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Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient

Jiménez-Sánchez et al.
Cell
Papers
August 2017
Authors and Affiliates
Alejandro Jiménez-Sánchez,1 Danish Memon,1,2 Stephane Pourpe,10 Harini Veeraraghavan,3 Yanyun Li,4 Hebert Alberto Vargas,5 Michael B. Gill,1 Kay J. Park,6 Oliver Zivanovic,7 Jason Konner,8 Jacob Ricca,4 Dmitriy Zamarin,4,10 Tyler Walther,10 Carol Aghajanian,8 Jedd D. Wolchok,4,9,10,11,12 Evis Sala,5 Taha Merghoub,4 Alexandra Snyder,10,11 and Martin L. Miller1 1Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK, 2European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 3Department of Medical Physics, 4Ludwig Collaborative/Swim Across America Laboratory, 5Department of Radiology, 6Department of Pathology, 7Gynecology Service, Department of Surgery, 8Gynecologic Medical Oncology Service, Department of Medicine, 9Parker Institute for Cancer Immunotherapy, 10Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA, 11Department of Medicine, Weill Cornell Medical College, New York, NY, USA, 12Immunology and Microbial Pathogenesis Programs, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA

Integrative clinical genomics of metastatic cancer

Robinson et al.
Nature
Papers
August 2017
Authors and Affiliates
Dan R. Robinson1,2, Yi-Mi Wu1,2, Robert J. Lonigro1, Pankaj Vats1, Erin Cobain3, Jessica Everett3, Xuhong Cao1, Erica Rabban1, Chandan Kumar-Sinha1,2, Victoria Raymond3, Scott Schuetze3, Ajjai Alva3, Javed Siddiqui1,2, Rashmi Chugh3, Francis Worden3, Mark M. Zalupski3, Jeffrey Innis4, Rajen J. Mody4, Scott A. Tomlins1,2, David Lucas2, Laurence H. Baker3, Nithya Ramnath3, Ann F. Schott3, Daniel F. Hayes3, Joseph Vijai5, Kenneth Offit5, Elena M. Stoffel3, J. Scott Roberts6, David C. Smith3, Lakshmi P. Kunju1,2, Moshe Talpaz7, Marcin Cieślik1,2 & Arul M. Chinnaiyan1,2,7,8,9 1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. 2Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. 3Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA. 4Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA. 5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. 6Department of Health Behavior & Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA. 7Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA. 8Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA. 9Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

Shrimali et al.
Cancer Immunology Research
Papers
August 2017
Authors and Affiliates
Rajeev K. Shrimali1, Shamim Ahmad1, Vivek Verma1, Peng Zeng1, Sudha Ananth1, Pankaj Gaur1, Rachel M. Gittelman2, Erik Yusko2, Catherine Sanders2, Harlan Robins2,3, Scott A. Hammond4, John E. Janik1, Mikayel Mkrtichyan1, Seema Gupta1, and Samir N. Khleif1 1Georgia Cancer Center, Augusta University, Augusta, Georgia. 2Adaptive Biotechnologies, Seattle, Washington. 3Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington. 4MedImmune LLC, Gaithersburg, Maryland.

An adolescent with granulomatous mycosis fungoides infiltrating skeletal muscle successfully treated with oral prednisone

Lewis et al.
Journal of the American Academy of Dermatology
Papers
July 2017
Authors and Affiliates
Daniel J. Lewis, BA,a,b Ashley E. Turkeltaub, BS,a Julia Dai, MD,c Priyadharsini Nagarajan, MD, PhD,d Kerri E. Rieger, MD, PhD,c,e Cesar A. Nunez, MD,f Youn H. Kim, MD,c and Madeleine Duvic, MDb School of Medicine, Baylor College of Medicinea; The Departments of Dermatology,b Pathology,d and Pediatric Oncology,f the University of Texas MD Anderson Cancer Center; and Departments of Dermatologyc and Pathology,e Stanford University.

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

O'Rourke et al.
Papers
Science Translational Medicine
July 2017
Authors and Affiliates
Donald M. O’Rourke,1 MacLean P. Nasrallah,2 Arati Desai,3 Jan J. Melenhorst,4 Keith Mansfield,5 Jennifer J. D. Morrissette,6 Maria Martinez-Lage,2 Steven Brem,1 Eileen Maloney,1 Angela Shen,7 Randi Isaacs,5 Suyash Mohan,8 Gabriela Plesa,4 Simon F. Lacey,4 Jean-Marc Navenot,4 Zhaohui Zheng,4 Bruce L. Levine,4 Hideho Okada,9 Carl H. June,4 Jennifer L. Brogdon,5 Marcela V. Maus10 1Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 2Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 3Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA. 5Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. 6Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 7Novartis Oncology, East Hanover, NJ 07936, USA. 8Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 9Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA. 10Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA.

Comprehensive T cell immunophenotyping and next generation sequencing from HPV-positive and -negative head and neck squamous cell carcinomas

Poropatich et al.
Journal of Pathology
Papers
July 2017
Authors and Affiliates
Kate Poropatich1, Joel Fontanarosa2, Suchitra Swaminathan3, Dave Dittmann1, Siqi Chen4, Sandeep Samant2, Bin Zhang4 1Department of Pathology, Northwestern University Feinberg School of Medicine Chicago, IL 60611, USA. 2Department of Otolaryngology, Northwestern University, Feinberg Medical School, Chicago, IL 60611, USA. 3Robert H Lurie Comprehensive Cancer Center, Department of Medicine-Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 4Robert H Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Adaptive from Innate: Human IFN-g+ CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults

Das et al.
Journal of Immunology
Papers
July 2017
Authors and Affiliates
Abhishek Das,* Kevin Rouault-Pierre,† Shraddha Kamdar,* Iria Gomez-Tourino,* Kristie Wood,‡ Ian Donaldson,x Charles A. Mein,x Dominique Bonnet,† Adrian C. Hayday,*,† and Deena L. Gibbons* *Peter Gorer Department of Immunobiology, King’s College London, London SE1 9RT, United Kingdom; †The Francis Crick Institute, London NW1 1AT, United Kingdom; ‡National Institute for Health Research Biomedical Research Centre Genomics Research Platform, Guy’s Hospital, London SE1 9RT, United Kingdom; and xGenome Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London EC1M 6BQ, United Kingdom

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

Heit et al.
Journal of Experimental Medicine
Papers
June 2017
Authors and Affiliates
Antje Heit,1 Frank Schmitz,3 Sarah Gerdts,1 Britta Flach,1 Miranda S. Moore,1 Jonathan A. Perkins,4,8 Harlan S. Robins,2,9 Alan Aderem,3 Paul Spearman,10 Georgia D. Tomaras,11 Stephen C. De Rosa,1,5 and M. Juliana McElrath1,5,6,7 1Vaccine and Infectious Disease Division and 2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 3Center for Infectious Disease Research, Seattle, WA, 4Department of Otolaryngology, 5Department of Laboratory Medicine, 6Department of Medicine, and 7Department of Global Health, University of Washington, Seattle, WA, 8Seattle Children's Hospital Research Institute, Seattle, WA, 9Adaptive Biotechnologies Corporation, Seattle, WA, 10Pediatric Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH, 11Duke Human Vaccine Institute, Duke University, Durham, NC

Dual Targeting Nanoparticle Stimulates the Immune System To Inhibit Tumor Growth

Kosmides et al.
ACS Nano
Papers
June 2017
Authors and Affiliates
Alyssa K. Kosmides†‡§, John-William Sidhom†§, Andrew Fraser†§, Catherine A. Bessell§∥, and Jonathan P. Schneck‡§∥ †Department of Biomedical Engineering, ‡Institute for Nanobiotechnology, §Institute for Cell Engineering, and ∥Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States
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