Characterisation of T cell receptor repertoires in coeliac disease

Lee LW, et al.
January 2023
Authors and Affiliates
Lik Wee Lee 1, Shahin Shafiani 1, Beryl Crossley 1, Ryan O Emerson 1, David Williamson 1, Anna Bunin 2, Justin Vargas 2, Arnold S Han 2, Ian M Kaplan 1, Peter H R Green 2, Ilan Kirsch 1, Govind Bhagat 3; 1Computational Biology and Translational Medicine, Adaptive Biotechnologies Corp, Seattle, Washington, USA. 2Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, New York, USA. 3Department of Pathology and Cell Biology and Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, New York, USA. gb96@cumc.columbia.edu

BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes

Takahashi H, et al.
Science Advances
November 2022
Authors and Affiliates
Hiroyuki Takahashi 1, Willem M Kühtreiber 1, Ryan C Keefe 1, Amanda H Lee 1, Anna Aristarkhova 1, Hans F Dias 1, Nathan Ng 1, Kacie J Nelson 1, Stephanie Bien 2, Danielle Scheffey 2, Denise L Faustman 1; 1 Immunobiology Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. 2 Adaptive Biotechnologies, Seattle, WA 98109, USA.

Temporal development of T cell receptor repertoires during childhood in health and disease

Mitchell AM, et al.
JCI Insight
September 2022
Authors and Affiliates
Angela M Mitchell 1, Erin E Baschal 1, Kristen A McDaniel 1, Kimber M Simmons 1, Laura Pyle 2, Kathleen Waugh 1, Andrea K Steck 1, Liping Yu 1, Peter A Gottlieb 1, Marian J Rewers 1, Maki Nakayama 1, Aaron W Michels 1; 1 Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, United States of America. 2 Department of Biostatistics and Informatics, University of Colorado School of Pubic Health, Aurora, United States of America.

Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis

Schneider-Hohendorf T, et al.
Journal of Experimental Medicine
September 2022
Authors and Affiliates
Tilman Schneider-Hohendorf #,1, Lisa Ann Gerdes #,2,3,4, Béatrice Pignolet #,5, Rachel Gittelman 6, Patrick Ostkamp 1, Florian Rubelt 7, Catarina Raposo 8, Björn Tackenberg 8,9, Marianne Riepenhausen 1, Claudia Janoschka 1, Christian Wünsch 1, Florence Bucciarelli 5, Andrea Flierl-Hecht 2,3,4, Eduardo Beltrán 2,3,4, Tania Kümpfel 2,3,4, Katja Anslinger 10, Catharina C Gross 1, Heidi Chapman 6, Ian Kaplan 6, David Brassat 8, Hartmut Wekerle 2,11, Martin Kerschensteiner 2,3,4, Luisa Klotz 1, Jan D Lünemann 1, Reinhard Hohlfeld 2,3, Roland Liblau #,5, Heinz Wiendl #,1, Nicholas Schwab #,1; 1 Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. 2 Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians Universität München, Munich, Germany. 3 Biomedical Center, Faculty of Medicine, Ludwig-Maximilians Universität München, Martinsried, Germany. 4 Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. 5 Toulouse Institute for infectious and inflammatory diseases (Infinity), University of Toulouse, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Paul Sabatier, Toulouse, France. 6 Adaptive Biotechnologies, Seattle, WA. 7 Roche Sequencing Solutions, Pleasanton, CA. 8 F. Hoffmann-La Roche Ltd, Basel, Switzerland. 9 Philipps-University, Department of Neurology, Marburg, Germany. 10 Institute of Legal Medicine, Ludwig-Maximilians Universität München, Munich, Germany. 11 Institute for Biological Intelligence, Martinsried, Germany. # Contributed equally.

T Cell Receptor Sequencing Reveals Reduced Clonal Breadth of T Cell Responses against SARS-CoV-2 after Natural Infection and Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Pradier A, et al.
Annals of Oncology
September 2022
Authors and Affiliates
A Pradier 1, A C Mamez 2, C Stephan 3, F Giannotti 3, S Masouridi-Levrat 3, S Wang 4, S Morin 3, D Neofytos 5, D L Vu 5, A Melotti 4, I Arm 6, C S Eberhardt 7, J Tamburini 4, L Kaiser 8, Y Chalandon 1, F Simonetta 9; 1 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 2 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland. Electronic address: anne-claire.mamez@hcuge.ch. 3 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland. 4 Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 5 Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland. 6 Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva, Switzerland. 7 Center for Vaccinology, University Hospitals of Geneva Division of General Pediatrics, Department of Woman, Child and Adolescent Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 8 Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland; Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva, Switzerland; Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland. 9 Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address: federico.simonetta@unige.ch.

Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4

Campisi L, et al.
Nature
August 2022
Authors and Affiliates
Laura Campisi 1, Shahab Chizari 2,3, Jessica S Y Ho 4, Anastasia Gromova 5,6,7,8, Frederick J Arnold 5,6,7,8, Lorena Mosca 9, Xueyan Mei 10, Yesai Fstkchyan 4, Denis Torre 11,12,13, Cindy Beharry 4, Marta Garcia-Forn 14,15,16,17, Miguel Jiménez-Alcázar 18, Vladislav A Korobeynikov 19, Jack Prazich 2,3, Zahi A Fayad 10, Marcus M Seldin 20, Silvia De Rubeis 14,15,16,17, Craig L Bennett 5,6,7,8, Lyle W Ostrow 21, Christian Lunetta 22,23, Massimo Squatrito 18, Minji Byun 24, Neil A Shneider 25, Ning Jiang 2,3, Albert R La Spada 26,27,28,29, Ivan Marazzi 30,31,32; 1 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. laura.campisi@mssm.edu. 2 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. 3 Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA. 4 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5 Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. 6 Department of Neurology, University of California, Irvine, Irvine, CA, USA. 7 Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. 8 UCI Institute for Neurotherapeutics, University of California, Irvine, Irvine, CA, USA. 9 Medical Genetics Unit, Department of Laboratory Medicine, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy. 10 BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 11 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 12 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 13 Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 14 Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 15 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 16 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 17 Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 18 Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain. 19 Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. 20 Department of Biological Chemistry, Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA. 21 Neuromuscular Division of the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 22 NEMO Clinical Center, Fondazione Serena Onlus, Milan, Italy. 23 Neurorehabilitation Department, Istituti Clinici Scientifici Maugeri, IRCCS, Milan, Italy. 24 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 25 Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA. 26 Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 27 Department of Neurology, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 28 Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 29 UCI Institute for Neurotherapeutics, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 30 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu. 31 Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu. 32 Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu.

The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages

Burn TN, et al.
Journal of Immunology
August 2022
Authors and Affiliates
Thomas N Burn 1,2, Charline Miot 3, Scott M Gordon 1,4, Erica J Culberson 3, Tamir Diamond 1,5, Portia A Kreiger 3, Katharina E Hayer 6, Anamika Bhattacharyya 7, Jessica M Jones 7, Craig H Bassing 8,3,9, Edward M Behrens 8,2; 1 Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. 2 Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA. 3 Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA. 4 Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA. 5 Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA. 6 Department of Biomedical and Health Bioinformatics, The Children's Hospital of Philadelphia, Philadelphia, PA. 7 Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC; and. 8 Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; bassing@chop.edu behrens@chop.edu. 9 Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity

Ruck T, et al.
August 2022
Authors and Affiliates
Tobias Ruck 1,2, Sumanta Barman 2, Andreas Schulte-Mecklenbeck 1, Steffen Pfeuffer 1, Falk Steffen 3, Christopher Nelke 1, Christina B Schroeter 2, Alice Willison 2, Michael Heming 1, Thomas Müntefering 2, Nico Melzer 1, Julia Krämer 1, Maren Lindner 1, Marianne Riepenhausen 1, Catharina C Gross 1, Luisa Klotz 1, Stefan Bittner 3, Paolo A Muraro 4, Tilman Schneider-Hohendorf 1, Nicholas Schwab 1, Gerd Meyer Zu Hörste 1, Norbert Goebels 2, Sven G Meuth 1 2, Heinz Wiendl 1; 1 Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, Germany. 2 Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany. 3 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany. 4 Department of Brain Sciences, Imperial College London, London, UK.

Symptom burden and immune dynamics 6 to 18 months following mild SARS-CoV-2 infection -a case-control study

Fjelltveit EB, et al.
August 2022
Authors and Affiliates
Elisabeth B Fjelltveit 1,2, Bjørn Blomberg 3,4, Kanika Kuwelker 3,5, Fan Zhou 1, Therese B Onyango 1, Karl A Brokstad 1,6, Rebecca Elyanow 7, Ian M Kaplan 7, Camilla Tøndel 3,8,9, Kristin G I Mohn 1,5, Türküler Özgümüş 10, Rebecca J Cox 1,2, Nina Langeland 3,4, Bergen COVID-19 Research Group; 1 Influenza Centre, Department of Clinical Science, University of Bergen; Bergen, Norway. 2 Department of Microbiology, Haukeland University Hospital; Bergen, Norway. 3 Department of Clinical Science, University of Bergen; Bergen, Norway. 4 National Advisory Unit for Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital; Bergen, Norway. 5 Department of Medicine, Haukeland University Hospital, Bergen, Norway. 6 Department of Safety, Chemistry and Biomedical Laboratory Sciences, Western Norway University of Applied Sciences, Bergen, Norway. 7 Adaptive Biotechnologies, Seattle, WA, USA. 8 Department of Research and Development, Haukeland University Hospital, Bergen, Norway. 9 Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. 10 Department of Global Public Health and Primary Care, University of Bergen; Bergen, Norway.

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Capelle CM, et al.
Cell Reports Medicine
May 2022
Authors and Affiliates
Christophe M Capelle 1,2, Séverine Ciré 1, Olivia Domingues 1, Isabelle Ernens 3, Fanny Hedin 4, Aurélie Fischer 3, Chantal J Snoeck 1, Wim Ammerlaan 5, Maria Konstantinou 4, Kamil Grzyb 6, Alexander Skupin 6,7, Cara L Carty 8, Christiane Hilger 1, Georges Gilson 9, Aljosa Celebic 10, Paul Wilmes 2,6, Antonio Del Sol 6,11,12, Ian M Kaplan 8, Fay Betsou 5,13, Tamir Abdelrahman 13, Antonio Cosma 4, Michel Vaillant 10, Guy Fagherazzi 3, Markus Ollert 1,14, Feng Q Hefeng 1; 1 Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg. 2 Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. 3 Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. 4 National Cytometry Platform, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. 5 Integrated BioBank of Luxembourg (IBBL), Dudelange, Luxembourg. 6 Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg. 7 Department of Neuroscience, University California San Diego, La Jolla, CA, USA. 8 Adaptive Biotechnologies, Seattle, WA, USA. 9 Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg. 10 Translational Medicine Operations Hub, Competence Centre for Methodology and Statistics, Luxembourg Institute of Health, Strassen, Luxembourg. 11 CIC bioGUNE, Bizkaia Technology Park, Derio, Spain. 12 IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. 13 Laboratoire National de Santé (LNS), Dudelange, Luxembourg. 14 Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), University of Southern Denmark, Odense, Denmark.