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T cells in patients with narcolepsy target self-antigens of hypocretin neurons

Latorre et al.
Nature
Papers
September 2018
Authors and Affiliates
Latorre D1,2, Kallweit U3,4, Armentani E1, Foglierini M1,5, Mele F1, Cassotta A1,2, Jovic S1, Jarrossay D1, Mathis J3, Zellini F6, Becher B7, Lanzavecchia A1, Khatami R8, Manconi M3,6, Tafti M9, Bassetti CL10, Sallusto F11,12 1Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland. 2Institute of Microbiology, ETH Zurich, Zurich, Switzerland. 3Department of Neurology, University Hospital, Bern, Switzerland. 4Institute of Immunology, University of Witten/Herdecke, Witten, Germany. 5Swiss Institute of Bioinformatics, Lausanne, Switzerland. 6Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Lugano, Switzerland. 7Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. 8Center for Sleep Research and Sleep Medicine, Clinic Barmelweid, Barmelweid, Switzerland. 9Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. 10Department of Neurology, University Hospital, Bern, Switzerland. 11Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland. 12Institute of Microbiology, ETH Zurich, Zurich, Switzerland.

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

Clave et al.
Science Translational Medicine
September 2018
Authors and Affiliates
Clave E1,2, Araujo IL1,2, Alanio C3,4,5, Patin E6,7,8, Bergstedt J9, Urrutia A3,4,5,10, Lopez-Lastra S5,11, Li Y5,11, Charbit B3, MacPherson CR3, Hasan M3, Melo-Lima BL1,2, Douay C1,2, Saut N12,13, Germain M14,15, Trégouët DA14,15, Morange PE12,13, Fontes M10,16, Duffy D3,4,5, Di Santo JP5,11, Quintana-Murci L6,7,8, Albert ML17,4,5,10, Toubert A18,2,19; Milieu Intérieur Consortium. Author information 1 Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, 75010 Paris, France. 2 INSERM, UMRS-1160, Alloimmunity-Autoimmunity-Transplantation, 75010 Paris, France. 3 Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France. 4 Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France. 5 INSERM, UMRS-1223, 75015 Paris, France. 6 Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France. 7 CNRS UMR-2000, 75015 Paris, France. 8 Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France. 9 Department of Automatic Control, Lund University, Lund SE-221, Sweden. 10 Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA. 11 Innate Immunity Unit, Institut Pasteur, 75015 Paris, France. 12 Laboratory of Haematology, La Timone Hospital, 13005 Marseille, France. 13 Aix Marseille University, INSERM, UMRS-1260, INRA U1260, Center for Cardiovascular and Nutrition Research (C2VN), 13005 Marseille, France. 14 Sorbonne Université, Université Paris 6/UPMC, INSERM, UMRS-1166, Genomics and Pathophysiology of Cardiovascular Diseases, 75013 Paris, France. 15 Institute for Cardiometabolism and Nutrition, 75013 Paris, France. 16 International Group for Data Analysis, Institut Pasteur, 75015 Paris, France. 17 Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France. antoine.toubert@univ-paris-diderot.fr albert.matthew@gene.com. 18 Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, 75010 Paris, France. antoine.toubert@univ-paris-diderot.fr albert.matthew@gene.com. 19 Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint-Louis, AP-HP, 75010 Paris, France.

Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease

Chung et al.
Hepatology Communications
Papers
August 2018
Authors and Affiliates
Brian K. Chung,1-4 Eva Kristine Klemsdal Henriksen,2-5 Kristin Kaasen Jørgensen,2,6 Tom H. Karlsen,2-5 Gideon M. Hirschfield,1,7 and Evaggelia Liaskou1 1Centre for Liver Research and National Institute for Health Research Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; 2Norwegian PSC Research Center, Depart- ment of Transplantation Medicine, Division of Surgery, Inflammatory Medicine, and Transplantation, Oslo University Hospital Rikshospi- talet, Oslo, Norway; 3Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 4Research Institute of Internal Medicine, Division of Surgery, Inflammatory Medicine, and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 5K.G. Jebsen Inflammation Research Center, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 6Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; 7Centre for Rare Diseases, Institute of Translational Medicine, Birmingham Health Partners, University Hospitals Birmingham, Birmingham, United Kingdom.

Quantifying size and diversity of the human T cell alloresponse

DeWolf et al.
JCI Insight
Papers
August 2018
Authors and Affiliates
Susan DeWolf,1 Boris Grinshpun,2 Thomas Savage,1 Sai Ping Lau,1 Aleksandar Obradovic,1 Brittany Shonts,1 Suxiao Yang,1 Heather Morris,1 Julien Zuber,1 Robert Winchester,3 Megan Sykes,1 and Yufeng Shen4 1Center for Translational Immunology, Department of Medicine, 2Department of Systems Biology, 3Division of Rheumatology, Department of Medicine, and 4Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, New York, USA.

Identification and Analysis of Islet Antigen–Specific CD8+ T Cells with T Cell Libraries

Ogura et al.
Journal of Immunology
Papers
August 2018
Authors and Affiliates
Hideki Ogura,* Paula Preston-Hurlburt,* Ana Luisa Perdigoto,† Matthew Amodio,‡ Smita Krishnaswamy,‡ Pamela Clark,* Hua Yu,* Dieter Egli,x Alexandra Fouts,+ Andrea K. Steck,+ and Kevan C. Herold*,† *Department of Immunobiology, Yale University, New Haven, CT 06520; †Department of Internal Medicine, Yale University, New Haven, CT 06520; ‡Department of Genetics and of Computer Science, Yale University, New Haven, CT 06520; xNaomi Berrie Diabetes Center, Division of Molecular Genetics, Columbia University, New York, NY 10032; +Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Duhen et al.
Nature Communications
Papers
July 2018
Authors and Affiliates
Thomas Duhen1, Rebekka Duhen2, Ryan Montler1, Jake Moses1, Tarsem Moudgil2, Noel F. de Miranda3, Cheri P. Goodall2, Tiffany C. Blair1, Bernard A. Fox2, Jason E. McDermott4, Shu-Ching Chang5, Gary Grunkemeier5, Rom Leidner2, Richard Bryan Bell2 & Andrew D. Weinberg1,2 1AgonOx, Inc., 4805 NE Glisan Street 2N35, Portland, OR 97213, USA. 2Earle A. Chiles Research Institute, Providence Cancer Institute, 4805 NE Glisan Street 2N35, Portland, OR 97213, USA. 3Department of Pathology, Leiden University Medical Center, P1-43, LUMC, Albinusdreef 2, 2333 Leiden, The Netherlands. 4Pacific Northwest National Laboratory, Computational Biology and Bioinformatics Group, MSIN: J4-33, 902 Battelle Boulevard, PO Box 999, Richland, WA 99352, USA. 5Medical Data Research Center, Providence Saint Joseph’s Health, 9205 SW Barnes Road, Portland, OR 97225, USA.

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

Escobar et al.
Nature
Papers
July 2018
Authors and Affiliates
Giulia Escobar1,2,3, Luigi Barbarossa2,3, Giulia Barbiera3, Margherita Norelli1,4, Marco Genua3, Anna Ranghetti2, Tiziana Plati3, Barbara Camisa4, Chiara Brombin5, Davide Cittaro 3,6, Andrea Annoni3, Attilio Bondanza1,4, Renato Ostuni3, Bernhard Gentner3,7 & Luigi Naldini1,2,3 1Vita-Salute San Raffaele University, 20132 Milan, Italy. 2Targeted Cancer Gene Therapy Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 3San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy. 4Division of Immunology, Transplant and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 5CUSSB-University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, 20132 Milan, Italy. 6Centre for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 7Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma

Hopkins et al.
JCI Insight
Papers
July 2018
Authors and Affiliates
Alexander C. Hopkins,1 Mark Yarchoan,1 Jennifer N. Durham,1 Erik C. Yusko,2 Julie A. Rytlewski,2 Harlan S. Robins,2 Daniel A. Laheru,1 Dung T. Le,1 Eric R. Lutz,1 and Elizabeth M. Jaffee1 1Johns Hopkins University, Sidney Kimmel Cancer Center, Skip Viragh Center for Pancreas Cancer, The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Baltimore, Maryland, USA. 2Adaptive Biotechnologies, Seattle, Washington, USA.

Hypomorphic Rag1 Mutations Alter the Preimmune Repertoire at Early Stages of Lymphoid Development

Ott de Bruin et al.
Blood
July 2018
Authors and Affiliates
L M Ott de Bruin 1 2, M Bosticardo 3, A Barbieri 4, S G Lin 5, J H Rowe 1, P L Poliani 6, K Ching 4, D Eriksson 7, N Landegren 7, O Kämpe 7, J P Manis 4, L D Notarangelo 3; 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA. 2Department of Pediatric Immunology, Wilhelmina Children's Hospital, Utrecht University Medical Center, Utrecht, The Netherlands. 3Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. 4Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA. 5Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA. 6Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; and. 7Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.

Antiviral T-Cells for Adenovirus in the Pre-Transplant Period: a Bridge Therapy for Severe Combined Immunodeficiency

Miller et al.
Biology of Blood and Marrow Transplantation
Papers
June 2018
Authors and Affiliates
Miller HK1, Hanley PJ2, Lang H3, Lazarski CA3, Chorvinsky EA3, McCormack S3, Roesch L4, Albihani S3, Dean M3, Hoq F3, Adams RH1, Bollard CM2, Keller MD5. 1Division of Blood and Marrow Transplantation, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona; Blood and Marrow Transplant, Division of Internal Medicine, Mayo Clinic Arizona, Phoenix, Arizona. 2Center for Cancer and Immunology Research, Children's National Health System, Washington, DC; Division of Blood and Marrow Transplantation, Children's National Health System, Washington, DC. 3Center for Cancer and Immunology Research, Children's National Health System, Washington, DC. 4Division of Blood and Marrow Transplantation, Children's National Health System, Washington, DC. 5Center for Cancer and Immunology Research, Children's National Health System, Washington, DC; Division of Allergy & Immunology, Children's National Health System, Washington, DC.
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