Therapeutic Area: Autoimmune
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3
Goettel et al.
Blood Journal
Papers
April 2015
Authors and Affiliates
Goettel JA1,2, Biswas S2,3, Lexmond WS1,2, Yeste A2,4, Passerini L5, Patel B2,4, Yang S6, Sun J2,3, Ouahed1,2, Shouval DS1,2, McCann KJ1, Horwitz BH2,7, Mathis D6, Milford EL2,8, Notarangelo LD2,9, Roncarolo MG5,10, Fiebiger E1,2, Marasco WA2,3, Bacchetta R5, Quintana FJ2,4, Pai SY2,11,12, Muise AM13, Snapper SB1,2,14
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston MA1; Department of Medicine, Harvard Medical School, Boston MA2; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston MA3; Center for Neurologic Diseases, Brigham and Women's Hospital, Boston MA4; Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, San Raffaele Telethon Institute for Gene Therapy, Milan, Italy5; Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA6; Department of Pathology, Brigham and Women's Hospital, Boston, MA7; Renal Division of Tissue Typing Laboratory, Brigham and Women's Hospital, Boston, MA8; Division of Immunology and the Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA9; Vita-Salute San Raffaele University, Milan, Italy10; Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA11; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA12; Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, CA13; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA14
CMV reactivation drives post-transplant T cell reconstitution and results in defects in the underlying TCRβ repertoire
Authors and Affiliates
Suessmuth Y1, Mukherjee R2, Watkins B3, Koura DT4, Finstermeier K5, Desmarais C5, Stempora L1, Horan JT3, Langston A4, Qayed M3, Khoury HJ4, Grizzle A3, Chessman JA1, Conger JA1, Robertson J1, Garrett A3, Kirk AD1, Waller EK4, Blazar BR6, Mehta AK1, Robins HS2, Kean LS7
1The Emory Transplant Center, Emory University School of medicine, Atlanta, GA; 2Fred Hutchinson Cancer Research Center, Seattle, WA; 3Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA; 4Winship Cancer Institute of Emory University, Atlanta, GA; 5Adaptive Biotechnologies Corp, Seattle, WA; 6Department of Pediatrics, Division of Blood and Morrow Transplantation, University of Minnesota School of Medicine, Minneapolis, MN; 7Ben Towne Center for Childhood Cancer Research, Seattle, WA
Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis
Salou et al
Annals of Clinical and Translational Neurology
Papers
April 2015
Authors and Affiliates
Salou M1, Garcia A2, Michel L3, Gainche-Salmon A4, Loussouarn D5, Nicol B1, Guillot F1, Hulin P6, Nedellec S6, Baron D7, Ramstein G8, Soulillou JP4, Brouard S2, Nicot AB7, Degauque N2, Laplaud DA9.
Generation of human memory stem T cells upon haploidentical T-replete hematopoietic stem cell transplantation
Cieri et al.
Blood Journal
Papers
March 2015
Authors and Affiliates
Cieri N1, Oliveira G1, Greco R2, Forcato M3, Taccioli C3, Cianciotti B1, Valtolina V1, Noviello M1, Vago L2, Bondanza A1, Lunghi F2, Marktel S2, Bellio L4, Bordignon C5, Bicciato S3, Peccatori J2, Ciceri F2, Bonini C1
Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious diseases, Program in Immunology and Bio-immunotherapy of Cancer (PIBIC), San Raffaele Scientific Institute, Milan, Italy1; Hematology and Bone Marrow Transplantation Unit, Department of Oncology, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy2; Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy3; Unit of Molecular and Functional Immunogenetics, Division of Regenerative Medicine, Stem cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy4; University Vita-Salute San Raffaele, Milan, Italy5
Immune Reconstitution / Immunocompetence in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplants
Leventhal et al.
Papers
Transplantation
February 2015
Authors and Affiliates
Leventhal JR1, Elliot MJ2, Yolcu ES2, Bozulic LD3, Tollerud DJ2, 3, Mathew JM1, Konieczna I1, Ison MG1, Galvin J1, Mehta J1, Badder MD2, Abecassis MMI1, Miller J1, Gallon L1, Ildstad ST2,3.
1Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; 2Institute for Cellular Therapeutics, University of Louisville, KY; 3Regenerex, LLC, Louisville, KY.
Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation
Nair et al.
Blood
Papers
February 2015
Authors and Affiliates
Nair S1, Boddupalli CS1, Verma R1, Liu J2, Yang R2, Pastores GM3, Mistry PK4, Dhodapkar MV5
1Section of Hematology and 2Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT; 3Department of Neurology and Pediatrics, New York University School of Medicine, New York, NY; and. 4Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT; Yale Liver Center and. 5Section of Hematology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT.
T-Cell Receptor Sequencing Reveals the Clonal Diversity and Overlap of Colonic Effector and FOXP3+ T Cells in Ulcerative Colitis
Lord et al.
Inflamm Bowel Dis
Papers
January 2015
Authors and Affiliates
Lord J1,2, Chen J1, Thirlby RC3, Sherwood AM4, Carlson CS4,5
Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA1; Departments of Gasterenterology2 and Surgery3, Virginia Mason Medical Center, Seattle, WA; Adaptive Biotechnologies, Seattle, WA4; Fred Hutchinton Cancer Research Center, Seattle, WA5
Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients
Morris et al.
Science Translational Medicine
January 2015
Authors and Affiliates
Morris H1, DeWolf S1, Robins H2, Sprangers B1, LoCascio SA1, Shonts BA1, Kawai T3, Wong W1, Yang S1, Zuber J1, Shen Y1, Sykes M1
Columbia University Medical Center, New York, NY1; Fred Hutchinson Cancer Research Center, Seattle, WA2; Massachusetts General Hospital, Boston, MA3
A Circulating Reservoir of Pathogenic-Like CD4+ T Cells Shares a Genetic and Phenotypic Signature with the Inflamed Synovial Micro-Environment
Authors and Affiliates
Spreafico R1,2, Rossetti M1,2, van Loosdregt J1, Wallace CA3, Massa M4, Magni-Manzoni S5, Gattorno M6, Martini A6, Lovell DJ7,8, Albani S1,2
Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, CA1; Singhealth Translational Immuology and Inflammation Centre, Singhealth and Duke-NUS Graduate Medical School, Singapore, Singapore2; Seattle Children's Hospital and Research Institute, Seattle, WA3; Lab Biotecnologie, Fondazione IRCCS Piloclinico San Matteo, Pavia, Italy4; Pediatric Rheumatology Unit, IRCCS Ospedale Pediatrico Bambino Gesu, Rome, Italy5; Second Pediatrics Division, University of Genoa and G Gaslini Institute, Genova, Italy6; Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH7; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH8