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Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients

Robinson et al.
Leukemia & Lymphoma
Papers
February 2018
Authors and Affiliates
Tara M. Robinsona, Gabrielle T. Princea, Chris Thoburnb, Erica Warlickc, Anna Fergusona, Yvette L. Kasamona, Ivan M. Borrelloa, Allan Hessa and B. Douglas Smitha aDepartment of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; bDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; cDepartment of Medicine, University of Minnesota Medical Center, St. Paul/Minneapolis, MN, USA

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

Wang et al.
Papers
Proceedings of the National Academy of Sciences
February 2018
Authors and Affiliates
Zheng Wanga, Evelyn E. Gurulea, Timothy P. Brennana, Jeffrey M. Geroldb, Kyungyoon J. Kwona, Nina N. Hosmanea, Mithra R. Kumara, Subul A. Bega, Adam A. Capoferria, Stuart C. Raya, Ya-Chi Hoc, Alison L. Hillb, Janet D. Silicianoa, and Robert F. Silicianoa,d aDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; bProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138; cDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536; and dHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205

Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non–Small Cell Lung Cancer

Mark et al.
American Journal of Respiratory and Critical Care Medicine
Papers
February 2018
Authors and Affiliates
Nicholas M. Mark1,2, Julia Kargl2,3, Stephanie E. Busch2, Grace H. Y. Yang2, Heather E. Metz2, Huajia Zhang2, Jesse J. Hubbard2, Sudhakar N. J. Pipavath4, David K. Madtes1,2, and A. McGarry Houghton1,2,5 1Division of Pulmonary and Critical Care, and 4Department of Radiology, University of Washington, Seattle, Washington; 2Clinical Research Division and 5Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; and 3Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria

Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study

Giaconne et al.
Lancet Oncology
Papers
January 2018
Authors and Affiliates
Giuseppe Giaccone, Chul Kim, Jillian Thompson, Colleen McGuire, Bhaskar Kallakury, Joeffrey J Chahine, Maria Manning, Robin Mogg, Wendy M Blumenschein, Ming T Tan, Deepa S Subramaniam, Stephen V Liu, Ian M Kaplan, Justine N McCutcheon Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA (Prof G Giaccone MD,C Kim MD, J Thompson MSN,C McGuire MSN,Prof B Kallakury MD,J J Chahine MS, M Manning MD, Prof M T Tan PhD,D S Subramaniam MD, S V Liu MD, J N McCutcheon BS); Merck and Co, Kenilworth, NJ, USA (R Mogg PhD, W M Blumenschein BA); and Adaptive Biotechnologies, Seattle, WA, USA(I M Kaplan PhD)

T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Kuhs et al.
Papers
PLOS ONE
January 2018
Authors and Affiliates
Krystle A. Lang Kuhs1,2, Shih-Wen Lin1 , Xing Hua1, Mark Schiffman1, Robert D. Burk3, Ana Cecilia Rodriguez4, Rolando Herrero4,5, Christian C. Abnet1, Neal D. Freedman1, Ligia A. Pinto6, David Hamm7, Harlan Robins7,8, Allan Hildesheim1, Jianxin Shi1, Mahboobeh Safaeian1 1National Cancer Institute, NIH, Bethesda, Maryland, United States of America, 2Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 3Albert Einstein College of Medicine, Bronx, New York, United States of America, 4Proyecto Epidemiólogico Guanacaste, Fundación INCIENSA, San José, Costa Rica, 5Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, France, 6HPV Immunology Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, 7Adaptive Biotechnologies, Seattle, Washington, United States of America, 8Fred Hutchinson Cancer Research Cancer, Seattle, Washington, United States of America

Nonlesional atopic dermatitis skin shares similar T-cell clones with lesional tissues

Brunner et al.
Allergy
Papers
December 2017
Authors and Affiliates
P. M. Brunner1, R. O. Emerson2, C. Tipton2, S. Garcet1, S. Khattri3, I. Coats1, J. G. Krueger1, E. Guttman-Yassky1,3 1The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA, 2Adaptive Biotechnologies Corporation, Seattle, WA, USA, 3Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

Bailey et al.
Nature Communications
Papers
December 2017
Authors and Affiliates
Stefanie R. Bailey1,2,3, Michelle H. Nelson1,2,3,7, Kinga Majchrzak1,2,3,8, Jacob S. Bowers1,2,3, Megan M. Wyatt1,2,3, Aubrey S. Smith1,2,3, Lillian R. Neal1,2,3, Keisuke Shirai4,9, Carmine Carpenito5,10, Carl H. June5, Michael J. Zilliox6 & Chrystal M. Paulos1,2,3 1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA. 2Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. 3Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. 4Hematology/Oncology Division, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. 5Department of Pathology and Laboratory Medicine, University of Pennsylvania Cancer Center, Philadelphia, PA 19104, USA. 6Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA. 7Aptevo Therapeutics, Seattle, WA 98121, USA. 8Present address: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, 02-787, Poland. 9Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 02714, USA. 10Present address: Eli Lilly and Company, New York, NY 10016, USA.

Abnormalities of T-cell receptor repertoire in CD4+ regulatory and conventional T cells in patients with RAG mutations: Implications for autoimmunity

Rowe et al.
Journal of Allergy and Clinical Immunology
Papers
December 2017
Authors and Affiliates
Jared H. Rowe, MD, PhDa, Brian D. Stadinski, PhDb, Lauren A. Henderson, MDa, Lisa Ott de Bruin, MDa, Ottavia Delmonte, MDa, Yu Nee Lee, PhDc, M. Teresa de la Morena, MDd, Rakesh K. Goyal, MDe, Anthony Hayward, MD, PhDf, Chiung-Hui Huang, PhDg, Maria Kanariou, MDh, Alejandra King, MDi, Taco W. Kuijpers, MDj, Jian Yi Soh, MDg, Benedicte Neven, MD, PhDk, Jolan E. Walter, MD, PhDl, Eric S. Huseby, PhDb, Luigi D. Notarangelo, MDm aThe Division of Immunology, Boston Children’s Hospital, Boston, Mass; bthe Department of Pathology, University of Massachusetts Medical School, Worcester, Mass; cthe Pediatric Department A and the Immunology Service, ‘‘Edmond and Lily Safra’’ Children’s Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; dthe Division of Allergy and Immunology, University of Texas, Southwestern Medical Center, Dallas, Tex; ethe Division of Hematology/Oncology/BMT, Children’s Mercy Hospital & Clinics, Kansas City, Mo; fthe Department of Pediatrics, Brown University, Providence, RI; gthe Department of Pediatrics, National University of Singapore, Singapore; hthe Department of Immunology-Histocompatibility, ‘‘Aghia Sophia’’ Children’s Hospital, Athens, Greece; ithe Division of Pediatric Immunology, Hospital Luis Calvo Mackenna, Santiago, Chile; jthe Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; kthe Pediatric Hematology-Immunology Department, Hospital Necker-Enfants Malades, AP-HP, Paris Descartes University, Sorbonne-Paris-Cite, Institut Imagine, Paris, France; lthe Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St Petersburg, Fla; and mthe Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

Carey et al.
Frontiers in Immunology
Papers
December 2017
Authors and Affiliates
Alison J. Carey1,2, Jennifer L. Hope3, Yvonne Mueller3, Adam J. Fike2, Ogan K. Kumova2, David V. Zessen3, 4, Eric A. Steegers5, Mirjam van der Burg3, Peter Katsikis3 1Pediatrics, Drexel University, United States, 2Microbiology and Immunology, Drexel University, United States, 3Immunology, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands, 4Biostatistics, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands, 5Obstetrics and Gynecology, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands

Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis

Nimer et al.
Neurology
Papers
December 2017
Authors and Affiliates
Faiez Al Nimer, MD, PhD*, Ivan Jelcic, PhD*, Christian Kempf, MD, Tom Pieper, MD, Herbert Budka, MD, Mireia Sospedra, PhD, Roland Martin, MD From the Neuroimmunology and Multiple Sclerosis Research Section (F.A.N., I.J., C.K., M.S., R.M.), Department of Neurology, University Hospital Zurich, Switzerland; Neuropediatric Clinic and Clinic for Neurorehabilitation (T.P.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; and Institute of Neuropathology (H.B.), University Hospital Zurich, Switzerland.
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