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Combination of ipilimumab and adoptive Cell Therapy with Tumor-infiltrating lymphocytes for Patients with Metastatic Melanoma

Mullinax et al.
Frontiers in Oncology
Papers
March 2018
Authors and Affiliates
John E. Mullinax1,2, MacLean Hall2, Sangeetha Prabhakaran3, Jeffrey Weber4, Nikhil Khushalani5, Zeynep Eroglu5, Andrew S. Brohl1,5, Joseph Markowitz2,5, Erica Royster5, Allison Richards5, Valerie Stark5, Jonathan S. Zager1,5, Linda Kelley2, Cheryl Cox2, Vernon K. Sondak5, James J. Mulé2,5, Shari Pilon-Thomas2,5 and Amod A. Sarnaik2,5 1Sarcoma Department, Moffitt Cancer Center, Tampa, FL, United States, 2Immunology Department, Moffitt Cancer Center, Tampa, FL, United States, 3Department of Surgery, University of New Mexico, Albuquerque, NM, United States, 4NYU Langone Medical Center, New York, NY, United States, 5Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, United States

Interim results of brentuximab vedotin in combination with nivolumab in patients with relapsed or refractory Hodgkin lymphoma

Herrera et al.
Blood
Papers
March 2018
Authors and Affiliates
Alex F. Herrera,1 Alison J. Moskowitz,2 Nancy L. Bartlett,3 Julie M. Vose,4 Radhakrishnan Ramchandren,5 Tatyana A. Feldman,6 Ann S. LaCasce,7 Stephen M. Ansell,8 Craig H. Moskowitz,2 Keenan Fenton,9 Carol Anne Ogden,9 David Taft,9 Qu Zhang,9 Kazunobu Kato,10 Mary Campbell,9 and Ranjana H. Advani11 1City of Hope National Medical Center, Duarte, CA; 2Memorial Sloan Kettering Cancer Center, New York, NY; 3Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO; 4University of Nebraska Medical Center, Omaha, NE; 5Karmanos Cancer Institute, Detroit, MI; 6Hackensack University Medical Center, Hackensack, NJ; 7Dana-Farber Cancer Institute, Boston, MA; 8Mayo Clinic, Rochester, MN; 9Seattle Genetics, Inc, Bothell, WA; 10Bristol-Myers Squibb, Princeton, NJ; and 11Stanford University Medical Center, Palo Alto, CA

Deep sustained response to daratumumab monotherapy associated with T-cell expansion in triple refractory myeloma

Usmani et al.
Experimental Hematology & Oncology
Papers
February 2018
Authors and Affiliates
Saad Z. Usmani1, Imran Khan2, Christopher Chiu3, David Foureau1, Lawrence J. Druhan1, Katherine Rigby1, Tineke Casneuf4, and A. Kate Sasser3 1Levine Cancer Institute/Carolinas Health Care System, 1021 Morehead Medical Drive, Charlotte, NC 28204 USA., 2Janssen Research & Development, LLC, Raritan, NJ USA., 3Janssen Research & Development, LLC, Spring House, PA USA., 4Janssen Research & Development, Beerse, Belgium.

RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis

Cortes et al.
Cancer Cell
Papers
February 2018
Authors and Affiliates
Jose R. Cortes,1 Alberto Ambesi-Impiombato,1 Lucile Couronné,2,3,4 S. Aidan Quinn,1 Christine S. Kim,1 Ana C. da Silva Almeida,1 Zachary West,1 Laura Belver,1 Marta Sanchez Martin,1 Laurianne Scourzic,5,6,7 Govind Bhagat,8 Olivier A. Bernard,5,6,7 Adolfo A. Ferrando,1,8,9 and Teresa Palomero1,8 1Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA, 2Department of Adult Hematology, Necker Hospital, Paris 75993, France, 3INSERM U 1163, CNRS ERL 8254, Institut Imagine, Paris 75015, France, 4Paris Descartes University, Paris 75006, France, 5Gustave Roussy, Villejuif 94805, France, 6INSERM U1170, Villejuif 94805, France, 7Universite Paris-Sud, Orsay 91400, France, 8Department of Pathology and Cell Biology, Columbia University Medical Center, 1130 St Nicholas Avenue, ICRC-401B, New York, NY 10032, USA, 9Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA

Alloreactive T cell Receptor Diversity Against Structurally Similar or Dissimilar HLA-DP Antigens Assessed by Deep Sequencing

Arrieta-Bolaños et al.
Frontiers in Immunology
Papers
February 2018
Authors and Affiliates
Esteban Arrieta-Bolaños1, Pietro Crivello1, Maximilian Metzing1, Thuja Meurer1, Müberra Ahci1, Julie Rytlewski2, Marissa Vignali2, Erik Yusko2, Peter van Balen3, Peter A. Horn4, J. H. Frederik Falkenburg3, and Katharina Fleischhauer1,5 1Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany, 2Adaptive Biotechnologies, Seattle, WA, United States, 3Department of Hematology, Leiden University Medical Center, Leiden, Netherlands, 4Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany, 5German Cancer Consortium (DKTK), Heidelberg, Germany Abstract Reference

Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in public receptors

Chu et al.
bioRxiv
Papers
February 2018
Authors and Affiliates
Nathaniel D. Chu1,2,3, Haixin Sarah Bi1,3,4, Ryan O. Emerson5, Anna M. Sherwood5, Michael E. Birnbaum1, Harlan S. Robins5,6, Eric J. Alm1,3,7 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA. 2Microbiology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA. 3Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA. 4Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA. 5Adaptive Biotechnologies, Seattle, WA. 6Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America 7Broad Institute, Cambridge, MA.

T cell Phenotype and T cell receptor repertoire in Patients with Major Depressive Disorder

Patas et al.
Frontiers in Immunology
Papers
February 2018
Authors and Affiliates
Kostas Patas1, Anne Willing1, Cüneyt Demiralay2, Jan Broder Engler1, Andreea Lupu1,3, Caren Ramien1, Tobias Schäfer4, Christian Gach4, Laura Stumm2, Kenneth Chan5, Marissa Vignali5, Petra C. Arck6, Manuel A. Friese1, Ole Pless4, Klaus Wiedemann2, Agorastos Agorastos2 and Stefan M. Gold1,7 1Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 2Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 3Immunomodulation Group, Cantacuzino National Research Institute, Bucharest, Romania, 4Fraunhofer IME ScreeningPort, Hamburg, Germany, 5Adaptive Biotechnologies, Seattle, WA, Unites States, 6Experimentelle Feto-Maternale Medizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 7Charité – Universitätsmedizin Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health (BIH), Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin (CBF), Berlin, Germany

Contraction of T cell richness in lung cancer brain metastases

Mansfield et al.
Papers
Scientific Reports
February 2018
Authors and Affiliates
Aaron S. Mansfield1, Hongzheng Ren2, Shari Sutor3, Vivekananda Sarangi4, Asha Nair4, Jaime Davila 4, Laura R. Elsbernd3, Julia B. Udell5, Roxana S. Dronca1, Sean Park6, Svetomir N. Markovic1, Zhifu Sun4, Kevin C. Halling2, Wendy K. Nevala3, Marie Christine Aubry2, Haidong Dong3 & Jin Jen2,7 1Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA. 2Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 3Department of Immunology, Mayo Clinic, Rochester, MN, USA. 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 5Center for International Blood and Marrow Transplant Research, Minneapolis, MN, USA. 6Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA. 7Genome Analysis Core and the Biomarker Discovery Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA

Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses

Pohlmeyer et al.
Papers
PLOS ONE
February 2018
Authors and Affiliates
Christopher W. Pohlmeyer1, Sarah B. Laskey1, Sarah E. Beck2, Daniel C. Xu1, Adam A. Capoferri1, Caroline C. Garliss1, Megan E. May1, Alison Livingston1, Walt Lichmira3, Richard D. Moore1, M. Sue Leffell1, Nicholas J. Butler4, Jennifer E. Thorne4, John A. Flynn1, Robert F. Siliciano1,5, Joel N. Blankson1,2 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2Department of Molecular and Comparative Pathobiology. Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3Spondylitis Association of America, Philadelphia, Pennsylvania United States of America, 4Department of Ophthalmology. Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 5Howard Hughes Medical Institute, Baltimore, Maryland, United States of America

Sex bias in MHC I-associated shaping of the adaptive immune system

Schneider-Hohendorf et al.
Papers
Proceedings of the National Academy of Sciences
February 2018
Authors and Affiliates
Tilman Schneider-Hohendorfa, Dennis Görlichb, Paula Savolac, Tiina Kelkkac, Satu Mustjokic, Catharina C. Grossa, Geoffrey C. Owensd, Luisa Klotza, Klaus Dornmaire, Heinz Wiendla, and Nicholas Schwaba aDepartment of Neurology, University of Muenster, 48149 Muenster, Germany; bInstitute of Biostatistics and Clinical Research, University of Muenster, 48149 Muenster, Germany; cHematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, 00029 Helsinki, Finland; dDepartment of Neurosurgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095; and eInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich, 80539 Munich, Germany
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