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Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells

Herati et al.
Papers
Science Immunology
February 2017
Authors and Affiliates
Ramin Sedaghat Herati,1,2 Alexander Muselman,1,2 Laura Vella,2,3 Bertram Bengsch,2,4 Kaela Parkhouse,5 Daniel Del Alcazar,1,2 Jonathan Kotzin,2,4 Susan A. Doyle,6 Pablo Tebas,1 Scott E. Hensley,2,4,5 Laura F. Su,1,2 Kenneth E. Schmader,6 E. John Wherry2,4 1Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 3Department of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA. 4Department of Mi- crobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 5Wistar Institute, Philadelphia, PA 19104, USA. 6Division of Geriatrics, De- partment of Medicine, Duke University Medical Center and Geriatric Research, Educa- tion, and Clinical Center, Durham VA Medical Center, Durham, NC 27705, USA.

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope

Song et al.
Nature Structural & Molecular Biology
Papers
February 2017
Authors and Affiliates
InYoung Song1,2, Anna Gil1, Rabinarayan Mishra1, Dario Ghersi3, Liisa K Selin1,2,5, and Lawrence J Stern1,2,4,5 1Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2Graduate Program in Immunology and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 3School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, USA. 4Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 5These authors contributed equally to this work.

Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney/Bone Marrow Transplantation to Induce Transplantation Tolerance

Sprangers et al.
American Journal of Transplantation
Papers
February 2017
Authors and Affiliates
Ben Sprangers1, Susan DeWolf1, Thomas M. Savage1, Tatsuaki Morokata2, Aleksandar Obradovic1, Samuel A. LoCascio1, Brittany Shonts1, Julien Zuber1, Sai ping Lau1, Ravi Shah1, Heather Morris1, Valeria Steshenko6, Emmanuel Zorn1, Frederic I. Preffer3, Sven Olek7, David M. Dombkowski3, Laurence A. Turka2,5, Robert Colvin3, Robert Winchester6, Tatsuo Kawai4, and Megan Sykes1,2 1Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital (MGH)/Harvard Medical School (HMS), Boston, MA, USA, 3Department of Pathology, MGH/ HMS, Boston, MA, USA, 4Transplantation Unit, Department of Surgery, MGH/HMS, Boston, MA, USA, 5Immune Tolerance Network, Seattle, WA, USA, 6Division of Rheumatology, Department of Medicine, Columbia University Medical Center, New York, NY, USA

Tracking the fate and origin of clinically relevant adoptively transferred CD8+ T cells in vivo

Chapuis et al.
Papers
Science Immunology
February 2017
Authors and Affiliates
Aude G. Chapuis,1 Cindy Desmarais,2 Ryan Emerson,2 Thomas M. Schmitt,1 Kendall C. Shibuya,1 Ivy P. Lai,1 Felecia Wagener,1 Jeffrey Chou,1 Ilana M. Roberts,1 David G. Coffey,1 Edus H. Warren,1 Harlan Robins,1,2 Philip D. Greenberg,1,3 Cassian Yee1 1Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. 2Adaptive Biotechnologies, Suite 200, 1551 Eastlake Avenue North, Seattle, WA 98103, USA. 3Department of Immunology, University of Washington, South Lake Union, Building E, 750 Republican Street, Seattle, WA 98109, USA.

PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR

Chong et al.
Blood
Papers
February 2017
Authors and Affiliates
Elise A. Chong,1 J. Joseph Melenhorst,2 Simon F. Lacey,2 David E. Ambrose,2 Vanessa Gonzalez,2 Bruce L. Levine,2 Carl H. June,2 and Stephen J. Schuster1 1Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; and 2Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Landscape of tumor-infiltrating T cell repertoire of human cancers

Li et al.
Nature Genetics
Papers
February 2017
Authors and Affiliates
Bo Li1,2, Taiwen Li1,3, Jean-Christophe Pignon4, Binbin Wang5, Jinzeng Wang5, Sachet Shukla6, Ruoxu Dou7, Qianming Chen3, F. Stephen Hodi8, Toni K. Choueiri9, Catherine Wu6, Nir Hacohen10, Sabina Signoretti4, Jun S. Liu2, and X. Shirley Liu1,2 1Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, Harvard University, Boston, MA, USA, 3State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, 4Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA, 5School of Life Science and Technology, Tongji University, China, Shanghai, China, 6Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA, 7Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 8Center for ImmunoOncology, Harvard Medical School, Boston, MA, USA, 9Kidney Cancer Center, Dana Farber Cancer Institute, Boston, MA, USA, 10Center for Cancer Immunotherapy, Massachusetts General Hospital, Boston, MA, USA

Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival

Miller et al.
Cancer Immunology Research
Papers
February 2017
Authors and Affiliates
Natalie J. Miller1, Candice D. Church1, Lichun Dong2, David Crispin3, Matthew P. Fitzgibbon3, Kristina Lachance1, Lichen Jing2, Michi Shinohara1, Ioannis Gavvovidis4,5, Gerald Willimsky5,6, Martin McIntosh3, Thomas Blankenstein4,5,7, David M. Koelle2,8,9, and Paul Nghiem1 1Dermatology/Medicine/Pathology, University of Washington, Seattle, Washington. 2Department of Medicine/Laboratory Medicine/Global Health, University of Washington, Seattle, Washington. 3Fred Hutchinson, Public Health Sciences Division, Seattle, Washington. 4Molecular Immunology and Gene Therapy, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. 5Institute of Immunology, Charit e, Berlin, Germany. 6German Cancer Research Center (DKFZ), Heidelberg, Germany. 7Berlin Institute of Health, Berlin, Germany. 8Fred Hutchinson, Vaccine and Infectious Disease Division, Seattle, Washington. 9Benaroya Research Institute, Seattle, Washington.

Ibrutinib Therapy Increases T Cell Repertoire Diversity in Patients with Chronic Lymphocytic Leukemia

Yin et al.
Journal of Immunology
Papers
January 2017
Authors and Affiliates
Qingsong Yin,*,†,1 Mariela Sivina,*,1 Harlan Robins,‡,x Erik Yusko,‡ Marissa Vignali,‡ Susan O’Brien,* Michael J. Keating,* Alessandra Ferrajoli,* Zeev Estrov,* Nitin Jain,* William G. Wierda,* and Jan A. Burger* *Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77230; †Department of Leukemia, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Henan Institute of Hematology, Zhengzhou, Henan 450009, China; ‡Adaptive Biotechnologies, Seattle, WA 98102; and xFred Hutchinson Cancer Research Center, Seattle, WA 98109

Evolution of Neoantigen Landscape During Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

Anagnostou et al.
Cancer Discovery
Papers
January 2017
Authors and Affiliates
Valsamo Anagnostou1,2*, Kellie N. Smith1,2, Patrick M. Forde1,2, Noushin Niknafs3, Rohit Bhattacharya3, James White1, Theresa Zhang4, Vilmos Adleff1, Jillian Phallen1, Neha Wali1, Carolyn Hruban1, Violeta B. Guthrie3, Kristen Rodgers5, Jarushka Naidoo1,2, Hyunseok Kang1, William Sharfman1, Christos Georgiades6, Franco Verde7, Peter Illei1,8, Qing Kay Li8, Edward Gabrielson1,8, Malcolm V. Brock1,5, Cynthia A. Zahnow1, Stephen B. Baylin1, Rob Scharpf1, Julie R. Brahmer1,2, Rachel Karchin3, Drew M. Pardoll1,2 and Victor E. Velculescu1,2,3,8 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 2The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA 3Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland 21204, USA, 4Personal Genome Diagnostics, Baltimore, MD 21224, USA, 5Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 6Department of Radiology and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 7Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 8Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

BRILIA: Integrated Tool for High-Throughput Annotation and Lineage Tree Assembly of B-Cell Repertoires

Lee et al.
Frontiers in Immunology
Papers
January 2017
Authors and Affiliates
Donald W. Lee1, Ilja V. Khavrutskii1, Anders Wallqvist1, Sina Bavari2, Christopher L. Cooper2, and Sidhartha Chaudhury1 1Biotechnology HPC Software Applications Institute (BHSAI), Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, USA, 2Molecular and Translational Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
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