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Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in public receptors

Chu et al.
bioRxiv
Papers
February 2018
Authors and Affiliates
Nathaniel D. Chu1,2,3, Haixin Sarah Bi1,3,4, Ryan O. Emerson5, Anna M. Sherwood5, Michael E. Birnbaum1, Harlan S. Robins5,6, Eric J. Alm1,3,7 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA. 2Microbiology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA. 3Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA. 4Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA. 5Adaptive Biotechnologies, Seattle, WA. 6Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America 7Broad Institute, Cambridge, MA.

T cell Phenotype and T cell receptor repertoire in Patients with Major Depressive Disorder

Patas et al.
Frontiers in Immunology
Papers
February 2018
Authors and Affiliates
Kostas Patas1, Anne Willing1, Cüneyt Demiralay2, Jan Broder Engler1, Andreea Lupu1,3, Caren Ramien1, Tobias Schäfer4, Christian Gach4, Laura Stumm2, Kenneth Chan5, Marissa Vignali5, Petra C. Arck6, Manuel A. Friese1, Ole Pless4, Klaus Wiedemann2, Agorastos Agorastos2 and Stefan M. Gold1,7 1Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 2Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 3Immunomodulation Group, Cantacuzino National Research Institute, Bucharest, Romania, 4Fraunhofer IME ScreeningPort, Hamburg, Germany, 5Adaptive Biotechnologies, Seattle, WA, Unites States, 6Experimentelle Feto-Maternale Medizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 7Charité – Universitätsmedizin Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health (BIH), Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin (CBF), Berlin, Germany

Contraction of T cell richness in lung cancer brain metastases

Mansfield et al.
Papers
Scientific Reports
February 2018
Authors and Affiliates
Aaron S. Mansfield1, Hongzheng Ren2, Shari Sutor3, Vivekananda Sarangi4, Asha Nair4, Jaime Davila 4, Laura R. Elsbernd3, Julia B. Udell5, Roxana S. Dronca1, Sean Park6, Svetomir N. Markovic1, Zhifu Sun4, Kevin C. Halling2, Wendy K. Nevala3, Marie Christine Aubry2, Haidong Dong3 & Jin Jen2,7 1Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA. 2Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 3Department of Immunology, Mayo Clinic, Rochester, MN, USA. 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 5Center for International Blood and Marrow Transplant Research, Minneapolis, MN, USA. 6Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA. 7Genome Analysis Core and the Biomarker Discovery Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA

Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses

Pohlmeyer et al.
Papers
PLOS ONE
February 2018
Authors and Affiliates
Christopher W. Pohlmeyer1, Sarah B. Laskey1, Sarah E. Beck2, Daniel C. Xu1, Adam A. Capoferri1, Caroline C. Garliss1, Megan E. May1, Alison Livingston1, Walt Lichmira3, Richard D. Moore1, M. Sue Leffell1, Nicholas J. Butler4, Jennifer E. Thorne4, John A. Flynn1, Robert F. Siliciano1,5, Joel N. Blankson1,2 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2Department of Molecular and Comparative Pathobiology. Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3Spondylitis Association of America, Philadelphia, Pennsylvania United States of America, 4Department of Ophthalmology. Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 5Howard Hughes Medical Institute, Baltimore, Maryland, United States of America

Sex bias in MHC I-associated shaping of the adaptive immune system

Schneider-Hohendorf et al.
Papers
Proceedings of the National Academy of Sciences
February 2018
Authors and Affiliates
Tilman Schneider-Hohendorfa, Dennis Görlichb, Paula Savolac, Tiina Kelkkac, Satu Mustjokic, Catharina C. Grossa, Geoffrey C. Owensd, Luisa Klotza, Klaus Dornmaire, Heinz Wiendla, and Nicholas Schwaba aDepartment of Neurology, University of Muenster, 48149 Muenster, Germany; bInstitute of Biostatistics and Clinical Research, University of Muenster, 48149 Muenster, Germany; cHematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, 00029 Helsinki, Finland; dDepartment of Neurosurgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095; and eInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich, 80539 Munich, Germany

Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients

Robinson et al.
Leukemia & Lymphoma
Papers
February 2018
Authors and Affiliates
Tara M. Robinsona, Gabrielle T. Princea, Chris Thoburnb, Erica Warlickc, Anna Fergusona, Yvette L. Kasamona, Ivan M. Borrelloa, Allan Hessa and B. Douglas Smitha aDepartment of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; bDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; cDepartment of Medicine, University of Minnesota Medical Center, St. Paul/Minneapolis, MN, USA

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

Wang et al.
Papers
Proceedings of the National Academy of Sciences
February 2018
Authors and Affiliates
Zheng Wanga, Evelyn E. Gurulea, Timothy P. Brennana, Jeffrey M. Geroldb, Kyungyoon J. Kwona, Nina N. Hosmanea, Mithra R. Kumara, Subul A. Bega, Adam A. Capoferria, Stuart C. Raya, Ya-Chi Hoc, Alison L. Hillb, Janet D. Silicianoa, and Robert F. Silicianoa,d aDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; bProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138; cDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536; and dHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205

Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non–Small Cell Lung Cancer

Mark et al.
American Journal of Respiratory and Critical Care Medicine
Papers
February 2018
Authors and Affiliates
Nicholas M. Mark1,2, Julia Kargl2,3, Stephanie E. Busch2, Grace H. Y. Yang2, Heather E. Metz2, Huajia Zhang2, Jesse J. Hubbard2, Sudhakar N. J. Pipavath4, David K. Madtes1,2, and A. McGarry Houghton1,2,5 1Division of Pulmonary and Critical Care, and 4Department of Radiology, University of Washington, Seattle, Washington; 2Clinical Research Division and 5Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; and 3Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria

Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study

Giaconne et al.
Lancet Oncology
Papers
January 2018
Authors and Affiliates
Giuseppe Giaccone, Chul Kim, Jillian Thompson, Colleen McGuire, Bhaskar Kallakury, Joeffrey J Chahine, Maria Manning, Robin Mogg, Wendy M Blumenschein, Ming T Tan, Deepa S Subramaniam, Stephen V Liu, Ian M Kaplan, Justine N McCutcheon Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA (Prof G Giaccone MD,C Kim MD, J Thompson MSN,C McGuire MSN,Prof B Kallakury MD,J J Chahine MS, M Manning MD, Prof M T Tan PhD,D S Subramaniam MD, S V Liu MD, J N McCutcheon BS); Merck and Co, Kenilworth, NJ, USA (R Mogg PhD, W M Blumenschein BA); and Adaptive Biotechnologies, Seattle, WA, USA(I M Kaplan PhD)

T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Kuhs et al.
Papers
PLOS ONE
January 2018
Authors and Affiliates
Krystle A. Lang Kuhs1,2, Shih-Wen Lin1 , Xing Hua1, Mark Schiffman1, Robert D. Burk3, Ana Cecilia Rodriguez4, Rolando Herrero4,5, Christian C. Abnet1, Neal D. Freedman1, Ligia A. Pinto6, David Hamm7, Harlan Robins7,8, Allan Hildesheim1, Jianxin Shi1, Mahboobeh Safaeian1 1National Cancer Institute, NIH, Bethesda, Maryland, United States of America, 2Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 3Albert Einstein College of Medicine, Bronx, New York, United States of America, 4Proyecto Epidemiólogico Guanacaste, Fundación INCIENSA, San José, Costa Rica, 5Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, France, 6HPV Immunology Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, 7Adaptive Biotechnologies, Seattle, Washington, United States of America, 8Fred Hutchinson Cancer Research Cancer, Seattle, Washington, United States of America
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