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Identification of patient-specific and tumor-shared T cell receptor sequences in renal cell carcinoma patients
Massa et al.
Oncotarget
Papers
February 2017
Authors and Affiliates
Chiara Massa1, Harlan Robins2, Cindy Desmarais2, Dagmar Riemann1, Corinna Fahldieck1, Paolo Fornara3, Barbara Seliger1
1Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany 2Adaptive Biotechnologies Corp, 98102 Seattle (WA), USA
3Clinic of Urology, Martin Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany
Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency
Calcedoa et al.
Papers
Proceedings of the National Academy of Sciences
February 2017
Authors and Affiliates
Roberto Calcedoa, Suryanarayan Somanathana, Qiuyue Qina, Michael R. Bettsb, Andrew J. Rechc, Robert H. Vonderheidec, Christian Muellerd, Terence R. Flotted, and James M. Wilsona
aGene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; bDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; cAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104; dDepartment of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655
CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin
Cheuk et al.
Immunity
Papers
February 2017
Authors and Affiliates
Stanley Cheuk,1 Heinrich Schlums,2 Irene Gallais Serezal,1,3 Elisa Martini,1 Samuel C. Chiang,2 Nicole Marquardt,3 Anna Gibbs,1 Ebba Detlofsson,1 Andrea Introini,1 Marianne Forkel,3 Charlotte Hoog,4 Annelie Tjernlund,1 Jakob Michaelsson,3 Lasse Folkersen,5 Jenny Mjosberg,3 Lennart Blomqvist,6 Marcus Ehrstrom,7 Mona Stahle,1,3 Yenan T. Bryceson,2,8 and Liv Eidsmo1,3
1Department of Medicine Solna, Karolinska Institutet, Stockholm 171 77, Sweden, 2Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 3Dermatology Department, Karolinska University Hospital, Stockholm 141 86, Sweden, 4Unit for Inflammation, Gastroenterology and Rheumatology, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 5Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Building 208, DK-2800 Kongens Lyngby 2800, Denmark, 6Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 7Department of Reconstructive Plastic Surgery, Karolinska University Hospital Solna, Stockholm 171 76, Sweden, 8Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway
3D: diversity, dynamics, differential testing – a proposed pipeline for analysis of next-generation sequencing T cell repertoire data
Zhang et al.
BMC Bioinformatics
Papers
February 2017
Authors and Affiliates
Li Zhang1,3, Jason Cham2, Alan Paciorek3, James Trager4, Nadeem Sheikh5, and Lawrence Fong2
1Division of Hematology and Oncology, Department of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, 550 16th Street, 6th Floor, UCSF Box 0981, San Francisco, CA 94158, USA. 2Division of Hematology and Oncology, Department of Medicine, University of California, Room HSE301, UCSF Box 1270, 513 Parnassus Ave, San Francisco, CA 94143-1270, USA. 3Department of Epidemiology and Biostatistics, University of California, San Francisco, 550 16th Street, 6th Floor, UCSF Box 0981, San Francisco, CA 94158, USA. 4Research and Development, Nkarta, Inc, 329 Oyster Point Blvd, South San Francisco, CA 94080, USA. 5Department of Research - Translational Biology, Dendreon Pharmaceuticals Inc, 1208 Eastlake Ave E, Seattle, WA 98102, USA.
Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells
Herati et al.
Papers
Science Immunology
February 2017
Authors and Affiliates
Ramin Sedaghat Herati,1,2 Alexander Muselman,1,2 Laura Vella,2,3 Bertram Bengsch,2,4 Kaela Parkhouse,5 Daniel Del Alcazar,1,2 Jonathan Kotzin,2,4 Susan A. Doyle,6 Pablo Tebas,1 Scott E. Hensley,2,4,5 Laura F. Su,1,2 Kenneth E. Schmader,6 E. John Wherry2,4
1Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 3Department of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA. 4Department of Mi- crobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 5Wistar Institute, Philadelphia, PA 19104, USA. 6Division of Geriatrics, De- partment of Medicine, Duke University Medical Center and Geriatric Research, Educa- tion, and Clinical Center, Durham VA Medical Center, Durham, NC 27705, USA.
Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope
Song et al.
Nature Structural & Molecular Biology
Papers
February 2017
Authors and Affiliates
InYoung Song1,2, Anna Gil1, Rabinarayan Mishra1, Dario Ghersi3, Liisa K Selin1,2,5, and Lawrence J Stern1,2,4,5
1Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2Graduate Program in Immunology and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 3School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, USA. 4Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 5These authors contributed equally to this work.
Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney/Bone Marrow Transplantation to Induce Transplantation Tolerance
Sprangers et al.
American Journal of Transplantation
Papers
February 2017
Authors and Affiliates
Ben Sprangers1, Susan DeWolf1, Thomas M. Savage1, Tatsuaki Morokata2, Aleksandar Obradovic1, Samuel A. LoCascio1, Brittany Shonts1, Julien Zuber1, Sai ping Lau1, Ravi Shah1, Heather Morris1, Valeria Steshenko6, Emmanuel Zorn1, Frederic I. Preffer3, Sven Olek7, David M. Dombkowski3, Laurence A. Turka2,5, Robert Colvin3, Robert Winchester6, Tatsuo Kawai4, and Megan Sykes1,2
1Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital (MGH)/Harvard Medical School (HMS), Boston, MA, USA, 3Department of Pathology, MGH/ HMS, Boston, MA, USA, 4Transplantation Unit, Department of Surgery, MGH/HMS, Boston, MA, USA, 5Immune Tolerance Network, Seattle, WA, USA, 6Division of Rheumatology, Department of Medicine, Columbia University Medical Center, New York, NY, USA
Tracking the fate and origin of clinically relevant adoptively transferred CD8+ T cells in vivo
Chapuis et al.
Papers
Science Immunology
February 2017
Authors and Affiliates
Aude G. Chapuis,1 Cindy Desmarais,2 Ryan Emerson,2 Thomas M. Schmitt,1 Kendall C. Shibuya,1 Ivy P. Lai,1 Felecia Wagener,1 Jeffrey Chou,1 Ilana M. Roberts,1 David G. Coffey,1 Edus H. Warren,1 Harlan Robins,1,2 Philip D. Greenberg,1,3 Cassian Yee1
1Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. 2Adaptive Biotechnologies, Suite 200, 1551 Eastlake Avenue North, Seattle, WA 98103, USA. 3Department of Immunology, University of Washington, South Lake Union, Building E, 750 Republican Street, Seattle, WA 98109, USA.
PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR
Chong et al.
Blood
Papers
February 2017
Authors and Affiliates
Elise A. Chong,1 J. Joseph Melenhorst,2 Simon F. Lacey,2 David E. Ambrose,2 Vanessa Gonzalez,2 Bruce L. Levine,2 Carl H. June,2 and Stephen J. Schuster1
1Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; and 2Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA