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Redirecting T-Cell Specificity to EGFR Using mRNA to Self-limit Expression of Chimeric Antigen Receptor
Caruso et al.
Journal of Immunotherapy
Papers
June 2016
Authors and Affiliates
Hillary G. Caruso,1,5 Hiroki Torikai,1 Ling Zhang,1 Sourindra Maiti,1 Jianliang Dai,2 Kim-Anh Do,2 Harjeet Singh,1 Helen Huls,1 Dean A. Lee,1,5 Richard E. Champlin,4 Amy B. Heimberger,3 and Laurence J.N. Cooper1,5
1Division of Pediatrics; Departments of 2Biostatistics; 3Neurosurgery; 4Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center; and 5The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX.
Next-generation IgVH sequencing CLL-like monoclonal B-cell lymphocytosis reveals frequent oligoclonality and ongoing hypermutation
Klinger et al.
Papers
May 2016
Authors and Affiliates
Mark Klinger1, Jianbiao Zheng1, Kojo S. Elenitoba-Johnson2, Sherrie L. Perkins3, Malek Faham1 and David W. Bahler3
1Sequenta, Inc., South San Francisco, CA, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 3Department of Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT
Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient
Chapuis et al.
Journal of Experimental Medicine
Papers
May 2016
Authors and Affiliates
Aude G. Chapuis,1 Sylvia M. Lee,1 John A. Thompson,2 Ilana M. Roberts,1 Kim A. Margolin,2 Shailender Bhatia,2 Heather L. Sloan,1 Ivy Lai,1 Lelecia Wagener,1 Kendall Shibuya,1 Jianhong Cao,1 Jedd D. Wolchok,3 Philip D. Greenberg,1,4 and Cassian Yee1
1Program in Immunology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA 98109, 2Division of Medical Oncology, Department of Medicine, University of Washington Medical, Center/FHCRC/Seattle Cancer Care Alliance, Seattle, WA 98109, 3Ludwig Center, Memorial Sloan-Kettering Cancer Center, New York, NY 100165, 4Department of Immunology, University of Washington School of Medicine, Seattle, WA 9819
Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects
Sheikh et al.
Cancer Research
Papers
May 2016
Authors and Affiliates
Sheikh NA1, Cham J2, Zhang L3, DeVries T1, Letarte S4, Pufnock J1, Hamm D5, Trager JB1, Fong L6.
1Research, Dendreon. 2Department of Medicine, University of California, San Francisco. 3Medicine, University of California, San Francisco. 4Bioanalytical Sciencies, Hospira. 5Adaptive Biotechnologies. 6Department of Medicine, University of California, San Francisco
Daratumumab Depletes CD38 + Immune-regulatory Cells, Promotes T-cell Expansion, and Skews T-cell Repertoire in Multiple Myeloma
Krejcik et al.
Blood
Papers
May 2016
Authors and Affiliates
Jakub Krejcik, MD1,2 ; Tineke Casneuf, PhD3 ; Inger S. Nijhof, MD1 ; Bie Verbist, PhD3 ; Jaime Bald, BS4 ; Torben Plesner, MD2 ; Khaja Syed, MS4 ; Kevin Liu, PhD5 ; Niels W.C.J. van de Donk, MD1 ; Brendan M. Weiss, MD6 ; Tahamtan Ahmadi, MD4 ; Henk M. Lokhorst, MD1 ; Tuna Mutis, MD1 ; and A. Kate Sasser, PhD4
1Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
2Vejle Hospital and University of Southern Denmark, Vejle, Denmark
3Janssen Research & Development, Beerse, Belgium
4Janssen Research & Development, LLC, Spring House, PA, USA
5Janssen Research & Development, LLC, Raritan, NJ, USA
6Division of Hematology-Oncology, Department of Medicine, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Novel technologies and emerging biomarkers for personalized cancer immunotherapy
Yuan et al.
Journal for ImmunoTherapy of Cancer
Papers
May 2016
Authors and Affiliates
Yuan J1, Hegde PS2, Clynes R3, Foukas PG4, Harari A5, Kleen TO6, Kvistborg P7, Maccalli C8, Maecker HT9, Page DB10, Robins H11, Song W12, Stack EC13, Wang E14, Whiteside TL15, Zhao Y16, Zwierzina H17, Butterfield LH18, Fox BA10.
1Memorial Sloan-Kettering Cancer Center, 1275 New York Ave Box 386, New York, NY 10065 USA. 2Genentech, Inc., 1 DNA Way South, San Francisco, CA 94080 USA. 3Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ 08648 USA. 4Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland ; Department of Pathology, University of Athens Medical School, "Attikon" University Hospital, 1st Rimini St, 12462 Haidari, Greece. 5Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland. 6Epiontis GmbH, Rudower Chaussee 29, 12489 Berlin, Germany. 7Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, Netherlands. 8Italian Network for Biotherapy of Tumors (NIBIT)-Laboratory, c/o Medical Oncology and Immunotherapy, University Hospital of Siena, V.le Bracci,16, Siena, 53100 Italy. 9Stanford University Medical Center, 299 Campus Drive, Stanford, CA 94303 USA.10Earle A. Chiles Research Institute, Providence Cancer Center, 4805 NE Glisan Street, Portland, OR 97213 USA. 11Adaptive Technologies, Inc., 1551 Eastlake Avenue East Suite 200, Seattle, WA 98102 USA. 12AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878 USA. 13PerkinElmer, 68 Elm Street, Hopkinton, MA 01784 USA. 14Sidra Medical and Research Center, PO Box 26999, Doha, Qatar. 15University of Pittsburgh Cancer Institute, 5117 Centre Ave, Suite 1.27, Pittsburgh, PA 15213 USA. 16National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850 USA. 17Innsbruck Medical University, Medizinische Klinik, Anichstrasse 35, Innsbruck, A-6020 Austria. 18Department of Medicine, Surgery and Immunology, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213 USA.
Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials
Kohrt et al.
Journal for ImmunoTherapy of Cancer
Journal of Immunotherapy
Papers
May 2016
Authors and Affiliates
Holbrook E. Kohrt1, Paul C. Tumeh2, Don Benson3, Nina Bhardwaj4, Joshua Brody5, Silvia Formenti6, Bernard A. Fox7, Jerome Galon8, Carl H. June9, Michael Kalos10, Ilan Kirsch11, Thomas Kleen12, Guido Kroemer13, Lewis Lanier14, Ron Levy15, H. Kim Lyerly16, Holden Maecker17, Aurelien Marabelle18, Jos Melenhorst19, Jeffrey Miller20, Ignacio Melero21, Kunle Odunsi22, Karolina Palucka23, George Peoples24, Antoni Ribas25, Harlan Robins26, William Robinson27, Tito Serafini28, Paul Sondel29, Eric Vivier30, Jeff Weber31, Jedd Wolchok32, Laurence Zitvogel33, Mary L. Disis34, Martin A. Cheever35 and on behalf of the Cancer Immunotherapy Trials Network (CITN)
1Division of Oncology, Stanford Cancer Institute, Stanford University Medical Center, Stanford, CA, USA.2Division of Dermatology, Department of Medicine, University of California Los Angeles, Los Angeles, CA USA.3Division of Hematology/Oncology, Ohio State University, Columbus, OH USA.4Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY USA.5Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, Ruttenberg Treatment Center, New York, NY USA. 6Department of Radiation Oncology, New York Weill Cornell Medical Center, New York, NY USA.7SOM-Molecular Microbiology & Immunology Department, Laboratory of Molecular and Tumor Immunology, OHSU Cancer Institute, Portland, OR USA. 8INSERM, Integrative Cancer Immunology Team, Cordeliers Research Center, Paris, France. 9Perelman School of Medicine, University of Pennsylvania, Pathology and Laboratory Medicine, Philadelphia, PA USA.10Cancer Immunobiology, Eli Lilly & Company, New York, NY USA. 11Translational Medicine, Adaptive Biotechnologies Corp, Seattle, WA USA. 12Immune Monitoring, Epiontis GmbH, Berlin, Germany. 13Faculty of Medicine, University of Paris Descartes, Paris, France. 14Department of Microbiology and Immunology, University of California, San Francisco, CA USA. 15Division of Oncology, Stanford School of Medicine, Stanford, CA USA. 16Duke University School of Medicine, Durham, NC USA. 17Human Immune Monitoring Center Shared Resource, Stanford Cancer Institute, Stanford, CA USA.18Léon Bérard Cancer Center, Lyon, France. 19Product Development and Correlative Sciences, Smilow Center for Translational Research, Philadelphia, PA USA. 20Division of Hematology, Experimental Therapeutics, University of Minnesota, Oncology and Transplantation, Minneapolis, MN USA. 21Centro de Investigacion Medica Aplicada, Universidad de Navarra, Avda. Pamplona, Spain. 22Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY USA. 23Baylor Institute for Immunology Research, Dallas, TX USA. 24Cancer Vaccine Development Program, Brooke Army Medical Center, Houston, TX USA. 25Tumor Immunology Program Area, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA USA. 26Adaptive Biotechnologies, Seattle, WA USA. 27Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA USA. 28Atreca, Inc, Redwood City, CA USA. 29Cellular & Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, WI USA. 30Centre d'Immunologie de Marseille-Luminy, Marseille, France. 31Moffitt Cancer Center, Tampa, FL USA. 32Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY USA. 33Institut National de la Santé et Recherche Médicale, Institut GrustaveRoussy, Villejuif, France. 34Tumor Vaccine Group, University of Washington, Seattle, WA USA.35Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1023 USA.
Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H1N1 influenza virus and its antigen-driven TCR usage signature in BALB/c mice
Lu et al.
Cellular & Molecular Immunology
Papers
May 2016
Authors and Affiliates
I-Na Lu1, Sophie Farinelle1, Aurélie Sausy1 and Claude P Muller1
1Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette L-4354, Luxembourg
High-throughput sequencing reveals restricted TCR VB usage and public TCRB clonotypes among pancreatic lymph node memory CD4+ T cells and their involvement in autoimmune diabetes
Marrero et al.
Molecular Immunology
Papers
May 2016
Authors and Affiliates
Idania Marrero,a,b Carlos Aguileraa,1 David E. Hamm,c Anthony Quinn,d Vipin Kumar,a,b
aTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA bDepartment of Medicine, University of California San Diego, La Jolla, CA 92037, USA cAdaptive Biotechnologies, 1551 Eastlake Ave E #200, Seattle, WA 98102, USA dDepartment of Biological Sciences, University of Toledo, 2801 W Bancroft St., Toledo, OH 43606, USA