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Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer

Sridharan et al.
British Journal of Cancer
Papers
July 2016
Authors and Affiliates
Vishwajith Sridharan1,2, Danielle N Margalit1, Stephanie A Lynch1, Mariano Severgnini3, Jun Zhou3, Nicole G Chau4, Guilherme Rabinowits4, Jochen H Lorch4, Peter S Hammerman4, F Stephen Hodi3,4, Robert I Haddad4, Roy B Tishler1 and Jonathan D Schoenfeld1 1Department of Radiation Oncology, Brigham and Women’s Hospital/Dana-Farber Cancer Center, Boston, MA, USA; 2Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA; 3Center for Immuno-oncology, Dana-Farber Cancer Institute, Boston, MA, USA and 4Department of Medical Oncology, Brigham and Women’s Hospital/Dana-Farber Cancer Center, Boston, MA, USA

Analyzing the CDR3 Repertoire with respect to TCR—Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS

Ma et al
Papers
Scientific Reports
July 2016
Authors and Affiliates
Long Ma1, Liwen Yang1, Bin Shi2, Xiaoyan He1, Aihua Peng1, Yuehong Li1, Teng Zhang1, Suhong Sun3, Rui Ma1 & Xinsheng Yao1 1Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563003, China, 2 Department of Laboratory Medicine, Zunyi Medical University, Zunyi 563003, China, 3Department of Breast Surgery, The first Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

T cell receptor diversity in the human thymus

Vanhanen et al.
Molecular Immunology
Papers
July 2016
Authors and Affiliates
Reetta Vanhanena, Nelli Heikkiläa , Kunal Aggarwalb, David Hammc, Heikki Tarkkilaa, Tommi Pätiläd, T. Sakari Jokirantaa, Jari Saramäkib, T. Petteri Arstilaa aMedicum, Department of Bacteriology and Immunology and Research Programs Unit, Immunobiology, University of Helsinki, 00014 Helsinki, Finland, bDepartment of Computer Science, Aalto University, FI-00076 Aalto, Espoo, Finland, cAdaptive Biotechnologies, 1551 Eastlake Ave. E, Seattle, WA, United States, dDepartment of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, 00290 Helsinki, Finland

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis

Rossetti et al.
Annals of Rheumatic Disease
Papers
June 2016
Authors and Affiliates
Maura Rossetti1,2,3, Roberto Spreafico1,2,4, Alessandro Consolaro5, Jing Yao Leong1,Camillus Chua1, Margherita Massa6, Suzan Saidin1, Silvia Magni-Manzoni7,Thaschawee Arkachaisri8, Carol A Wallace9, Marco Gattorno5, Alberto Martini5,Daniel J Lovell10, Salvatore Albani1 1SingHealth Translational Immunology and Inflammation Centre, SingHealth and Duke-NUS Graduate Medical School, Singapore, Singapore, 2Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, California, USA, 3Department of Pathology and Laboratory Medicine, University of California Los Angeles,Los Angeles, California, USA, 4Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA, 5Second Pediatrics Division, University of Genoa and G Gaslini Institute, Genova, Italy, 6Lab Biotecnologie, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 7Pediatric Rheumatology Unit, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 8Duke-NUS Graduate Medical School and Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, 9Seattle Children's Hospital and Research Institute, Seattle, Washington, USA, 10Division of Rheumatology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

Younes et al.
JCI
Papers
June 2016
Authors and Affiliates
Souheil-Antoine Younes,1 Michael L. Freeman,1 Joseph C. Mudd,2Carey L. Shive,1 Arnold Reynaldi,3 Soumya Panigrahi,1 Jacob D. Estes,4Claire Deleage,4 Carissa Lucero,4 Jodi Anderson,5 Timothy W. Schacker,5 Miles P. Davenport,3 Joseph M. McCune,6 Peter W. Hunt,7Sulggi A. Lee,7 Sergio Serrano-Villar,8 Robert L. Debernardo,9 Jeffrey M. Jacobson,10 David H. Canaday,1 Rafick-Pierre Sekaly,11 Benigno Rodriguez,1 Scott F. Sieg,1 and Michael M. Lederman1 1Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, Cleveland, Ohio, USA. 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. 3Kirby Institute for Infection and Immunity, University of New South Wales, Sydney, New South Wales, Australia. 4AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. 5Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. 6Division of Experimental Medicine and7HIV/AIDS Division, Department of Medicine, UCSF, San Francisco, California, USA. 8Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain. 9Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA. 10Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. 11Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.

Redirecting T-Cell Specificity to EGFR Using mRNA to Self-limit Expression of Chimeric Antigen Receptor

Caruso et al.
Journal of Immunotherapy
Papers
June 2016
Authors and Affiliates
Hillary G. Caruso,1,5 Hiroki Torikai,1 Ling Zhang,1 Sourindra Maiti,1 Jianliang Dai,2 Kim-Anh Do,2 Harjeet Singh,1 Helen Huls,1 Dean A. Lee,1,5 Richard E. Champlin,4 Amy B. Heimberger,3 and Laurence J.N. Cooper1,5 1Division of Pediatrics; Departments of 2Biostatistics; 3Neurosurgery; 4Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center; and 5The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX.

Next-generation IgVH sequencing CLL-like monoclonal B-cell lymphocytosis reveals frequent oligoclonality and ongoing hypermutation

Klinger et al.
Papers
May 2016
Authors and Affiliates
Mark Klinger1, Jianbiao Zheng1, Kojo S. Elenitoba-Johnson2, Sherrie L. Perkins3, Malek Faham1 and David W. Bahler3 1Sequenta, Inc., South San Francisco, CA, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 3Department of Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT

Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient

Chapuis et al.
Journal of Experimental Medicine
Papers
May 2016
Authors and Affiliates
Aude G. Chapuis,1 Sylvia M. Lee,1 John A. Thompson,2 Ilana M. Roberts,1 Kim A. Margolin,2 Shailender Bhatia,2 Heather L. Sloan,1 Ivy Lai,1 Lelecia Wagener,1 Kendall Shibuya,1 Jianhong Cao,1 Jedd D. Wolchok,3 Philip D. Greenberg,1,4 and Cassian Yee1 1Program in Immunology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA 98109, 2Division of Medical Oncology, Department of Medicine, University of Washington Medical, Center/FHCRC/Seattle Cancer Care Alliance, Seattle, WA 98109, 3Ludwig Center, Memorial Sloan-Kettering Cancer Center, New York, NY 100165, 4Department of Immunology, University of Washington School of Medicine, Seattle, WA 9819

Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects

Sheikh et al.
Cancer Research
Papers
May 2016
Authors and Affiliates
Sheikh NA1, Cham J2, Zhang L3, DeVries T1, Letarte S4, Pufnock J1, Hamm D5, Trager JB1, Fong L6. 1Research, Dendreon. 2Department of Medicine, University of California, San Francisco. 3Medicine, University of California, San Francisco. 4Bioanalytical Sciencies, Hospira. 5Adaptive Biotechnologies. 6Department of Medicine, University of California, San Francisco
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