Therapeutic Area: Autoimmune

Suppression by Tfr cells leads to durable and selective inhibition of B cell effector function

Sage et al.
Nature Immunology
Papers
October 2016
Authors and Affiliates
Peter T Sage1,2, Noga Ron-Harel3, Vikram R Juneja1,2, Debattama R Sen4, Seth Maleri1,2, Waradon Sungnak2,5, Vijay K Kuchroo2,5, W Nicholas Haining4, Nicolas Chevrier6, Marcia Haigis3 & Arlene H Sharpe1,2,7 1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA. 2Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts, USA. 3Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. 4Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. 5Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 6FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA. 7Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Kordasti et al.
Blood
Papers
September 2016
Authors and Affiliates
Shahram Kordasti,1,2,* Benedetta Costantini,1,2,* Thomas Seidl,1,* Pilar Perez Abellan,2 Marc Martinez Llordella,3 Donal McLornan,2 Kirsten E. Diggins,4 Austin Kulasekararaj,2 Cinzia Benfatto,1 Xingmin Feng,5 Alexander Smith,1,2 Syed A. Mian,1 Rossella Melchiotti,6 Emanuele de Rinaldis,6 Richard Ellis,6 Nedyalko Petrov,6 Giovanni A. M. Povoleri,3 Sun Sook Chung,1 N. Shaun B. Thomas,1 Farzin Farzaneh,1 Jonathan M. Irish,4 Susanne Heck,6 Neal S. Young,5 Judith C. W. Marsh,1,2 and Ghulam J. Mufti1,2 1Department of Haematological Medicine, King’s College London, London, United Kingdom; 2Haematological Medicine, King’s College Hospital, London, United Kingdom; 3Division of Transplantation Immunology & Mucosal Biology, King’s College London, London, United Kingdom; 4Department of Cancer Biology, Vanderbilt University, Nashville, TN; 5Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; and 6National Institute for Health Research Biomedical Research Centre, King’s College London, London, United Kingdom

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis

Rossetti et al.
Annals of Rheumatic Disease
Papers
June 2016
immuneAccess
Authors and Affiliates
Maura Rossetti1,2,3, Roberto Spreafico1,2,4, Alessandro Consolaro5, Jing Yao Leong1,Camillus Chua1, Margherita Massa6, Suzan Saidin1, Silvia Magni-Manzoni7,Thaschawee Arkachaisri8, Carol A Wallace9, Marco Gattorno5, Alberto Martini5,Daniel J Lovell10, Salvatore Albani1 1SingHealth Translational Immunology and Inflammation Centre, SingHealth and Duke-NUS Graduate Medical School, Singapore, Singapore, 2Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, California, USA, 3Department of Pathology and Laboratory Medicine, University of California Los Angeles,Los Angeles, California, USA, 4Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA, 5Second Pediatrics Division, University of Genoa and G Gaslini Institute, Genova, Italy, 6Lab Biotecnologie, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 7Pediatric Rheumatology Unit, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 8Duke-NUS Graduate Medical School and Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, 9Seattle Children's Hospital and Research Institute, Seattle, Washington, USA, 10Division of Rheumatology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Daratumumab Depletes CD38 + Immune-regulatory Cells, Promotes T-cell Expansion, and Skews T-cell Repertoire in Multiple Myeloma

Krejcik et al.
Blood
Papers
May 2016
Authors and Affiliates
Jakub Krejcik, MD1,2 ; Tineke Casneuf, PhD3 ; Inger S. Nijhof, MD1 ; Bie Verbist, PhD3 ; Jaime Bald, BS4 ; Torben Plesner, MD2 ; Khaja Syed, MS4 ; Kevin Liu, PhD5 ; Niels W.C.J. van de Donk, MD1 ; Brendan M. Weiss, MD6 ; Tahamtan Ahmadi, MD4 ; Henk M. Lokhorst, MD1 ; Tuna Mutis, MD1 ; and A. Kate Sasser, PhD4 1Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands 2Vejle Hospital and University of Southern Denmark, Vejle, Denmark 3Janssen Research & Development, Beerse, Belgium 4Janssen Research & Development, LLC, Spring House, PA, USA 5Janssen Research & Development, LLC, Raritan, NJ, USA 6Division of Hematology-Oncology, Department of Medicine, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

High-throughput sequencing reveals restricted TCR VB usage and public TCRB clonotypes among pancreatic lymph node memory CD4+ T cells and their involvement in autoimmune diabetes

Marrero et al.
Molecular Immunology
Papers
May 2016
Authors and Affiliates
Idania Marrero,a,b Carlos Aguileraa,1 David E. Hamm,c Anthony Quinn,d Vipin Kumar,a,b aTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA bDepartment of Medicine, University of California San Diego, La Jolla, CA 92037, USA cAdaptive Biotechnologies, 1551 Eastlake Ave E #200, Seattle, WA 98102, USA dDepartment of Biological Sciences, University of Toledo, 2801 W Bancroft St., Toledo, OH 43606, USA

On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments

Toor
Papers
The Royal Society Interface
January 2016
Authors and Affiliates
Toor AA1, Toor AA2, Rahmani M3, Manjili MH4 1Bone Marrow Transplant Program, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA 2School of Engineering, Virginia Commonwealth University, Richmond, VA, USA. 3Hematology and Oncology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA. 4Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA.

Short-term assessment of BCR repertoires of SLE patients after high dose glucocorticoid therapy with high-throughput sequencing

Shi et al.
Papers
January 2016
Authors and Affiliates
Bin Shi,1 Jiang Yu,2 Long Ma,3 Qingqing Ma,4 Chunmei Liu,5 Suhong Sun,6 Rui Ma,3 Xinsheng Yao3 1Department of Laboratory Medicine, Zunyi Medical University, Zunyi, 563000 China. 2Cell Engineering Laboratory, The First Affiliated Hospital of ZunYi Medical University, Zunyi, China. 3Department of Immunology, Research Center for Medicine and Biology, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, 563000 China. 4Central Laboratory, Guizhou Aerospace Hospital, Zunyi, China. 5Department of Nephropathy and Rheumatology, The First Affiliated Hospital of ZunYi Medical University, Zunyi, China. 6Department of Breast Surgery, The First Affiliated Hospital of ZunYi Medical University, Zunyi, China.

High-throughput sequencing of immune repertoires in multiple sclerosis

Lossius et al.
Annals of Clinical and Translational Neurology
January 2016
Authors and Affiliates
Andreas Lossius1,2,3, Jorunn N. Johansen1, Frode Vartdal1,3 & Trygve Holmøy3,4 1Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway 2Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway 3Institute of Clinical Medicine, University of Oslo, Oslo, Norway 4Department of Neurology, Akershus University Hospital, Lørenskog, Norway