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Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease

Mattoo et al.
Papers
The Journal of Allergy and Clinical Immunology
May 2016
Authors and Affiliates
Hamid Mattoo1, Vinay S. Mahajan1, Takashi Maehara2, Vikram Deshpande1, Emanuel Della-Torre1, Zachary S. Wallace1, Maria Kulikova1, Jefte M. Drijvers1, Joe Daccache1, Mollie N. Carruthers1, Flavia Castellino1, James R. Stone1, John H. Stone3, Shiv Pillai4. 1Massachusetts General Hospital, Harvard Medical School, Boston, Mass. 2Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Fukuoka, Japan. 3Massachusetts General Hospital, Harvard Medical School, Boston, Mass. 4Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing

Schneider-Hohendorf et al.
Nature Communications
Papers
April 2016
Authors and Affiliates
Tilman Schneider-Hohendorf1, Hema Mohan1, Christian G. Bien2, Johanna Breuer1, Albert Becker3, Dennis Gorlich4, Tanja Kuhlmann5, Guido Widman6, Sebastian Herich1, Christiane Elpers7, Nico Melzer1, Klaus Dornmair8,9,10, Gerhard Kurlemann7, Heinz Wiendl1, & Nicholas Schwab1 1Department of Neurology, University of Munster, Germany. 2 Epilepsy Center Bethel, Bielefeld, Germany. 3 Institute of Neuropathology, University Hospital Bonn, Bonn, Germany. 4 Institute of Biostatistics and Clinical Research, University of Munster, Munster, Germany. 5Department of Neuropathology, University of Munster, Munster, Germany. 6Department of Epileptology, University of Bonn, Bonn, Germany. 7 Children’s Hospital of the University Medical Center, University of Munster, Munster, Germany. 8 Institute for Clinical Neuroimmunology, Ludwig-Maximilians-University Munich, Munich, Germany. 9 Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany. 10 Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University Munich, Munich, Germany.

Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals

Felgentreff et al.
Journal of Clinical Immunology
Papers
April 2016
Authors and Affiliates
Kerstin Felgentreff1,2 & Sachin N. Baxi1 & Yu Nee Lee1 & Kerry Dobbs1 & Lauren A. Henderson1 & Krisztian Csomos3 & Erdyni N. Tsitsikov4 & Mary Armanios5 & Jolan E. Walter1,3 & Luigi D. Notarangelo1,6 1Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 2 Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany. 3 Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 4 Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 5 Departments of Oncology, Pathology and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Harvard Stem Cell Institute, Harvard University, Boston, MA, USA.

Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide

Kanakry et al.
Journal of Clinical Investigation
Papers
April 2016
Authors and Affiliates
Christopher G. Kanakry,1 David G. Coffey,2,3 Andrea M.H. Towlerton,2 Ante Vulic,1 Barry E. Storer,2 Jeffrey Chou,2,3 Cecilia C.S. Yeung,2,4 Christopher D. Gocke,1 Harlan S. Robins,5 Paul V. O’Donnell,2,3 Leo Luznik,1 and Edus H. Warren2,3 1 Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, USA. 3 Department of Medicine and 4 Department of Pathology, University of Washington, Seattle, Washington, USA. 5 Public Health Sciences Division, FHCRC, Seattle, Washington, USA.

Conventional and Regulatory CD4+ T Cells That Share Identical TCRs Are Derived from Common Clones

Wolf et al.
Papers
PLOS ONE
April 2016
Authors and Affiliates
Kyle J. Wolf1, Ryan O. Emerson2, Jeanette Pingel1, R. Mark Buller1, Richard J. DiPaolo1 1 Department of Molecular Microbiology and Immunology, Saint Louis University, School of Medicine, Saint Louis, Missouri, United States of America, 2 Adaptive Biotechnologies Corporation, Seattle, Washington, United States of America Abstract Reference

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

Turtle et al.
Papers
The Journal of Clinical Investigation
April 2016
Authors and Affiliates
Cameron J. Turtle,1,2 Laïla-Aïcha Hanafi,1 Carolina Berger,1,2 Theodore A. Gooley,1 Sindhu Cherian,3 Michael Hudecek,1 Daniel Sommermeyer,1Katherine Melville,1 Barbara Pender,1 Tanya M. Budiarto,1 Emily Robinson,1 Natalia N. Steevens,1 Colette Chaney,1 Lorinda Soma,3 Xueyan Chen,3 Cecilia Yeung,3,4 Brent Wood,3,4 Daniel Li,5 Jianhong Cao,1 Shelly Heimfeld,1 Michael C. Jensen,1,6 Stanley R. Riddell,1,2,7 and David G. Maloney1,2 1 Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, USA. 2 Department of Medicine, 3 Department of Laboratory Medicine, and 4 Department of Pathology, University of Washington, Seattle, Washington, USA. 5 Juno Therapeutics, Seattle, Washington, USA. 6 Seattle Children’s Research Institute, Seattle, Washington, USA. 7 Institute for Advanced Study, Technical University of Munich, Munich, Germany

Immune DNA signature of T-cell infiltration in breast tumor exomes

Levy et al.
bioRxiv
Papers
April 2016
Authors and Affiliates
Eric Levy,1,2 Rachel Marty,2,3 Valentina Garate-Calderon,4,5 Brian Woo,6 Michelle Dow,1,2 Ricardo Armisen,4,5 Hannah Carter,3,6,7 Olivier Harismendy,1,6 1Division of Biomedical Informatics, Department of Medicine, University of California San Diego 2Bioinformatics and Systems Biology Graduate Program, University of California San Diego 3Division of Medical Genetics, Department of Medicine, University of California San Diego 4Centro de Investigación y Tratamiento del Cancer, Facultad de Medicina, Universidad de Chile 5Center for Excellence in Precision Medicine, Pfizer Chile 6Moores Cancer Center, University of California San Diego 7Institute for Genomic Medicine, University of California San Diego.

Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice

Carey et al.
Journal of Immunology
Papers
March 2016
Authors and Affiliates
Alison J. Carey*,†, Donald T. Gracias†,1, Jillian L. Thayer†, Alina C. Boesteanu†,2,Ogan K. Kumova†, Yvonne M. Mueller†,‡, Jennifer L. Hope†,‡, Joseph A. Fraietta§,David B. H. van Zessen‡,¶ and Peter D. Katsikis†,‡ *Pediatrics, Drexel University College of Medicine, Philadelphia, PA 19102; †Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102; ‡Immunology, Erasmus University Medical Center, 015 N Rotterdam, the Netherlands; §Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104; and ¶Bioinformatics, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands

TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination

Hsu et al.
Cancer Immunology Research
Papers
March 2016
Authors and Affiliates
Melody S. Hsu1,2, Shaina Sedighim1, Tina Wang1,3, Joseph P. Antonios1,4, Richard G. Everson1, Alexander M. Tucker1, Lin Du5, Ryan Emerson6, Erik Yusko6, Catherine Sanders6, Harlan S. Robins6,7, William H. Yong8,9, Tom B. Davidson1,2,8, Gang Li5,8, Linda M. Liau1,8, and Robert M. Prins1,8,10, 1Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California. 2Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California. 3Department of Medicine (Hematology/Oncology), David Geffen School of Medicine at UCLA, Los Angeles, California. 4Medical Scientist Training Program, David Geffen School of Medicine at UCLA, Los Angeles, California. 5Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, California. 6Adaptive Biotechnologies, Seattle, Washington. 7Fred Hutchinson Cancer Research Center, Seattle, Washington. 8Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California. 9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. 10Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
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