Therapeutic Area: Autoimmune

In vivo enrichment of diabetogenic T cells

Thelin et al.
Diabetes
Papers
April 2017
Authors and Affiliates
Martin A. Thelin1, Stephan Kissler1, Frederic Vigneault3, Alexander L. Watters3, Des White2,3, Sandeep T. Koshy2,3,4, Sarah A. Vermillion3, David J. Mooney2,3, Thomas Serwold1 and Omar A. Ali3 1Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA, 02215, USA
, 2School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA., 3Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, USA., 4Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

The Lower Limit of Regulatory CD4+ Foxp3+ TCRb Repertoire Diversity Required To Control Autoimmunity

Yu et al.
Journal of Immunology
Papers
March 2017
Authors and Affiliates
Aixin Yu,* Michael J. Dee,* Dennis Adeegbe,*, Connor J. Dwyer,* Norman H. Altman,† and Thomas R. Malek*,‡ *Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136; †Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136; and ‡Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

Cheuk et al.
Immunity
Papers
February 2017
immuneAccess
Authors and Affiliates
Stanley Cheuk,1 Heinrich Schlums,2 Irene Gallais Serezal,1,3 Elisa Martini,1 Samuel C. Chiang,2 Nicole Marquardt,3 Anna Gibbs,1 Ebba Detlofsson,1 Andrea Introini,1 Marianne Forkel,3 Charlotte Hoog,4 Annelie Tjernlund,1 Jakob Michaelsson,3 Lasse Folkersen,5 Jenny Mjosberg,3 Lennart Blomqvist,6 Marcus Ehrstrom,7 Mona Stahle,1,3 Yenan T. Bryceson,2,8 and Liv Eidsmo1,3 1Department of Medicine Solna, Karolinska Institutet, Stockholm 171 77, Sweden, 2Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 3Dermatology Department, Karolinska University Hospital, Stockholm 141 86, Sweden, 4Unit for Inflammation, Gastroenterology and Rheumatology, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 5Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Building 208, DK-2800 Kongens Lyngby 2800, Denmark, 6Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 7Department of Reconstructive Plastic Surgery, Karolinska University Hospital Solna, Stockholm 171 76, Sweden, 8Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway

Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney/Bone Marrow Transplantation to Induce Transplantation Tolerance

Sprangers et al.
American Journal of Transplantation
Papers
February 2017
Authors and Affiliates
Ben Sprangers1, Susan DeWolf1, Thomas M. Savage1, Tatsuaki Morokata2, Aleksandar Obradovic1, Samuel A. LoCascio1, Brittany Shonts1, Julien Zuber1, Sai ping Lau1, Ravi Shah1, Heather Morris1, Valeria Steshenko6, Emmanuel Zorn1, Frederic I. Preffer3, Sven Olek7, David M. Dombkowski3, Laurence A. Turka2,5, Robert Colvin3, Robert Winchester6, Tatsuo Kawai4, and Megan Sykes1,2 1Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital (MGH)/Harvard Medical School (HMS), Boston, MA, USA, 3Department of Pathology, MGH/ HMS, Boston, MA, USA, 4Transplantation Unit, Department of Surgery, MGH/HMS, Boston, MA, USA, 5Immune Tolerance Network, Seattle, WA, USA, 6Division of Rheumatology, Department of Medicine, Columbia University Medical Center, New York, NY, USA

BRILIA: Integrated Tool for High-Throughput Annotation and Lineage Tree Assembly of B-Cell Repertoires

Lee et al.
Frontiers in Immunology
Papers
January 2017
Authors and Affiliates
Donald W. Lee1, Ilja V. Khavrutskii1, Anders Wallqvist1, Sina Bavari2, Christopher L. Cooper2, and Sidhartha Chaudhury1 1Biotechnology HPC Software Applications Institute (BHSAI), Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, USA, 2Molecular and Translational Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA

Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes

Seay et al
JCI Insight
Papers
December 2016
immuneAccess
Authors and Affiliates
Howard R. Seay,1 Erik Yusko,2 Stephanie J. Rothweiler,1 Lin Zhang,1 Amanda L. Posgai,1 Martha Campbell-Thompson,1 Marissa Vignali,2 Ryan O. Emerson,2 John S. Kaddis,3 Dave Ko,3 Maki Nakayama,4 Mia J. Smith,5 John C. Cambier,5 Alberto Pugliese,6 Mark A. Atkinson,1 Harlan S. Robins,2,7 and Todd M. Brusko1 1Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, Florida, USA. 2Adaptive Biotechnologies Corporation, Seattle, Washington, USA. 3Department of Information Sciences, City of Hope National Medical Center, Duarte, California, USA. 4Barbara Davis Center for Childhood Diabetes and 5Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA. 6Diabetes Research Institute and Departments of Medicine, Microbiology, and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA. 7Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites

Thome et al
Papers
Science Immunology
December 2016
immuneAccess
Authors and Affiliates
Joseph J. C. Thome,1,2* Boris Grinshpun,3* Brahma V. Kumar,1 Masaru Kubota,1,4 Yoshiaki Ohmura,1,4 Harvey Lerner,5 Gregory D. Sempowski,6 Yufeng Shen,3 Donna L. Farber1,2,4† 1 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA. 2 Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. 3 Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA. 4 Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA. 5 LiveOnNY, New York, NY 10001, USA. 6 Human Vaccine Institute, Duke University, Durham, NC 27710, USA.

Discovery of T-Cell Receptor Beta Motifs Specific to HLA-B27+ Ankylosing Spondylitis by Deep Repertoire Sequence Analysis

Faham et al
Arthritis & Rheumatology
Papers
December 2016
Authors and Affiliates
Malek Faham, MD, PhD1*, Victoria Carlton, PhD1, Martin Moorhead, PhD1, Jianbiao Zheng, PhD1, Mark Klinger, PhD1, Francois Pepin, PhD1, Thomas Asbury, PhD1, Marissa Vignali, PhD1, Ryan O. Emerson, PhD1, Harlan S. Robins, PhD 1,2, James Ireland, MSc3, Emily Baechler-Gillespie, PhD4, and Robert D. Inman, MD5 1Adaptive Biotechnologies Corp., South San Francisco, CA and Seattle, WA; 2Fred Hutchinson Cancer Research Center, Seattle WA, 3Alternate Allele Consulting, Orinda, CA; 4University of Minnesota, Minneapolis, MN; 5Toronto Western Hospital, University of Toronto, Toronto, ON

Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating αβ T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients

Dandekar et al.
Frontiers in Immunology
Papers
December 2016
Authors and Affiliates
Sugandha Dandekar1, Hemani Wijesuriya2, Tim Geiger3, David Hamm3, Gary W. Mathern4,5,6,7 and Geoffrey C. Owens4* 1Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 2Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 3Adaptive Biotechnologies Inc., Seattle, WA, USA, 4Department of Neurosurgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 5Intellectual and Developmental Disabilities Research Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 6Brain Research Institute, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA, 7Mattel Children’s Hospital, Los Angeles, CA, USA

Autoimmune Renal Disease Is Exacerbated by S1P- Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney

Krebs et al.
Immunity
Papers
November 2016
Authors and Affiliates
Christian F. Krebs,1 Hans-Joachim Paust,1 Sonja Krohn,1 Tobias Koyro,1 Silke R. Brix,1 Jan-Hendrik Riedel,1 Patricia Bartsch,1 Thorsten Wiech,2 Catherine Meyer-Schwesinger,1 Jiabin Huang,3 Nicole Fischer,3 Philipp Busch,4 Hans-Willi Mittrucker,5 Ulrich Steinhoff,6 Brigitta Stockinger,7 Laura Garcia Perez,8 Ulrich O. Wenzel,1 Matthias Janneck,1 Oliver M. Steinmetz,1 Nicola Gagliani,4 Rolf A.K. Stahl,1 Samuel Huber,8 Jan-Eric Turner,1 and Ulf Panzer1,9 1Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 2Institut für Pathologie, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 3Institut für Medizinische Mikrobiologie, Virologie, und Hygiene, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 4Klinik für Allgemeinchirurgie, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 5Institut für Immunologie, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 6Philipps-Universität Marburg, Institut für Medizinische Mikrobiologie und Krankenhaushygiene, 35043 Marburg, Germany. 7The Francis Crick Institute, Midland Road, London NW1 1AT, UK. 8Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany. 9Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany.