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TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence

Reuben et al.
Cancer Discovery
Papers
October 2017
Authors and Affiliates
Alexandre Reuben1,2, Rachel Gittelman3, Jianjun Gao4, Jiexin Zhang5, Erik C. Yusko3, Chang-Jiun Wu2, Ryan Emerson3, Jianhua Zhang2, Christopher Tipton3, Jun Li2, Kelly Quek2,6, Vancheswaran Gopalakrishnan1, Runzhe Chen2,6, Luis M. Vence7, Tina Cascone6, Marissa Vignali3, Junya Fujimoto8, Jaime Rodriguez-Canales8, Edwin R. Parra8, Latasha D. Little2, Curtis Gumbs2, Marie-Andrée Forget9, Lorenzo Federico9, Cara Haymaker9, Carmen Behrens8, Sharon Benzeno3, Chantale Bernatchez9, Boris Sepesi10, Don L. Gibbons6, Jennifer A. Wargo1,2, William N. William Jr6, Stephen Swisher10, John V. Heymach6, Harlan Robins3,11, J. Jack Lee12, Padmanee Sharma4,7, James P. Allison7, P. Andrew Futreal2, Ignacio I. Wistuba8, and Jianjun Zhang2,6 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. 3Adaptive Biotechnologies, Seattle, Washington. 4Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 5Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 6Department of Thoracic/Head and Neck Medical Oncology, The Univer- sity of Texas MD Anderson Cancer Center, Houston, Texas. 7Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 8Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 9Department of Melanoma Medical Oncology, The University of Texas MD Ander- son Cancer Center, Houston, Texas. 10Department of Thoracic Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 11Department of Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington. 12Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Adipose Tissue is Enriched for Activated and Late-differentiated CD8+ T cells, and Shows Distinct CD8+ Receptor Usage, Compared to Blood in HIV-infected Persons

Koethe et al.
Journal of Acquired Immune Deficiency Syndromes
Papers
October 2017
Authors and Affiliates
John R. Koethe, MD, MS1,2, Wyatt McDonnell, BS3,4, Arion Kennedy, PhD5, Chike O. Abana, BS3, Mark Pilkinton, MD, PhD1,2, Ian Setliff, BS3,4, Ivelin Georgiev, PhD3,4, Louise Barnett, BS1, Cindy C. Hager, BS1, Rita Smith, BS1, Spyros A. Kalams, MD1,3, Alyssa Hasty, PhD2,5, Simon Mallal, MBBS1,3 1Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, 2VA Tennessee Valley Healthcare System, Nashville Tennessee, 3Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, 4Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, 5Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee

Clinically resolved psoriatic lesions contain psoriasis- specific IL-17–producing αβ T cell clones

Matos et al.
Journal of Clinical Investigation
Papers
October 2017
Authors and Affiliates
Tiago R. Matos,1,2,3 John T. O’Malley,1 Elizabeth L. Lowry,1 David Hamm,4 Ilan R. Kirsch,4 Harlan S. Robins,4 Thomas S. Kupper,1 James G. Krueger,5 and Rachael A. Clark1 1Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal. 3Academic Medical Center, Department of Dermatology, University of Amsterdam, Amsterdam, The Netherlands. 4Adaptive Biotechnologies, Seattle, Washington, USA. 5Department of Dermatology, Rockefeller University, New York, New York, USA.

An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis

Nicol et al.
Journal of Autoimmunity
Papers
October 2017
Authors and Affiliates
Bryan Nicola, b, Marion Saloua, b, Isabel Vogela, c, Alexandra Garciaa, c, Emilie Dugasta, c, Jeremy Morillea, b, c, Stephanie Kilensa, Eric Charpentierd, Audrey Donnartd, Steven Nedellece, Marylene Jacq-Foucherf, Fabienne Le Freref, Sandrine Wiertlewskie, f, Arnaud Bourreilleg, h, Sophie Brouarda, c, Laure Michela, b, f, Laurent Davida, i, j, k, l, m, Pierre-Antoine Gourrauda, Nicolas Degauquea, c, Arnaud B. Nicota, b, c, Laureline Berthelota, b, c, David-Axel Laplauda, b, f, g aCentre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universite de Nantes, Nantes, France bFaculte de M edecine, Universite de Nantes, Nantes, France cInstitut de Transplantation Urologie Nephrologie (ITUN), CHU Nantes, Nantes, France dINSERM UMR1087, CNRS UMR6291, Universite de Nantes, l'institut du thorax, Nantes, F-44000, France eSFR François Bonamy, Cellular and Tissue Imaging Core Facility (MicroPICell), Nantes, France fService de Neurologie, CHU Nantes, Nantes, France gINSERM 015, Centre d’Investigation Clinique, Nantes, France hInstitut des Maladies de l'Appareil Digestif, CIC-04 Inserm, CHU Nantes, Nantes, France iINSERM UMS 016, SFR Francois Bonamy, iPSC Core Facility, Nantes, France jUMR CNRS 3556, Nantes, F-44000, France kUniversite de Nantes, Nantes, F-44000, France lCHU de Nantes, Nantes, F-44000, France mLabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France

Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response

Soukup et al.
Papers
Scientific Reports
September 2017
Authors and Affiliates
Klara Soukup1,4, Angela Halfmann1, Barbara Dillinger1, Fiona Poyer1, Katharina Martin1, Bernadette Blauensteiner1, Maximilian Kauer2, Mario Kuttke3, Gernot Schabbauer3 & Alexander M. Dohnal1,5 1Tumour Immunology, St. Anna Kinderkrebsforschung, Children’s Cancer Research Institute, Vienna, Austria. 2Bioinformatics, St. Anna Kinderkrebsforschung, Children’s Cancer Research Institute, Vienna, Austria. 3Institute for Physiology, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. 4Present address: Department of Fundamental Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland. 5Present address: APEIRON Biologics AG, Vienna, Austria

Staged development of long lived TCRαβ Th17 resident memory T cell population to Candida albicans after skin infection

Park et al.
Journal of Allergy and Clinical Immunology
Papers
September 2017
Authors and Affiliates
Chang Ook Park, MD, PhD1,5, Xiujun Fu, MD, PhD2, Xiaodong Jiang, MD, PhD1, Youdong Pan, PhD1, Jessica E. Teague, PhD1, Nicholas Collins, PhD3, Tian Tian, MD, PhD1, John T. O’Malley, MD, PhD1, Ryan O. Emerson, PhD4, Ji Hye Kim, MS5, Yookyung Jung, PhD2, Rei Watanabe, MD, PhD1, Robert C. Fuhlbrigge, MD, PhD1, Francis R. Carbone, PhD3, Thomas Gebhardt, MD, PhD3, Rachael A. Clark, MD, PhD1, Charles P. Lin, PhD2, and Thomas S. Kupper, MD1 1Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA, 2Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA, 3Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia, 4Adaptive Biotechnologies, Seattle, Washington, USA, 5Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University, College of Medicine, Seoul, Korea

Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade

Le et al.
Papers
Science
August 2017
Authors and Affiliates
Dung T. Le,1,2,3 Jennifer N. Durham,1,2,3 Kellie N. Smith,1,3 Hao Wang,3 Bjarne R. Bartlett,2,4 Laveet K. Aulakh,2,4 Steve Lu,2,4 Holly Kemberling,3 Cara Wilt,3 Brandon S. Luber,3 Fay Wong,2,4 Nilofer S. Azad,1,3 Agnieszka A. Rucki,1,3 Dan Laheru,3 Ross Donehower,3 Atif Zaheer,5 George A. Fisher,6 Todd S. Crocenzi,7 James J. Lee,8 Tim F. Greten,9 Austin G. Duffy,9 Kristen K. Ciombor,10 Aleksandra D. Eyring,11 Bao H. Lam,11 Andrew Joe,11 S. Peter Kang,11 Matthias Holdhoff,3 Ludmila Danilova,1,3 Leslie Cope,1,3 Christian Meyer,3 Shibin Zhou,1,3,4 Richard M. Goldberg,12 Deborah K. Armstrong,3 Katherine M. Bever,3 Amanda N. Fader,13 Janis Taube,1,3 Franck Housseau,1,3 David Spetzler,14 Nianqing Xiao,14 Drew M. Pardoll,1,3 Nickolas Papadopoulos,3,4 Kenneth W. Kinzler,3,4 James R. Eshleman,15 Bert Vogelstein,1,3,4 Robert A. Anders,1,3,15 Luis A. Diaz Jr.1,2,3 1Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA. 2Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA. 3Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA. 4Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA. 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. 6Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. 7Providence Cancer Center at Providence Health & Services, Portland, OR 97213, USA. 8Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA. 9Gastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. 10Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. 11Merck & Co. Inc., Kenilworth, NJ 07033, USA. 12West Virginia University Cancer Institute, Morgantown, WV 26506, USA. 13Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD 21287, USA. 14Caris Life Sciences, Phoenix, AZ 85040, USA. 15Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE)

Radwan et al.
BMC Cancer
Papers
August 2017
Authors and Affiliates
Noura Radwan1, Ryan Phillips1, Ashley Ross2,3, Steven P. Rowe4, Michael A. Gorin3, Emmanuel S. Antonarakis2, Curtiland Deville1,2, Stephen Greco1, Samuel Denmeade2,3, Channing Paller2, Daniel Y. Song1,2,3, Maximilian Diehn5, Hao Wang2, Michael Carducci2,3, Kenneth J. Pienta2,3, Martin G. Pomper1,2,3,4, Theodore L. DeWeese1,2,3, Adam Dicker6, Mario Eisenberger2,3 and Phuoc T. Tran1,2,3 1Department of Radiation Oncology & Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB2 Rm 406, Baltimore, MD 21231, USA. 2Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 4The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 5Department of Radiation Oncology, Stanford University, Stanford, CA, USA. 6Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development

Stengel et al.
Papers
Proceedings of the National Academy of Sciences
August 2017
Authors and Affiliates
Kristy R. Stengela, Kelly R. Barnetta, Jing Wangb, Qi Liub, Emily Hodgesa, Scott W. Hieberta,b, and Srividya Bhaskarac aDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232; bVanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37027; and cDepartment of Radiation Oncology and Oncological Sciences, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT 84103
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