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Suppression by Tfr cells leads to durable and selective inhibition of B cell effector function

Sage et al.
Nature Immunology
Papers
October 2016
Authors and Affiliates
Peter T Sage1,2, Noga Ron-Harel3, Vikram R Juneja1,2, Debattama R Sen4, Seth Maleri1,2, Waradon Sungnak2,5, Vijay K Kuchroo2,5, W Nicholas Haining4, Nicolas Chevrier6, Marcia Haigis3 & Arlene H Sharpe1,2,7 1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA. 2Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts, USA. 3Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. 4Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. 5Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 6FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA. 7Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming

Tleugabulova et al.
Journal of Immunology
Papers
October 2016
Authors and Affiliates
Mayra Cruz Tleugabulova*, Nichole K. Escalante*, Shenglou Deng†, Stephanie Fieve*, June Ereño-Orbea‡, Paul B. Savage†, Jean-Philippe Julien*,‡,§ and Thierry Mallevaey* *Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; †Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602; ‡The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada; and §Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Deep Sequencing of T-Cell Receptor DNA as a biomarker of clonally expanded TILs in breast cancer after immunotherapy

Page et al.
Cancer Immunology Research
Papers
September 2016
Authors and Affiliates
David B. Page1,2, Jianda Yuan1, David Redmond3, Y Hanna Wen1, Jeremy C. Durack1, Ryan Emerson4, Stephen Solomon1, Zhiwan Dong1, Phillip Wong1, Christopher Comstock1, Adi Diab5, Janice Sung1, Majid Maybody1, Elizabeth Morris1, Edi Brogi1, Monica Morrow1, Virgilio Sacchini1, Olivier Elemento3, Harlan Robins6, Sujata Patil1, James P. Allison5, Jedd D. Wolchok1,3, Clifford Hudis1,3, Larry Norton1,3, and Heather McArthur1,3 1Medical Oncology, Providence Portland Medical Center / Robert W. Franz Cancer Research Center and Earl A. Chiles Research Institute; 2Memorial Sloan-Kettering Cancer Center; 3Weill Cornell Medical College 4Adaptive Biotechnologies; 5Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center; 6Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medical College; 7Human Biology Division, Fred Hutchinson Cancer Research Center; 8Immunology, University of Texas MD Anderson Cancer Center; 9Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center; 10Medicine, Breast Medicine Service, Memorial Sloan-Kettering Cancer Center

ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells

Boddupalli et al.
Papers
The Journal of Clinical Investigation
September 2016
Authors and Affiliates
Chandra Sekhar Boddupalli1, Shiny Nair1, Simon M. Gray2, Heba N. Nowyhed3, Rakesh Verma1. Joanna A. Gibson4,Clara Abraham1, Deepak Narayan5, Juan Vasquez6, Catherine C. Hedrick3, Richard A. Flavell2,7, Kavita M. Dhodapkar6, Susan M. Kaech2,7, and Madhav V. Dhodapkar1,2 1Department of Medicine, and 2Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA. 3La Jolla Institute for Allergy and Immunology, Division of Inflammation Biology, La Jolla, California, USA. 4Department of Pathology, 5Department of Surgery, 6Department of Pediatrics, and 7Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut, USA.

The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma

Keane et al.
Clinical Cancer Research
Papers
September 2016
Authors and Affiliates
1,2Colm Keane, 1,2Clare Gould, 1Kimberley Jones, 3David Hamm, 5,6Dipti Talaulikar, 1Jonathan Ellis, 1Frank Vari, 2,7Simone Birch 1Erica Han, 2Peter Wood, 1Kim-Anh Le-Cao, 4Michael R. Green, 1Pauline Crooks, 5Sanjiv Jain, 1,2Josh Tobin, 1Raymond J. Steptoe, 1,2Maher K. Gandhi. 1University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Australia;2Princess Alexandra Hospital, Brisbane, Queensland, Australia; 3Adaptive Biotechnologies, Seattle, WA, USA, 4Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska, USA. 5Canberra Hospital, Canberra, Australian Capital Territory; 6Australian National University Medical School, Australian Capital Territory; 7Pathology Queensland, Brisbane, Queensland, Australia.

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Kordasti et al.
Blood
Papers
September 2016
Authors and Affiliates
Shahram Kordasti,1,2,* Benedetta Costantini,1,2,* Thomas Seidl,1,* Pilar Perez Abellan,2 Marc Martinez Llordella,3 Donal McLornan,2 Kirsten E. Diggins,4 Austin Kulasekararaj,2 Cinzia Benfatto,1 Xingmin Feng,5 Alexander Smith,1,2 Syed A. Mian,1 Rossella Melchiotti,6 Emanuele de Rinaldis,6 Richard Ellis,6 Nedyalko Petrov,6 Giovanni A. M. Povoleri,3 Sun Sook Chung,1 N. Shaun B. Thomas,1 Farzin Farzaneh,1 Jonathan M. Irish,4 Susanne Heck,6 Neal S. Young,5 Judith C. W. Marsh,1,2 and Ghulam J. Mufti1,2 1Department of Haematological Medicine, King’s College London, London, United Kingdom; 2Haematological Medicine, King’s College Hospital, London, United Kingdom; 3Division of Transplantation Immunology & Mucosal Biology, King’s College London, London, United Kingdom; 4Department of Cancer Biology, Vanderbilt University, Nashville, TN; 5Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; and 6National Institute for Health Research Biomedical Research Centre, King’s College London, London, United Kingdom

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease

Henriksen et al.
Journal of Hepatology
Papers
September 2016
Authors and Affiliates
Eva Kristine Klemsdal Henriksen1,2,3,4, Kristin Kaasen Jørgensen1,5, Fatemeh Kaveh3,4,6, Kristian Holm1,2,3,4, David Hamm7, Johanna Olweus3,8,9, Espen Melum1,2,3,10, Brian K. Chung1,4,13, Tor J. Eide4,11, Knut E.A. Lundin10,12, Kirsten Muri Boberg1,3,4,10, Tom H. Karlsen1,2,3,4,10,Gideon M. Hirschfield13, Evaggelia Liaskou13,⇑ 1Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 2Research Institute of Internal Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 3K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 4Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 5Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; 6Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway; 7Adaptive Biotechnologies Corp., Seattle, WA, USA; 8Department of Cancer Immunology, Institute for Cancer Research,Oslo University Hospital Radiumhospitalet, Oslo, Norway; 9K.G. Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 10Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 11Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway; 12Centre for Immune Regulation, Faculty of Medicine, University of Oslo, Oslo, Norway; 13Centre for Liver Research and NIHR Birmingham Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK

Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100

Morrow et al.
Molecular Therapy — Oncolytics
Papers
September 2016
Authors and Affiliates
Matthew P Morrow1, Kimberly A Kraynyak1, Albert J Sylvester1, Xuefei Shen1, Dinah Amante1, Lindsay Sakata1, Lamar Parker2, Jian Yan1, Jean Boyer1, Christian Roh1, Laurent Humeau1, Amir S Khan1, Kate Broderick1, Kathleen Marcozzi-Pierce1, Mary Giear1, Jessica Lee1, Cornelia L Trimble3, J Joseph Kim1, Niranjan Y Sardesai1, David B Weiner4 and Mark L Bagarazzi1 1 Inovio Pharmaceuticals, Plymouth Meeting, Pennsylvania, USA; 2 Unified Women’s Clinical Research, Winston-Salem, North Carolina, USA; 3 Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 4 The Wistar Institute, Philadelphia, Pennsylvania, USA

Chemotherapy and radiation therapy elicits tumor specific T cell responses in a breast cancer patient

Bernal-Estéve et al.
BMC Cancer
Papers
August 2016
Authors and Affiliates
David Bernal-Estévez 1,2 , Ramiro Sánchez 3 , Rafael E. Tejada 4 and Carlos Parra-López 1,5 1Immunology and Traslational Medicine Research Group, Graduated School in Biomedical Sciences, Department of Microbiology, Medical School, Universidad Nacional de Colombia, Carrera 30 #45-03 Building 471, office 304, Bogotá, Colombia South-America. 2Immunology and Clinical Oncology Bernal-Estévez et al. BMC Cancer (2016) 16:591 Page 12 of 13 Research Group (GIIOC), Fundación Salud de los Andes, Calle 44 No. 58-05, Bogotá, Colombia South-America. 3Clínica del Seno, Carrera 11 # 68-36, Bogotá, Colombia South-America. 4Hospital Occidente de Kennedy E.S.E., Servicio de Oncología, Bogotá, Colombia South-America. 5 Facultad de Medicina, Departamento de Microbiología, Universidad Nacional de Colombia, Carrera 30 Calle 45, Bogotá, Colombia.
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