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Adaptive from Innate: Human IFN-g+ CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults
Das et al.
Journal of Immunology
Papers
July 2017
Authors and Affiliates
Abhishek Das,* Kevin Rouault-Pierre,† Shraddha Kamdar,* Iria Gomez-Tourino,* Kristie Wood,‡ Ian Donaldson,x Charles A. Mein,x Dominique Bonnet,† Adrian C. Hayday,*,† and Deena L. Gibbons*
*Peter Gorer Department of Immunobiology, King’s College London, London SE1 9RT, United Kingdom; †The Francis Crick Institute, London NW1 1AT, United Kingdom; ‡National Institute for Health Research Biomedical Research Centre Genomics Research Platform, Guy’s Hospital, London SE1 9RT, United Kingdom; and xGenome Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London EC1M 6BQ, United Kingdom
Vaccination establishes clonal relatives of germinal center T cells in the blood of humans
Heit et al.
Journal of Experimental Medicine
Papers
June 2017
Authors and Affiliates
Antje Heit,1 Frank Schmitz,3 Sarah Gerdts,1 Britta Flach,1 Miranda S. Moore,1 Jonathan A. Perkins,4,8 Harlan S. Robins,2,9 Alan Aderem,3 Paul Spearman,10 Georgia D. Tomaras,11 Stephen C. De Rosa,1,5 and M. Juliana McElrath1,5,6,7
1Vaccine and Infectious Disease Division and 2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 3Center for Infectious Disease Research, Seattle, WA, 4Department of Otolaryngology, 5Department of Laboratory Medicine, 6Department of Medicine, and 7Department of Global Health, University of Washington, Seattle, WA, 8Seattle Children's Hospital Research Institute, Seattle, WA, 9Adaptive Biotechnologies Corporation, Seattle, WA, 10Pediatric Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH, 11Duke Human Vaccine Institute, Duke University, Durham, NC
Dual Targeting Nanoparticle Stimulates the Immune System To Inhibit Tumor Growth
Kosmides et al.
ACS Nano
Papers
June 2017
Authors and Affiliates
Alyssa K. Kosmides†‡§, John-William Sidhom†§, Andrew Fraser†§, Catherine A. Bessell§∥, and Jonathan P. Schneck‡§∥
†Department of Biomedical Engineering, ‡Institute for Nanobiotechnology, §Institute for Cell Engineering, and ∥Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States
Research Techniques Made Simple: High-Throughput Sequencing of the T-Cell Receptor
Matos et al.
Journal of Investigative Dermatology
Papers
June 2017
Authors and Affiliates
Tiago R. Matos1, Menno A. de Rie1, and Marcel B.M. Teunissen1
1Academic Medical Center, Department of Dermatology, University of Amsterdam, Amsterdam, The Netherlands
Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
Savola et al.
Nature Communications
Papers
June 2017
Authors and Affiliates
P. Savola1,2, T. Kelkka1,2, H.L. Rajala1, A. Kuuliala3, K. Kuuliala3, S. Eldfors4, P. Ellonen4, S. Lagstrom4, M. Lepisto4, T. Hannunen4, E.I. Andersson1, R.K. Khajuria1, T. Jaatinen5, R. Koivuniemi6, H. Repo3, J. Saarela4, K. Porkka1, M. Leirisalo-Repo6, & S. Mustjoki1,2
1Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Haartmaninkatu 8, FIN-00290 Helsinki, Finland. 2Department of Clinical Chemistry and Hematology, University of Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland. 3Bacteriology and Immunology, Medicum, University of Helsinki, Haartmaninkatu 3, FIN-00290 Helsinki, Finland. 4Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Tukholmankatu 8, FIN-00290 Helsinki, Finland. 5Histocompatibility Testing Laboratory, Finnish Red Cross Blood Service, Kivihaantie 7, FIN-00310 Helsinki, Finland. 6Department of Rheumatology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, FIN-00290 Helsinki, Finland.
Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity
Allenspach et al.
Letter to the Editor: Journal of Allergy and Clinical Immunology
Papers
May 2017
Authors and Affiliates
Eric J. Allenspach, MD, PhDa,b Laura S. Finn, MDc,d Mara H. Rendi, MD, PhDd Ahmet Eken, PhDb Akhilesh K. Singh, PhDb Mohamed Oukka, PhDb Sean D. Taylor, PhDb Matthew C. Altman, MDe,f Corinne L. Fligner, MDd,g Hans D. Ochs, MDa,b David J. Rawlings, MDa,b Troy R. Torgerson, MD, PhDa,b
aThe Department of Pediatrics, University of Washington School of Medicine, bThe Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, cThe Department of Laboratories, Seattle Children’s Hospital, dThe Department of Pathology, University of Washington School of Medicine, eBenaroya Research Institute, fThe Department of Medicine, University of Washington School of Medicine, and gThe Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington
Fractionated radiation therapy stimulates anti-tumor immunity mediated by both resident and infiltrating polyclonal T-cell populations when combined with PD1 blockade
Dovedi et al.
Clinical Cancer Research
Papers
May 2017
Authors and Affiliates
Simon J. Dovedi1,2, Eleanor J. Cheadle1, Amy L. Popple1, Edmund Poon2, Michelle Morrow2, Ross Stewart2, Erik C. Yusko3, Catherine M. Sanders3, Marissa Vignali3, Ryan O. Emerson3, Harlan S. Robins4, Robert W. Wilkinson2, Jamie Honeychurch1, Timothy M. Illidge1
1Targeted Therapy Group, Targeted Therapy Group, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Christie Hospital, Manchester Academic Health Sciences Centre, United Kingdom. 2MedImmune Ltd, Granta Park, Cambridge, United Kingdom. 3Adaptive Biotechnologies, Seattle, Washington, United States of America. 4Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses
Lavin et al.
Cell
Papers
May 2017
Authors and Affiliates
Yonit Lavin,1,2,3 Soma Kobayashi,1,2,3 Andrew Leader,1,2,3 El-ad David Amir,2,3,9 Naama Elefant,10 Camille Bigenwald,1,2,3 Romain Remark,1,2,3 Robert Sweeney,6,7 Christian D. Becker,4 Jacob H. Levine,11 Klaus Meinhof,4 Andrew Chow,1,2,3 Seunghee Kim-Shulze,2,3,9 Andrea Wolf,6 Chiara Medaglia,10 Hanjie Li,10 Julie A. Rytlewski,12 Ryan O. Emerson,12 Alexander Solovyov,1,3,5,8 Benjamin D. Greenbaum,1,3,5,8 Catherine Sanders,12 Marissa Vignali,12 Mary Beth Beasley,8 Raja Flores,6 Sacha Gnjatic,2,3,5,9 Dana Pe’er,11 Adeeb Rahman,2,3,7,9 Ido Amit,10 and Miriam Merad1,2,3,9
1Department of Oncological Sciences 2The Precision Immunology Institute 3Tisch Cancer Institute 4Division of Pulmonology 5Division of Hematology/Oncology 6Department of Thoracic Surgery 7Department of Genetics and Genomic Sciences 8Department of Pathology 9Human Immune Monitoring Center Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA 10Department of Immunology, Weizmann Institute, Rehovot 76100, Israel 11Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA 12Adaptive Biotechnologies Inc., Seattle, WA 98102, USA
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis
Snyder et al.
Papers
PLOS Medicine
May 2017
Authors and Affiliates
Alexandra Snyder1,2, Tavi Nathanson3, Samuel A. Funt1,2, Arun Ahuja3, Jacqueline Buros Novik3, Matthew D. Hellmann1,2, Eliza Chang3, Bulent Arman Aksoy3, Hikmat Al-Ahmadie4, Erik Yusko5, Marissa Vignali5, Sharon Benzeno5, Mariel Boyd1, Meredith Moran1, Gopa Iyer1,2, Harlan S. Robins5,6, Elaine R. Mardis7, Taha Merghoub1, Jeff Hammerbacher3, Jonathan E. Rosenberg1, Dean F. Bajorin1,2
1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 2Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America, 3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, 4Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 5Adaptive Biotechnologies, Seattle, Washington, United States of America, 6Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 7Department of Pediatrics, Institute for Genomic Medicine, The Research Institute at Nationwide Children’s Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America