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Case report for recurrent and new-onset SLE patients treated by high-dose glucocorticoid therapy

Yu et al.
Medicine
Papers
December 2017
Authors and Affiliates
Jiang Yu, MMa,b, Bin Shi, MMa,c, Long Ma, MMa, Chunmei Liu, MMd, Suhong Sun, MMe, Rui Ma, MSa, Yuehong Qiu, MMf, Xinsheng Yao, MD, PhDa aDepartment of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, bCell Engineering Laboratory, The First Affiliated Hospital of ZunYi Medical University, cDepartment of Laboratory Medicine, Zunyi Medical University, dDepartment of Nephropathy and Rheumatology, eDepartment of Breast Surgery, The first Affiliated Hospital of ZunYi Medical University, Zunyi, fDepartment of Gastroenterology,Rizhao People’s Hospital, Rizhao, China.

Deep sequencing of blood and gut T-cell receptor β-chains reveals gluten-induced immune signatures in celiac disease

Yohannes et al.
Papers
Scientific Reports
December 2017
Authors and Affiliates
Dawit A. Yohannes1,2, Tobias L. Freitag1,3, Andrea de Kauwe1,2, Katri Kaukinen4, Kalle Kurppa5, Pirjo Wacklin6, Markku Mäki5, T. Petteri Arstila1,3, Robert P. Anderson7,9, Dario Greco8,10 & Päivi Saavalainen1,2 1Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland. 2Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. 3Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. 4Department of Internal Medicine, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 5Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland. 6Finnish Red Cross Blood Transfusion Service, Helsinki, Finland. 7Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. 8Institute of Biotechnology, University of Helsinki, Helsinki, Finland. 9Present address: ImmusanT, Inc., Cambridge, MA, USA. 10Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano et al
Nature
Papers
December 2017
Authors and Affiliates
Giovanni Germano1,2, Simona Lamba1, Giuseppe Rospo1, Ludovic Barault1,2, Alessandro Magrì1,2, Federica Maione1, Mariangela Russo1,2, Giovanni Crisafulli1,2, Alice Bartolini1, Giulia Lerda1,2, Giulia Siravegna1,2, Benedetta Mussolin1, Roberta Frapolli3, Monica Montone1, Federica Morano4, Filippo de Braud4,5, Nabil Amirouchene-Angelozzi1,6, Silvia Marsoni1, Maurizio D’Incalci3, Armando Orlandi7, Enrico Giraudo1,8, Andrea Sartore-Bianchi9, Salvatore Siena5,9, Filippo Pietrantonio4, Federica Di Nicolantonio1,2 & Alberto Bardelli1,2 1Candiolo Cancer Institute – FPO, IRCCS, Candiolo 10060, Turin, Italy. 2University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy. 3IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan 20156, Italy. 4Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy. 5Department of Oncology and Hemat-Oncology Università degli Studi di Milano, Milan 20122, Italy. 6FIRC Institute of Molecular Oncology (IFOM), Milan 20139, Italy. 7Policlinico Universitario A. Gemelli, Roma 00168, Italy. 8University of Torino, Department of Science and Drug Technology, Turin 10125, Italy. 9Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan 20142, Italy.

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

Riaz et al.
Cell
Papers
November 2017
Authors and Affiliates
Nadeem Riaz,1,2,3 Jonathan J. Havel,1 Vladimir Makarov,1,3 Alexis Desrichard,1 Walter J. Urba,4 Jennifer S. Sims,1,3 F. Stephen Hodi,5 Salvador Martin-Algarra,6 Rajarsi Mandal,7 William H. Sharfman,8 Shailender Bhatia,9 Wen-Jen Hwu,10 Thomas F. Gajewski,11 Craig L. Slingluff, Jr.,12 Diego Chowell,1,3 Sviatoslav M. Kendall,1,3 Han Chang,13 Rachna Shah,1 Fengshen Kuo,3 Luc G.T. Morris,3,7 John-William Sidhom,14 Jonathan P. Schneck,14 Christine E. Horak,13 Nils Weinhold,2 and Timothy A. Chan1,2,3 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 2Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 3Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 4Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR 97213, USA 5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 6Medical Oncology, Clinica Universidad de Navarra, Instituto de Investigacion Sanitaria de Navarra, 31008 Pamplona, Spain 7Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 8Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA 9Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98105, USA 10Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 11Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA 12Department of Surgery and University of Virginia Cancer Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA 13Bristol-Myers Squibb, Princeton, NJ 08648, USA 14Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Balachandran et al.
Nature
Papers
November 2017
Authors and Affiliates
Vinod P. Balachandran1,2,3, Marta Łuksza4, Julia N. Zhao1,2,3, Vladimir Makarov5,6, John Alec Moral1,2,3, Romain Remark7, Brian Herbst2, Gokce Askan2,8, Umesh Bhanot8, Yasin Senbabaoglu9, Daniel K. Wells10, Charles Ian Ormsby Cary10, Olivera Grbovic-Huezo2, Marc Attiyeh1,2, Benjamin Medina1, Jennifer Zhang1, Jennifer Loo1, Joseph Saglimbeni2, Mohsen Abu-Akeel9, Roberta Zappasodi9, Nadeem Riaz6,11, Martin Smoragiewicz12, Z. Larkin Kelley13,14, Olca Basturk8, Mithat Gönen15, Arnold J. Levine4, Peter J. Allen1,2, Douglas T. Fearon13,14, Miriam Merad7, Sacha Gnjatic7, Christine A. Iacobuzio-Donahue2,5,8, Jedd D. Wolchok3,9,16,17,18, Ronald P. DeMatteo1,2, Timothy A. Chan3,5,6,11, Benjamin D. Greenbaum19, Taha Merghoub3,9,18 & Steven D. Leach1,2,5,20 1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 2David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 4The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey, USA. 5Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 6Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 7Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 8Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 9Swim Across America/Ludwig Collaborative Laboratory, New York, New York, USA. 10Parker Institute for Cancer Immunotherapy, San Francisco, California, USA. 11Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 12Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. 13Cold Spring Harbor Laboratory, New York, New York, USA. 14Department of Microbiology and Immunology, Weill Cornell Medical School, New York, New York, USA. 15Department of Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 16Melanoma and Immunotherapeutics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 17Weill Cornell Medical College, Cornell University, New York, New York, USA. 18Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 19Tisch Cancer Institute, Departments of Medicine, Hematology and Medical Oncology, Oncological Sciences, and Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 20Dartmouth Norris Cotton Cancer Center, Lebanon, New Hampshire, USA

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation

Bigley et al.
Journal of Allergy and Clinical Immunology
Papers
November 2017
Authors and Affiliates
Venetia Bigley, MD, PhD,a,b Sheetal Maisuria, MSc,c Urszula Cytlak, PhD,a Laura Jardine, MD,a,b Matthew A. Care, PhD,d Kile Green, MSc,a Merry Gunawan, PhD,a Paul Milne, PhD,a Rachel Dickinson, PhD,a Sarah Wiscombe, MD,a David Parry, PhD,e Rainer Doffinger, MD, PhD,f Arian Laurence, MD, PhD,a,b Claudia Fonseca, Lic,g Oda Stoevesandt, PhD,g Andrew Gennery, MD, PhD,a,b Andrew Cant, MD, PhD,b Reuben Tooze, MD, PhD,d A. John Simpson, MD, PhD,a,b Sophie Hambleton, MD, PhD,a,b Sinisa Savic, MD, PhD,h Gina Doody, PhD,d and Matthew Collin, MD, PhDa,b aThe Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne; bNewcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne; cLeeds Institute of Rheumatic and Musculoskeletal Medicine, dLeeds Institute of Cancer and Pathology, eLeeds Institute of Biomedical and Clinical Sciences, and hthe National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit and Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; fthe Department of Clinical Biochemistry and Immunology, Addenbrookes Hospital, Cambridge; and gCambridge Protein Arrays, Babraham Research Campus, Cambridge.

The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

Briere et al.
Cancer Immunology
Immunotherapy
November 2017
Authors and Affiliates
David Briere1, Niranjan Sudhakar1, David M. Woods2, Jill Hallin1, Lars D. Engstrom1, Ruth Aranda1, Harrah Chiang1, Andressa L. Sodré2, Peter Olson1, Jeffrey S. Weber2, James G. Christensen1 1Mirati Therapeutics, Inc., 9393 Towne Center Dr, Suite 200, San Diego, CA 92121, 2NYU Langone Medical Center, New York, NY 10016, USA

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro

Schmitt et al.
Nature Biotechnology
Papers
November 2017
Authors and Affiliates
Thomas M Schmitt1, David H Aggen2, Kumiko Ishida-Tsubota1, Sebastian Ochsenreither3, David M Kranz2 & Philip D Greenberg1,4 1Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 2Department of Biochemistry, University of Illinois at Urbana–Champaign, Urbana, Illinois, USA. 3Department of Hematology, Oncology, and Tumor Immunology, Charité Campus Benjamin Franklin, Berlin, Germany. 4Departments of Immunology and Medicine, University of Washington, Seattle, Washington, USA

Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA

Tian et al.
Nature Communications
Papers
November 2017
Authors and Affiliates
Yuan Tian1, Mariana Babor1, Jerome Lane1, Veronique Schulten1, Veena S. Patil1, Grégory Seumois1, Sandy L. Rosales1, Zheng Fu2, Gaelle Picarda3, Julie Burel1, Jose Zapardiel-Gonzalo1, Rashika N. Tennekoon1,4, Aruna D. De Silva1,4, Sunil Premawansa5, Gayani Premawansa6, Ananda Wijewickrama7, Jason A. Greenbaum2, Pandurangan Vijayanand1, Daniela Weiskopf1, Alessandro Sette1 & Bjoern Peters1 1Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 2Bioinformatics Core Facility, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 3Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 4Genetech Research Institute, Colombo 00800, Sri Lanka. 5Department of Zoology and Environment Sciences, Science Faculty, University of Colombo, Colombo 00700, Sri Lanka. 6North Colombo Teaching Hospital, Ragama 11010, Sri Lanka. 7National Institute of Infectious Diseases, Gothatuwa, Angoda 10620, Sri Lanka.

Radiotherapy and CTLA-4 blockade shape the TCR repertoire of tumor-infiltrating T cells

Rudqvist et al.
Cancer Immunology Research
Papers
November 2017
Authors and Affiliates
Nils-Petter Rudqvist1, Karsten A. Pilones1, Claire Lhuillier1, Erik Wennerberg1, John-William Sidhom2, Ryan O. Emerson3, Harlan S. Robins3,4, Jonathan Schneck2, Silvia C. Formenti1, Sandra Demaria1,5 1Department of Radiation Oncology, Weill Cornell Medicine, New York, NY 10065, USA, 2Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 3Adaptive Biotechnologies, 1551 Eastlake Ave. E, Seattle, WA 98102, USA, 4Public Health Sciences Division, Fred Hutchinson Cancer Research, 100 Fairview Ave. N., Seattle, WA 98109, USA, 5Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA
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