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Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response

Soukup et al.
Papers
Scientific Reports
September 2017
Authors and Affiliates
Klara Soukup1,4, Angela Halfmann1, Barbara Dillinger1, Fiona Poyer1, Katharina Martin1, Bernadette Blauensteiner1, Maximilian Kauer2, Mario Kuttke3, Gernot Schabbauer3 & Alexander M. Dohnal1,5 1Tumour Immunology, St. Anna Kinderkrebsforschung, Children’s Cancer Research Institute, Vienna, Austria. 2Bioinformatics, St. Anna Kinderkrebsforschung, Children’s Cancer Research Institute, Vienna, Austria. 3Institute for Physiology, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. 4Present address: Department of Fundamental Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland. 5Present address: APEIRON Biologics AG, Vienna, Austria

Staged development of long lived TCRαβ Th17 resident memory T cell population to Candida albicans after skin infection

Park et al.
Journal of Allergy and Clinical Immunology
Papers
September 2017
Authors and Affiliates
Chang Ook Park, MD, PhD1,5, Xiujun Fu, MD, PhD2, Xiaodong Jiang, MD, PhD1, Youdong Pan, PhD1, Jessica E. Teague, PhD1, Nicholas Collins, PhD3, Tian Tian, MD, PhD1, John T. O’Malley, MD, PhD1, Ryan O. Emerson, PhD4, Ji Hye Kim, MS5, Yookyung Jung, PhD2, Rei Watanabe, MD, PhD1, Robert C. Fuhlbrigge, MD, PhD1, Francis R. Carbone, PhD3, Thomas Gebhardt, MD, PhD3, Rachael A. Clark, MD, PhD1, Charles P. Lin, PhD2, and Thomas S. Kupper, MD1 1Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA, 2Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA, 3Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia, 4Adaptive Biotechnologies, Seattle, Washington, USA, 5Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University, College of Medicine, Seoul, Korea

Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade

Le et al.
Papers
Science
August 2017
Authors and Affiliates
Dung T. Le,1,2,3 Jennifer N. Durham,1,2,3 Kellie N. Smith,1,3 Hao Wang,3 Bjarne R. Bartlett,2,4 Laveet K. Aulakh,2,4 Steve Lu,2,4 Holly Kemberling,3 Cara Wilt,3 Brandon S. Luber,3 Fay Wong,2,4 Nilofer S. Azad,1,3 Agnieszka A. Rucki,1,3 Dan Laheru,3 Ross Donehower,3 Atif Zaheer,5 George A. Fisher,6 Todd S. Crocenzi,7 James J. Lee,8 Tim F. Greten,9 Austin G. Duffy,9 Kristen K. Ciombor,10 Aleksandra D. Eyring,11 Bao H. Lam,11 Andrew Joe,11 S. Peter Kang,11 Matthias Holdhoff,3 Ludmila Danilova,1,3 Leslie Cope,1,3 Christian Meyer,3 Shibin Zhou,1,3,4 Richard M. Goldberg,12 Deborah K. Armstrong,3 Katherine M. Bever,3 Amanda N. Fader,13 Janis Taube,1,3 Franck Housseau,1,3 David Spetzler,14 Nianqing Xiao,14 Drew M. Pardoll,1,3 Nickolas Papadopoulos,3,4 Kenneth W. Kinzler,3,4 James R. Eshleman,15 Bert Vogelstein,1,3,4 Robert A. Anders,1,3,15 Luis A. Diaz Jr.1,2,3 1Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA. 2Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA. 3Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA. 4Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA. 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. 6Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. 7Providence Cancer Center at Providence Health & Services, Portland, OR 97213, USA. 8Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA. 9Gastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. 10Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. 11Merck & Co. Inc., Kenilworth, NJ 07033, USA. 12West Virginia University Cancer Institute, Morgantown, WV 26506, USA. 13Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD 21287, USA. 14Caris Life Sciences, Phoenix, AZ 85040, USA. 15Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE)

Radwan et al.
BMC Cancer
Papers
August 2017
Authors and Affiliates
Noura Radwan1, Ryan Phillips1, Ashley Ross2,3, Steven P. Rowe4, Michael A. Gorin3, Emmanuel S. Antonarakis2, Curtiland Deville1,2, Stephen Greco1, Samuel Denmeade2,3, Channing Paller2, Daniel Y. Song1,2,3, Maximilian Diehn5, Hao Wang2, Michael Carducci2,3, Kenneth J. Pienta2,3, Martin G. Pomper1,2,3,4, Theodore L. DeWeese1,2,3, Adam Dicker6, Mario Eisenberger2,3 and Phuoc T. Tran1,2,3 1Department of Radiation Oncology & Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB2 Rm 406, Baltimore, MD 21231, USA. 2Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 4The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 5Department of Radiation Oncology, Stanford University, Stanford, CA, USA. 6Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development

Stengel et al.
Papers
Proceedings of the National Academy of Sciences
August 2017
Authors and Affiliates
Kristy R. Stengela, Kelly R. Barnetta, Jing Wangb, Qi Liub, Emily Hodgesa, Scott W. Hieberta,b, and Srividya Bhaskarac aDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232; bVanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37027; and cDepartment of Radiation Oncology and Oncological Sciences, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT 84103

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient

Jiménez-Sánchez et al.
Cell
Papers
August 2017
Authors and Affiliates
Alejandro Jiménez-Sánchez,1 Danish Memon,1,2 Stephane Pourpe,10 Harini Veeraraghavan,3 Yanyun Li,4 Hebert Alberto Vargas,5 Michael B. Gill,1 Kay J. Park,6 Oliver Zivanovic,7 Jason Konner,8 Jacob Ricca,4 Dmitriy Zamarin,4,10 Tyler Walther,10 Carol Aghajanian,8 Jedd D. Wolchok,4,9,10,11,12 Evis Sala,5 Taha Merghoub,4 Alexandra Snyder,10,11 and Martin L. Miller1 1Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK, 2European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 3Department of Medical Physics, 4Ludwig Collaborative/Swim Across America Laboratory, 5Department of Radiology, 6Department of Pathology, 7Gynecology Service, Department of Surgery, 8Gynecologic Medical Oncology Service, Department of Medicine, 9Parker Institute for Cancer Immunotherapy, 10Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA, 11Department of Medicine, Weill Cornell Medical College, New York, NY, USA, 12Immunology and Microbial Pathogenesis Programs, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA

Integrative clinical genomics of metastatic cancer

Robinson et al.
Nature
Papers
August 2017
Authors and Affiliates
Dan R. Robinson1,2, Yi-Mi Wu1,2, Robert J. Lonigro1, Pankaj Vats1, Erin Cobain3, Jessica Everett3, Xuhong Cao1, Erica Rabban1, Chandan Kumar-Sinha1,2, Victoria Raymond3, Scott Schuetze3, Ajjai Alva3, Javed Siddiqui1,2, Rashmi Chugh3, Francis Worden3, Mark M. Zalupski3, Jeffrey Innis4, Rajen J. Mody4, Scott A. Tomlins1,2, David Lucas2, Laurence H. Baker3, Nithya Ramnath3, Ann F. Schott3, Daniel F. Hayes3, Joseph Vijai5, Kenneth Offit5, Elena M. Stoffel3, J. Scott Roberts6, David C. Smith3, Lakshmi P. Kunju1,2, Moshe Talpaz7, Marcin Cieślik1,2 & Arul M. Chinnaiyan1,2,7,8,9 1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. 2Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. 3Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA. 4Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA. 5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. 6Department of Health Behavior & Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA. 7Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA. 8Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA. 9Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

Shrimali et al.
Cancer Immunology Research
Papers
August 2017
Authors and Affiliates
Rajeev K. Shrimali1, Shamim Ahmad1, Vivek Verma1, Peng Zeng1, Sudha Ananth1, Pankaj Gaur1, Rachel M. Gittelman2, Erik Yusko2, Catherine Sanders2, Harlan Robins2,3, Scott A. Hammond4, John E. Janik1, Mikayel Mkrtichyan1, Seema Gupta1, and Samir N. Khleif1 1Georgia Cancer Center, Augusta University, Augusta, Georgia. 2Adaptive Biotechnologies, Seattle, Washington. 3Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington. 4MedImmune LLC, Gaithersburg, Maryland.

An adolescent with granulomatous mycosis fungoides infiltrating skeletal muscle successfully treated with oral prednisone

Lewis et al.
Journal of the American Academy of Dermatology
Papers
July 2017
Authors and Affiliates
Daniel J. Lewis, BA,a,b Ashley E. Turkeltaub, BS,a Julia Dai, MD,c Priyadharsini Nagarajan, MD, PhD,d Kerri E. Rieger, MD, PhD,c,e Cesar A. Nunez, MD,f Youn H. Kim, MD,c and Madeleine Duvic, MDb School of Medicine, Baylor College of Medicinea; The Departments of Dermatology,b Pathology,d and Pediatric Oncology,f the University of Texas MD Anderson Cancer Center; and Departments of Dermatologyc and Pathology,e Stanford University.

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

O'Rourke et al.
Papers
Science Translational Medicine
July 2017
Authors and Affiliates
Donald M. O’Rourke,1 MacLean P. Nasrallah,2 Arati Desai,3 Jan J. Melenhorst,4 Keith Mansfield,5 Jennifer J. D. Morrissette,6 Maria Martinez-Lage,2 Steven Brem,1 Eileen Maloney,1 Angela Shen,7 Randi Isaacs,5 Suyash Mohan,8 Gabriela Plesa,4 Simon F. Lacey,4 Jean-Marc Navenot,4 Zhaohui Zheng,4 Bruce L. Levine,4 Hideho Okada,9 Carl H. June,4 Jennifer L. Brogdon,5 Marcela V. Maus10 1Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 2Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 3Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA. 5Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. 6Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 7Novartis Oncology, East Hanover, NJ 07936, USA. 8Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 9Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA. 10Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA.
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