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High-throughput sequencing of the T cell receptor b gene identifies aggressive early-stage mycosis fungoides

De Masson et al.
Papers
Science Translational Medicine
May 2018
Authors and Affiliates
Adele de Masson,1 John T. O’Malley,1 Christopher P. Elco,1 Sarah S. Garcia,1 Sherrie J. Divito,1 Elizabeth L. Lowry,1 Marianne Tawa,1 David C. Fisher,2 Phillip M. Devlin,3 Jessica E. Teague,1 Nicole R. Leboeuf,1 Ilan R. Kirsch,4 Harlan Robins,4 Rachael A. Clark,1 Thomas S. Kupper1 1Department of Dermatology, Brigham and Women’s Hospital, and the Center for Cutaneous Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA. 2Center for Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. 3Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA. 4Adaptive Biotechnologies, Seattle, WA 98102, USA.

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

Mathew et al.
Papers
Scientific Reports
May 2018
Authors and Affiliates
James M. Mathew1,2, Jessica H.-Voss1, Ann LeFever3, Iwona Konieczna1, Cheryl Stratton3, Jie He1, Xuemei Huang1, Lorenzo Gallon1,4, Anton Skaro1, Mohammed Javeed Ansari1,4 & Joseph R. Leventhal1,5 1Department of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. 2Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. 3Mathews Center for Cellular Therapy, Northwestern Memorial Hospital, Chicago, IL, 60611, USA. 4Department of Medicine, Division of Nephrology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. 5TRACT Therapeutics, Inc; 125W. Oak Street; Suite D, Chicago, IL, 60610, USA.

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Fraietta et al.
Nature
Papers
May 2018
Authors and Affiliates
Joseph A. Fraietta1,2,3,4, Christopher L. Nobles5, Morgan A. Sammons6,10, Stefan Lundh1,2, Shannon A. Carty2,11, Tyler J. Reich1,2, Alexandria P. Cogdill1,2, Jennifer J. D. Morrissette3, Jamie E. DeNizio7,8, Shantan Reddy5, Young Hwang5, Mercy Gohil1,2,Irina Kulikovskaya1,2, Farzana Nazimuddin1,2, Minnal Gupta1,2, Fang Chen1,2, John K. Everett5, Katherine A. Alexander6, Enrique Lin-Shiao6, Marvin H. Gee9, Xiaojun Liu1,2, Regina M. Young1,2, David Ambrose1,2, Yan Wang1,2, Jun Xu1,2, Martha S. Jordan2,3, Katherine T. Marcucci1,2, Bruce L. Levine1,2,3, K. Christopher Garcia9, Yangbing Zhao1,2, Michael Kalos1,2,3, David L. Porter1,2,7, Rahul M. Kohli5,7,8, Simon F. Lacey1,2,3, Shelley L. Berger6, Frederic D. Bushman5, Carl H. June1,2,3,4 &J. Joseph Melenhorst1,2,3,4 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 2Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 4Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. 5Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 6Department of Cell and Developmental Biology, Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 7Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 8Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 9Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. 10Present address: Department of Biology, University at Albany, State University of New York, Albany, NY, USA. 11Present address: Department of Internal Medicine and Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade

Ariyan et al.
Cancer Immunology Research
Papers
April 2018
Authors and Affiliates
Charlotte E. Ariyan1, Mary Sue Brady1, Robert H. Siegelbaum2, Jian Hu1, Danielle M. Bello1, Jamie Rand1, Charles Fisher3, Robert A. Lefkowitz4, Kathleen S. Panageas5, Melissa Pulitzer6, Marissa Vignali7, Ryan Emerson7, Christopher Tipton7, Harlan Robins7, Taha Merghoub8, Jianda Yuan8, Achim Jungbluth6, Jorge Blando9, Padmanee Sharma9, Alexander Y. Rudensky10, Jedd D. Wolchok8,10, and James P. Allison9 1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. 2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. 3Department of Anesthesia, Memorial Sloan Kettering Cancer Center, New York, New York. 4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. 5Department of Statistics, Memorial Sloan Kettering Cancer Center, New York, New York. 6Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. 7Adaptive Biotechnology, Seattle, Washington. 8Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. 9Department of Immunology, MD Anderson Cancer Center, Houston, Texas. 10Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York.

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

James et al.
Cell Chemical Biology
Papers
April 2018
Authors and Affiliates
Charlotte A. James,1,2 Krystle K.Q. Yu,1 Martine Gilleron,3 Jacques Prandi,3 Vijayendar R. Yedulla,4 Zuzanna Z. Moleda,4 Eleonora Diamanti,5 Momin Khan,5 Varinder K. Aggarwal,5 Josephine F. Reijneveld,6 Peter Reinink,6 Stefanie Lenz,6 Ryan O. Emerson,7 Thomas J. Scriba,8 Michael N.T. Souter,9,10 Dale I. Godfrey,9,10 Daniel G. Pellicci,9,10 D. Branch Moody,11 Adriaan J. Minnaard,4 Chetan Seshadri,1 and Ildiko Van Rhijn6,11 1Department of Medicine, University of Washington Medical Center, 750 Republican Street, Suite E663, Seattle, WA 98115, USA 2Department of Pathology, Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA 98195, USA 3Institut de Pharmacologie et Biologie Structurale, IPBS, Universite ́ de Toulouse, CNRS, UPS, Toulouse, France 4Stratingh Institute for Chemistry, University of Groningen, 9747AG Groningen, the Netherlands 5School of Chemistry, University of Bristol, Bristol BS8 1TS, UK 6Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands 7Adaptive Biotechnologies, Seattle, WA 98102, USA 8South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town 7935, South Africa 9Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia 10Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia 11Department of Rheumatology, Allergy & Immunology, Brigham and Women’s Hospital, 60 Fenwood Road, Room 6006V, Boston, MA 02115, USA

Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo

Kooreman et al.
Cell Stem Cell
Papers
April 2018
Authors and Affiliates
Nigel G. Kooreman,1,2,3,4,13 Youngkyun Kim,1,2,3,7 Patricia E. de Almeida,1,2,3 Vittavat Termglinchan,1,2,3 Sebastian Diecke,8,9,10 Ning-Yi Shao,1,2,3 Tzu-Tang Wei,1,2,3 Hyoju Yi,1,2,3,7 Devaveena Dey,1,2,3 Raman Nelakanti,1,2,3 Thomas P. Brouwer,1,2,3,4 David T. Paik,1,2,3 Idit Sagiv-Barfi,5 Arnold Han,6,11,12 Paul H.A. Quax,4 Jaap F. Hamming,4 Ronald Levy,5 Mark M. Davis,6,11,12 and Joseph C. Wu1,2,3,14 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA 2Stanford Cardiovascular Institute of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA 3Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA 4Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands 5Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA 6Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA 7Convergent Research Consortium for Immunologic Disease, Seoul St. Mary’s Hospital, Catholic University of Korea, Seoul 06591, Korea 8Max Delbru€ck Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rossle Strasse 10, 13125 Berlin, Germany 9DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany 10Berlin Institute of Health (BIH), Berlin, Germany 11Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA 12The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA

ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial

Wrangle et al.
Lancet Oncology
Papers
April 2018
Authors and Affiliates
John M Wrangle1, Vamsidhar Velcheti2, Manish R Patel3, Elizabeth Garrett-Mayer1, Elizabeth G Hill1, James G Ravenel1, Jeffrey S Miller3, Mohammad Farhad4, Kate Anderton1, Kathryn Lindsey1, Michele Taffaro-Neskey1, Carol Sherman1, Samantha Suriano1, Marzena Swiderska-Syn1, Amy Sion1, Joni Harris1, Andie R Edwards1, Julie A Rytlewski5, Catherine M Sanders5, Erik C Yusko5, Mark D Robinson6, Carsten Krieg1, William L Redmond4, Jack O Egan7, Peter R Rhode7, Emily K Jeng7, Amy D Rock7, Hing C Wong7, Mark P Rubinstein8 1Department of Medicine, Division of Hematology and Oncology, and Department of Surgery Medical University of South Carolina, Charleston, SC, USA. 2Cleveland Clinic, Cleveland, OH, USA. 3Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, USA. 4Earle A Chiles Research Institute, Portland, OR, USA. 5Adaptive Biotechnologies, Seattle, WA, USA. 6Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. 7Altor BioScience, Miramar, FL, USA. 8Department of Medicine, Division of Hematology and Oncology, and Department of Surgery Medical University of South Carolina, Charleston, SC, USA.

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

Forde et al.
New England Journal of Medicine
Papers
April 2018
Authors and Affiliates
P.M. Forde, J.E. Chaft, K.N. Smith, V. Anagnostou, T.R. Cottrell, M.D. Hellmann, M. Zahurak, S.C. Yang, D.R. Jones, S. Broderick, R.J. Battafarano, M.J. Velez, N. Rekhtman, Z. Olah, J. Naidoo, K.A. Marrone, F. Verde, H. Guo, J. Zhang, J.X. Caushi, H.Y. Chan, J.-W. Sidhom, R.B. Scharpf, J. White, E. Gabrielson, H. Wang, G.L. Rosner, V. Rusch, J.D. Wolchok, T. Merghoub, J.M. Taube, V.E. Velculescu, S.L. Topalian, J.R. Brahmer, and D.M. Pardoll From the Bloomberg-Kimmel Institute for Cancer Immunotherapy and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (P.M.F., K.N.S., V.A., T.R.C., M.Z., S.C.Y., S.B., R.J.B., J.N., K.A.M., F.V., H.G., J.Z., J.X.C., H.Y.C., J.-W.S., R.B.S., J.W., E.G., H.W., G.L.R., J.M.T., V.E.V., S.L.T., J.R.B., D.M.P.); Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine (J.E.C., M.D.H., D.R.J., M.J.V., N.R., Z.O., V.R., J.D.W., T.M.) and the Ludwig Collaborative (J.D.W., T.M.) - all in New York; the Parker Institute for Cancer Immunotherapy, San Francisco (J.D.W., T.M.); and Swim Across America Laboratory, Charlotte, NC (J.D.W., T.M.).

Compositional characteristics of human peripheral TRBV pseudogene rearrangements

Shi et al.
Papers
Scientific Reports
April 2018
Authors and Affiliates
Bin Shi2,3, Long Ma1, Xiaoyan He1, Peipei Wu3, Peng Wang1, Xiaomei Wang1, Rui Ma1 & Xinsheng Yao1 1Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China. 2Department of Laboratory Medicine, The first Affiliated Hospital of Zunyi Medical University, Zunyi, China. 3School of Laboratory Medicine, Zunyi Medical University, Zunyi, China.

Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis

Rathbone et al.
Journal of Neurology
Neurosurgery
Papers
Psychiatry
April 2018
Authors and Affiliates
Emma Rathbone,1 Lindsay Durant,1 James Kinsella,1 Antony R Parker,2 Ghaniah Hassan-Smith,1 Michael R Douglas,3,4 S John Curnow5 1Centre for Translational Inflammation Research Institute of Inflammation and Ageing, College of Medical and Dental Sciences University of Birmingham, Birmingham, UK 2The Binding Site Group Ltd, Birmingham, UK 3Department of Neurology, Dudley Group NHS Foundation Trust, Russells Hall Hospital, Birmingham, UK 4School of Life and Health Sciences, Aston University, Birmingham, UK 5Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2WB, UK
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