Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis

Bonami RH, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Rachel H Bonami 1,2,3, Christina E Thurman 4, Sonam Verma 5, Camille S Westlake 4, Lindsay E Nyhoff 4, Bridgette B Barron 4, Andrea Reboldi 6, Peggy L Kendall 2,3,4,5; 1 Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. 2 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. 3 Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Nashville, TN, United States. 4 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States. 5 Department of Medicine, Division of Allergy and Immunology, Washington University School of Medicine, St. Louis, MO, United States. 6 Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, United States.

Durable Expansion of TCR-δ Meta-Clonotypes After BCG Revaccination in Humans

James CA, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Charlotte A James 1, Krystle K Q Yu 1, Koshlan Mayer-Blackwell 2, Andrew Fiore-Gartland 2, Malisa T Smith 1, Erik D Layton 1, John L Johnson 3, Willem A Hanekom 4, Thomas J Scriba 4, Chetan Seshadri 1,5; 1 Department of Medicine, University of Washington, Seattle, WA, United States. 2 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. 3 Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, United States. 4 South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. 5 Tuberculosis Research and Training Center, University of Washington, Seattle, WA, United States.

KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Li J, et al.
Science
May 2022
Authors and Affiliates
Jing Li 1, Maxim Zaslavsky 2, Yapeng Su 3, Jing Guo 4, Michael J Sikora 5, Vincent van Unen 1, Asbjørn Christophersen 6,7,8, Shin-Heng Chiou 1, Liang Chen 1, Jiefu Li 9, Xuhuai Ji 10, Julie Wilhelmy 1, Alana M McSween 1, Brad A Palanski 11, Venkata Vamsee Aditya Mallajosyula 1, Nathan A Bracey 1, Gopal Krishna R Dhondalay 12, Kartik Bhamidipati 13, Joy Pai 13, Lucas B Kipp 14, Jeffrey E Dunn 14, Stephen L Hauser 15, Jorge R Oksenberg 15, Ansuman T Satpathy 16, William H Robinson 17,18, Cornelia L Dekker 19, Lars M Steinmetz 5,20,21, Chaitan Khosla 11,22,23, Paul J Utz 1,18, Ludvig M Sollid 6,7,8,24, Yueh-Hsiu Chien 1,4, James R Heath 3,25, Nielsen Q Fernandez-Becker 26, Kari C Nadeau 1 12, Naresha Saligrama 1, Mark M Davis 1,9,4; 1 Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. 2 Program in Computer Science, Stanford University, Stanford, CA, USA. 3 Institute for Systems Biology, Seattle, WA, USA. 4 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. 5 Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. 6 K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway. 7 Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 8 Department of Immunology, University of Oslo, Oslo, Norway. 9 The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. 10 Human Immune Monitoring Center, Stanford University School of Medicine, Stanford, CA, USA. 11 Department of Chemistry, Stanford University, Stanford, CA, USA. 12 Sean N. Parker Center for Allergy and Asthma Research, Department of Medicine, Stanford University, Stanford, CA, USA. 13 Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA. 14 Division of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. 15 Department of Neurology and UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. 16 Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. 17 VA Palo Alto Health Care System, Palo Alto, CA, USA. 18 Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA. 19 Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. 20 Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA. 21 European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany. 22 Department of Chemical Engineering, Stanford University, Stanford, CA, USA. 23 Stanford ChEM-H, Stanford University, Stanford, CA, USA. 24 Department of Immunology, Oslo University Hospital, Oslo, Norway. 25 Department of Bioengineering, University of Washington, Seattle, WA, USA. 26 Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, CA, USA.

SARS-CoV-2 (COVID-19)-specific T cell and B cell responses in convalescent rheumatoid arthritis: Monozygotic twins pair case observation

Arruda LCM, et al.
Scandinavian Journal of Immunology
May 2022
Authors and Affiliates
Lucas C M Arruda 1, Ahmed Gaballa 1, Rui Da Silva Rodrigues 2, Bartek Makower 3, Michael Uhlin 1,2,4; 1 Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden. 2 Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden. 3 Mabtech AB, Nacka Strand, Sweden. 4 Department of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden.

Randomized Mechlorethamine/Chlormethine Induced Dermatitis Assessment Study (MIDAS) Establishes Benefit of Topical Triamcinolone 0.1% Ointment Cotreatment in Mycosis Fungoides

Alexander-Savino CV, et al.
February 2022
Authors and Affiliates
Carolina V Alexander-Savino 1, Catherine G Chung 2, Elaine S Gilmore 1, Sean M Carroll 1, Brian Poligone 3,4; 1 Rochester Skin Lymphoma Medical Group, 6800 Pittsford Palmyra Rd, Suite 150, Fairport, NY, 14450, USA. 2 Dermatology and Pathology, The Ohio State University, Columbus, OH, 43210, USA. 3 Rochester Skin Lymphoma Medical Group, 6800 Pittsford Palmyra Rd, Suite 150, Fairport, NY, 14450, USA. bpoligone@roclymphoma.com. 4 Rochester General Hospital Research Institute, Rochester, NY, 14621, USA. bpoligone@roclymphoma.com.

The T-cell clonal response to SARS-CoV-2 vaccination in inflammatory bowel disease patients is augmented by anti-TNF therapy and often deficient in antibody-responders

Li D, et al.
January 2022
Authors and Affiliates
Dalin Li, Alexander Xu, Emebet Mengesha, Rebecca Elyanow, Rachel M Gittelman, Heidi Chapman, John C Prostko, Edwin C Frias, James L Stewart, Valeriya Pozdnyakova, Philip Debbas, Angela Mujukian, Arash A Horizon, Noah Merin, Sandy Joung, Gregory J Botwin, Kimia Sobhani, Jane C Figueiredo, Susan Cheng, Ian M Kaplan, Dermot P B McGovern, Akil Merchant, Gil Y Melmed, Jonathan Braun;

K 2P 18.1 translates T cell receptor signals into thymic regulatory T cell development

Ruck T, et al.
November 2021
Authors and Affiliates
Tobias Ruck #,1,2, Stefanie Bock #,3, Steffen Pfeuffer 4, Christina B Schroeter 4, Derya Cengiz 4,3, Paul Marciniak 4,3, Maren Lindner 3, Alexander Herrmann 4, Marie Liebmann 3, Stjepana Kovac 3, Lukas Gola 3, Leoni Rolfes 4, Marc Pawlitzki 4 3, Nils Opel 5, Tim Hahn 5, Udo Dannlowski 5, Thomas Pap 6, Felix Luessi 7, Julian A Schreiber 8,9, Bernhard Wünsch 8, Tanja Kuhlmann 10, Guiscard Seebohm 9, Björn Tackenberg 11, Patricia Seja 12, Frank Döring 13, Erhard Wischmeyer 13, Achmet Imam Chasan 14, Johannes Roth 14, Luisa Klotz 3, Gerd Meyer Zu Hörste 3, Heinz Wiendl 3, Tobias Marschall 15, Stefan Floess 16, Jochen Huehn 16, Thomas Budde 17, Tobias Bopp 18, Stefan Bittner 7, Sven G Meuth 4,3; 1 Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. tobias.ruck@med.uni-duesseldorf.de. 2 Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. tobias.ruck@med.uni-duesseldorf.de. 3 Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. 4 Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. 5 Institute for Translational Psychiatry, University of Münster, Münster, Germany. 6 Institute of Experimental Musculoskeletal Medicine (IMM), University of Münster, Münster, Germany. 7 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. 8 Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany. 9 Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases (IfGH), University of Münster, Münster, Germany. 10 Institute of Neuropathology, University of Münster, Münster, Germany. 11 Department of Neurology, Philipps-University, Marburg, Germany. 12 Laboratory of Neurobiology, University of Helsinki, Helsinki, Finland. 13 Molecular Electrophysiology, Institute of Physiology and Center of Mental Health, University of Würzburg, Würzburg, Germany. 14 Institute of Immunology, University of Münster, Münster, Germany. 15 Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. 16 Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany. 17 Institute for Physiology I, University of Münster, Münster, Germany. 18 Institute of Immunology, Focus Program Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. # Contributed equally.

Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

Lee JW, et al.
September 2021
Authors and Affiliates
Jihoon W Lee 1, Yapeng Su 2,3,4, Priyanka Baloni 5, Daniel Chen 5, Ana Jimena Pavlovitch-Bedzyk 6, Dan Yuan 5, Venkata R Duvvuri 5, Rachel H Ng 5, Jongchan Choi 5, Jingyi Xie 5, Rongyu Zhang 5, Kim Murray 5, Sergey Kornilov 5, Brett Smith 5, Andrew T Magis 5, Dave S B Hoon 7, Jennifer J Hadlock 5, Jason D Goldman 8,9,10, Nathan D Price 5,11, Raphael Gottardo 12,13,14, Mark M Davis 6,5,16, Leroy Hood 5,9, Philip D Greenberg 17,18, James R Heath 19,20; 1 Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 2 Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. suyapeng.tju@gmail.com. 3 Institute for Systems Biology, Seattle, WA, USA. suyapeng.tju@gmail.com. 4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. suyapeng.tju@gmail.com. 5 Institute for Systems Biology, Seattle, WA, USA. 6 Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. 7 St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA. 8 Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USA. 9 Providence St. Joseph Health, Renton, WA, USA. 10 Division of Allergy & Infectious Diseases, University of Washington, Seattle, WA, USA. 11 Department of Bioengineering, University of Washington, Seattle, WA, USA. 12 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 13 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 14 Department of Statistics, University of Washington, Seattle, WA, USA. 15 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. 16 The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. 17 Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pgreen@uw.edu. 18 Departments of Immunology and Medicine, University of Washington, Seattle, WA, USA. pgreen@uw.edu. 19 Institute for Systems Biology, Seattle, WA, USA. jim.heath@isbscience.org. 20 Department of Bioengineering, University of Washington, Seattle, WA, USA. jim.heath@isbscience.org.

Acute exercise increases immune responses to SARS CoV-2 in a previously infected man

Baker FL, et al.
September 2021
Authors and Affiliates
Forrest L Baker 1,2, Kyle A Smith 1, Tiffany M Zúñiga 1, Helena Batatinha 1, Grace M Niemiro 2, Charles R Pedlar 3, Shane C Burgess 4,5, Emmanuel Katsanis 2,6,5,7,8, Richard J Simpson 1,2,6,5; 1 Department of Nutritional Sciences, University of Arizona, Tucson, AZ, United States. 2 Department of Pediatrics, University of Arizona, Tucson, AZ, USA. 3 Faculty of Sport, Health and Applied Performance Science, St. Mary's University, London, United Kingdom. 4 Department of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, United States. 5 Department of Immunobiology, University of Arizona, Tucson, AZ, United States. 6 The University of Arizona Cancer Center, Tucson, AZ, USA. 7 Department of Medicine, University of Arizona, Tucson, AZ, United States. 8Department of Pathology, University of Arizona, Tucson, AZ, United States.