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Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Duhen et al.
Nature Communications
Papers
July 2018
Authors and Affiliates
Thomas Duhen1, Rebekka Duhen2, Ryan Montler1, Jake Moses1, Tarsem Moudgil2, Noel F. de Miranda3, Cheri P. Goodall2, Tiffany C. Blair1, Bernard A. Fox2, Jason E. McDermott4, Shu-Ching Chang5, Gary Grunkemeier5, Rom Leidner2, Richard Bryan Bell2 & Andrew D. Weinberg1,2 1AgonOx, Inc., 4805 NE Glisan Street 2N35, Portland, OR 97213, USA. 2Earle A. Chiles Research Institute, Providence Cancer Institute, 4805 NE Glisan Street 2N35, Portland, OR 97213, USA. 3Department of Pathology, Leiden University Medical Center, P1-43, LUMC, Albinusdreef 2, 2333 Leiden, The Netherlands. 4Pacific Northwest National Laboratory, Computational Biology and Bioinformatics Group, MSIN: J4-33, 902 Battelle Boulevard, PO Box 999, Richland, WA 99352, USA. 5Medical Data Research Center, Providence Saint Joseph’s Health, 9205 SW Barnes Road, Portland, OR 97225, USA.

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

Escobar et al.
Nature
Papers
July 2018
Authors and Affiliates
Giulia Escobar1,2,3, Luigi Barbarossa2,3, Giulia Barbiera3, Margherita Norelli1,4, Marco Genua3, Anna Ranghetti2, Tiziana Plati3, Barbara Camisa4, Chiara Brombin5, Davide Cittaro 3,6, Andrea Annoni3, Attilio Bondanza1,4, Renato Ostuni3, Bernhard Gentner3,7 & Luigi Naldini1,2,3 1Vita-Salute San Raffaele University, 20132 Milan, Italy. 2Targeted Cancer Gene Therapy Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 3San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy. 4Division of Immunology, Transplant and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 5CUSSB-University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, 20132 Milan, Italy. 6Centre for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 7Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma

Hopkins et al.
JCI Insight
Papers
July 2018
Authors and Affiliates
Alexander C. Hopkins,1 Mark Yarchoan,1 Jennifer N. Durham,1 Erik C. Yusko,2 Julie A. Rytlewski,2 Harlan S. Robins,2 Daniel A. Laheru,1 Dung T. Le,1 Eric R. Lutz,1 and Elizabeth M. Jaffee1 1Johns Hopkins University, Sidney Kimmel Cancer Center, Skip Viragh Center for Pancreas Cancer, The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Baltimore, Maryland, USA. 2Adaptive Biotechnologies, Seattle, Washington, USA.

Hypomorphic Rag1 Mutations Alter the Preimmune Repertoire at Early Stages of Lymphoid Development

Ott de Bruin et al.
Blood
July 2018
Authors and Affiliates
L M Ott de Bruin 1 2, M Bosticardo 3, A Barbieri 4, S G Lin 5, J H Rowe 1, P L Poliani 6, K Ching 4, D Eriksson 7, N Landegren 7, O Kämpe 7, J P Manis 4, L D Notarangelo 3; 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA. 2Department of Pediatric Immunology, Wilhelmina Children's Hospital, Utrecht University Medical Center, Utrecht, The Netherlands. 3Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. 4Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA. 5Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA. 6Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; and. 7Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.

Antiviral T-Cells for Adenovirus in the Pre-Transplant Period: a Bridge Therapy for Severe Combined Immunodeficiency

Miller et al.
Biology of Blood and Marrow Transplantation
Papers
June 2018
Authors and Affiliates
Miller HK1, Hanley PJ2, Lang H3, Lazarski CA3, Chorvinsky EA3, McCormack S3, Roesch L4, Albihani S3, Dean M3, Hoq F3, Adams RH1, Bollard CM2, Keller MD5. 1Division of Blood and Marrow Transplantation, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona; Blood and Marrow Transplant, Division of Internal Medicine, Mayo Clinic Arizona, Phoenix, Arizona. 2Center for Cancer and Immunology Research, Children's National Health System, Washington, DC; Division of Blood and Marrow Transplantation, Children's National Health System, Washington, DC. 3Center for Cancer and Immunology Research, Children's National Health System, Washington, DC. 4Division of Blood and Marrow Transplantation, Children's National Health System, Washington, DC. 5Center for Cancer and Immunology Research, Children's National Health System, Washington, DC; Division of Allergy & Immunology, Children's National Health System, Washington, DC.

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation

Chavez et al.
Papers
Theranostics
June 2018
Authors and Affiliates
Michael Chavez1, Matthew T. Silvestrini1, Elizabeth S. Ingham1, Brett Z. Fite1, Lisa M. Mahakian1, Sarah M. Tam1, Asaf Ilovitsh1, Arta M. Monjazeb2, William J. Murphy3, Neil E. Hubbard4, Ryan R. Davis5, Clifford G. Tepper5, Alexander D. Borowsky4, Katherine W. Ferrara1 1University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA, 2University of California, Davis, Department of Radiation Oncology, 4501 X Street, Sacramento, CA 95817, 3University of California, Davis, Department of Dermatology, 2921 Stockton Blvd., Institute for Regenerative Cures, Suite 1630, Sacramento, CA 95817, USA, 4University of California, Davis, Center for Comparative Medicine, Davis, CA 95616, USA, 5University of California, Davis School of Medicine, Department of Biochemistry and Molecular Medicine, 4645 Second Avenue, Sacramento, CA 95817, USA

Kinetics of intratumoral immune cell activation during chemoradiation for cervical cancer

Dorta-Estremera et al.
Biology
International Journal of Radiation Oncology
Papers
Physics
June 2018
Authors and Affiliates
Stephanie Dorta-Estremera, Ph.D.1, Lauren E. Colbert, M.D.2, Nookala Sita Mahalakshmi Krishna, M.S.1, Ananta V. Yanamandra, M.S.1, Guojun Yang1, Andrea Delgado2, Megan Mikkelson2, Patricia Eifel, M.D.2, Anuja Jhingran, M.D.2, MD, Lilie Lin M.D.2, James Welsh, M.D.2, Kathleen Schmeler, M.D.3, K. Jagannadha Sastry, Ph.D.1, Ann Klopp, M.D, Ph.D.2 Department of Immunology1, Department of Radiation Oncology2 and Department of Gynecologic Oncology and Reproductive Medicine3 at The University of Texas MD Anderson Cancer Center

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Zacharakis et al.
Nature Medicine
Papers
June 2018
Authors and Affiliates
Nikolaos Zacharakis1, Harshini Chinnasamy1, Mary Black1, Hui Xu1, Yong-Chen Lu1, Zhili Zheng1, Anna Pasetto1, Michelle Langhan1, Thomas Shelton1, Todd Prickett1, Jared Gartner1, Li Jia1, Katarzyna Trebska-McGowan2, Robert P. Somerville1, Paul F. Robbins1, Steven A. Rosenberg1, Stephanie L. Goff1 and Steven A. Feldman1 1Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 2Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA

Unique features and clinical importance of acute alloreactive immune responses

Inman et al.
JCI Insight
Papers
May 2018
Authors and Affiliates
Charlotte F. Inman,1 Suzy A. Eldershaw,1 Joanne E. Croudace,1 Nathaniel J. Davies,1 Archana Sharma-Oates,2 Tanuja Rai,1 Hayden Pearce,1 Mirjana Sirovica,1 Y.L. Tracey Chan,1 Kriti Verma,1 Jianmin Zuo,1 Sandeep Nagra,3 Francesca Kinsella,1 Jane Nunnick,3 Rasoul Amel-Kashipaz,3 Charles Craddock,3 Ram Malladi,1,3 and Paul Moss1,3 1Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, and 2Centre for Computational Biology, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. 3Birmingham Health Partners, Department of Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom.
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