Therapeutic Area: Infectious Disease

Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice

Carey et al.
Journal of Immunology
Papers
March 2016
immuneAccess
Authors and Affiliates
Alison J. Carey*,†, Donald T. Gracias†,1, Jillian L. Thayer†, Alina C. Boesteanu†,2,Ogan K. Kumova†, Yvonne M. Mueller†,‡, Jennifer L. Hope†,‡, Joseph A. Fraietta§,David B. H. van Zessen‡,¶ and Peter D. Katsikis†,‡ *Pediatrics, Drexel University College of Medicine, Philadelphia, PA 19102; †Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102; ‡Immunology, Erasmus University Medical Center, 015 N Rotterdam, the Netherlands; §Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104; and ¶Bioinformatics, Erasmus University Medical Center, 3015 CN Rotterdam, the Netherlands

Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses

Jing et al.
Journal of Hepatology
Papers
January 2016
Authors and Affiliates
Jing L#1, Laing KJ#1, Dong L1, Russell RM1, Barlow RS2, Haas JG3,4, Ramchandani MS1, Johnston C1, Buus S5, Redwood AJ6, White KD7, Mallal SA6,7, Phillips EJ6,7, Posavad CM8,9, Wald A1,10,8,9, Koelle DM1,2,8,9,11. 1 Department of Medicine, University of Washington, Seattle, USA. 2 Department of Global Health, University of Washington, Seattle, USA. 3 Max von Pettenkofer-Institute, Munich, Germany. 4 Division of Pathway Medicine, University of Edinburgh, United Kingdom. 5 Laboratory of Experimental Immunology, University of Copenhagen, Copenhagen, Denmark. 6 Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia. 7 Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA. 8 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, USA. 9 Department of Laboratory Medicine, University of Washington, Seattle, USA. 10 Department of Epidemiology, University of Washington, Seattle, USA. 11 Benaroya Research Institute, Seattle, USA. # Contributed equally.

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

Hanley, et al.
Papers
Science Translational Medicine Editorial
April 2015
Authors and Affiliates
Patrick J. Hanley,1,2,3 Jan J. Melenhorst,4 Sarah Nikiforow,5 Phillip Scheinberg,4 James W. Blaney,1 Gail Demmler-Harrison,6 C. Russell Cruz,1,3 Sharon Lam,1,2,3 Robert A. Krance,1,6,7 Kathryn S. Leung,1,6 Caridad A. Martinez,1,6 Hao Liu,1 Daniel C. Douek,8 Helen E. Heslop,1,6,7 Cliona M. Rooney,1,2,6,7,9 Elizabeth J. Shpall,10 A. John Barrett,4 John R. Rodgers,2 Catherine M. Bollard1,2,3,6,7* 1Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA. 2 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. 3 Program for Cell Enhancement and Technologies for Immunotherapy, The Sheikh Zayed Institute for Pediatric Surgical Innovation, the Center for Cancer and Immunology Research, and the Division of Blood and Marrow Transplantation, Children’s National Health System and The George Washington University, Washington, DC 20052, USA. 4 Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. 5 Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney St., Boston, MA 02115, USA. 6 Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. 7 Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. 8 Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 9 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. 10Department of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX 77030, USA.

High Expression of CD26 Accurately Identified Human Bacterial-reactive MR1-restricted MAIT cells

Sharma et al.
Journal of Immunology
Papers
February 2015
Authors and Affiliates
Sharma PK1, Wong EB2,3, Napier RJ1, Bishai WR3,4, Ndung'u T2,3, Kasprowicz VO2,5,6, Lewinsohn DA7,9, Lewinsohn DM1,8,9, Gold MC1,8,9 Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, OR1; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Durban, South Africa2; Division of Infections Diseases, Massachusetts General Hospital, Boston, MA3; Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD4; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA5; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, South Africa6; Pediatrics, Oregon Health & Science University, Portland OR7; Portland VA Medical Center, Portland, OR8; Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR9

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

Conti et al.
Journal of Experimental Medicine
Papers
September 2014
Authors and Affiliates
Heather R. Conti,1 Alanna C. Peterson,1 Lucas Brane,1 Anna R. Huppler,5Nydiaris Hernández-Santos,1 Natasha Whibley,1 Abhishek V. Garg,1Michelle R. Simpson-Abelson,1 Gregory A. Gibson,4 Anna J. Mamo,1Lisa C. Osborne,6 Shrinivas Bishu,2 Nico Ghilardi,7 Ulrich Siebenlist,8Simon C. Watkins,4 David Artis,6 Mandy J. McGeachy,1,3 and Sarah L. Gaffen1,3 1Division of Rheumatology and Clinical Immunology, and 2Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, 3Department of Immunology, and 4Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA 15261, 5Department of Infectious Diseases, Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224, 6Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 7Department of Immunology, Genentech Inc., South San Francisco, CA 94080, 8Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852

Membrane association of the CD3ε signaling domain is required for optimal T cell development and function

Bettini et al.
Journal of Immunology
Papers
July 2014
Authors and Affiliates
Bettini ML1, Guy C1, Dash P1, Vignali KM1, Hamm DE2, Dobbins J3, Gagnon E3, Thomas PG1, Wucherpfennig KW3, Vignali DA4. 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN. 2Adaptive Biotechnologies, Seattle, WA. 3Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA. 4Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.

Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

Maldonado et al.
Papers
Science Translational Medicine
January 2014
Authors and Affiliates
Maldonado L1*, Teague JE2*, Morrow MP3*, Jotova I4, Wu TC5, Wang C6, Desmarais C7, Boyer JD8, Tycko B4, Robins HS9, Clark RA2, Trimble CL1,5,10 1 Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. 2 Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA. 3 Inovio Pharmaceuticals Inc., 1787 Sentry Parkway West, Building 18, Suite 400, Blue Bell, PA 19422, USA. 4 Department of Pathology and Cell Biology and Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10025, USA. 5 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. 6 Oncology Biostatistics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. 7 Adaptive Biotechnologies, 1551 Eastlake Avenue, Seattle, WA 98102, USA. 8 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 9 Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. 10 Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. * Contributed equally