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Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation

Chavez et al.
Papers
Theranostics
June 2018
Authors and Affiliates
Michael Chavez1, Matthew T. Silvestrini1, Elizabeth S. Ingham1, Brett Z. Fite1, Lisa M. Mahakian1, Sarah M. Tam1, Asaf Ilovitsh1, Arta M. Monjazeb2, William J. Murphy3, Neil E. Hubbard4, Ryan R. Davis5, Clifford G. Tepper5, Alexander D. Borowsky4, Katherine W. Ferrara1 1University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA, 2University of California, Davis, Department of Radiation Oncology, 4501 X Street, Sacramento, CA 95817, 3University of California, Davis, Department of Dermatology, 2921 Stockton Blvd., Institute for Regenerative Cures, Suite 1630, Sacramento, CA 95817, USA, 4University of California, Davis, Center for Comparative Medicine, Davis, CA 95616, USA, 5University of California, Davis School of Medicine, Department of Biochemistry and Molecular Medicine, 4645 Second Avenue, Sacramento, CA 95817, USA

Kinetics of intratumoral immune cell activation during chemoradiation for cervical cancer

Dorta-Estremera et al.
Biology
International Journal of Radiation Oncology
Papers
Physics
June 2018
Authors and Affiliates
Stephanie Dorta-Estremera, Ph.D.1, Lauren E. Colbert, M.D.2, Nookala Sita Mahalakshmi Krishna, M.S.1, Ananta V. Yanamandra, M.S.1, Guojun Yang1, Andrea Delgado2, Megan Mikkelson2, Patricia Eifel, M.D.2, Anuja Jhingran, M.D.2, MD, Lilie Lin M.D.2, James Welsh, M.D.2, Kathleen Schmeler, M.D.3, K. Jagannadha Sastry, Ph.D.1, Ann Klopp, M.D, Ph.D.2 Department of Immunology1, Department of Radiation Oncology2 and Department of Gynecologic Oncology and Reproductive Medicine3 at The University of Texas MD Anderson Cancer Center

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Zacharakis et al.
Nature Medicine
Papers
June 2018
Authors and Affiliates
Nikolaos Zacharakis1, Harshini Chinnasamy1, Mary Black1, Hui Xu1, Yong-Chen Lu1, Zhili Zheng1, Anna Pasetto1, Michelle Langhan1, Thomas Shelton1, Todd Prickett1, Jared Gartner1, Li Jia1, Katarzyna Trebska-McGowan2, Robert P. Somerville1, Paul F. Robbins1, Steven A. Rosenberg1, Stephanie L. Goff1 and Steven A. Feldman1 1Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 2Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA

Unique features and clinical importance of acute alloreactive immune responses

Inman et al.
JCI Insight
Papers
May 2018
Authors and Affiliates
Charlotte F. Inman,1 Suzy A. Eldershaw,1 Joanne E. Croudace,1 Nathaniel J. Davies,1 Archana Sharma-Oates,2 Tanuja Rai,1 Hayden Pearce,1 Mirjana Sirovica,1 Y.L. Tracey Chan,1 Kriti Verma,1 Jianmin Zuo,1 Sandeep Nagra,3 Francesca Kinsella,1 Jane Nunnick,3 Rasoul Amel-Kashipaz,3 Charles Craddock,3 Ram Malladi,1,3 and Paul Moss1,3 1Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, and 2Centre for Computational Biology, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. 3Birmingham Health Partners, Department of Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom.

High-throughput sequencing of the T cell receptor b gene identifies aggressive early-stage mycosis fungoides

De Masson et al.
Papers
Science Translational Medicine
May 2018
Authors and Affiliates
Adele de Masson,1 John T. O’Malley,1 Christopher P. Elco,1 Sarah S. Garcia,1 Sherrie J. Divito,1 Elizabeth L. Lowry,1 Marianne Tawa,1 David C. Fisher,2 Phillip M. Devlin,3 Jessica E. Teague,1 Nicole R. Leboeuf,1 Ilan R. Kirsch,4 Harlan Robins,4 Rachael A. Clark,1 Thomas S. Kupper1 1Department of Dermatology, Brigham and Women’s Hospital, and the Center for Cutaneous Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA. 2Center for Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. 3Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA. 4Adaptive Biotechnologies, Seattle, WA 98102, USA.

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

Mathew et al.
Papers
Scientific Reports
May 2018
Authors and Affiliates
James M. Mathew1,2, Jessica H.-Voss1, Ann LeFever3, Iwona Konieczna1, Cheryl Stratton3, Jie He1, Xuemei Huang1, Lorenzo Gallon1,4, Anton Skaro1, Mohammed Javeed Ansari1,4 & Joseph R. Leventhal1,5 1Department of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. 2Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. 3Mathews Center for Cellular Therapy, Northwestern Memorial Hospital, Chicago, IL, 60611, USA. 4Department of Medicine, Division of Nephrology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. 5TRACT Therapeutics, Inc; 125W. Oak Street; Suite D, Chicago, IL, 60610, USA.

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Fraietta et al.
Nature
Papers
May 2018
Authors and Affiliates
Joseph A. Fraietta1,2,3,4, Christopher L. Nobles5, Morgan A. Sammons6,10, Stefan Lundh1,2, Shannon A. Carty2,11, Tyler J. Reich1,2, Alexandria P. Cogdill1,2, Jennifer J. D. Morrissette3, Jamie E. DeNizio7,8, Shantan Reddy5, Young Hwang5, Mercy Gohil1,2,Irina Kulikovskaya1,2, Farzana Nazimuddin1,2, Minnal Gupta1,2, Fang Chen1,2, John K. Everett5, Katherine A. Alexander6, Enrique Lin-Shiao6, Marvin H. Gee9, Xiaojun Liu1,2, Regina M. Young1,2, David Ambrose1,2, Yan Wang1,2, Jun Xu1,2, Martha S. Jordan2,3, Katherine T. Marcucci1,2, Bruce L. Levine1,2,3, K. Christopher Garcia9, Yangbing Zhao1,2, Michael Kalos1,2,3, David L. Porter1,2,7, Rahul M. Kohli5,7,8, Simon F. Lacey1,2,3, Shelley L. Berger6, Frederic D. Bushman5, Carl H. June1,2,3,4 &J. Joseph Melenhorst1,2,3,4 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 2Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 4Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. 5Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 6Department of Cell and Developmental Biology, Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 7Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 8Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 9Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. 10Present address: Department of Biology, University at Albany, State University of New York, Albany, NY, USA. 11Present address: Department of Internal Medicine and Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade

Ariyan et al.
Cancer Immunology Research
Papers
April 2018
Authors and Affiliates
Charlotte E. Ariyan1, Mary Sue Brady1, Robert H. Siegelbaum2, Jian Hu1, Danielle M. Bello1, Jamie Rand1, Charles Fisher3, Robert A. Lefkowitz4, Kathleen S. Panageas5, Melissa Pulitzer6, Marissa Vignali7, Ryan Emerson7, Christopher Tipton7, Harlan Robins7, Taha Merghoub8, Jianda Yuan8, Achim Jungbluth6, Jorge Blando9, Padmanee Sharma9, Alexander Y. Rudensky10, Jedd D. Wolchok8,10, and James P. Allison9 1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. 2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. 3Department of Anesthesia, Memorial Sloan Kettering Cancer Center, New York, New York. 4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. 5Department of Statistics, Memorial Sloan Kettering Cancer Center, New York, New York. 6Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. 7Adaptive Biotechnology, Seattle, Washington. 8Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. 9Department of Immunology, MD Anderson Cancer Center, Houston, Texas. 10Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York.

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

James et al.
Cell Chemical Biology
Papers
April 2018
Authors and Affiliates
Charlotte A. James,1,2 Krystle K.Q. Yu,1 Martine Gilleron,3 Jacques Prandi,3 Vijayendar R. Yedulla,4 Zuzanna Z. Moleda,4 Eleonora Diamanti,5 Momin Khan,5 Varinder K. Aggarwal,5 Josephine F. Reijneveld,6 Peter Reinink,6 Stefanie Lenz,6 Ryan O. Emerson,7 Thomas J. Scriba,8 Michael N.T. Souter,9,10 Dale I. Godfrey,9,10 Daniel G. Pellicci,9,10 D. Branch Moody,11 Adriaan J. Minnaard,4 Chetan Seshadri,1 and Ildiko Van Rhijn6,11 1Department of Medicine, University of Washington Medical Center, 750 Republican Street, Suite E663, Seattle, WA 98115, USA 2Department of Pathology, Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA 98195, USA 3Institut de Pharmacologie et Biologie Structurale, IPBS, Universite ́ de Toulouse, CNRS, UPS, Toulouse, France 4Stratingh Institute for Chemistry, University of Groningen, 9747AG Groningen, the Netherlands 5School of Chemistry, University of Bristol, Bristol BS8 1TS, UK 6Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands 7Adaptive Biotechnologies, Seattle, WA 98102, USA 8South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town 7935, South Africa 9Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia 10Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia 11Department of Rheumatology, Allergy & Immunology, Brigham and Women’s Hospital, 60 Fenwood Road, Room 6006V, Boston, MA 02115, USA
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