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Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence
Bailey et al.
Nature Communications
Papers
December 2017
Authors and Affiliates
Stefanie R. Bailey1,2,3, Michelle H. Nelson1,2,3,7, Kinga Majchrzak1,2,3,8, Jacob S. Bowers1,2,3, Megan M. Wyatt1,2,3, Aubrey S. Smith1,2,3, Lillian R. Neal1,2,3, Keisuke Shirai4,9, Carmine Carpenito5,10, Carl H. June5, Michael J. Zilliox6 & Chrystal M. Paulos1,2,3
1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA. 2Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. 3Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. 4Hematology/Oncology Division, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. 5Department of Pathology and Laboratory Medicine, University of Pennsylvania Cancer Center, Philadelphia, PA 19104, USA. 6Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA. 7Aptevo Therapeutics, Seattle, WA 98121, USA. 8Present address: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, 02-787, Poland. 9Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 02714, USA. 10Present address: Eli Lilly and Company, New York, NY 10016, USA.
Abnormalities of T-cell receptor repertoire in CD4+ regulatory and conventional T cells in patients with RAG mutations: Implications for autoimmunity
Rowe et al.
Journal of Allergy and Clinical Immunology
Papers
December 2017
Authors and Affiliates
Jared H. Rowe, MD, PhDa, Brian D. Stadinski, PhDb, Lauren A. Henderson, MDa, Lisa Ott de Bruin, MDa, Ottavia Delmonte, MDa, Yu Nee Lee, PhDc, M. Teresa de la Morena, MDd, Rakesh K. Goyal, MDe, Anthony Hayward, MD, PhDf, Chiung-Hui Huang, PhDg, Maria Kanariou, MDh, Alejandra King, MDi, Taco W. Kuijpers, MDj, Jian Yi Soh, MDg, Benedicte Neven, MD, PhDk, Jolan E. Walter, MD, PhDl, Eric S. Huseby, PhDb, Luigi D. Notarangelo, MDm
aThe Division of Immunology, Boston Children’s Hospital, Boston, Mass; bthe Department of Pathology, University of Massachusetts Medical School, Worcester, Mass; cthe Pediatric Department A and the Immunology Service, ‘‘Edmond and Lily Safra’’ Children’s Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; dthe Division of Allergy and Immunology, University of Texas, Southwestern Medical Center, Dallas, Tex; ethe Division of Hematology/Oncology/BMT, Children’s Mercy Hospital & Clinics, Kansas City, Mo; fthe Department of Pediatrics, Brown University, Providence, RI; gthe Department of Pediatrics, National University of Singapore, Singapore; hthe Department of Immunology-Histocompatibility, ‘‘Aghia Sophia’’ Children’s Hospital, Athens, Greece; ithe Division of Pediatric Immunology, Hospital Luis Calvo Mackenna, Santiago, Chile; jthe Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; kthe Pediatric Hematology-Immunology Department, Hospital Necker-Enfants Malades, AP-HP, Paris Descartes University, Sorbonne-Paris-Cite, Institut Imagine, Paris, France; lthe Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St Petersburg, Fla; and mthe Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates
Carey et al.
Frontiers in Immunology
Papers
December 2017
Authors and Affiliates
Alison J. Carey1,2, Jennifer L. Hope3, Yvonne Mueller3, Adam J. Fike2, Ogan K. Kumova2, David V. Zessen3, 4, Eric A. Steegers5, Mirjam van der Burg3, Peter Katsikis3
1Pediatrics, Drexel University, United States, 2Microbiology and Immunology, Drexel University, United States, 3Immunology, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands, 4Biostatistics, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands, 5Obstetrics and Gynecology, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands
Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis
Nimer et al.
Neurology
Papers
December 2017
Authors and Affiliates
Faiez Al Nimer, MD, PhD*, Ivan Jelcic, PhD*, Christian Kempf, MD, Tom Pieper, MD, Herbert Budka, MD, Mireia Sospedra, PhD, Roland Martin, MD
From the Neuroimmunology and Multiple Sclerosis Research Section (F.A.N., I.J., C.K., M.S., R.M.), Department of Neurology, University Hospital Zurich, Switzerland; Neuropediatric Clinic and Clinic for Neurorehabilitation (T.P.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; and Institute of Neuropathology (H.B.), University Hospital Zurich, Switzerland.
Case report for recurrent and new-onset SLE patients treated by high-dose glucocorticoid therapy
Yu et al.
Medicine
Papers
December 2017
Authors and Affiliates
Jiang Yu, MMa,b, Bin Shi, MMa,c, Long Ma, MMa, Chunmei Liu, MMd, Suhong Sun, MMe, Rui Ma, MSa, Yuehong Qiu, MMf, Xinsheng Yao, MD, PhDa
aDepartment of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, bCell Engineering Laboratory, The First Affiliated Hospital of ZunYi Medical University, cDepartment of Laboratory Medicine, Zunyi Medical University, dDepartment of Nephropathy and Rheumatology, eDepartment of Breast Surgery, The first Affiliated Hospital of ZunYi Medical University, Zunyi, fDepartment of Gastroenterology,Rizhao People’s Hospital, Rizhao, China.
Deep sequencing of blood and gut T-cell receptor β-chains reveals gluten-induced immune signatures in celiac disease
Yohannes et al.
Papers
Scientific Reports
December 2017
Authors and Affiliates
Dawit A. Yohannes1,2, Tobias L. Freitag1,3, Andrea de Kauwe1,2, Katri Kaukinen4, Kalle Kurppa5, Pirjo Wacklin6, Markku Mäki5, T. Petteri Arstila1,3, Robert P. Anderson7,9, Dario Greco8,10 & Päivi Saavalainen1,2
1Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland. 2Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. 3Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. 4Department of Internal Medicine, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 5Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland. 6Finnish Red Cross Blood Transfusion Service, Helsinki, Finland. 7Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. 8Institute of Biotechnology, University of Helsinki, Helsinki, Finland. 9Present address: ImmusanT, Inc., Cambridge, MA, USA. 10Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth
Germano et al
Nature
Papers
December 2017
Authors and Affiliates
Giovanni Germano1,2, Simona Lamba1, Giuseppe Rospo1, Ludovic Barault1,2, Alessandro Magrì1,2, Federica Maione1, Mariangela Russo1,2, Giovanni Crisafulli1,2, Alice Bartolini1, Giulia Lerda1,2, Giulia Siravegna1,2, Benedetta Mussolin1, Roberta Frapolli3, Monica Montone1, Federica Morano4, Filippo de Braud4,5, Nabil Amirouchene-Angelozzi1,6, Silvia Marsoni1, Maurizio D’Incalci3, Armando Orlandi7, Enrico Giraudo1,8, Andrea Sartore-Bianchi9, Salvatore Siena5,9, Filippo Pietrantonio4, Federica Di Nicolantonio1,2 & Alberto Bardelli1,2
1Candiolo Cancer Institute – FPO, IRCCS, Candiolo 10060, Turin, Italy. 2University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy. 3IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan 20156, Italy. 4Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy. 5Department of Oncology and Hemat-Oncology Università degli Studi di Milano, Milan 20122, Italy. 6FIRC Institute of Molecular Oncology (IFOM), Milan 20139, Italy. 7Policlinico Universitario A. Gemelli, Roma 00168, Italy. 8University of Torino, Department of Science and Drug Technology, Turin 10125, Italy. 9Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan 20142, Italy.
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab
Riaz et al.
Cell
Papers
November 2017
Authors and Affiliates
Nadeem Riaz,1,2,3 Jonathan J. Havel,1 Vladimir Makarov,1,3 Alexis Desrichard,1 Walter J. Urba,4 Jennifer S. Sims,1,3 F. Stephen Hodi,5 Salvador Martin-Algarra,6 Rajarsi Mandal,7 William H. Sharfman,8 Shailender Bhatia,9 Wen-Jen Hwu,10 Thomas F. Gajewski,11 Craig L. Slingluff, Jr.,12 Diego Chowell,1,3 Sviatoslav M. Kendall,1,3 Han Chang,13 Rachna Shah,1 Fengshen Kuo,3 Luc G.T. Morris,3,7 John-William Sidhom,14 Jonathan P. Schneck,14 Christine E. Horak,13 Nils Weinhold,2 and Timothy A. Chan1,2,3
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 2Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 3Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 4Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR 97213, USA 5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 6Medical Oncology, Clinica Universidad de Navarra, Instituto de Investigacion Sanitaria de Navarra, 31008 Pamplona, Spain 7Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 8Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
9Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98105, USA 10Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 11Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA 12Department of Surgery and University of Virginia Cancer Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA 13Bristol-Myers Squibb, Princeton, NJ 08648, USA 14Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
Balachandran et al.
Nature
Papers
November 2017
Authors and Affiliates
Vinod P. Balachandran1,2,3, Marta Łuksza4, Julia N. Zhao1,2,3, Vladimir Makarov5,6, John Alec Moral1,2,3, Romain Remark7, Brian Herbst2, Gokce Askan2,8, Umesh Bhanot8, Yasin Senbabaoglu9, Daniel K. Wells10, Charles Ian Ormsby Cary10, Olivera Grbovic-Huezo2, Marc Attiyeh1,2, Benjamin Medina1, Jennifer Zhang1, Jennifer Loo1, Joseph Saglimbeni2, Mohsen Abu-Akeel9, Roberta Zappasodi9, Nadeem Riaz6,11, Martin Smoragiewicz12, Z. Larkin Kelley13,14, Olca Basturk8, Mithat Gönen15, Arnold J. Levine4, Peter J. Allen1,2, Douglas T. Fearon13,14, Miriam Merad7, Sacha Gnjatic7, Christine A. Iacobuzio-Donahue2,5,8, Jedd D. Wolchok3,9,16,17,18, Ronald P. DeMatteo1,2, Timothy A. Chan3,5,6,11, Benjamin D. Greenbaum19, Taha Merghoub3,9,18 & Steven D. Leach1,2,5,20
1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 2David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 4The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey, USA. 5Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 6Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 7Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 8Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 9Swim Across America/Ludwig Collaborative Laboratory, New York, New York, USA. 10Parker Institute for Cancer Immunotherapy, San Francisco, California, USA. 11Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 12Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. 13Cold Spring Harbor Laboratory, New York, New York, USA. 14Department of Microbiology and Immunology, Weill Cornell Medical School, New York, New York, USA. 15Department of Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 16Melanoma and Immunotherapeutics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 17Weill Cornell Medical College, Cornell University, New York, New York, USA. 18Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 19Tisch Cancer Institute, Departments of Medicine, Hematology and Medical Oncology, Oncological Sciences, and Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 20Dartmouth Norris Cotton Cancer Center, Lebanon, New Hampshire, USA