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Daratumumab Depletes CD38 + Immune-regulatory Cells, Promotes T-cell Expansion, and Skews T-cell Repertoire in Multiple Myeloma

Krejcik et al.
Blood
Papers
May 2016
Authors and Affiliates
Jakub Krejcik, MD1,2 ; Tineke Casneuf, PhD3 ; Inger S. Nijhof, MD1 ; Bie Verbist, PhD3 ; Jaime Bald, BS4 ; Torben Plesner, MD2 ; Khaja Syed, MS4 ; Kevin Liu, PhD5 ; Niels W.C.J. van de Donk, MD1 ; Brendan M. Weiss, MD6 ; Tahamtan Ahmadi, MD4 ; Henk M. Lokhorst, MD1 ; Tuna Mutis, MD1 ; and A. Kate Sasser, PhD4 1Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands 2Vejle Hospital and University of Southern Denmark, Vejle, Denmark 3Janssen Research & Development, Beerse, Belgium 4Janssen Research & Development, LLC, Spring House, PA, USA 5Janssen Research & Development, LLC, Raritan, NJ, USA 6Division of Hematology-Oncology, Department of Medicine, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Novel technologies and emerging biomarkers for personalized cancer immunotherapy

Yuan et al.
Journal for ImmunoTherapy of Cancer
Papers
May 2016
Authors and Affiliates
Yuan J1, Hegde PS2, Clynes R3, Foukas PG4, Harari A5, Kleen TO6, Kvistborg P7, Maccalli C8, Maecker HT9, Page DB10, Robins H11, Song W12, Stack EC13, Wang E14, Whiteside TL15, Zhao Y16, Zwierzina H17, Butterfield LH18, Fox BA10. 1Memorial Sloan-Kettering Cancer Center, 1275 New York Ave Box 386, New York, NY 10065 USA. 2Genentech, Inc., 1 DNA Way South, San Francisco, CA 94080 USA. 3Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ 08648 USA. 4Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland ; Department of Pathology, University of Athens Medical School, "Attikon" University Hospital, 1st Rimini St, 12462 Haidari, Greece. 5Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland. 6Epiontis GmbH, Rudower Chaussee 29, 12489 Berlin, Germany. 7Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, Netherlands. 8Italian Network for Biotherapy of Tumors (NIBIT)-Laboratory, c/o Medical Oncology and Immunotherapy, University Hospital of Siena, V.le Bracci,16, Siena, 53100 Italy. 9Stanford University Medical Center, 299 Campus Drive, Stanford, CA 94303 USA.10Earle A. Chiles Research Institute, Providence Cancer Center, 4805 NE Glisan Street, Portland, OR 97213 USA. 11Adaptive Technologies, Inc., 1551 Eastlake Avenue East Suite 200, Seattle, WA 98102 USA. 12AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878 USA. 13PerkinElmer, 68 Elm Street, Hopkinton, MA 01784 USA. 14Sidra Medical and Research Center, PO Box 26999, Doha, Qatar. 15University of Pittsburgh Cancer Institute, 5117 Centre Ave, Suite 1.27, Pittsburgh, PA 15213 USA. 16National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850 USA. 17Innsbruck Medical University, Medizinische Klinik, Anichstrasse 35, Innsbruck, A-6020 Austria. 18Department of Medicine, Surgery and Immunology, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213 USA.

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

Kohrt et al.
Journal for ImmunoTherapy of Cancer
Journal of Immunotherapy
Papers
May 2016
Authors and Affiliates
Holbrook E. Kohrt1, Paul C. Tumeh2, Don Benson3, Nina Bhardwaj4, Joshua Brody5, Silvia Formenti6, Bernard A. Fox7, Jerome Galon8, Carl H. June9, Michael Kalos10, Ilan Kirsch11, Thomas Kleen12, Guido Kroemer13, Lewis Lanier14, Ron Levy15, H. Kim Lyerly16, Holden Maecker17, Aurelien Marabelle18, Jos Melenhorst19, Jeffrey Miller20, Ignacio Melero21, Kunle Odunsi22, Karolina Palucka23, George Peoples24, Antoni Ribas25, Harlan Robins26, William Robinson27, Tito Serafini28, Paul Sondel29, Eric Vivier30, Jeff Weber31, Jedd Wolchok32, Laurence Zitvogel33, Mary L. Disis34, Martin A. Cheever35 and on behalf of the Cancer Immunotherapy Trials Network (CITN) 1Division of Oncology, Stanford Cancer Institute, Stanford University Medical Center, Stanford, CA, USA.2Division of Dermatology, Department of Medicine, University of California Los Angeles, Los Angeles, CA USA.3Division of Hematology/Oncology, Ohio State University, Columbus, OH USA.4Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY USA.5Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, Ruttenberg Treatment Center, New York, NY USA. 6Department of Radiation Oncology, New York Weill Cornell Medical Center, New York, NY USA.7SOM-Molecular Microbiology & Immunology Department, Laboratory of Molecular and Tumor Immunology, OHSU Cancer Institute, Portland, OR USA. 8INSERM, Integrative Cancer Immunology Team, Cordeliers Research Center, Paris, France. 9Perelman School of Medicine, University of Pennsylvania, Pathology and Laboratory Medicine, Philadelphia, PA USA.10Cancer Immunobiology, Eli Lilly & Company, New York, NY USA. 11Translational Medicine, Adaptive Biotechnologies Corp, Seattle, WA USA. 12Immune Monitoring, Epiontis GmbH, Berlin, Germany. 13Faculty of Medicine, University of Paris Descartes, Paris, France. 14Department of Microbiology and Immunology, University of California, San Francisco, CA USA. 15Division of Oncology, Stanford School of Medicine, Stanford, CA USA. 16Duke University School of Medicine, Durham, NC USA. 17Human Immune Monitoring Center Shared Resource, Stanford Cancer Institute, Stanford, CA USA.18Léon Bérard Cancer Center, Lyon, France. 19Product Development and Correlative Sciences, Smilow Center for Translational Research, Philadelphia, PA USA. 20Division of Hematology, Experimental Therapeutics, University of Minnesota, Oncology and Transplantation, Minneapolis, MN USA. 21Centro de Investigacion Medica Aplicada, Universidad de Navarra, Avda. Pamplona, Spain. 22Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY USA. 23Baylor Institute for Immunology Research, Dallas, TX USA. 24Cancer Vaccine Development Program, Brooke Army Medical Center, Houston, TX USA. 25Tumor Immunology Program Area, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA USA. 26Adaptive Biotechnologies, Seattle, WA USA. 27Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA USA. 28Atreca, Inc, Redwood City, CA USA. 29Cellular & Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, WI USA. 30Centre d'Immunologie de Marseille-Luminy, Marseille, France. 31Moffitt Cancer Center, Tampa, FL USA. 32Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY USA. 33Institut National de la Santé et Recherche Médicale, Institut GrustaveRoussy, Villejuif, France. 34Tumor Vaccine Group, University of Washington, Seattle, WA USA.35Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1023 USA.

High-throughput sequencing reveals restricted TCR VB usage and public TCRB clonotypes among pancreatic lymph node memory CD4+ T cells and their involvement in autoimmune diabetes

Marrero et al.
Molecular Immunology
Papers
May 2016
Authors and Affiliates
Idania Marrero,a,b Carlos Aguileraa,1 David E. Hamm,c Anthony Quinn,d Vipin Kumar,a,b aTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA bDepartment of Medicine, University of California San Diego, La Jolla, CA 92037, USA cAdaptive Biotechnologies, 1551 Eastlake Ave E #200, Seattle, WA 98102, USA dDepartment of Biological Sciences, University of Toledo, 2801 W Bancroft St., Toledo, OH 43606, USA

Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease

Mattoo et al.
Papers
The Journal of Allergy and Clinical Immunology
May 2016
Authors and Affiliates
Hamid Mattoo1, Vinay S. Mahajan1, Takashi Maehara2, Vikram Deshpande1, Emanuel Della-Torre1, Zachary S. Wallace1, Maria Kulikova1, Jefte M. Drijvers1, Joe Daccache1, Mollie N. Carruthers1, Flavia Castellino1, James R. Stone1, John H. Stone3, Shiv Pillai4. 1Massachusetts General Hospital, Harvard Medical School, Boston, Mass. 2Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Fukuoka, Japan. 3Massachusetts General Hospital, Harvard Medical School, Boston, Mass. 4Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing

Schneider-Hohendorf et al.
Nature Communications
Papers
April 2016
Authors and Affiliates
Tilman Schneider-Hohendorf1, Hema Mohan1, Christian G. Bien2, Johanna Breuer1, Albert Becker3, Dennis Gorlich4, Tanja Kuhlmann5, Guido Widman6, Sebastian Herich1, Christiane Elpers7, Nico Melzer1, Klaus Dornmair8,9,10, Gerhard Kurlemann7, Heinz Wiendl1, & Nicholas Schwab1 1Department of Neurology, University of Munster, Germany. 2 Epilepsy Center Bethel, Bielefeld, Germany. 3 Institute of Neuropathology, University Hospital Bonn, Bonn, Germany. 4 Institute of Biostatistics and Clinical Research, University of Munster, Munster, Germany. 5Department of Neuropathology, University of Munster, Munster, Germany. 6Department of Epileptology, University of Bonn, Bonn, Germany. 7 Children’s Hospital of the University Medical Center, University of Munster, Munster, Germany. 8 Institute for Clinical Neuroimmunology, Ludwig-Maximilians-University Munich, Munich, Germany. 9 Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany. 10 Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University Munich, Munich, Germany.

Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals

Felgentreff et al.
Journal of Clinical Immunology
Papers
April 2016
Authors and Affiliates
Kerstin Felgentreff1,2 & Sachin N. Baxi1 & Yu Nee Lee1 & Kerry Dobbs1 & Lauren A. Henderson1 & Krisztian Csomos3 & Erdyni N. Tsitsikov4 & Mary Armanios5 & Jolan E. Walter1,3 & Luigi D. Notarangelo1,6 1Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 2 Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany. 3 Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 4 Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 5 Departments of Oncology, Pathology and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Harvard Stem Cell Institute, Harvard University, Boston, MA, USA.

Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide

Kanakry et al.
Journal of Clinical Investigation
Papers
April 2016
Authors and Affiliates
Christopher G. Kanakry,1 David G. Coffey,2,3 Andrea M.H. Towlerton,2 Ante Vulic,1 Barry E. Storer,2 Jeffrey Chou,2,3 Cecilia C.S. Yeung,2,4 Christopher D. Gocke,1 Harlan S. Robins,5 Paul V. O’Donnell,2,3 Leo Luznik,1 and Edus H. Warren2,3 1 Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, USA. 3 Department of Medicine and 4 Department of Pathology, University of Washington, Seattle, Washington, USA. 5 Public Health Sciences Division, FHCRC, Seattle, Washington, USA.

Conventional and Regulatory CD4+ T Cells That Share Identical TCRs Are Derived from Common Clones

Wolf et al.
Papers
PLOS ONE
April 2016
Authors and Affiliates
Kyle J. Wolf1, Ryan O. Emerson2, Jeanette Pingel1, R. Mark Buller1, Richard J. DiPaolo1 1 Department of Molecular Microbiology and Immunology, Saint Louis University, School of Medicine, Saint Louis, Missouri, United States of America, 2 Adaptive Biotechnologies Corporation, Seattle, Washington, United States of America Abstract Reference
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