Tagliaferri3, Jonathan Zalevsky3, Ute Hoch3, Christie Fanton3, Sandra Aung3, Patrick Hwu1, Brendan D. Curti4, Nizar M. Tannir1, Mario Sznol2, Adi Diab1; 1. The University of Texas MD Anderson Cancer Center, Houston, TX 2. Yale School of Medicine, New Haven, CT 3. Nektar Therapeutics, San Francisco, CA 4. Providence Cancer Institute and Earle A. Chiles Research Institute, Portland, OR *These authors contributed equally

AIRE expression controls the peripheral selection of autoreactive B cells

Sng et al.
Science Immunology
April 2019
Authors and Affiliates
Sng J1, Ayoglu B2, Chen JW1, Schickel JN1, Ferre EMN3, Glauzy S1, Romberg N4,5, Hoenig M6, Cunningham-Rundles C7, Utz PJ2,8, Lionakis MS3, Meffre E9 1 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA. 2 School of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA. 3 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA. 4 Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA, USA. 5 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 6 Department of Pediatrics, University Medical Centre Ulm, Ulm, Germany. 7 Division of Allergy and Immunology, Department of Medicine, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA. 8 Institute for Immunity, Transplantation, and Infection (ITI), Stanford University, Stanford, CA 94305, USA. 9 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA. eric.meffre@yale.edu.

Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease

Whangbo et al.
Blood Advances
April 2019
Authors and Affiliates
Whangbo JS1,2,3,4, Kim HT5,6, Nikiforow S3,4, Koreth J3,4, Alho AC3,4,7, Falahee B3,4, Kim S3,4, Dusenbury K3,4, Fields MJ3,4, Reynolds CG3,4, Alyea EP 3rd3,4, Armand P3,4, Cutler CS3,4, Ho VT3,4, Antin JH3,4, Soiffer RJ3,4, Ritz J3,4 1 Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA. 2 Department of Pediatric Oncology and. 3 Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston MA. 4 Harvard Medical School, Boston, MA. 5 Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, MA. 6 Harvard School of Public Health, Boston, MA; and. 7 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Immune profiling of a patient with alemtuzumab-associated progressive multifocal leukoencephalopathy

Gerevini et al.
Multiple Sclerosis
April 2019
Authors and Affiliates
Gerevini S1, Capra R2, Bertoli D3, Sottini A4, Imberti L4; Department of Neuroradiology, IRCCS San Raffaele Hospital, Milan, Italy. 2 Multiple Sclerosis Center, ASST Spedali Civili di Brescia, Brescia, Italy. 3 Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy/Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy. 4 Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.

Mobilization of CD8þ T Cells via CXCR4 Blockade Facilitates PD-1 Checkpoint Therapy in Human Pancreatic Cancer

Seo et al.
Clinical Cancer Research
April 2019
Authors and Affiliates
Seo YD1, Jiang X#1, Sullivan KM#1, Jalikis FG2, Smythe KS3, Abbasi A1, Vignali M4, Park JO1, Daniel SK1, Pollack SM3, Kim TS1, Yeung R1, Crispe IN2, Pierce RH3, Robins H3,4, Pillarisetty VG5; 1Department of Surgery, University of Washington, Seattle, Washington. 2 Department of Pathology, University of Washington, Seattle, Washington. 3 Fred Hutchinson Cancer Research Center, Seattle, Washington. 4 Adaptive Biotechnologies, Seattle, Washington. 5 Department of Surgery, University of Washington, Seattle, Washington. vgp@uw.edu. # Contributed equally

The effect of anti-CTLA4 treatment on peripheral and intra-tumoral T cells in patients with hepatocellular carcinoma

Agdashian et al.
Cancer Immunology and Immunotherapy
April 2019
Authors and Affiliates
Agdashian D1, ElGindi M1, Xie C1, Sandhu M1, Pratt D2, Kleiner DE2, Figg WD3, Rytlewski JA4, Sanders C4, Yusko EC4, Wood B5, Venzon D6, Brar G1, Duffy AG1, Greten TF7,8, Korangy F1. 1 Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, Bethesda, MD, 20892, USA. 2 Laboratory of Pathology, Center for Cancer Research (CCR) National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 3 Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 4 Adaptive Biotechnologies, Seattle, WA, USA. 5 Center for Interventional Oncology, Radiology and Imaging Sciences and Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA. 6 Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 7 Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, Bethesda, MD, 20892, USA. tim.greten@nih.gov. 8 NCI CCR Liver Cancer Program, Bethesda, MD, USA.

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Sawant et al.
Nature Immunology
April 2019
Authors and Affiliates
Sawant DV1,2, Yano H1,3, Chikina M4, Zhang Q1,5, Liao M1,6, Liu C1, Callahan DJ1,3, Sun Z7, Sun T7, Tabib T8, Pennathur A9, Corry DB10, Luketich JD9, Lafyatis R8, Chen W7, Poholek AC1,11, Bruno TC1,12,13, Workman CJ1, Vignali DAA14,15,16; 1 Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 2 Department of Inflammation and Oncology, Discovery Research, Amgen, South San Francisco, CA, USA. 3 Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 4 Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 5 Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. 6 The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. 7 Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA. 8 Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 9 Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 10 Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 11 Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 12 Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. 13 Cancer Immunology & Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. 14 Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dvignali@pitt.edu. 15 Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu. 16 Cancer Immunology & Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu.
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