Browse our 650+ Publications​

Latest Publications

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

Chapuis et al.
Nature Medicine
June 2019
Authors and Affiliates
Chapuis AG1,2,3, Egan DN2,3, Bar M2,3, Schmitt TM1,2, McAfee MS1,2, Paulson KG1,2,3, Voillet V4, Gottardo R4,5, Ragnarsson GB1,2,6, Bleakley M1,2,3, Yeung CC2,3, Muhlhauser P3, Nguyen HN1,7, Kropp LA1,2,8, Castelli L1,2,8, Wagener F1,2, Hunter D1,2, Lindberg M1,2,9, Cohen K4, Seese A4, McElrath MJ2,3,4, Duerkopp N1,2, Gooley TA2,5, Greenberg PD10,11,12,13. Author information 1 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 3 University of Washington School of Medicine, Seattle, WA, USA. 4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 5 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 6 Landspítali Háskólasjúkrahús, Reykjavík, Iceland. 7 Alpine Biotech, Seattle, WA, USA. 8 Therapeutic Products Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 9 School of Informatics, University of Edinburgh, Edinburgh, UK. 10 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pgreen@u.washington.edu. 11 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pgreen@u.washington.edu. 12 University of Washington School of Medicine, Seattle, WA, USA. pgreen@u.washington.edu. 13 Departments of Immunology and Medicine, University of Washington, Seattle, WA, USA. pgreen@u.washington.edu.

Defining Virus-specific CD8+ TCR Repertoires for Therapeutic Regeneration of T Cells against Chronic Hepatitis E

Soon et al.
Journal of Hepatology
June 2019
Authors and Affiliates
Soon CF1, Behrendt P2, Todt D3, Manns MP1, Wedemeyer H4, Sällberg Chen M5, Cornberg M6. Author information 1 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. 2 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), partner site Hannover, Braunschweig, Germany; Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research. 3 Department for Molecular and Medical Virology, Ruhr-Universität Bochum, Bochum, Germany. 4 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), partner site Hannover, Braunschweig, Germany; Department of Gastroenterology and Hepatology, University Clinic Essen, Essen, Germany. 5 Department of Dental Medicine and Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. 6 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), partner site Hannover, Braunschweig, Germany; Centre for Individualised Infection Medicine (CIIM), Hannover, Germany; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. Electronic address: Cornberg.Markus@mh-hannover.de.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Wong et al.
Communications Biology
June 2019
Authors and Affiliates
Wong EB#1,2,3,4, Gold MC#5,6,7, Meermeier EW5, Xulu BZ1, Khuzwayo S1, Sullivan ZA1, Mahyari E8, Rogers Z1, Kløverpris H1,4,9, Sharma PK6, Worley AH6, Lalloo U10, Baijnath P10,11, Ambaram A11, Naidoo L11, Suleman M11,12, Madansein R13,14, McLaren JE15, Ladell K15, Miners KL15, Price DA15,16, Behar SM17, Nielsen M18,19, Kasprowicz VO1,20,21, Leslie A1,4, Bishai WR22, Ndung'u T1,19,20,21,23, Lewinsohn DM5,6,7. Author information 1 1Africa Health Research Institute, KwaZulu-Natal, South Africa. 2 2Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA USA. 3 3Harvard Medical School, Boston, MA USA. 4 4Division of Infection and Immunity, University College London, London, UK. 5 5Department of Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, OR USA. 6 6VA Portland Health Care System, Portland, OR USA. 7 7Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR USA. 8 8Division of Bioinformatics and Computational Biology (BCB), Department of Medical Informatics and Clinical Epidemiology (DMICE), Oregon Health & Science University, Portland, OR USA. 9 9Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. 10 10Durban University of Technology, Durban, South Africa. 11 Department of Pulmonology, Inkosi Albert Luthuli Hospital, Durban, South Africa. 12 12Department of Pulmonology & Critical Care, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 13 13Department of Cardiothoracic Surgery, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 14 14Centre for AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. 15 15Institute of Infection & Immunity, Cardiff University School of Medicine, Cardiff, Wales UK. 16 16Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA. 17 17Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA USA. 18 18Center for Biological Sequence Analysis, Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark. 19 19Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, Buenos Aires, Argentina. 20 20HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 21 21The Ragon Institute of MGH, MIT, and Harvard, Harvard Medical School, Cambridge, MA USA. 22 22Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD USA. 23 23Max Planck Institute for Infection Biology, Berlin, Germany. # Contributed equally

A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen

Ahmed et al.
Cell
May 2019
Authors and Affiliates
Ahmed R1, Omidian Z1, Giwa A2, Cornwell B1, Majety N1, Bell DR3, Lee S3, Zhang H4, Michels A5, Desiderio S6, Sadegh-Nasseri S1, Rabb H7, Gritsch S8, Suva ML9, Cahan P10, Zhou R11, Jie C12, Donner T7, Hamad ARA13; Author information 1 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 2 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 3 Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA. 4 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. 5 Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO 80045, USA. 6 Department of Molecular Biology and Genetics and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 7 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 8 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. 9 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. 10 Department of Molecular Biology and Genetics and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 11 Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA. Electronic address: rz24@columbia.edu. 12 Department of Biochemistry and Nutrition, Des Moines University, Des Moines, IA 50312, USA. 13 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: ahamad@jhmi.edu.

Checkpoint blockade immunotherapy enhances the frequency and effector function of murine tumor-infiltrating T cells but does not alter TCRβ diversity

Kuehm et al.
Cancer Immunology and Immunotherapy
May 2019
Authors and Affiliates
Kuehm LM1, Wolf K1, Zahour J1, DiPaolo RJ1,2, Teague RM3,4; 1 Molecular Microbiology and Immunology Department, Saint Louis University School of Medicine, 1100 South Grand Blvd, St. Louis, MO, 63104, USA. 2 Alvin J. Siteman National Cancer Institute Comprehensive Cancer Center, St. Louis, MO, USA. 3 Molecular Microbiology and Immunology Department, Saint Louis University School of Medicine, 1100 South Grand Blvd, St. Louis, MO, 63104, USA. ryan.teague@health.slu.edu. 4 Alvin J. Siteman National Cancer Institute Comprehensive Cancer Center, St. Louis, MO, USA. ryan.teague@health.slu.edu.

Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis

Tomescu-Baciu et al.
Journal of Neuroimmunology
May 2019
Authors and Affiliates
Tomescu-Baciu A1, Johansen JN1, Holmøy T2, Greiff V3, Stensland M4, de Souza GA4, Vartdal F1, Lossius A5; 1 Department of Immunology and Transfusion Medicine, Faculty of Medicine, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway. 2 Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 3 Department of Immunology and Transfusion Medicine, Faculty of Medicine, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 4 Department of Immunology and Transfusion Medicine, Faculty of Medicine, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway; Proteomics Core Facility, Oslo University Hospital Rikshospitalet, NO-0372 Oslo, Norway. 5 Department of Immunology and Transfusion Medicine, Faculty of Medicine, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway; Department of Neurology, Akershus University Hospital, Lørenskog, Norway. Electronic address: andreas.lossius@medisin.uio.no.

Human urothelial bladder cancer generates a clonal immune response: The results of T-cell receptor sequencing

Sankin et al.
Urologic Oncology
May 2019
Authors and Affiliates
Sankin A1, Chand D2, Schoenberg M3, Zang X2. 1 Department of Urology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY. Electronic address: asankin@montefiore.org. 2 Department of Urology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY; Department of Microbiology and Immunology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY. 3 Department of Urology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

Voorwerk et al.
Nature Medicine
May 2019
Authors and Affiliates
Voorwerk L1, Slagter M1,2,3, Horlings HM4, Sikorska K5, van de Vijver KK4,6, de Maaker M7, Nederlof I7, Kluin RJC8, Warren S9, Ong S9, Wiersma TG10, Russell NS10, Lalezari F11, Schouten PC7, Bakker NAM3,12, Ketelaars SLC1, Peters D13, Lange CAH11, van Werkhoven E5, van Tinteren H5, Mandjes IAM5, Kemper I14, Onderwater S14, Chalabi M1,15, Wilgenhof S14, Haanen JBAG1,14, Salgado R16,17, de Visser KE3,12, Sonke GS14, Wessels LFA2,3, Linn SC7,14, Schumacher TN1,3, Blank CU1,14, Kok M18,19. 1 Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 2 Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 3 Oncode Institute, Utrecht, the Netherlands. 4 Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 5 Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 6 Department of Pathology, Ghent University Hospital, Ghent, Belgium. 7 Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 8 Genomics Core Facility, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 9 NanoString Technologies, Inc., Seattle, WA, USA. 10 Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 11 Department of Radiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 12 Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 13 Core Facility Molecular Pathology & Biobanking, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 14 Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 15 Department of Gastrointestinal Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 16 Department of Pathology, GZA-ZNA Ziekenhuizen, Antwerp, Belgium. 17 Division of Research, Peter Mac Callum Cancer Center, Melbourne, Victoria, Australia. 18 Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. m.kok@nki.nl. 19 Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. m.kok@nki.nl.

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Klotz et al.
Science Translational Medicine
May 2019
Authors and Affiliates
Klotz L1, Eschborn M2, Lindner M2, Liebmann M2, Herold M2, Janoschka C2, Torres Garrido B2, Schulte-Mecklenbeck A2, Gross CC2, Breuer J2, Hundehege P2, Posevitz V2, Pignolet B3, Nebel G4, Glander S5, Freise N6, Austermann J6, Wirth T2, Campbell GR7, Schneider-Hohendorf T2, Eveslage M8, Brassat D3, Schwab N2, Loser K9, Roth J6, Busch KB4, Stoll M5,10, Mahad DJ7, Meuth SG2, Turner T11, Bar-Or A12, Wiendl H2,13; 1 University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de. 2 University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. 3 CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France. 4 University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany. 5 University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany. 6 University of Münster, Department of Immunology, 48149 Münster, Germany. 7 University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK. 8 University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany. 9 University Hospital Münster, Department of Dermatology, 48149 Münster, Germany. 10 Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands. 11 Sanofi Genzyme, Cambridge, MA 02142, USA. 12 Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 13 Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.

A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation

Fernandez et al.
Journal of Experimental Medicine
April 2019
Authors and Affiliates
Fernandez IZ#1, Baxter RM#1, Garcia-Perez JE1, Vendrame E2, Ranganath T2, Kong DS1, Lundquist K3, Nguyen T4, Ogolla S1, Black J5, Galambos C5, Gumbart JC3, Dawany N6, Kelsen JR7, de Zoeten EF4, Quinones R8, Eissa H8, Verneris MR8, Sullivan KE9, Rochford R1, Blish CA2,10, Kedl RM#11, Dutmer CM#12, Hsieh EWY#13,14; 1 Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO. 2 Department of Medicine, Stanford University School of Medicine, Stanford, CA. 3 School of Physics, Georgia Institute of Technology, Atlanta, GA. 4 Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO. 5 Department of Pathology and Laboratory Medicine, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO. 6 Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA. 7 Department of Pediatrics, Division of Gastroenterology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 8 Department of Pediatrics, Division of Hematology/Oncology and Blood and Marrow Transplantation, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO. 9 Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 10 Immunology Program, School of Medicine, Stanford University, Stanford, CA. 11 Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO ross.kedl@ucdenver.edu. 12 Department of Pediatrics, Section of Allergy and Immunology, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO cullen.dutmer@childrenscolorado.org. 13 Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO elena.hsieh@ucdenver.edu. 14 Department of Pediatrics, Section of Allergy and Immunology, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO. # Contributed equally
Previous Next