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Identifying and Tracking Low-Frequency Virus-Specific TCR Clonotypes Using High-Throughput Sequencing
Wolf et al.
Cancer Reports
November 2018
Authors and Affiliates
Wolf K1, Hether T2, Gilchuk P3, Kumar A3, Rajeh A4, Schiebout C4, Maybruck J5, Buller RM1, Ahn TH6, Joyce S3, DiPaolo RJ7.
1 Department of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, MO 63104, USA.
2 Adaptive Biotechnologies, Seattle, WA 98102, USA.
3 Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
4 Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, MO 63104, USA.
5 Federal Bureau of Investigation, Washington, DC 20535, USA.
6 Department of Computer Science, Saint Louis University, Saint Louis, MO 63104, USA; Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, MO 63104, USA.
7 Department of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, MO 63104, USA. Electronic address: richard.dipaolo@health.slu.edu.
Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma
Blank et al.
Nature Medicine
November 2018
Authors and Affiliates
Blank CU1,2, Rozeman EA3,4, Fanchi LF4, Sikorska K5, van de Wiel B6, Kvistborg P4, Krijgsman O4, van den Braber M4, Philips D4, Broeks A6, van Thienen JV3, Mallo HA3, Adriaansz S3, Ter Meulen S7, Pronk LM5, Grijpink-Ongering LG5, Bruining A8, Gittelman RM9, Warren S10, van Tinteren H5, Peeper DS4, Haanen JBAG3,4, van Akkooi ACJ7, Schumacher TN11.
1
Medical Oncology Department, Netherlands Cancer Institute, Amsterdam, The Netherlands. c.blank@nki.nl.
2
Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands. c.blank@nki.nl.
3
Medical Oncology Department, Netherlands Cancer Institute, Amsterdam, The Netherlands.
4
Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
5
Department of Biometrics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
6
Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
7
Surgical Oncology Department, Netherlands Cancer Institute, Amsterdam, The Netherlands.
8
Department of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
9
Adaptive Biotechnologies, Seattle, WA, USA.
10
NanoString Technologies, Inc., Seattle, WA, USA.
11
Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands. t.schumacher@nki.nl.
Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro
Sanchez-Schmitz et al.
Frontiers in Immunology
November 2018
Authors and Affiliates
Sanchez-Schmitz G1,2,3, Stevens CR1, Bettencourt IA1, Flynn PJ1, Schmitz-Abe K2,3,4,5, Metser G1, Hamm D6, Jensen KJ7,8,9, Benn C7,8, Levy O1,2,3,5
1 Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
2 Precision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
3 Harvard Medical School, Harvard University, Boston, MA, United States.
4 Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, United States.
5 Broad Institute of Harvard and MIT, Cambridge, MA, United States.
6 Adaptive Biotechnologies, Seattle, WA, United States.
7 Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
8 Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
9 Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs Lyngby, Denmark.
Early expansion of donor-specific Tregs in tolerant kidney transplant recipients
Savage et al.
JCI Insight
November 2018
Authors and Affiliates
Savage TM1, Shonts BA1, Obradovic A1, Dewolf S1, Lau S1, Zuber J1, Simpson MT1, Berglund E1, Fu J1, Yang S1, Ho SH1, Tang Q2, Turka LA3,4, Shen Y5, Sykes M1,6,7
1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, New York, USA.
2 Department of Surgery, University of California San Francisco, San Francisco, California, USA.
3 Center for Translational Sciences, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
4 Immune Tolerance Network, Bethesda, Maryland, USA.
5 Center for Computational Biology and Bioinformatics, Department of Systems Biology, Columbia University, New York, New York, USA.
6 Department of Microbiology & Immunology, Columbia University Medical Center, Columbia University, New York, New York, USA.
7 Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York, USA.
A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus
Chen et al.
Cancer Reports
November 2018
Authors and Affiliates
Chen S1, Luperchio TR2, Wong X2, Doan EB1, Byrd AT1, Roy Choudhury K3, Reddy KL2, Krangel MS4.
1 Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
2 Department of Biological Chemistry, Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA.
3 Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA.
4 Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: krang001@mc.duke.edu.
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients
Naing et al.
Cancer Cell
November 2018
Authors and Affiliates
Naing A1, Infante JR2, Papadopoulos KP3, Chan IH4, Shen C5, Ratti NP4, Rojo B4, Autio KA5, Wong DJ6, Patel MR7, Ott PA8, Falchook GS9, Pant S10, Hung A4, Pekarek KL4, Wu V4, Adamow M5, McCauley S4, Mumm JB4, Wong P5, Van Vlasselaer P4, Leveque J4, Tannir NM1, Oft M11.
1 MD Anderson Cancer Center, Houston, TX, USA.
2 Sarah Cannon Research Institute / Tennessee Oncology, PLLC, Nashville, TN, USA.
3 START Center for Cancer Care, San Antonio, TX, USA.
4ARMO BioSciences, Eli Lilly and Company, Redwood City, CA, USA.
5Memorial Sloan Kettering Cancer Center, New York, NY, USA.
6 University of California Los Angeles (UCLA), Los Angeles, CA, USA.
7 Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, FL, USA.
8 Dana-Farber Cancer Institute, Boston, MA, USA.
9 Sarah Cannon Research Institute at HealthONE, Denver, CO, USA.
10 Oklahoma University, Oklahoma City, OK, USA.
11 ARMO BioSciences, Eli Lilly and Company, Redwood City, CA, USA. Electronic address: martinoft@gmail.com.
Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo
Richmond et al.
Journal of Investigative Dermatology
November 2018
Authors and Affiliates
Richmond JM1, Strassner JP1, Rashighi M1, Agarwal P1, Garg M1, Essien KI1, Pell LS1, Harris JE2
1 Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
2 Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address: john.harris@umassmed.edu.
Viral genetics modulate orolabial HSV-1 shedding in humans
Ramchandani et al.
Journal of Infectious Diseases
November 2018
Authors and Affiliates
Ramchandani MS1, Jing L1, Russell RM1, Tran T1, Laing KJ1, Magaret AS2,3,4, Selke S2,3, Cheng A3, Huang ML2, Xie H2, Strachan E5, Greninger AL2, Roychoudhury P2, Jerome KR2,4, Wald A1,6,2,4, Koelle DM1,2,7,4,8
1 Department of Medicine, University of Washington, Seattle, USA.
2 Department of Laboratory Medicine, University of Washington, Seattle, USA.
3 Department of Biostatistics, University of Washington, Seattle, USA.
4 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, USA.
5 Department of Psychiatry, University of Washington, Seattle, USA.
6 Department of Epidemiology, University of Washington, Seattle, USA.
7 Global Health, University of Washington, Seattle, USA.
8 Benaroya Research Institute, Seattle, USA.
Neoadjuvant ipilimumab (3 mg/kg or 10 mg/kg) and high dose IFN-α2b in locally/regionally advanced melanoma: safety, efficacy and impact on T-cell repertoire
Tarhini et al.
Journal for ImmunoTherapy of Cancer
October 2018
Authors and Affiliates
Tarhini A1,2, Lin Y3, Lin H3, Rahman Z3, Vallabhaneni P3, Mendiratta P4, Pingpank JF3, Holtzman MP3, Yusko EC5, Rytlewski JA5, Rao UNM3, Ferris RL3, Kirkwood JM3
1 UPMC Hillman Cancer Center, Pittsburgh, USA. tarhina1@ccf.org.
2 Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute and Case Comprehensive Cancer Center, 9500 Euclid Ave CA6-157, Cleveland, OH, 44195, USA. tarhina1@ccf.org.
3 UPMC Hillman Cancer Center, Pittsburgh, USA.
4 Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute and Case Comprehensive Cancer Center, 9500 Euclid Ave CA6-157, Cleveland, OH, 44195, USA.
5 Adaptive Biotechnologies, Seattle, USA.