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Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy

Zhang et al.
Papers
Science Advances
May 2017
Authors and Affiliates
Jingyu Zhang,1,2 Dai Liu,3 Guangfu Li,3 Kevin F. Staveley-O’Carroll,3 Julie N. Graff,4 Zihai Li,1,5 Jennifer D. Wu1,5 1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA. 2CanCure LLC, Everett, WA 98208, USA. 3School of Medicine, University of Missouri, Columbia, MO 65211, USA. 4Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA. 5Cancer Immunology Program, Hollings Cancer Center, Charleston, SC 29425, USA.

T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ

Oftedal et al.
Journal of Autoimmunity
Papers
April 2017
Authors and Affiliates
Bergithe E. Oftedal a,b, Brita Ardesjo Lundgren a,c, David Hammd, Poh-Yi Gane, Stephen R. Holdsworthe, Christopher N. Hahna,i, Andreas W. Schreiberf,i,Hamish S. Scotta,f,g,h,i aDepartment of Genetics and Molecular Pathology, Centre for Cancer Biology, An Alliance Between SA Pathology and the University of South Australia, Adelaide, Australia, bDepartment of Clinical Science, University of Bergen, Norway, cDepartment of Medical Biochemistry and Microbiology, Uppsala University, Sweden, dAdaptive Biotechnologies, 1551 Eastlake Ave E #200, Seattle, WA, 98102, USA, eCentre for Inflammatory Diseases, Monash University Department of Medicine, Clayton, Australia, fACRF Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, Australia gSchool of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Australia, hSchool of Biological Sciences, University of Adelaide, Australia, iSchool of Medicine, University of Adelaide, Adelaide, Australia

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

Emerson et al.
Nature Genetics
Papers
April 2017
Authors and Affiliates
Ryan O Emerson1,4, William S DeWitt1,2,4, Marissa Vignali1, Jenna Gravley3, Joyce K Hu1, Edward J Osborne1, Cindy Desmarais1, Mark Klinger1, Christopher S Carlson3, John A Hansen3, Mark Rieder1,5 & Harlan S Robins1,2,5 1Adaptive Biotechnologies, Seattle, Washington, USA. 2Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 3Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 4These authors contributed equally to this work. 5These authors jointly directed this work.

In vivo enrichment of diabetogenic T cells

Thelin et al.
Diabetes
Papers
April 2017
Authors and Affiliates
Martin A. Thelin1, Stephan Kissler1, Frederic Vigneault3, Alexander L. Watters3, Des White2,3, Sandeep T. Koshy2,3,4, Sarah A. Vermillion3, David J. Mooney2,3, Thomas Serwold1 and Omar A. Ali3 1Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA, 02215, USA
, 2School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA., 3Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, USA., 4Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Huang et al.
Nature
Papers
April 2017
Authors and Affiliates
Alexander C. Huang1,2,3,4, Michael A. Postow5,6, Robert J. Orlowski1,2,3,4, Rosemarie Mick3,4,7, Bertram Bengsch2,4,8, Sasikanth Manne2,8, Wei Xu1,3, Shannon Harmon1,3, Josephine R. Giles2,4,8, Brandon Wenz1,3, Matthew Adamow9, Deborah Kuk10, Katherine S. Panageas10, Cristina Carrera5,11, Phillip Wong9,12, Felix Quagliarello2,8, Bradley Wubbenhorst1,3, Kurt D’Andrea1,3, Kristen E. Pauken2,8, Ramin S. Herati1,2,3, Ryan P. Staupe2,8, Jason M. Schenkel13, Suzanne McGettigan1,3, Shawn Kothari1, Sangeeth M. George2,4,8, Robert H. Vonderheide1,2,3,4, Ravi K. Amaravadi1,3, Giorgos C. Karakousis3,14, Lynn M. Schuchter1,3, Xiaowei Xu3,15, Katherine L. Nathanson1,3,4, Jedd D. Wolchok5,12, Tara C. Gangadhar1,3, and E. John Wherry2,3,4,8 1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 4Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, Pennsylvania, USA. 5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 6Weill Cornell Medical College, New York, New York, USA. 7Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 8Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 9Immune Monitoring Facility, Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 10Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 11Department of Dermatology, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain. 12Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, New York, USA. 13Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA. 14Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 15Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

Stevanović et al.
Papers
Science
April 2017
Authors and Affiliates
Sanja Stevanović,1 Anna Pasetto,2 Sarah R. Helman,1 Jared J. Gartner,2 Todd D. Prickett,2 Bryan Howie,3 Harlan S. Robins,3,4 Paul F. Robbins,2 Christopher A. Klebanoff,5,6 Steven A. Rosenberg,2 Christian S. Hinrichs1 1Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA. 2Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA. 3Adaptive Biotechnologies, Seattle, WA 98102, USA. 4Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. 5Center for Cell Engineering and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. 6Parker Institute for for Cancer Immunotherapy, New York, NY 10065, US

Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Ogunjimi et al.
Papers
Scientific Reports
April 2017
Authors and Affiliates
B. Ogunjimi 1,2,3,4,5,6, J. Van den Bergh4, P. Meysman6,7,8, S. Heynderickx4,9, K. Bergs10, H. Jansen10, E. Leuridan11, A. Vorsters11, H. Goossens10,12, K. Laukens6,7,8, N. Cools4, Viggo Van Tendeloo4,6,9, N. Hens1,2,6, P. Van Damme6,11, Evelien Smits4,6,9,13 & Ph. Beutels1,6,14 1Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 2Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium. 3Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium. 4Laboratory of Experimental Hematology (LEH), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 5Department of Pediatrics, Ghent University Hospital, Ghent, Belgium. 6Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), Antwerp, Belgium. 7Advanced Database Research and Modelling (ADReM), Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium. 8Biomedical Informatics Research Network Antwerp (BIOMINA), University of Antwerp/Antwerp University Hospital, Edegem, Belgium. 9Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Edegem, Belgium. 10Department of Laboratory Medicine, Antwerp University Hospital, Edegem, Belgium. 11Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 12Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 13Center for Oncological Research Antwerp, University of Antwerp, Antwerp, Belgium. 14School of Public Health and Community Medicine, The University of New South Wales, Sydney, Australia.

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

Roh et al.
Papers
Science Translational Medicine
March 2017
Authors and Affiliates
Whijae Roh,1,2 Pei-Ling Chen,1,3 Alexandre Reuben,4 Christine N. Spencer,1 Peter A. Prieto,4 John P. Miller,5 Vancheswaran Gopalakrishnan,4 Feng Wang,1 Zachary A. Cooper,1,4 Sangeetha M. Reddy,6 Curtis Gumbs,1 Latasha Little,1 Qing Chang,1 Wei-Shen Chen,1,3 Khalida Wani,7 Mariana Petaccia De Macedo,7,8 Eveline Chen,7 Jacob L. Austin-Breneman,4 Hong Jiang,4 Jason Roszik,1,9 Michael T. Tetzlaff,3 Michael A. Davies,9 Jeffrey E. Gershenwald,4 Hussein Tawbi,9 Alexander J. Lazar,4,7 Patrick Hwu,9 Wen-Jen Hwu,9 Adi Diab,9 Isabella C. Glitza,9 Sapna P. Patel,9 Scott E. Woodman,9 Rodabe N. Amaria,9 Victor G. Prieto,3 Jianhua Hu,10 Padmanee Sharma,11,12 James P. Allison,11 Lynda Chin,13 Jianhua Zhang,14 Jennifer A. Wargo,1,4 P. Andrew Futreal1 1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 2Cancer Biology Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA. 3Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 5Oncology Research for Biologics and Immunotherapy Translation, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 6Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 7Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 8Pathology Department, A.C. Camargo Cancer Center, São Paulo, SP-01509-010, Brazil. 9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 10Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 11Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 12Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 13University of Texas System, Austin, TX 78701, USA. 14Applied Cancer Science Institute, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

The Lower Limit of Regulatory CD4+ Foxp3+ TCRb Repertoire Diversity Required To Control Autoimmunity

Yu et al.
Journal of Immunology
Papers
March 2017
Authors and Affiliates
Aixin Yu,* Michael J. Dee,* Dennis Adeegbe,*, Connor J. Dwyer,* Norman H. Altman,† and Thomas R. Malek*,‡ *Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136; †Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136; and ‡Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136
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