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Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency

Wong et al.
Papers
The Journal of Immunology
August 2016
Authors and Affiliates
Gabriel K. Wong,1,2 David Millar,3,4 Sarah Penny,1 James M. Heather,5 Punam Mistry,1 Nico Buettner,1 Jane Bryon,6 Aarnoud P. Huissoon,2 and Mark Cobbold3,4 1Medical Research Council Centre for Immune Regulation, University of Birmingham, Edgbaston B15 2TT, United Kingdom; 2West Midlands Primary Immunodeficiency Centre, Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom; 3Cancer Center, Massachusetts General Hospital, Boston MA 02114; 4Department of Medicine, Harvard Medical School, Charlestown, MA 02129; 5Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom; and 6Regional Genetics Laboratory, Birmingham Women’s Hospital, Birmingham B15 2TG, United Kingdom

A Public Database of Memory and Naive B- Cell Receptor Sequences

DeWitt et al.
Papers
PLOS ONE
August 2016
Authors and Affiliates
William S. DeWitt1, Paul Linda2,3, Thomas M. Snyder1, Anna M. Sherwood1, Marissa Vignali1, Christopher S. Carlson2, Philip D. Greenberg2, Natalie Duerkopp2, Ryan O. Emerson1, Harlan S. Robins1,2 1Adaptive Biotechnologies, Seattle, United States of America, 2Fred Hutchinson Cancer Research Center, Seattle, United States of America, 3University of Washington, Seattle, United States of America

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Meermeier et al.
Nature Communications
Papers
August 2016
Authors and Affiliates
Erin W. Meermeier1, Bruno F. Laugel2, Andrew K. Sewell2, Alexandra J. Corbett3, Jamie Rossjohn2,4,5, James McCluskey3, Melanie J. Harriff6,7, Tamera Franks7, Marielle C. Gold1,6,7 & David M. Lewinsohn1,6,7 1 Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239 USA. 2 Institute of Infection and Immunity, HenryWellcome Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK. 3 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia. 4 Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia. 5 ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia. 6 Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA. 7 Department of Research, VA Portland Health Care Center, Portland, Oregon 97239, USA

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

Wallin et al.
Nature Communications
Papers
August 2016
Authors and Affiliates
Jeffrey J. Wallin1, Johanna C. Bendell2, Roel Funke1, Mario Sznol3, Konstanty Korski4, Suzanne Jones2, Genevive Hernandez1, James Mier5, Xian He1, F. Stephen Hodi6, Mitchell Denker1, Vincent Leveque1, Marta Canamero4, Galina Babitski4, Hartmut Koeppen1, James Ziai1, Neeraj Sharma1, Fabien Gaire4, Daniel S. Chen1, Daniel Waterkamp1, Priti S. Hegde1 & David F. McDermott5 1 Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA. 2 GI Oncology Research, Drug Development Unit, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 100, Nashville, Tennessee, 37203, USA. 3 Department of Internal Medicine and Melanoma Unit, Yale Cancer Center, New Haven, Connecticut 06511, USA. 4 Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany. 5 Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusets 02215, USA. 6 Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue, Boston, Massachusets 02215, USA.

Tumor- and neoantigen-reactive T-cell receptors can be identified based on their frequency in fresh tumor

Pasetto et al.
Cancer Immunology Research
Papers
July 2016
Authors and Affiliates
Anna Pasetto1 , Alena Gros1 , Paul F Robbins1 , Drew C Deniger1 , Todd D Prickett1 , Rodrigo Matus-Nicodemos2,3 , Daniel C Douek3 , Bryan Howie4 , Harlan Robins4,5 , Maria R Parkhurst1 , Jared Gartner1 , Katarzyna Trebska-McGowan1 , Jessica S Crystal1 , Steven A Rosenberg1 * 1Surgery Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA, 2Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA, 3Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA, 4Adaptive Biotechnologies, Seattle, WA 98102, USA, 5Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer

Sridharan et al.
British Journal of Cancer
Papers
July 2016
Authors and Affiliates
Vishwajith Sridharan1,2, Danielle N Margalit1, Stephanie A Lynch1, Mariano Severgnini3, Jun Zhou3, Nicole G Chau4, Guilherme Rabinowits4, Jochen H Lorch4, Peter S Hammerman4, F Stephen Hodi3,4, Robert I Haddad4, Roy B Tishler1 and Jonathan D Schoenfeld1 1Department of Radiation Oncology, Brigham and Women’s Hospital/Dana-Farber Cancer Center, Boston, MA, USA; 2Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA; 3Center for Immuno-oncology, Dana-Farber Cancer Institute, Boston, MA, USA and 4Department of Medical Oncology, Brigham and Women’s Hospital/Dana-Farber Cancer Center, Boston, MA, USA

Analyzing the CDR3 Repertoire with respect to TCR—Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS

Ma et al
Papers
Scientific Reports
July 2016
Authors and Affiliates
Long Ma1, Liwen Yang1, Bin Shi2, Xiaoyan He1, Aihua Peng1, Yuehong Li1, Teng Zhang1, Suhong Sun3, Rui Ma1 & Xinsheng Yao1 1Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563003, China, 2 Department of Laboratory Medicine, Zunyi Medical University, Zunyi 563003, China, 3Department of Breast Surgery, The first Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

T cell receptor diversity in the human thymus

Vanhanen et al.
Molecular Immunology
Papers
July 2016
Authors and Affiliates
Reetta Vanhanena, Nelli Heikkiläa , Kunal Aggarwalb, David Hammc, Heikki Tarkkilaa, Tommi Pätiläd, T. Sakari Jokirantaa, Jari Saramäkib, T. Petteri Arstilaa aMedicum, Department of Bacteriology and Immunology and Research Programs Unit, Immunobiology, University of Helsinki, 00014 Helsinki, Finland, bDepartment of Computer Science, Aalto University, FI-00076 Aalto, Espoo, Finland, cAdaptive Biotechnologies, 1551 Eastlake Ave. E, Seattle, WA, United States, dDepartment of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, 00290 Helsinki, Finland

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis

Rossetti et al.
Annals of Rheumatic Disease
Papers
June 2016
Authors and Affiliates
Maura Rossetti1,2,3, Roberto Spreafico1,2,4, Alessandro Consolaro5, Jing Yao Leong1,Camillus Chua1, Margherita Massa6, Suzan Saidin1, Silvia Magni-Manzoni7,Thaschawee Arkachaisri8, Carol A Wallace9, Marco Gattorno5, Alberto Martini5,Daniel J Lovell10, Salvatore Albani1 1SingHealth Translational Immunology and Inflammation Centre, SingHealth and Duke-NUS Graduate Medical School, Singapore, Singapore, 2Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, California, USA, 3Department of Pathology and Laboratory Medicine, University of California Los Angeles,Los Angeles, California, USA, 4Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA, 5Second Pediatrics Division, University of Genoa and G Gaslini Institute, Genova, Italy, 6Lab Biotecnologie, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 7Pediatric Rheumatology Unit, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 8Duke-NUS Graduate Medical School and Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, 9Seattle Children's Hospital and Research Institute, Seattle, Washington, USA, 10Division of Rheumatology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

Younes et al.
JCI
Papers
June 2016
Authors and Affiliates
Souheil-Antoine Younes,1 Michael L. Freeman,1 Joseph C. Mudd,2Carey L. Shive,1 Arnold Reynaldi,3 Soumya Panigrahi,1 Jacob D. Estes,4Claire Deleage,4 Carissa Lucero,4 Jodi Anderson,5 Timothy W. Schacker,5 Miles P. Davenport,3 Joseph M. McCune,6 Peter W. Hunt,7Sulggi A. Lee,7 Sergio Serrano-Villar,8 Robert L. Debernardo,9 Jeffrey M. Jacobson,10 David H. Canaday,1 Rafick-Pierre Sekaly,11 Benigno Rodriguez,1 Scott F. Sieg,1 and Michael M. Lederman1 1Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, Cleveland, Ohio, USA. 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. 3Kirby Institute for Infection and Immunity, University of New South Wales, Sydney, New South Wales, Australia. 4AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. 5Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. 6Division of Experimental Medicine and7HIV/AIDS Division, Department of Medicine, UCSF, San Francisco, California, USA. 8Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain. 9Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA. 10Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. 11Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
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