Therapeutic Area: Autoimmune

Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis

Rathbone et al.
Journal of Neurology
Neurosurgery
Papers
Psychiatry
April 2018
Authors and Affiliates
Emma Rathbone,1 Lindsay Durant,1 James Kinsella,1 Antony R Parker,2 Ghaniah Hassan-Smith,1 Michael R Douglas,3,4 S John Curnow5 1Centre for Translational Inflammation Research Institute of Inflammation and Ageing, College of Medical and Dental Sciences University of Birmingham, Birmingham, UK 2The Binding Site Group Ltd, Birmingham, UK 3Department of Neurology, Dudley Group NHS Foundation Trust, Russells Hall Hospital, Birmingham, UK 4School of Life and Health Sciences, Aston University, Birmingham, UK 5Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2WB, UK

Abnormalities of T-cell receptor repertoire in CD4+ regulatory and conventional T cells in patients with RAG mutations: Implications for autoimmunity

Rowe et al.
Journal of Allergy and Clinical Immunology
Papers
December 2017
immuneAccess
Authors and Affiliates
Jared H. Rowe, MD, PhDa, Brian D. Stadinski, PhDb, Lauren A. Henderson, MDa, Lisa Ott de Bruin, MDa, Ottavia Delmonte, MDa, Yu Nee Lee, PhDc, M. Teresa de la Morena, MDd, Rakesh K. Goyal, MDe, Anthony Hayward, MD, PhDf, Chiung-Hui Huang, PhDg, Maria Kanariou, MDh, Alejandra King, MDi, Taco W. Kuijpers, MDj, Jian Yi Soh, MDg, Benedicte Neven, MD, PhDk, Jolan E. Walter, MD, PhDl, Eric S. Huseby, PhDb, Luigi D. Notarangelo, MDm aThe Division of Immunology, Boston Children’s Hospital, Boston, Mass; bthe Department of Pathology, University of Massachusetts Medical School, Worcester, Mass; cthe Pediatric Department A and the Immunology Service, ‘‘Edmond and Lily Safra’’ Children’s Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; dthe Division of Allergy and Immunology, University of Texas, Southwestern Medical Center, Dallas, Tex; ethe Division of Hematology/Oncology/BMT, Children’s Mercy Hospital & Clinics, Kansas City, Mo; fthe Department of Pediatrics, Brown University, Providence, RI; gthe Department of Pediatrics, National University of Singapore, Singapore; hthe Department of Immunology-Histocompatibility, ‘‘Aghia Sophia’’ Children’s Hospital, Athens, Greece; ithe Division of Pediatric Immunology, Hospital Luis Calvo Mackenna, Santiago, Chile; jthe Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; kthe Pediatric Hematology-Immunology Department, Hospital Necker-Enfants Malades, AP-HP, Paris Descartes University, Sorbonne-Paris-Cite, Institut Imagine, Paris, France; lthe Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St Petersburg, Fla; and mthe Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Case report for recurrent and new-onset SLE patients treated by high-dose glucocorticoid therapy

Yu et al.
Medicine
Papers
December 2017
Authors and Affiliates
Jiang Yu, MMa,b, Bin Shi, MMa,c, Long Ma, MMa, Chunmei Liu, MMd, Suhong Sun, MMe, Rui Ma, MSa, Yuehong Qiu, MMf, Xinsheng Yao, MD, PhDa aDepartment of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, bCell Engineering Laboratory, The First Affiliated Hospital of ZunYi Medical University, cDepartment of Laboratory Medicine, Zunyi Medical University, dDepartment of Nephropathy and Rheumatology, eDepartment of Breast Surgery, The first Affiliated Hospital of ZunYi Medical University, Zunyi, fDepartment of Gastroenterology,Rizhao People’s Hospital, Rizhao, China.

Deep sequencing of blood and gut T-cell receptor β-chains reveals gluten-induced immune signatures in celiac disease

Yohannes et al.
Papers
Scientific Reports
December 2017
Authors and Affiliates
Dawit A. Yohannes1,2, Tobias L. Freitag1,3, Andrea de Kauwe1,2, Katri Kaukinen4, Kalle Kurppa5, Pirjo Wacklin6, Markku Mäki5, T. Petteri Arstila1,3, Robert P. Anderson7,9, Dario Greco8,10 & Päivi Saavalainen1,2 1Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland. 2Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. 3Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. 4Department of Internal Medicine, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 5Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland. 6Finnish Red Cross Blood Transfusion Service, Helsinki, Finland. 7Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. 8Institute of Biotechnology, University of Helsinki, Helsinki, Finland. 9Present address: ImmusanT, Inc., Cambridge, MA, USA. 10Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes

Gomez-Tourino et al.
Nature Communications
Papers
November 2017
immuneAccess
Authors and Affiliates
Iria Gomez-Tourino1,2,3, Yogesh Kamra1, Roman Baptista1,2, Anna Lorenc1 & Mark Peakman1,2 1Department of Immunobiology, Faculty of Life Sciences & Medicine, King’s College London, 2nd Floor, Borough Wing, Guy’s Hospital, London SE1 9RT, UK. 2National Institute for Health Research, Biomedical Research Centre at Guy’s and St Thomas’ Hospital Foundation Trust and King’s College London, Guy’s Hospital, London SE1 9RT, UK. 3Present address: Immunology Laboratory, Biomedical Research Center (CINBIO), Centro Singular de Investigación de Galicia, University of Vigo, Campus Universitario de Vigo, Pontevedra 36310, Spain

In Silico Prediction Analysis of Idiotope-Driven T–B Cell Collaboration in Multiple Sclerosis

Høglund et al.
Frontiers in Immunology
Papers
October 2017
Authors and Affiliates
Rune A. Høglund1,2, Andreas Lossius1,3, Jorunn N. Johansen3, Jane Homan4, Jūratė Šaltytė Benth2,5, Harlan Robins6, Bjarne Bogen2,3,7, Robert D. Bremel4 and Trygve Holmøy1,2 1Department of Neurology, Akershus University Hospital, Lørenskog, Norway, 2Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 3Faculty of Medicine, Department of Immunology and Transfusion Medicine, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway, 4EigenBio LLC, Madison, WI, United States, 5Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway, 6Adaptive Biotechnologies, Seattle, WA, United States, 7Centre for Immune Regulation, University of Oslo, Oslo, Norway

Clinically resolved psoriatic lesions contain psoriasis- specific IL-17–producing αβ T cell clones

Matos et al.
Journal of Clinical Investigation
Papers
October 2017
Authors and Affiliates
Tiago R. Matos,1,2,3 John T. O’Malley,1 Elizabeth L. Lowry,1 David Hamm,4 Ilan R. Kirsch,4 Harlan S. Robins,4 Thomas S. Kupper,1 James G. Krueger,5 and Rachael A. Clark1 1Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal. 3Academic Medical Center, Department of Dermatology, University of Amsterdam, Amsterdam, The Netherlands. 4Adaptive Biotechnologies, Seattle, Washington, USA. 5Department of Dermatology, Rockefeller University, New York, New York, USA.

An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis

Nicol et al.
Journal of Autoimmunity
Papers
October 2017
Authors and Affiliates
Bryan Nicola, b, Marion Saloua, b, Isabel Vogela, c, Alexandra Garciaa, c, Emilie Dugasta, c, Jeremy Morillea, b, c, Stephanie Kilensa, Eric Charpentierd, Audrey Donnartd, Steven Nedellece, Marylene Jacq-Foucherf, Fabienne Le Freref, Sandrine Wiertlewskie, f, Arnaud Bourreilleg, h, Sophie Brouarda, c, Laure Michela, b, f, Laurent Davida, i, j, k, l, m, Pierre-Antoine Gourrauda, Nicolas Degauquea, c, Arnaud B. Nicota, b, c, Laureline Berthelota, b, c, David-Axel Laplauda, b, f, g aCentre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universite de Nantes, Nantes, France bFaculte de M edecine, Universite de Nantes, Nantes, France cInstitut de Transplantation Urologie Nephrologie (ITUN), CHU Nantes, Nantes, France dINSERM UMR1087, CNRS UMR6291, Universite de Nantes, l'institut du thorax, Nantes, F-44000, France eSFR François Bonamy, Cellular and Tissue Imaging Core Facility (MicroPICell), Nantes, France fService de Neurologie, CHU Nantes, Nantes, France gINSERM 015, Centre d’Investigation Clinique, Nantes, France hInstitut des Maladies de l'Appareil Digestif, CIC-04 Inserm, CHU Nantes, Nantes, France iINSERM UMS 016, SFR Francois Bonamy, iPSC Core Facility, Nantes, France jUMR CNRS 3556, Nantes, F-44000, France kUniversite de Nantes, Nantes, F-44000, France lCHU de Nantes, Nantes, F-44000, France mLabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France

Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity

Allenspach et al.
Letter to the Editor: Journal of Allergy and Clinical Immunology
Papers
May 2017
immuneAccess
Authors and Affiliates
Eric J. Allenspach, MD, PhDa,b Laura S. Finn, MDc,d Mara H. Rendi, MD, PhDd Ahmet Eken, PhDb Akhilesh K. Singh, PhDb Mohamed Oukka, PhDb Sean D. Taylor, PhDb Matthew C. Altman, MDe,f Corinne L. Fligner, MDd,g Hans D. Ochs, MDa,b David J. Rawlings, MDa,b Troy R. Torgerson, MD, PhDa,b aThe Department of Pediatrics, University of Washington School of Medicine, bThe Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, cThe Department of Laboratories, Seattle Children’s Hospital, dThe Department of Pathology, University of Washington School of Medicine, eBenaroya Research Institute, fThe Department of Medicine, University of Washington School of Medicine, and gThe Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington

T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ

Oftedal et al.
Journal of Autoimmunity
Papers
April 2017
Authors and Affiliates
Bergithe E. Oftedal a,b, Brita Ardesjo Lundgren a,c, David Hammd, Poh-Yi Gane, Stephen R. Holdsworthe, Christopher N. Hahna,i, Andreas W. Schreiberf,i,Hamish S. Scotta,f,g,h,i aDepartment of Genetics and Molecular Pathology, Centre for Cancer Biology, An Alliance Between SA Pathology and the University of South Australia, Adelaide, Australia, bDepartment of Clinical Science, University of Bergen, Norway, cDepartment of Medical Biochemistry and Microbiology, Uppsala University, Sweden, dAdaptive Biotechnologies, 1551 Eastlake Ave E #200, Seattle, WA, 98102, USA, eCentre for Inflammatory Diseases, Monash University Department of Medicine, Clayton, Australia, fACRF Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, Australia gSchool of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Australia, hSchool of Biological Sciences, University of Adelaide, Australia, iSchool of Medicine, University of Adelaide, Adelaide, Australia