Browse our 650+ Publications​

Latest Publications

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation

Bigley et al.
Journal of Allergy and Clinical Immunology
Papers
November 2017
Authors and Affiliates
Venetia Bigley, MD, PhD,a,b Sheetal Maisuria, MSc,c Urszula Cytlak, PhD,a Laura Jardine, MD,a,b Matthew A. Care, PhD,d Kile Green, MSc,a Merry Gunawan, PhD,a Paul Milne, PhD,a Rachel Dickinson, PhD,a Sarah Wiscombe, MD,a David Parry, PhD,e Rainer Doffinger, MD, PhD,f Arian Laurence, MD, PhD,a,b Claudia Fonseca, Lic,g Oda Stoevesandt, PhD,g Andrew Gennery, MD, PhD,a,b Andrew Cant, MD, PhD,b Reuben Tooze, MD, PhD,d A. John Simpson, MD, PhD,a,b Sophie Hambleton, MD, PhD,a,b Sinisa Savic, MD, PhD,h Gina Doody, PhD,d and Matthew Collin, MD, PhDa,b aThe Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne; bNewcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne; cLeeds Institute of Rheumatic and Musculoskeletal Medicine, dLeeds Institute of Cancer and Pathology, eLeeds Institute of Biomedical and Clinical Sciences, and hthe National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit and Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; fthe Department of Clinical Biochemistry and Immunology, Addenbrookes Hospital, Cambridge; and gCambridge Protein Arrays, Babraham Research Campus, Cambridge.

The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

Briere et al.
Cancer Immunology
Immunotherapy
November 2017
Authors and Affiliates
David Briere1, Niranjan Sudhakar1, David M. Woods2, Jill Hallin1, Lars D. Engstrom1, Ruth Aranda1, Harrah Chiang1, Andressa L. Sodré2, Peter Olson1, Jeffrey S. Weber2, James G. Christensen1 1Mirati Therapeutics, Inc., 9393 Towne Center Dr, Suite 200, San Diego, CA 92121, 2NYU Langone Medical Center, New York, NY 10016, USA

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro

Schmitt et al.
Nature Biotechnology
Papers
November 2017
Authors and Affiliates
Thomas M Schmitt1, David H Aggen2, Kumiko Ishida-Tsubota1, Sebastian Ochsenreither3, David M Kranz2 & Philip D Greenberg1,4 1Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 2Department of Biochemistry, University of Illinois at Urbana–Champaign, Urbana, Illinois, USA. 3Department of Hematology, Oncology, and Tumor Immunology, Charité Campus Benjamin Franklin, Berlin, Germany. 4Departments of Immunology and Medicine, University of Washington, Seattle, Washington, USA

Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA

Tian et al.
Nature Communications
Papers
November 2017
Authors and Affiliates
Yuan Tian1, Mariana Babor1, Jerome Lane1, Veronique Schulten1, Veena S. Patil1, Grégory Seumois1, Sandy L. Rosales1, Zheng Fu2, Gaelle Picarda3, Julie Burel1, Jose Zapardiel-Gonzalo1, Rashika N. Tennekoon1,4, Aruna D. De Silva1,4, Sunil Premawansa5, Gayani Premawansa6, Ananda Wijewickrama7, Jason A. Greenbaum2, Pandurangan Vijayanand1, Daniela Weiskopf1, Alessandro Sette1 & Bjoern Peters1 1Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 2Bioinformatics Core Facility, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 3Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 4Genetech Research Institute, Colombo 00800, Sri Lanka. 5Department of Zoology and Environment Sciences, Science Faculty, University of Colombo, Colombo 00700, Sri Lanka. 6North Colombo Teaching Hospital, Ragama 11010, Sri Lanka. 7National Institute of Infectious Diseases, Gothatuwa, Angoda 10620, Sri Lanka.

Radiotherapy and CTLA-4 blockade shape the TCR repertoire of tumor-infiltrating T cells

Rudqvist et al.
Cancer Immunology Research
Papers
November 2017
Authors and Affiliates
Nils-Petter Rudqvist1, Karsten A. Pilones1, Claire Lhuillier1, Erik Wennerberg1, John-William Sidhom2, Ryan O. Emerson3, Harlan S. Robins3,4, Jonathan Schneck2, Silvia C. Formenti1, Sandra Demaria1,5 1Department of Radiation Oncology, Weill Cornell Medicine, New York, NY 10065, USA, 2Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 3Adaptive Biotechnologies, 1551 Eastlake Ave. E, Seattle, WA 98102, USA, 4Public Health Sciences Division, Fred Hutchinson Cancer Research, 100 Fairview Ave. N., Seattle, WA 98109, USA, 5Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA

T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes

Gomez-Tourino et al.
Nature Communications
Papers
November 2017
Authors and Affiliates
Iria Gomez-Tourino1,2,3, Yogesh Kamra1, Roman Baptista1,2, Anna Lorenc1 & Mark Peakman1,2 1Department of Immunobiology, Faculty of Life Sciences & Medicine, King’s College London, 2nd Floor, Borough Wing, Guy’s Hospital, London SE1 9RT, UK. 2National Institute for Health Research, Biomedical Research Centre at Guy’s and St Thomas’ Hospital Foundation Trust and King’s College London, Guy’s Hospital, London SE1 9RT, UK. 3Present address: Immunology Laboratory, Biomedical Research Center (CINBIO), Centro Singular de Investigación de Galicia, University of Vigo, Campus Universitario de Vigo, Pontevedra 36310, Spain

T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire

Beausang et al.
Proceedings of the National Academy of Sciences
November 2017
Authors and Affiliates
Beausang JF1, Wheeler AJ2, Chan NH2, Hanft VR2, Dirbas FM2, Jeffrey SS2, Quake SR3,4,5; 1 Department of Bioengineering, Stanford University, Stanford, CA 94305. 2 Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305. 3 Department of Bioengineering, Stanford University, Stanford, CA 94305; quake@stanford.edu. 4 Department of Applied Physics, Stanford University, Stanford, CA 94305. 5 Chan Zuckerberg Biohub, San Francisco, CA 94518.

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma

Stromnes et al.
Cancer Immunology Research
October 2017
Authors and Affiliates
Stromnes IM1,2, Hulbert A3,2, Pierce RH3,2, Greenberg PD1,2,4, Hingorani SR1,4,5; 1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. ingunn@umn.edu pgreen@uw.edu srh@fhcrc.org. 2 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington. 3 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. 4 Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington. 5 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Comparative immunologic characterization of autoimmune giant cell myocarditis with ipilimumab

Reuben et al.
OncoImmunology
Papers
October 2017
Authors and Affiliates
Alexandre Reubena, Mariana Petaccia de Macedob, Jennifer McQuadec, Aron Joond, Zhiyong Rene,Tiffany Calderoneb, Brandy Connerb, Khalida Wanib, Zachary A. Coopera,f,z, Hussein Tawbic, Michael T. Tetzlaffb,e, Robert F. Paderag, Jean-Bernard Durandh, Alexander J. Lazarb,e, Jennifer A. Wargoa,f, and Michael A. Daviesb,c,i aDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; bTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; cMelanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; dBiostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; ePathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; fGenomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; gDepartment of Pathology, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA; hCardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; iSystems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

In Silico Prediction Analysis of Idiotope-Driven T–B Cell Collaboration in Multiple Sclerosis

Høglund et al.
Frontiers in Immunology
Papers
October 2017
Authors and Affiliates
Rune A. Høglund1,2, Andreas Lossius1,3, Jorunn N. Johansen3, Jane Homan4, Jūratė Šaltytė Benth2,5, Harlan Robins6, Bjarne Bogen2,3,7, Robert D. Bremel4 and Trygve Holmøy1,2 1Department of Neurology, Akershus University Hospital, Lørenskog, Norway, 2Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 3Faculty of Medicine, Department of Immunology and Transfusion Medicine, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway, 4EigenBio LLC, Madison, WI, United States, 5Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway, 6Adaptive Biotechnologies, Seattle, WA, United States, 7Centre for Immune Regulation, University of Oslo, Oslo, Norway