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Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
Seay et al
JCI Insight
Papers
December 2016
Authors and Affiliates
Howard R. Seay,1 Erik Yusko,2 Stephanie J. Rothweiler,1 Lin Zhang,1 Amanda L. Posgai,1 Martha Campbell-Thompson,1 Marissa Vignali,2 Ryan O. Emerson,2 John S. Kaddis,3 Dave Ko,3 Maki Nakayama,4 Mia J. Smith,5 John C. Cambier,5 Alberto Pugliese,6 Mark A. Atkinson,1 Harlan S. Robins,2,7 and Todd M. Brusko1
1Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, Florida, USA. 2Adaptive Biotechnologies Corporation, Seattle, Washington, USA. 3Department of Information Sciences, City of Hope National Medical Center, Duarte, California, USA. 4Barbara Davis Center for Childhood Diabetes and 5Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA. 6Diabetes Research Institute and Departments of Medicine, Microbiology, and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA. 7Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
Tran et al.
New England Journal of Medicine
Papers
December 2016
Authors and Affiliates
Eric Tran, Ph.D., Paul F. Robbins, Ph.D., Yong‐Chen Lu, Ph.D., Todd D. Prickett, Ph.D., Jared J. Gartner, M.Sc., Li Jia, M.Sc., Anna Pasetto, Ph.D., Zhili Zheng, Ph.D., Satyajit Ray, Ph.D., Eric M. Groh, M.D., Isaac R. Kriley, M.D., and Steven A. Rosenberg, M.D., Ph.D.
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites
Thome et al
Papers
Science Immunology
December 2016
Authors and Affiliates
Joseph J. C. Thome,1,2* Boris Grinshpun,3* Brahma V. Kumar,1 Masaru Kubota,1,4 Yoshiaki Ohmura,1,4 Harvey Lerner,5 Gregory D. Sempowski,6 Yufeng Shen,3 Donna L. Farber1,2,4†
1 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA. 2 Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. 3 Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA. 4 Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA. 5 LiveOnNY, New York, NY 10001, USA. 6 Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Discovery of T-Cell Receptor Beta Motifs Specific to HLA-B27+ Ankylosing Spondylitis by Deep Repertoire Sequence Analysis
Faham et al
Arthritis & Rheumatology
Papers
December 2016
Authors and Affiliates
Malek Faham, MD, PhD1*, Victoria Carlton, PhD1, Martin Moorhead, PhD1, Jianbiao Zheng, PhD1, Mark Klinger, PhD1, Francois Pepin, PhD1, Thomas Asbury, PhD1, Marissa Vignali, PhD1, Ryan O. Emerson, PhD1, Harlan S. Robins, PhD 1,2, James Ireland, MSc3, Emily Baechler-Gillespie, PhD4, and Robert D. Inman, MD5
1Adaptive Biotechnologies Corp., South San Francisco, CA and Seattle, WA; 2Fred Hutchinson Cancer Research Center, Seattle WA, 3Alternate Allele Consulting, Orinda, CA; 4University of Minnesota, Minneapolis, MN; 5Toronto Western Hospital, University of Toronto, Toronto, ON
Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating αβ T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients
Dandekar et al.
Frontiers in Immunology
Papers
December 2016
Authors and Affiliates
Sugandha Dandekar1, Hemani Wijesuriya2, Tim Geiger3, David Hamm3, Gary W. Mathern4,5,6,7 and Geoffrey C. Owens4*
1Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 2Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 3Adaptive Biotechnologies Inc., Seattle, WA, USA, 4Department of Neurosurgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 5Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 6Brain Research Institute, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 7Mattel Children’s Hospital, Los Angeles, CA, USA
Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs
Chamoto et al
Journal of Immunology
Papers
December 2016
Authors and Affiliates
Kenji Chamoto*,1, Tingxi Guo*,†,1, Stephen W. Scally‡, Yuki Kagoya*, Mark Ancruzowski*,†, Chung-Hsi Wang*,†, Muhammed A. Rahman*, Kayoko Saso*, Marcus O. Butler*,†,§, Priscilla P. L. Chiu¶,‖, Jean-Philippe Julien†,‡,# and Naoto Hirano*,†
*Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; †Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ‡Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada; §Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ¶Division of Pediatric Surgery, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; ‖Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada; and #Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells
Boddupalli et al
Journal of Clinical Investigation
Papers
December 2016
Authors and Affiliates
Chandra Sekhar Boddupalli,1 No ar Bar,1 Krishna Kadaveru,2 Michael Krauthammer,3,4 Natopol Pornputtapong,4 Zifeng Mai,2 Stephan Ariyan,5 Deepak Narayan,5 Harriet Kluger,1,6 Yanhong Deng,7 Rakesh Verma,1 Rituparna Das,1 Antonella Bacchiocchi,8 Ruth Halaban,8 Mario Sznol,1,6 Madhav V. Dhodapkar,1,6,9 and Kavita M. Dhodapkar2,6
1Department of Medicine, 2Department of Pediatrics, 3Program for Computational Biology and Bioinformatics, 4Department of Pathology, 5Department of Surgery, 6Yale Cancer Center, 7Yale Center for Analytic Sciences, 8Department of Dermatology, 9Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity
Crittenden et al.
Papers
Scientific Reports
December 2016
Authors and Affiliates
Marka R. Crittenden1,2, Lauren Zebertavage3, Gwen Kramer1, Shelly Bambina1, David Friedman1, Victoria Troesch1, Tiffany Blair3, Jason R. Baird1, Alejandro Alice1 & Michael J. Gough1
1Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, 97213, USA. 2The Oregon Clinic, Portland, OR, 97213, USA. 3Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, 97239, USA.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade
Johnson et al.
New England Journal of Medicine
Papers
November 2016
Authors and Affiliates
Douglas B. Johnson, M.D.,1 Justin M. Balko, PharmD, Ph.D.,1,2,4 Margaret L. Compton, M.D.,5 Spyridon Chalkias, M.D.,10,11 Joshua Gorham, B.A.,14 Yaomin Xu, Ph.D.,6,8,9 Mellissa Hicks, Ph.D.,1 Igor Puzanov, M.D.,1 Matthew R. Alexander, M.D., Ph.D.,1 Tyler L. Bloomer, M.D.,1 Jason Becker, M.D.,1 David A. Slosky, M.D.,1,3 Elizabeth J. Phillips, M.D.,1 Mark A. Pilkinton, M.D., Ph.D.,1 Laura Craig-Owens, M.D.,5 Nina Kola, M.D.,16 Gregory Plautz, M.D.,16 Daniel S. Reshef, M.D.,16 Jonathan S. Deutsch, M.D.,16 Raquel P. Deering, Ph.D.,17 Benjamin A. Olenchock, M.D., Ph.D.,12 Andrew H. Lichtman, M.D.,13 Dan M. Roden, M.D.,1,7,8 Christine E. Seidman, M.D.,12,14,15 Igor J. Koralnik, M.D.,11 Jonathan G. Seidman, Ph.D.,12,14 Robert D. Hoffman, M.D., Ph.D.,5 Janis M. Taube, M.D.,18,19 Luis A. Diaz, Jr., M.D.,20 Robert A. Anders, M.D.,18 Jeffrey A. Sosman, M.D.,1 and Javid J. Moslehi, M.D.1,2,3
1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
2Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN
3Department of Cardio-Oncology Program, Vanderbilt University Medical Center, Nashville, TN
4Department of Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, TN
5Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN
6Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
7Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN
8Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN
9Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN
10Department of Medicine, Beth Israel Deaconess Medicine Center, Boston, MA
11Division of Neuro-Immunology, Beth Israel Deaconess Medicine Center, Boston, MA
12Department of Medicine, Brigham and Women’s Hospital, Boston, MA
13Department of Pathology, Brigham and Women’s Hospital, Boston, MA
14Department of Genetics, Howard Hughes Medical Institute, Boston, MA
15Harvard Medical School, Howard Hughes Medical Institute, Boston, MA
16Bristol Myers Squibb, New York, NY
17Neon Therapeutics, Cambridge, MA
18Department of Pathology, Johns Hopkins University, Baltimore, MD
19Department of Dermatology, Johns Hopkins University, Baltimore, MD
20Department of Oncology, Johns Hopkins University, Baltimore, MD