Therapeutic Area: Autoimmune

Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis

Henderson et al.
Arthritis & Rheumatology
Papers
January 2016
immuneAccess
Authors and Affiliates
Lauren A. Henderson, MD, MMSc1 ; Stefano Volpi, MD1 ; Francesco Frugoni, MS1 ; Erin Janssen, MD, PhD1 ; Susan Kim, MD, MMSc1 ; Robert P. Sundel, MD1 ; Fatma Dedeoglu, MD1 ; Mindy S. Lo, MD, PhD1 ; Melissa M. Hazen, MD1 ; Mary Beth Son, MD1 ; Ronald Mathieu, MStox, MPHD2 ; David Zurakowski, PhD3 ; Neng Yu, MD4 ; Tatiana Lebedeva, PhD4 ; Robert C. Fuhlbrigge, MD, PhD1,5; Jolan E. Walter, MD, PhD1,6; Yu Nee Lee, PhD1 ; Peter A. Nigrovic, MD1,7; Luigi D. Notarangelo, MD1,8 1Division of Immunology, Boston Children’s Hospital, Boston, MA 2Division of Hematology and Oncology, Boston Children’s Hospital, Boston, MA 3Department of Anesthesia, Boston Children’s Hospital, Boston, MA 4American Red Cross Blood Services-East Division, New England HLA Services, Dedham, MA 5Department of Dermatology, Brigham and Women’s Hospital, Boston, MA 6Division of Pediatric Allergy/Immunology, Massachusetts General Hospital for Children, Boston, MA, USA 7Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA 8Harvard Stem Cell Institute, Boston, MA

Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis

Shuldt et al.
Papers
PLOS ONE
December 2015
Authors and Affiliates
Nathaniel J. Schuldt1,3, Jennifer L. Auger1,3, Kristin A. Hogquist1,2,3, Bryce A. Binstadt1,3 1Departments of Pediatrics, University of Minnesota, Minneapolis, United States of America, 2Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, United States of America, 3Center for Immunology, University of Minnesota, Minneapolis, United States of America

Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome

Johansen et al.
Clinical Immunology
Papers
October 2015
Authors and Affiliates
Johansen JN1, Vartdal F2, Desmarais C3, Tutturen AE4, de Souza GA5, Lossius A6, Holmøy T7. 1Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. 2Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 3Adaptive Biotechnologies, Seattle, WA, USA. 4Centre for Immune Regulation, Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. 5Centre for Immune Regulation, Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Centre for Immune Regulation, Department of Immunology, University of Oslo, Oslo, Norway. 6Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway. Electronic address: andreas.lossius@rr-research.no. 7Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.

Planas et al.
Annals of Clinical and Translational Neurology
Papers
September 2015
Authors and Affiliates
Planas R1, Metz I2, Ortiz Y1, Vilarrasa N1, Jelčić I1, Salinas-Riester G3, Heesen C4, Brück W2, Martin R1, Sospedra M1. 1Neuroimmunology and MS Research (nims), Department of Neurology, University Zurich Frauenklinikstrasse 26, 8091, Zürich, Switzerland. 2Institute of Neuropathology, University Medical Center Göttingen Göttingen, Germany. 3Department of Developmental Biochemistry, DNA Microarray and Deep-Sequencing Facility, Faculty of Medicine, University Medical Center Göttingen Göttingen, Germany. 4Institute for Neuroimmunology and Clinical MS Research (inims), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf Falkenried 94, 20251, Hamburg, Germany.

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome

Kolhatkar et al.
Journal of Experimental Medicine
Papers
September 2015
immuneAccess
Authors and Affiliates
Kolhatkar NS1, Brahmandam A2, Thouvenel CD2, Becker-Herman S2, Jacobs HM2, Schwartz MA1, Allenspach EJ1, Khim S2,Panigrahi AK3, Luning Prak ET3, Thrasher AJ4, Notarangelo LD5, Candotti F6, Torgerson TR2, Sanz I7, Rawlings DJ8. 1Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195. 2Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101. 3Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104. 4Molecular Immunology Unit, Section of Molecular and Cellular Immunology, Centre for Immunodeficiency, University College London Institute of Child Health, London WC1N 1EH, England, UK. 5Department of Immunology, Children's Hospital Boston, Boston, MA 09210. 6Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892. 7Lowance Center for Human Immunology and Division of Rheumatology, Department of Medicine, Emory University, Atlanta, GA 30322 Lowance Center for Human Immunology and Division of Rheumatology, Department of Medicine, Emory University, Atlanta, GA 30322. 8Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101

Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing

Thapa et al.
Papers
June 2015
Authors and Affiliates
Dharma R Thapa1, Raffi Tonikian1, 2, Chao Sun1, Mei Liu1, Andrea Dearth1, Michelle Petri3,Francois Pepin4, Ryan O Emerson4 and Ann Ranger1 Biogen, 250 Binney Street, Cambridge1, MA 02142, USA. Novartis Pharmaceuticals Canada Inc, 385 Bouchard Blvd., Dorval, QC H9S 1A9, Canada2. Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore, MD 21205, USA3. Adaptive Biotechnologies, 1551 Eastlake Ave E, #200, Seattle, WA 98102, USA4 .

TCR ITAM multiplicity is required for the generation of follicular helper T-cells

Hwang et al.
Nature Communications
Papers
June 2015
Authors and Affiliates
Hwang S1, Palin AC1, Li L1, Song KD1, Lee J1, Herz J2, Tubo N3, Chu H3, Pepper M3, Lesourne R1, Zvezdova E1, Pinkhasov J1, Jenkins MK3, McGavern D2, Love PE1. 1Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Room 2B-210, Building 6B, Bethesda, Maryland 20892, USA. 2Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. 3Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.