Therapeutic Area: Autoimmune
T cell clonal expansions in ileal Crohn’s disease are associated with smoking behaviour and postoperative recurrence
Authors and Affiliates
Allez M1,2, Auzolle C1, Ngollo M2, Bottois H2, Chardiny V2, Corraliza AM3, Salas A3, Perez K2, Stefanescu C4, Nancey S5, Buisson A6, Pariente B7, Fumery M8, Sokol H9, Tréton X10, Barnich N11, Seksik P9, Le Bourhis L2; REMIND Study Group;
Author information
1
Department of Gastroenterology, Hopital Saint Louis, Paris, France.
2
INSERM U1160, Hôpital Saint-Louis, Paris, France.
3
Hospital Clinic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain.
4
Service de Gastroentérologie, MICI et Assistance Nutritive, Hôpital Beaujon, Clichy, France.
5
Department of Gastroenterology, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre Benite, Lyon, France.
6
Gastroenterology Department, University Hospital Estaing, Clermont-Ferrand, France.
7
Department of Gastroenterology, Hopital Claude huriez, Lille, France.
8
Hepato-Gastroenterology Department, CHU Amiens, Amiens, France.
9
Department of Gastroenterology, Hopital Saint-Antoine, Paris, Île-de-France, France.
10
Service de Gastroentérologie, MICI et Assistance Nutritive, Hopital Beaujon, Clichy, France.
11
M2iSH, UMR Inserm U1071, USC INRA 2018, Université d'Auvergne, Clermont Ferrand, France.
Strong Selection of a Few Dominant CD8 Clones in a TLR7-Dependent Autoimmune Mouse Model
Authors and Affiliates
Peter A. Morawski and Silvia Bolland
Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health,
Rockville, MD 20852
Altered T Cell Receptor Beta Repertoire Patterns in Pediatric Ulcerative Colitis
Authors and Affiliates
Werner L1,2, Nunberg MY1,2, Rechavi E2,3,4,5, Lev A2,3,4,5, Braun T1,2, Haberman Y1,2, Lahad A1,2, Shteyer E6, Schvimer M7, Somech R2,3,4,5, Weiss B1,2, Lee YN2,3,4,5, Shouval DS1,2.
1
Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
2
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
3
Pediatric Department A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
4
Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
5
Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
6
Juliet Keidan Institute of Pediatric Gastroenterology, Hepatology and Nutrition, Shaare Zedek Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israel.
7
Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel.
Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa
Povoleri et al.
Nature Immunology
December 2018
Authors and Affiliates
Povoleri GAM1,2, Nova-Lamperti E1,2, Scottà C1,2, Fanelli G1,2, Chen YC3, Becker PD1,2, Boardman D1,2, Costantini B4, Romano M1,2, Pavlidis P1,2, McGregor R1,2, Pantazi E1,2, Chauss D5, Sun HW6, Shih HY7, Cousins DJ8, Cooper N9, Powell N1,2, Kemper C10, Pirooznia M3, Laurence A11, Kordasti S4, Kazemian M12, Lombardi G1,2, Afzali B13,14,15
1
MRC, Centre for Transplantation, King's College London, London, UK.
2
National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.
3
Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
4
Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
5
Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
6
Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
7
Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
8
Department of Infection, Immunity and Inflammation, NIHR Leicester Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK.
9
Department of Medicine, Imperial College London, London, UK.
10
Complement and Inflammation Research Section, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
11
Institute of Cellular Medicine, Newcastle University, Newcastle, UK.
12
Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA.
13
MRC, Centre for Transplantation, King's College London, London, UK. behdad.afzali@nih.gov.
14
Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov.
15
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov.
High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata
Authors and Affiliates
de Jong A1, Jabbari A1, Dai Z1, Xing L2, Lee D1, Li MM1, Duvic M3, Hordinsky M4, Norris DA5, Price V6, Mackay-Wiggan J1, Clynes R1, Christiano AM1,7
1 Department of Dermatology and.
2 Department of Pathology, Columbia University, New York, New York, USA.
3 Department of Dermatology, MD Anderson Cancer Center, Houston, Texas, USA.
4 Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA.
5 Department of Dermatology, University of Colorado, Denver, Colorado, USA.
6 Department of Dermatology, UCSF, San Francisco, California, USA.
7 Department of Genetics and Development, Columbia University, New York, New York, USA.
Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis
Authors and Affiliates
Ivan Jelcic,1 Faiez Al Nimer,1,2 Jian Wang,1 Verena Lentsch,1 Raquel Planas,1 Ilijas Jelcic,1 Aleksandar Madjovski,1 Sabrina Ruhrmann,2 Wolfgang Faigle,1 Katrin Frauenknecht,3 Clemencia Pinilla,4 Radleigh Santos,5 Christian Hammer,6,7 Yaneth Ortiz,1 Lennart Opitz,8 Hans Gronlund,9 Gerhard Rogler,10 Onur Boyman,11 Richard Reynolds,12 Andreas Lutterotti,1 Mohsen Khademi,2 Tomas Olsson,2 Fredrik Piehl,2 Mireia Sospedra,1 and Roland Martin1
1Neuroimmunology and MS Research Section (NIMS), Neurology Clinic, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 2Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, 17176 Stockholm, Sweden 3Institute of Neuropathology, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 4Torrey Pines Institute for Molecular Studies (TPIMS), San Diego, CA, USA 5Torrey Pines Institute for Molecular Studies (TPIMS), Port St. Lucie, FL, USA 6School of Life Sciences, E cole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland 7Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland 8Functional Genomics Center Zurich, Swiss Federal Institute of Technology and University of Zurich, 8057 Zurich, Switzerland 9Therapeutic Immune Design Unit, Department of Clinical Neuroscience, Karolinska Institutet, 17176 Stockholm, Sweden 10Department of Gastroenterology and Hepatology, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 11Department of Immunology, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 12Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
T cells in patients with narcolepsy target self-antigens of hypocretin neurons
Authors and Affiliates
Latorre D1,2, Kallweit U3,4, Armentani E1, Foglierini M1,5, Mele F1, Cassotta A1,2, Jovic S1, Jarrossay D1, Mathis J3, Zellini F6, Becher B7, Lanzavecchia A1, Khatami R8, Manconi M3,6, Tafti M9, Bassetti CL10, Sallusto F11,12
1Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland. 2Institute of Microbiology, ETH Zurich, Zurich, Switzerland. 3Department of Neurology, University Hospital, Bern, Switzerland. 4Institute of Immunology, University of Witten/Herdecke, Witten, Germany. 5Swiss Institute of Bioinformatics, Lausanne, Switzerland. 6Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Lugano, Switzerland. 7Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. 8Center for Sleep Research and Sleep Medicine, Clinic Barmelweid, Barmelweid, Switzerland. 9Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. 10Department of Neurology, University Hospital, Bern, Switzerland. 11Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland. 12Institute of Microbiology, ETH Zurich, Zurich, Switzerland.
Identification and Analysis of Islet Antigen–Specific CD8+ T Cells with T Cell Libraries
Ogura et al.
Journal of Immunology
Papers
August 2018
Authors and Affiliates
Hideki Ogura,* Paula Preston-Hurlburt,* Ana Luisa Perdigoto,† Matthew Amodio,‡ Smita Krishnaswamy,‡ Pamela Clark,* Hua Yu,* Dieter Egli,x Alexandra Fouts,+ Andrea K. Steck,+ and Kevan C. Herold*,†
*Department of Immunobiology, Yale University, New Haven, CT 06520; †Department of Internal Medicine, Yale University, New Haven, CT 06520; ‡Department of Genetics and of Computer Science, Yale University, New Haven, CT 06520; xNaomi Berrie Diabetes Center, Division of Molecular Genetics, Columbia University, New York, NY 10032; +Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045
Hypomorphic Rag1 Mutations Alter the Preimmune Repertoire at Early Stages of Lymphoid Development
Authors and Affiliates
L M Ott de Bruin 1 2, M Bosticardo 3, A Barbieri 4, S G Lin 5, J H Rowe 1, P L Poliani 6, K Ching 4, D Eriksson 7, N Landegren 7, O Kämpe 7, J P Manis 4, L D Notarangelo 3;
1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
2Department of Pediatric Immunology, Wilhelmina Children's Hospital, Utrecht University Medical Center, Utrecht, The Netherlands.
3Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
4Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.
5Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA.
6Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; and.
7Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.