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Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating αβ T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients

Dandekar et al.
Frontiers in Immunology
Papers
December 2016
Authors and Affiliates
Sugandha Dandekar1, Hemani Wijesuriya2, Tim Geiger3, David Hamm3, Gary W. Mathern4,5,6,7 and Geoffrey C. Owens4* 1Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 2Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 3Adaptive Biotechnologies Inc., Seattle, WA, USA, 4Department of Neurosurgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 5Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 6Brain Research Institute, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 7Mattel Children’s Hospital, Los Angeles, CA, USA

Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs

Chamoto et al
Journal of Immunology
Papers
December 2016
Authors and Affiliates
Kenji Chamoto*,1, Tingxi Guo*,†,1, Stephen W. Scally‡, Yuki Kagoya*, Mark Ancruzowski*,†, Chung-Hsi Wang*,†, Muhammed A. Rahman*, Kayoko Saso*, Marcus O. Butler*,†,§, Priscilla P. L. Chiu¶,‖, Jean-Philippe Julien†,‡,# and Naoto Hirano*,† *Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; †Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ‡Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada; §Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ¶Division of Pediatric Surgery, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; ‖Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada; and #Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells

Boddupalli et al
Journal of Clinical Investigation
Papers
December 2016
Authors and Affiliates
Chandra Sekhar Boddupalli,1 No ar Bar,1 Krishna Kadaveru,2 Michael Krauthammer,3,4 Natopol Pornputtapong,4 Zifeng Mai,2 Stephan Ariyan,5 Deepak Narayan,5 Harriet Kluger,1,6 Yanhong Deng,7 Rakesh Verma,1 Rituparna Das,1 Antonella Bacchiocchi,8 Ruth Halaban,8 Mario Sznol,1,6 Madhav V. Dhodapkar,1,6,9 and Kavita M. Dhodapkar2,6 1Department of Medicine, 2Department of Pediatrics, 3Program for Computational Biology and Bioinformatics, 4Department of Pathology, 5Department of Surgery, 6Yale Cancer Center, 7Yale Center for Analytic Sciences, 8Department of Dermatology, 9Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity

Crittenden et al.
Papers
Scientific Reports
December 2016
Authors and Affiliates
Marka R. Crittenden1,2, Lauren Zebertavage3, Gwen Kramer1, Shelly Bambina1, David Friedman1, Victoria Troesch1, Tiffany Blair3, Jason R. Baird1, Alejandro Alice1 & Michael J. Gough1 1Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, 97213, USA. 2The Oregon Clinic, Portland, OR, 97213, USA. 3Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, 97239, USA.

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

Johnson et al.
New England Journal of Medicine
Papers
November 2016
Authors and Affiliates
Douglas B. Johnson, M.D.,1 Justin M. Balko, PharmD, Ph.D.,1,2,4 Margaret L. Compton, M.D.,5 Spyridon Chalkias, M.D.,10,11 Joshua Gorham, B.A.,14 Yaomin Xu, Ph.D.,6,8,9 Mellissa Hicks, Ph.D.,1 Igor Puzanov, M.D.,1 Matthew R. Alexander, M.D., Ph.D.,1 Tyler L. Bloomer, M.D.,1 Jason Becker, M.D.,1 David A. Slosky, M.D.,1,3 Elizabeth J. Phillips, M.D.,1 Mark A. Pilkinton, M.D., Ph.D.,1 Laura Craig-Owens, M.D.,5 Nina Kola, M.D.,16 Gregory Plautz, M.D.,16 Daniel S. Reshef, M.D.,16 Jonathan S. Deutsch, M.D.,16 Raquel P. Deering, Ph.D.,17 Benjamin A. Olenchock, M.D., Ph.D.,12 Andrew H. Lichtman, M.D.,13 Dan M. Roden, M.D.,1,7,8 Christine E. Seidman, M.D.,12,14,15 Igor J. Koralnik, M.D.,11 Jonathan G. Seidman, Ph.D.,12,14 Robert D. Hoffman, M.D., Ph.D.,5 Janis M. Taube, M.D.,18,19 Luis A. Diaz, Jr., M.D.,20 Robert A. Anders, M.D.,18 Jeffrey A. Sosman, M.D.,1 and Javid J. Moslehi, M.D.1,2,3 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 2Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 3Department of Cardio-Oncology Program, Vanderbilt University Medical Center, Nashville, TN 4Department of Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, TN 5Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 6Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 7Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 8Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 9Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 10Department of Medicine, Beth Israel Deaconess Medicine Center, Boston, MA 11Division of Neuro-Immunology, Beth Israel Deaconess Medicine Center, Boston, MA 12Department of Medicine, Brigham and Women’s Hospital, Boston, MA 13Department of Pathology, Brigham and Women’s Hospital, Boston, MA 14Department of Genetics, Howard Hughes Medical Institute, Boston, MA 15Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 16Bristol Myers Squibb, New York, NY 17Neon Therapeutics, Cambridge, MA 18Department of Pathology, Johns Hopkins University, Baltimore, MD 19Department of Dermatology, Johns Hopkins University, Baltimore, MD 20Department of Oncology, Johns Hopkins University, Baltimore, MD

Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus−Specific Memory B Cells

Boisvert et al.
Journal of Immunology
Papers
November 2016
Authors and Affiliates
Maude Boisvert,*,1 Wanrui Zhang,†,1 Elizabeth J. Elrod,† Nicole F. Bernard,‡,x Jean-Pierre Villeneuve,*,{ Julie Bruneau,*,‖ Joseph Marcotrigiano,# Naglaa H. Shoukry,*,{ and Arash Grakoui†,** *Centre de Recherche du Centre Hospitalier de l’Universite ́ de Montre ́al, Montreal, Quebec H2X 0A9, Canada; †Yerkes National Primate Research Center, Emory Vaccine Center, Atlanta, GA 30329; ‡Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada; xDivision of Experimental Medicine, McGill University, Mon- treal, Quebec H3A 1A3, Canada; {De ́partement de Me ́decine,‖ Faculte ́ de Me ́decine, Uni- versite ́ de Montre ́al, Montreal, Quebec H3T 1J4, Canada; De ́partement de Me ́decine Familiale et de Me ́decine D’Urgence, Faculte ́ de Me ́decine, Universite ́ de Montre ́al, Mon- treal, Quebec H3T 1J4, Canada; #Center for Advanced Biotechnology and Medicine, De- partment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854; and **Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329 Maude Boisvert, Wanrui Zhang, Elizabeth J. Elrod, Nicole F. Bernard, Jean-Pierre Villeneuve, Julie Bruneau, Joseph Marcotrigiano, Naglaa H. Shoukry and Arash Grakoui

Autoimmune Renal Disease Is Exacerbated by S1P- Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney

Krebs et al.
Immunity
Papers
November 2016
Authors and Affiliates
Christian F. Krebs,1 Hans-Joachim Paust,1 Sonja Krohn,1 Tobias Koyro,1 Silke R. Brix,1 Jan-Hendrik Riedel,1 Patricia Bartsch,1 Thorsten Wiech,2 Catherine Meyer-Schwesinger,1 Jiabin Huang,3 Nicole Fischer,3 Philipp Busch,4 Hans-Willi Mittrucker,5 Ulrich Steinhoff,6 Brigitta Stockinger,7 Laura Garcia Perez,8 Ulrich O. Wenzel,1 Matthias Janneck,1 Oliver M. Steinmetz,1 Nicola Gagliani,4 Rolf A.K. Stahl,1 Samuel Huber,8 Jan-Eric Turner,1 and Ulf Panzer1,9 1Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 2Institut für Pathologie, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 3Institut für Medizinische Mikrobiologie, Virologie, und Hygiene, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 4Klinik für Allgemeinchirurgie, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 5Institut für Immunologie, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 6Philipps-Universität Marburg, Institut für Medizinische Mikrobiologie und Krankenhaushygiene, 35043 Marburg, Germany. 7The Francis Crick Institute, Midland Road, London NW1 1AT, UK. 8Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 9Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany.

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Subudhia et al.
Papers
Proceedings of the National Academy of Sciences
October 2016
Authors and Affiliates
Sumit K. Subudhia,1, Ana Aparicioa,1, Jianjun Gaoa, Amado J. Zuritaa, John C. Araujoa, Christopher J. Logothetisa, Salahaldin A. Tahira, Brinda R. Korivib, Rebecca S. Slackc, Luis Venced, Ryan O. Emersone, Erik Yuskoe, Marissa Vignalie, Harlan S. Robinse,f, Jingjing Sung, James P. Allisond,g,2, and Padmanee Sharmaa,d,g,2 aDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; bDepartment of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; cDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; dImmunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; eAdaptive Biotechnologies, Seattle, WA 98102; fFred Hutchinson Cancer Research Center, Seattle, WA 98102; and gDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

Anti-PD-1 increases the clonality and activity of tumor infiltrating antigen specific T cells induced by a potent immune therapy consisting of vaccine and metronomic cyclophosphamide

Weir et al
Journal for ImmunoTherapy of Cancer
Papers
October 2016
Authors and Affiliates
Genevieve M. Weir1*, Olga Hrytsenko1, Tara Quinton1, Neil L. Berinstein2,3, Marianne M. Stanford1,4 and Marc Mansour1 1 Immunovaccine Inc., 1344 Summer St., Halifax, NS B3H 0A8, Canada. 2 Sunnybrook Research Institute, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada. 3 University of Toronto, 27 King’s College Cir, Toronto, ON M5S 1A1, Canada. 4 Department of Microbiology & Immunology, Dalhousie University, 5850 College St., Room 7C, Halifax, NS B3H 4R2, Canada.

Efficient Culture of Human Naive and Memory B Cells for Use as APCs

Su et al.
Journal of Immunology
Papers
October 2016
Authors and Affiliates
Kuei-Ying Su,*,†,1 Akiko Watanabe,*,1 Chen-Hao Yeh,* Garnett Kelsoe,*,‡ and Masayuki Kuraoka* *Department of Immunology, Duke University, Durham, NC 27710; †Tzu Chi Med- ical Center, Hualien 970, Taiwan; and ‡Human Vaccine Institute, Duke University, Durham, NC 27710
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